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| 1 | Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease:An observation on non-absorbable antibiotics显示文摘AIM: To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis of irritable bowel disease (IBS) in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO. METHODS: A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis.. RESULTS: When the patients underwent a 'breath test', 33 (45.2%) showed the presence of a SIBO. After treatment with rifaximin 1200 mg/d for seven days in 32 patients, 19 (59.4%) showed a negative 'breath test' one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, 'breath test' remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative 'breath test' in one patient only. CONCLUSION: (1) about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; (2) only a 'breath test' with lactulose (or with glucose in subjects with an intolerance to lactose) can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and (3) the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO. | I Esposito A de Leone G Di Gregorio S Giaquinto L de Magistris A Ferrieri G Riegler | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 3 | Recurrent aggressive mesenteric desmoid tumor successfully treated with sorafenib: A case report and literature review显示文摘BACKGROUND Desmoid tumors(DT) are locally advanced but histologically benign monoclonal neoplasms that can occur from any musculoaponeurotic structure. The aim of this report is to analyze a rare clinical case of an aggressive intra-abdominal DT successfully treated with sorafenib.CASE SUMMARY A 36-year-old man presented with increasing colicky abdominal pain and a selfpalpable mass in his left abdomen. Fourteen years earlier he was diagnosed with a large intra-abdominal tumor, which adhered to the left colonic flexure, part of the major gastric curvature and the spleen. Subsequent exploratory laparotomy revealed a voluminous mass in the epigastrium, arising from the posterior surface of the stomach and invading the superior mesenteric vessels, transverse mesocolon and the small bowel mesentery. As the tumor was unresectable, a jejunojejunal bypass was performed. Traditional therapeutic interventions proved insufficient, and the patient was started on sorafenib with a subsequent fulldisease response.CONCLUSIONDT's pathogenesis has been associated with mutations in the adenomatous polyposis coli(APC) gene or beta-catenin gene CTNNB1, sex steroids or previous surgical trauma. Local treatment modalities, such as surgery or radiotherapy, are implemented in aggressively progressing or symptomatic patients. Sorafenib is a hopeful therapeutic option against DTs, while several pharmacological agents have been successfully used. | Aikaterini Mastoraki Dimitrios Schizas Chrysovalantis Vergadis Leon Naar Alexios Strimpakos Michail G Vailas Natasha Hasemaki George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos | 2019 | World Journal of Clinical Oncology2019，10，4： | 4 |
| 4 | Loss of glom erular function and tubulointerstitial fibrosis cause or effect显示文摘 | Albert C M O Leon G F | 1994 | Kidney Internationall1994，45，： | 1 |
| 5 | Incidence and susceptibility to therapy- related myeloid neoplasms 显示文摘 | Leone G Fianchi L Pagano L | 2010 | Chem Biol Interact2010，184，12： | 1 |
| 6 | Facilitated transport of copper through bulk liquid membranes containing different carriers : compared kinetic study 显示文摘 | Leon G Guzman M A | 2008 | Desalination2008，223，13： | 1 |
| 7 | E2F3 activity is regulated during the cell cycle and is required for the induction of S phase显示文摘 | LEONE G DEGREGORI J YAN Z | 1998 | Genes Dev1998，12，14： | 1 |
| 8 | Existence and construction of finite frames显示文摘 | CASAZZA P G LEON M | 2006 | J Concr Appl Math2006，4，3： | 1 |
| 9 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 10 | Short-lasting unilateral neuralgiform headache with tearing and conjunctival injection: the first 'symptomatic' case显示文摘 | Bussone G Leone M Volta GD | 1991 | Cephalagia1991，11，3： | 1 |
| 11 | Gastric leak after sleeve gastrectomy : analysis of its management 显示文摘 | de Aretxabala X Leon Wiedmaier G | 2011 | Obes Surg2011，21，8： | 1 |
| 12 | Monochromatic excimer light 308 nm in the treatment of vitiligo : a pilot study 显示文摘 | Leone G Lacovelli P Paro A | 2003 | J Eur Acad Dermatol Venereol2003，17，： | 1 |
| 13 | The dependency of microstructure and properties of nanostructured coatings on plasma spray conditions 显示文摘 | Leon L Shaw Daniel G | 2000 | Surface and Coatings Technology2000，130，： | 1 |
| 14 | Human challenges in polar and space enviroument显示文摘 | SANDAL G M LEON G R PALINKAS L A | 2006 | Reviews in Environmental Science and Bio/technology2006，，5： | 1 |
| 15 | Preliminary evidence ofan adolescent HIV/AIDS peer education program显示文摘 | Mahat G Scoloveno MA De Leon T | 2008 | J PediatrNurs2008，23，5： | 1 |
| 16 | Laparoscopic management of small bowel obstruction: indications and outcome显示文摘 | Leon E L Metzger A Tsiotos G G | 1998 | J Gastrointest Surg1998，2，2： | 1 |
| 17 | Impact of cold flow improvers on soybean bio-diesel blend 显示文摘 | Chuang-Wei Chiu Leon G Schumacher | 2004 | Biomass and Bio-energy2004，27，： | 1 |
| 18 | Hemorrhagic complications of anticoagulant treatment显示文摘 | Leone MN Raskob G Landefeld S et a1 | 2001 | Chest2001，119，1： | 1 |
| 19 | Power-electronic systems for the grid integration of renewable energy sources: A survey 显示文摘 | CARRASCO J M FRANQUELO L G BIALASIEWICZ J T GALVAN E GUISADO R C P PRATS M A M LEON J I MORENO N | 2006 | IEEE Transactions on Industrial Electronics2006，53，4： | 1 |
| 20 | Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression显示文摘 | Perissinotto E Cavalloni G Leone F | | 0，，2： | 1 |
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