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| 1 | Effects of resveratrol and other polyphenols in hepatic steatosis显示文摘Non-alcoholic fatty liver disease covers a wide spectrum of liver pathologies which range from simple steatosis to non-alcoholic steatohepatitis.Polyphenols are members of a very large family of plant-derived compounds that can have beneficial effects on human health,and thus their study has become an increasingly important area of human nutrition research.The aim of the present review is to compile published data concerning the effects of both isolated polyphenols as well as polyphenol extracts,on hepatocyte and liver fat accumulation under different steatosis-inducing conditions.The results reported clearly show that this group of biomolecules is able to reduce fat accumulation,but further studies are needed to establish the optimal dose and treatment period length.With regard to the potential mechanisms of action,there is a good consensus.The anti-lipidogenic effect of polyphenols is mainly due to reduced fatty acid and triacylglycerol synthesis,increased in fatty acid oxidation,and reduced of oxidative stress and inflammation.As a general conclusion,it can be stated that polyphenols are biomolecules which produce hepatoprotective effects.To date,these beneficial effects have been demonstrated in cultured cells and animal models.Thus,studies performed in humans are needed before these molecules can be considered as truly useful tools in the prevention of liver steatosis. | Leixuri Aguirre Maria Puy Portillo Elizabeth Hijona Luis Buja | 2014 | World Journal of Gastroenterology2014，20，23： | 11 |
| 2 | Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet显示文摘 | Goiuri Alberdi Víctor M. Rodríguez M. Teresa Macarulla Jonatan Miranda Itziar Churruca María P. Portillo | 2013 | Nutrition2013，，： | 3 |
| 3 | Food groups, diet quality and colorectal cancer risk in the Basque Country显示文摘BACKGROUND The results obtained to date concerning food groups,diet quality and colorectal cancer(CRC)risk vary according to criteria used and the study populations.AIM To study the relationships between food groups,diet quality and CRC risk,in an adult population of the Basque Country(North of Spain).METHODS This observational study included 308 patients diagnosed with CRC and 308 ageand sex-matched subjects as controls.During recruitment,dietary,anthropometric,lifestyle,socioeconomic,demographic and health status information was collected.Adherence to the dietary recommendations was evaluated utilizing the Healthy Eating Index for the Spanish Diet and the MedDietScore.Conditional logistic regressions were used to evaluate the associations of food group intakes,diet quality scores,categorized in tertiles,with CRC risk.RESULTS The adjusted models for potential confounding factors showed a direct association between milk and dairy products consumption,in particular high-fat cheeses[odds ratio(OR)third tertile vs first tertile=1.87,95%confidence intervals(CI):1.11-3.16],and CRC risk.While the consumption of fiber-containing foods,especially whole grains(OR third tertile vs first tertile=0.62,95%CI:0.39-0.98),and fatty fish(OR third tertile vs first tertile=0.53,95%CI:0.27-0.99)was associated with a lower risk for CRC.Moreover,higher MD adherence was associated with a reduced CRC risk in adjusted models(OR third tertile vs first tertile=0.40,95%CI:0.20-0.80).CONCLUSION Direct associations were found for high-fat cheese,whereas an inverse relation was reported for fiber-containing foods and fatty fish,as well as adherence to a Mediterranean dietary pattern. | Iker Alegria-Lertxundi Carmelo Aguirre Luis Bujanda Francisco J Fernandez Francisco Polo JoseMªOrdovas MªCarmen Etxezarraga Inaki Zabalza Mikel Larzabal Isabel Portillo Marian M de Pancorbo Koldo Garcia-Etxebarria Ana MªRocandio Marta Arroyo-Izaga | 2020 | World Journal of Gastroenterology2020，26，28： | 3 |
| 4 | Colorectal and interval cancers of the Colorectal Cancer Screening Program in the Basque Country (Spain)显示文摘AIM To assess proportions, related conditions and survival of interval cancer(IC).METHODS The programme has a linkage with different clinical databases and cancer registers to allow suitable evaluation. This evaluation involves the detection of ICs after a negative faecal inmunochemical test(FIT), interval cancer FIT(IC-FIT) prior to a subsequent invitation, and the detection of ICs after a positive FIT and confirmatory diagnosis without colorectal cancer(CRC) detected and before the following recommended c o l o n o s c o p y, I C-c o l o n o s c o p y. W e c o n d u c t e d a retrospective observational study analyzing from January 2009 to December 2015 1193602 invited people onto the Programme(participation rate of 68.6%).RESULTS Two thousand five hundred and eighteen cancers were diagnosed through the programme, 18 cases of IC-colonoscopy were found before the recommended follow-up(43542 colonoscopies performed) and 186 IC-FIT were identified before the following invitation of the 769200 negative FITs. There was no statistically significant relation between the predictor variables of ICs with sex, age and deprivation index, but there was relation between location and stage. Additionally, it was observed that there was less risk when the location was distal rather than proximal(OR = 0.28, 95%CI: 0.20-0.40, P < 0.0001), with no statistical significance when the location was in the rectum as opposed to proximal. When comparing the screen-detected cancers(SCs) with ICs, significant differences in survival were found(P < 0.001); being the 5-years survival for SCs 91.6% and IC-FIT 77.8%.CONCLUSION These findings in a Population Based CRC Screening Programme indicate the need of population-based studies that continue analyzing related factors to improve their detection and reducing harm. | Isabel Portillo Eunate Arana-Arri Isabel Idigoras Isabel Bilbao Lorea Martínez-Indart Luis Bujanda Inaki Gutierrez-Ibarluzea | 2017 | World Journal of Gastroenterology2017，23，15： | 2 |
| 5 | Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress显示文摘 | S. Gómez-Zorita A. Fernández-Quintela M. T. Macarulla L. Aguirre E. Hijona L. Bujanda F. Milagro J. A. Martínez M. P. Portillo | 2011 | British Journal of Nutrition2011，，2： | 2 |
| 6 | Properties of Chemical Bath Deposited PbS Thin Films Doped with Cd2+显示文摘 | Oscar Portillo Moreno Melissa Chavez Portillo Miriam Moreno Flores Javier Martinez Juarez Gustavo Abarca Avila Rosendo Lozada Morales Orlando Zelaya Angel | 2011 | 材料科学与工程(中英文A版)2011，1，6： | 2 |
| 7 | Characterization and design of the digital pointing subsystem for optical communication demonstrator显示文摘 | CAROLINE Racho ANGEL Portillo | 1999 | SPIE1999，3615，： | 2 |
| 8 | Intermittent Androgen Deprivation for Locally Advanced and Metastatic Prostate Cancer: Results from a Randomised Phase 3 Study of the South European Uroncological Group显示文摘 | Fernando E.C. Calais da Silva Aldo V. Bono Peter Whelan Maurizio Brausi Anton Marques Queimadelos Jose A. Portillo Martin Ziya Kirkali Fernando M.V. Calais da Silva Chris Robertson | 2009 | European Urology2009，，6： | 2 |
| 9 | Characterization of Chemical Bath Deposited CdSe Thin Films Doped with S^2-显示文摘 | Jorge Indalecio Contreras Rascon Oscar Portillo Moreno Gustavo Abarca Avila Jorge R. Cerna Juan Hernandez Tecorralco Javler Martinez Juare Rosendo Lozada Morales Orlando Zelaya Angel | 2011 | 材料科学与工程(中英文B版)2011，1，5： | 2 |
| 10 | Nitrate stimulation of indigenous nitrate-reducing, sulfide-oxidising bacterial community in wastewater anaerobic blofilms 显示文摘 | Juan Garcia-de-Lomas Alfonso Corzo Portillo M Carmen | 2007 | Water Research2007，41，14： | 1 |
| 11 | Nitric-oxide-directed synaptie remodeling in the adult mamml CNS 显示文摘 | Sunieo C R Portillo F Gonzalez Forero D | 2005 | Neuroscience2005，25，6： | 1 |
| 12 | Stu-dy of the Role of a Particulate Folatebinding Protein in the Uptake of 5-Methyltetrahydrofolate显示文摘 | Antony AC Kane MA Portillo RM | 1985 | J Biol Chem1985，260，14： | 1 |
| 13 | Long-term calciantion/ carbonation cycling and thermal pretreatment for CO2 capture by limestone and dolomite显示文摘 | CHEN Z X SONG H S PORTILLO M | 2009 | Energy & Fuels2009，23，3： | 1 |
| 14 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 15 | Fine pointingcontrol for optical communications显示文摘 | Portillo A A Ortiz G G Racho C | 2001 | IEEE Aerospace Conference Proceedings2001，3，： | 1 |
| 16 | Photoluminescence of Rhodamine 6G-doped amorphous TiO2 thin films grown by sol-gel 显示文摘 | PALOMINO M R TORRES K J LOZADA M R PORTILLO M O GARCIA R M ZELAYA A O | 2007 | Vacuum2007，81，1112： | 1 |
| 17 | Laparoscopic monitored colonoscopic polypectomy:long-term follow-up显示文摘 | Franklin ME Jr Portillo G | 2009 | World J Surg2009，33，6： | 1 |
| 18 | The use of porcine small intestinal submucosa as a prosthetic material for laparoscopic hernia repair in infected and poten- tially contaminated fields: long-term follow-up 显示文摘 | FRANKLIN M E TREVI? O J M PORTILLO G | 2008 | Surg En- dose2008，22，： | 1 |
| 19 | Transcriptional regulation of cadherins during develotmaent and carcinogenesis 显示文摘 | Peinado H Portillo F Carlo A | 2004 | lnt J Dev Biol2004，48，36： | 1 |
| 20 | Percutane- ous nephrostomy versus ureterat stents for diversion of hydrone- phrosis caused by stones: a prospective, randomized clinical trial 显示文摘 | Mokhmalji H Braun PM Martinez Portillo FJ | 2001 | J Urol2001，165，： | 1 |
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