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| 1 | Pancreatits after endoscopic retrograde cholangio-pancreatography显示文摘Pancreatitis is the most common complication after endoscopic retrograde cholangio-pancreatography (ERCP); the reported incidence of this complication varies from less than 1% to 40%, but a rate of 4%-8% is reported in most prospective studies involving non-selected patients. Differences in criteria for defining pancreatitis, methods of data collection, and patient populations (i.e. number of high-risk patients included in the published series) are factors that are likely to affect the varying rates of post-ERCP pancreatitis. The severity of post-ERCP pancreatitis (PEP) can range from a minor inconvenience with one or two days of added hospitalization with full recovery to a devastating illness with pancreatic necrosis, multiorgan failure, permanent disability, and even death. Although, most episodes of PEP are mild (about 90%), a small percentage of patients (about 10%) develop moderate or severe pancreatitis. In the past, PEP was often viewed as an unpredictable and unavoidable complication, with no realistic strategy for its avoidance. New data have aided in stratifi cation of patients into PEP risk categories and new measures have been introduced to decrease the risk of PEP. As most ERCPs are performed on an outpatient basis, the majority of patients will not develop PEP and can be discharged. Alternatively, early detection of those patients who will go on to develop PEP can guide decisions regarding hospital admission and aggressive management. In the last decade, great efforts have been addressed toward prevention of this complication. Points of emphasis have included technical measures, pharmacological prophylaxis, and patient selection. This review provides a comprehensive, evidence-based assessment of published data on PEP and current suggestions for its avoidance. | Ayman M Abdel Aziz Glen A Lehman | 2007 | World Journal of Gastroenterology2007，13，19： | 19 |
| 2 | Pyruvate kinase M2 regulates homologous recombination- mediated DNA double-strand break repair显示文摘到 genotoxic 治疗的抵抗是治疗失败和肿瘤复发的一个主要原因。激活 DNA 损坏反应(DDR ) 并且允许癌症房间逃离 genotoxic 治疗的致命的效果的内在的机制仍然保持不清楚。这里,我们揭开通过的意外机制 pyruvate kinase M2 (PKM2 ) ,在癌症房间的高度表示的 PK isoform 和癌症的一个主人管理者新陈代谢的 reprogramming,与 DDR 集成直接支持 DNA 双海滨裂缝(DSB ) 修理。响应电离放射和氧化应力,在导致它的原子累积的 T328 的 ATM phosphorylates PKM2。pT328-PKM2 被要求并且对足够支持通过到在 DNA 的 DSB 和切除术的增加 CtIPs 招募的 T126 上的交往 CtBP 蛋白质(CtIP ) 的 phosphorylation 的调停的 DNA DSB 修理结束的相应再结合(HR ) 。ATM-PKM2-CtIP 轴的混乱敏化癌症房间到许多损坏 DNA 代理人和 PARP1 抑制。而且,增加了原子 pT328-PKM2 水平在 glioblastoma 病人与显著地更坏的幸存被联系。联合,这些数据倡导者是的指向 PKM2 策略的使用不仅破坏癌症新陈代谢而且禁止抵抗的重要机制到 genotoxic 治疗的一个工具。 | Steven T. Sizemore Manchao Zhang Ju Hwan Cho Gina M. Sizemore Brian Hurwitz Balveen Kaur Norman L. Lehman Michael C. Ostrowski Pierre A. Robe Weili Miao Yinsheng Wang Arnab Chakravarti Fen Xia | 2018 | Cell Research2018，28，11： | 5 |
| 3 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 3 |
| 4 | Phase-II Study of Gemcitabine and Cisplatin in Patients with Metastatic Biliary and Gallbladder Cancer显示文摘 | Jeffrey A. Meyerhardt Andrew X. Zhu Keith Stuart David P. Ryan Lawrence Blaszkowsky Nicole Lehman Craig C. Earle Matthew H. Kulke Pankaj Bhargava Charles S. Fuchs | 2008 | Digestive Diseases and Sciences2008，，2： | 2 |
| 5 | 原位肝移植术后成功进行内镜下吻合口狭窄治疗:胆总管狭窄的复发率 | Alazmi W.M. Fogel E.L. Watkins J.L. G. Lehman 程妍 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，11： | 2 |
| 6 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 7 | Biliary tract complications after orthotopic liver transplantation with choledochocholedochostomy anastomosis: endoscopic findings and results of therapy显示文摘 | Rungsun Rerknimitr Stuart Sherman Evan L. Fogel Cem Kalayci Lawrence Lumeng Naga Chalasani Paul Kwo Glen A. Lehman | 2002 | Gastrointestinal Endoscopy2002，，2： | 2 |
| 8 | Colonoscopic miss rates of adenomas determined by back-to-back colonoscopies显示文摘 | DK Rex CS Cutler GT Lemmel EY Rahmani DW Clark DJ Helper GA Lehman DG Mark | 1997 | Gastroenterology1997，，： | 2 |
| 9 | Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones显示文摘 | James A. DiSario Martin L. Freeman David J. Bjorkman Padraic MacMathuna Bret T. Petersen Philip E. Jaffe Thomas G. Morales Lee J. Hixson Stuart Sherman Glen A. Lehman M. Mazen Jamal Firas H. Al-Kawas Mukul Khandelwal Joseph P. Moore Gregory A. Derfus Priy | 2004 | Gastroenterology2004，，： | 2 |
| 10 | Efficacy of diclofenac in the prevention of post-ERCP pancreatitis in predominantly high-risk patients: a randomized double-blind prospective trial显示文摘 | Young Koog Cheon Kwang Bum Cho James L. Watkins Lee McHenry Evan L. Fogel Stuart Sherman Suzette Schmidt Laura Lazzell-Pannell Glen A. Lehman | 2007 | Gastrointestinal Endoscopy2007，，6： | 2 |
| 11 | Fertility and cytological studies of a dihaploid plant of alfalfa(Medicago sativa显示文摘 | Clement W M Lehman W F | 1962 | Crop Sci1962，2，： | 1 |
| 12 | Screening women at high risk for breast cancer with mammography and magnetic resonance imaging显示文摘 | Lehman CD Blume JD Weatherall P | 2005 | Cancer2005，103，9： | 1 |
| 13 | PGC-1alpha deficiency causes multi-system energy metabolic derangements:muscle dysfunction, abnormal weight control and hepatic steatosis显示文摘 | Leone T C Lehman J J Finck B N | 2005 | PLoS Biol2005，3，4： | 1 |
| 14 | Plant diversity and ecosystem productivity:Theoretical considerations显示文摘 | Tilman D Lehman C L Bristow C E | 1997 | Proceedings of the National Academy of Sciences1997，94，： | 1 |
| 15 | Integrated magnetic full wave converter with flexible output inductor显示文摘 | Liang Yan Dayu Q Lehman B | 2003 | IEEE Transactions on Power Electronics2003，18，2： | 1 |
| 16 | Endoscopic sphincterotomy complicatrions and their management: an attempt at consensus显示文摘 | Cotton PB Lehman G Vennes J | 1991 | Gastrointest Endosc1991，37，3： | 1 |
| 17 | The role of BNP testing in heart failure显示文摘 | Doust J Lehman R Glasziou P | 2006 | Am Fam Physician2006，7，11： | 1 |
| 18 | Difficult bille duct stones 显示文摘 | McHenr i L Lehman G | 2006 | Curt Treat Options Gastroenterol2006，9，2： | 1 |
| 19 | A new classification of thoracolumbar injuries:the importance of injury morphology,the integrity of the posterior ligamentous complex, and neurologic status显示文摘 | Vaccaro AR Lehman RA Jr Hurlbert R J | 2005 | Spine2005，30，20： | 1 |
| 20 | Straight -forward ver- sus anatomic trajectory technique of thoracic pedicle screw fixation : a biomechanical analysis 显示文摘 | Lehman RA Jr Polly DW Jr Kuklo TR | 2003 | Spine2003，28，： | 1 |
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