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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Douglas gemmill: determining fabrication orientations for rapid prototyping with stereolithography apparatus显示文摘 | Lan P T Chon S Y Chen L L | 1997 | Computer-Aided Design1997，29，1： | 2 |
| 3 | Telomerase activity in pleural effusions diagnostic significance显示文摘 | CHENG T Y LEE M H LAN R S | 1998 | J Clin Oncol1998，16，4： | 2 |
| 4 | The prevalence of dementia in urban and rural areas of China显示文摘 | Jianping Jia Fen Wang Cuibai Wei Aihong Zhou Xiangfei Jia Fang Li Muni Tang Lan Chu Youlong Zhou Chunkui Zhou Yong Cui Qi Wang Weishan Wang Peng Yin Nan Hu Xiumei Zuo Haiqing Song Wei Qin Liyong Wu Dan Li Longfei Jia Juexian Song Ying Han Yi Xing Peijie Y | 2013 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2013，，： | 2 |
| 5 | 显示文摘 | Chen L C Hsu C Y Lan W H | 2003 | Solid-State Electronics2003，47，： | 1 |
| 6 | Characterization of polymorphisms of transferrin receptor and their association with susceptibility to ETEC F4ab/ac in pigs 显示文摘 | WANG Y REN J LAN L | 2007 | J Anim Breed Genet2007，124，4： | 1 |
| 7 | Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients显示文摘 | Dai Y Sui W Lan H | 2009 | Rheumatol Int2009，29，7： | 1 |
| 8 | Use of genetic mouse models in the study of diabetic nephropathy显示文摘 | Allen T J Cooper M E Lan H Y | 2004 | Curr Diab Rep2004，4，6： | 1 |
| 9 | Transcriptional profile of shrimp white spot syndrome virus(WSSV)genes with DNA microarray显示文摘 | Lan Y Xu X Yang F | 2006 | Archives of Hrology2006，151，： | 1 |
| 10 | Effect of Nb microalloying and hot rolling on microstructure and properties of Ultrathin Cast Strip Steels produced by the Castrip Process显示文摘 | Kelvin Y Xie Lan Yao Chen Zhu | 2011 | Metallurgical and Materials Transactions A2011，8，42： | 1 |
| 11 | 'Alternatively actlvated' dendritic cells preferentially secrete IL-10, expand Foxp5 + CIM + T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig显示文摘 | Lan Y Y Wang Z Raimondi G | 2006 | J Immunol2006，177，9： | 1 |
| 12 | Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion 显示文摘 | Zaqzaq D Lukyanov Y Lan L | 2006 | Lab Invest2006，86，12： | 1 |
| 13 | PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resis- tance in patients显示文摘 | Nagata Y Lan KH Zhou X | 2004 | Cancer Cell2004，6，2： | 1 |
| 14 | Hypoxanthine (HX) inhibition of in vitro meiotic resumption in goat oocytes 显示文摘 | Ma S Lan G Miao Y | 2003 | Mol Reprod Dev2003，66，3： | 1 |
| 15 | Real-Time Noncrosstalk Sonar Sys|em by Short Optimized Pulse Position Modulation Sequences 显示文摘 | Meng Q H Lan S Y Yao Z J | 2009 | IEEE Transactions on Instrumentation and Measurement2009，58，10： | 1 |
| 16 | Ag/AgBr/TiO2 visible light photocatalyst for destruction of azodyes and bacteria显示文摘 | Hu C Lan Y Q Qu J H | 2006 | Journal of Physical Chemistry B2006，110，9： | 1 |
| 17 | Moisture adsorption rates by different forms of rice 显示文摘 | Lan Y Kunze O R | 1996 | Trans of the ASAE1996，39，3： | 1 |
| 18 | PTEN activation contributes to tumor inhibition by trastuzumab,and loss of PTEN predicts trastuzumab resistance in patients显示文摘 | Nagata Y Lan K H Zhou X | | 0，，02： | 1 |
| 19 | Identification of a divergent Oacetyltransferase gene oaclb from Shigella flexneri serotype 1b strains显示文摘 | Sun Q Lan R Wang Y | | 0，，21： | 1 |
| 20 | Influence of environmen-tal factors on prevalence,symptoms,and pathologic process of chronic prostatitis/chronic pelvic pain syn-drome in northwest China显示文摘 | Lan T Wang YM Chen Y | | 0，，5： | 1 |
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