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| 1 | Critical illness polyneuropathy and myopathy:a systematic review显示文摘Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles,respectively.Clinically,they manifest as limb and respiratory muscle weakness.Critical illness polyneuropathy/myopathy in isolation or combination increases intensive care unit morbidity via the inability or difficulty in weaning these patients off mechanical ventilation.Many patients continue to suffer from decreased exercise capacity and compromised quality of life for months to years after the acute event.Substantial progress has been made lately in the understanding of the pathophysiology of critical illness polyneuropathy and myopathy.Clinical and ancillary test results should be carefully interpreted to differentiate critical illness polyneuropathy/myopathy from similar weaknesses in this patient population.The present review is aimed at providing the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical,diagnostic,differentiating,and treatment information for this debilitating neurological disease. | Chunkui Zhou Limin Wu Fengming Ni Wei Ji Jiang Wu Hongliang Zhang | 2014 | Neural Regeneration Research2014，9，1： | 15 |
| 2 | The prevalence of dementia in urban and rural areas of China显示文摘 | Jianping Jia Fen Wang Cuibai Wei Aihong Zhou Xiangfei Jia Fang Li Muni Tang Lan Chu Youlong Zhou Chunkui Zhou Yong Cui Qi Wang Weishan Wang Peng Yin Nan Hu Xiumei Zuo Haiqing Song Wei Qin Liyong Wu Dan Li Longfei Jia Juexian Song Ying Han Yi Xing Peijie Y | 2013 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2013，，： | 2 |
| 3 | Suppression of corneal neovascularization by PEDF release from human amniotic membranes invest ophthalmol显示文摘 | Chunkui S Jing S Sarah X | 2004 | Vis Sci2004，45，6： | 1 |
| 4 | Suppression of Corneal Neovescularization by PEDF Release from Human Amniotic Membranes显示文摘 | Chunkui Shao Jing Sima Sarah X | 2004 | Invest Ophthalmol Vis Sci2004，45，： | 1 |
| 5 | Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in glioma U87 cells显示文摘Studies have shown that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exhibits strong induction of apoptosis in human glioma cells. It remains unclear whether the mitochondrion pathway, an important apoptosis signaling pathway, is involved in TRAIL-induced glioma cell apoptosis. In the present study, in vitro cultured human glioma U87 cells were treated with human recombinant soluble TRAIL. Apoptosis of glioma U87 cells, mitochondrial transmembrane potential (ΔΨm), cytoplasmic cytochrome c concentration and changes in caspase-3, -8 and -9 activity following human recombinant soluble TRAIL treatment were investigated to determine the mechanism of glioma U87 cell apoptosis induced by TRAIL. Additionally, blocking caspase-8 resulted in TRAIL-induced mitochondrion pathway activation, suggesting that TRAIL, through activating caspase-8, initiated a series of mitochondrial events and resulted in apoptosis of glioma U87 cells. | Fei Zhong Xiangyuan Wu Chunkui Shao Qu Lin Min Dong Jingyun Wen Xiaokun Ma Li Wei | 2010 | Neural Regeneration Research2010，5，17： | 0 |
| 6 | Post-traumatic stress disorder:a psychiatric disorder requiring urgent attention显示文摘Post-traumatic stress disorder(PTSD)is a severe and heterogenous psychiatric disorder that was first defined as a mental disorder in 1980.Currently,the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition(DSM-5)and the International Classification of Diseases 11th Edition(ICD-11)offer the most widely accepted diagnostic guidelines for PTSD.In both diagnostic categories,experiencing a traumatic event(TE)is the necessary criterion for diagnosing PTSD.The TEs described in the DSM-5 include actual or threatened death,serious injury,sexual violence,and other extreme stressors,either directly or indirectly.More than 70%of adults worldwide are exposed to a TE at least once in their lifetime,and approximately 10%of individuals develop PTSD after experiencing a TE.The important features of PTSD are intrusion or re-experiencing fear memories,pervasive sense of threat,active avoidance,hyperarousal symptoms,and negative alterations of cognition and mood.Individuals with PTSD have high comorbidities with other psychiatric diseases,including major depressive disorder,generalized anxiety disorder,and substance use disorder.Multiple lines of evidence suggest that the pathophysiology of PTSD is complex,involving abnormal neural circuits,molecular mechanisms,and genetic mechanisms.A combination of both psychotherapy and pharmacotherapy is used to treat PTSD,but has limited efficacy in patients with refractory PTSD.Because of the high prevalence,heavy burden,and limited treatments,PTSD is a psychiatric disorder that requires urgent attention.In this review,we summarize and discuss the diagnosis,prevalence,TEs,pathophysiology,and treatments of PTSD and draw attention to its prevention. | Jun Du Huapeng Diao Xiaojuan Zhou Chunkui Zhang Yifei Chen Yan Gao Yizheng Wang | 2022 | Medical Review2022，2，3： | 0 |
| 7 | STN-ANT plasticity is crucial for the motor control in Parkinson’s disease model显示文摘Dear Editor,Motor control as a function of the basal ganglia circuit is crucial for every aspect of life and movement disorders,such as Parkinson’s disease(PD).In PD,the progressive denervation of dopamine in the dorsal striatum leads to inhibition of the direct pathway and facilitation of the indirect pathway and results in activation of the subthalamic nucleus(STN)and globus pallidus internus(GPi),two important nuclei in the motor loop of basal ganglia. | Hui Zhang Chunkui Zhang Zhongwei Qu Bing Li Yujuan Su Xia Li Yan Gao Yizheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
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