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| 1 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 2 | Dextran sulfate sodium-induced acute colitis impairs dermal lymphatic function in mice显示文摘AIM: To investigate whether dermal lymphatic function and architecture are systemically altered in dextran sulfate sodium(DSS)-induced acute colitis.METHODS: Balb/c mice were administered 4% DSS in lieu of drinking water ad libitum for 7 d and monitored to assess disease activity including body weight, diarrhea severity, and fecal bleeding. Control mice received standard drinking water with no DSS. Changes in mesenteric lymphatics were assessed following oral administration of a fluorescently-labelled fatty acid analogue, while dermal lymphatic function and architecture was longitudinally characterized using dynamic near-infrared fluorescence(NIRF) imaging following intradermal injection of indocyanine green(ICG) at the base of the tail or to the dorsal aspect of the left paw prior to, 4, and 7 d after DSSadministration. We also measured dye clearance rate after injection of Alexa680-bovine serum albumin(BSA). NIRF imaging data was analyzed to reveal lymphatic contractile activity after selecting fixed regions of interest(ROIs) of the same size in fluorescent lymphatic vessels on fluorescence images. The averaged fluorescence intensity within the ROI of each fluorescence image was plotted as a function of imaging time and the lymphatic contraction frequency was computed by assessing the number of fluorescent pulses arriving at a ROI. RESULTS: Mice treated with DSS developed acute inflammation with clinical symptoms of loss of body weight, loose feces/watery diarrhea, and fecal blood, all of which were aggravated as disease progressed to 7 d. Histological examination of colons of DSS-treated mice confirmed acute inflammation, characterized by segmental to complete loss of colonic mucosa with an associated chronic inflammatory cell infiltrate that extended into the deeper layers of the wall of the colon, compared to control mice. In situ intravital imaging revealed that mice with acute colitis showed significantly fewer fluorescent mesenteric lymphatic vessels, indicating impaired uptake of a lipid tracer within mesenteric lymphatics. Our in vivo NIRF imaging data demonstrated dilated dermal lymphatic vessels, which were confirmed by immunohistochemical staining of lymphatic vessels, and significantly reduced lymphatic contractile function in the skin of mice with DSS-induced acute colitis. Quantification of the fluorescent intensity remaining in the depot as a function of time showed that there was significantly higher Alexa680-BSA fluorescence in mice with DSSinduced acute colitis compared to pre-treatment with DSS, indicative of impaired lymphatic drainage.CONCLUSION: The lymphatics are locally and systemically altered in acute colitis, and functional NIRF imaging is useful for noninvasively monitoring systemic lymphatic changes during inflammation. | Germaine D Agollah Grace Wu Ho-Lan Peng Sunkuk Kwon | 2015 | World Journal of Gastroenterology2015，21，45： | 2 |
| 3 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 4 | Effects of thermal and chemical surface-flame interaction on flame quenching显示文摘 | KIM K T LEE D H KWON S | 2006 | Combust and Flame2006，146，： | 1 |
| 5 | Adjuvant carboplatin and paclitaxel chemotherapy interposed with involved field radiation for advanced endometrial cancer显示文摘 | Lupe K D'Souza DP Kwon JS | 2009 | Gynecol Oncol2009，114，1： | 1 |
| 6 | 显示文摘 | Kang SM Kwon HM Kim D | 2000 | Yonsei Med J2000，41，1： | 1 |
| 7 | Regulation of ILlheta-mediated MUC2 gene in NCI-H292 human airway epithelial cells显示文摘 | Kim Y D Kwon E J Raque G H | 2000 | Biochem Biophys Res Commum2000，274，5： | 1 |
| 8 | CPW-fed planar ultra wideband antenna having a frequency band notch function 显示文摘 | KIM Y KWON D H | 2004 | Electronics Letters2004，40，7： | 1 |
| 9 | High-performance, nano-structured LiMnPO4 synthesized via a polyol method 显示文摘 | WANG D Y BUQA H CROUZET M DEGHENGHI G DREZENT EXNAR I KWON N H MINERS J H POLETTO L GRATZEL M | 2009 | J Power Sources2009，189，1： | 1 |
| 10 | Structural evolution of a high Tc ferroelectric xBi (Znl/2Til/2 )O3 -( 1-x) PbTiO3 solid solution 显示文摘 | Zhang X D Kwon D Kim B G | 2008 | Applied Physics Letters2008，92，82： | 1 |
| 11 | Inhibitory effect of soybean and fermented soyben products on the chemically induced mutagenesis显示文摘 | Yoon K D Kwon D J Hong S S | 1996 | Kor J Appl Microbiol Biolechnol1996，24，： | 1 |
| 12 | Structural character- ization of wavelength-dependent Raman scattering and laser-in- duced crystallization of silicon thin films显示文摘 | LEE Y J KWON J D KIM D H etal | 2013 | Thin Solid Films2013，542，： | 1 |
| 13 | Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance(MDR) reversal activity显示文摘 | Min Y D Kwon H C Yang M C | 2007 | Arch Pharm Res2007，30，1： | 1 |
| 14 | Satellite Selection Scheme for Reducing Handover Attempts in LEO Satellite Communication Systems显示文摘 | KWON Y YOUNG Y J SUNG D | 1998 | International Journal of Satellite Communications1998，16，4： | 1 |
| 15 | Evaluation of fracture toughness by small-punch testing techniques using sharp notched specimens显示文摘 | Ju J B Jang J Kwon D | 2003 | International Journal of Pressure Vessels & Piping2003，80，4： | 1 |
| 16 | et al The Effect of the Steam Temperature Fluctuations During Steady State Operation on the Remnant Life of the Super- heater Header显示文摘 | Kwon O Myers M Karstensen A D Knowles | 2006 | International Journal of Pressure Vessels and Piping2006，83，： | 1 |
| 17 | Computational model of emotion generation for human-robot interaction based on the cognitive appraisal theory显示文摘 | Kim H R Kwon D S | 2010 | Journal of Intelligent and Robotic Systems Theory and Applications2010，60，2： | 1 |
| 18 | Rolled fingerprint construction using MRF-based nonrigid image registration显示文摘 | KWON D YUN I D LEE S U | 2010 | Image Processing2010，19，12： | 1 |
| 19 | Segmentingthe Non-adopter Category in the Diffusion of InternetBanking显示文摘 | LEE E J KWON K N SCHUMANN D W | 2005 | International Journal of Bank Market-ing2005，23，5： | 1 |
| 20 | Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage显示文摘 | Liu XH Kwon D Schielke GP | 1999 | J Cereb Blood Flow Metab1999，19，10： | 1 |
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