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| 1 | Disease activity and cancer risk in inflammatory bowel disease associated with primary sclerosing cholangitis显示文摘AIM: To investigate the phenotype of inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD). METHODS: Data from 75 PSC-IBD patients evaluated in our tertiary center between 1963 and 2006 were collected and compared to 150 IBD patients without PSC, matched for sex, birth date, IBD diagnosis date and initial disease location regarding ileal, different colonic segments, and rectum, respectively. RESULTS: While PSC-IBD patients received more 5-aminosalicylates (8.7 years/patient vs 2.9 years/ patient, P < 0.001), they required less immuno-suppressors (24% vs 46% at 10 years; P < 0.001) and less intestinal resection (10% vs 44% at 10 years, P < 0.001). The 25-year cumulative rate of colectomy was 25.1% in PSC-IBD and 37.3% in controls (P = 0.004). The 25-year cumulative rate of colorectal cancer was 23.4% in PSC-IBD vs 0% in controls (P = 0.002). PSC was the only independent risk factor for the development of colorectal cancer (OR = 10.8; 95% CI, 3.7-31.3). Overall survival rate without liver transplantation was reduced in PSC-IBD patients (67% vs 91% in controls at 25 years, P = 0.001).CONCLUSION: This study confirms that patients with PSC-IBD have a particular disease phenotype independent of the initial disease location. Although their disease is less active and they use more 5-aminosalicylates, they present a higher risk of colorectal cancer. | Harry Sokol Jacques Cosnes Olivier Chazouilleres Laurent Beaugerie Emmanuel Tiret Raoul Poupon Philippe Seksik | 2008 | World Journal of Gastroenterology2008，14，22： | 10 |
| 2 | Clinical,serological and genetic predictors of inflammatory bowel disease course显示文摘Patients with extensive or complicated Crohn's disease(CD) at diagnosis should be treated straightaway with immunosuppressive therapy according to the most recent guidelines.In patients with localized and uncomplicated CD at diagnosis,early use of immunosuppressive therapy is debated for preventing disease progression and limiting the disabling clinical impact.In this context,there is a need for predictors of benign or unfavourable subsequent clinical course,in order to avoid over-treating with risky drugs those patients who would have experienced spontaneous mid-term asymptomatic disease without progression towards irreversible intestinal lesions.At diagnosis,an age below 40 years,the presence of perianal lesions and the need for treating the first flare with steroids have been consistently associated with an unfavourable subsequent 5-year or 10-year clinical course.The positive predictive value of unfavourable course in patients with 2 or 3 predictors ranges between 0.75 and 0.95 in population-based and referral centre cohorts.Consequently,the use of these predictors can be integrated into the elements that influence individual decisions.In the CD postoperative context,keeping smoking and history of prior resection are the stron-gest predictors of disease symptomatic recurrence.However,these clinical predictors alone are not as reliable as severity of early postoperative endoscopic recurrence in clinical practice.In ulcerative colitis(UC),extensive colitis at diagnosis is associated with unfavourable clinical course in the first 5 to 10 years of the disease,and also with long-term colectomy and colorectal inflammation-associated colorectal cancer.In patients with extensive UC at diagnosis,a rapid step-up strategy aiming to achieve sustained deep remission should therefore be considered.At the moment,no reliable serological or genetic predictor of inflammatory bowel disease clinical course has been identified. | Laurent Beaugerie Harry Sokol | 2012 | World Journal of Gastroenterology2012，18，29： | 8 |
| 3 | Wnt signaling through T-cell factor phosphorylation显示文摘胚胎的发信号小径经常从缺省压抑导致一个开关到目标基因的 transcriptional 激活。Wnt 发信号的主要后果是 β 的稳定;把因素(TCF ) 与 T 房间联系并且从抑压者把他们“变换成” transcriptional 使活跃之物的 -catenin, 。为这个变换遗体负责的分子的机制糟糕理解。几研究由 phosphorylation 在 TCF 的规定上报导了,还它的生理的意义是不清楚的:在一些情况中,它看起来支持目标基因激活,在其它 Wnt 依赖的抄写被禁止。这评论由 Wnt 发信号在 TCF 功能的上下文依赖者 translational 以后规定的理解集中于最近的进步。 | Sergei Y Sokol | 2011 | Cell Research2011，21，7： | 5 |
| 4 | Faecalibacterium prausnitzii and human intestinal health显示文摘 | S Miquel R Martín O Rossi LG Bermúdez-Humarán JM Chatel H Sokol M Thomas JM Wells P Langella | 2013 | Current Opinion in Microbiology2013，，： | 3 |
| 5 | High-pressure synthesis and characterization of diamond from a sulfur–carbon system显示文摘 | Yu Pal’yanov Yu Borzdov I Kupriyanov V Gusev A Khokhryakov A Sokol | 2001 | Diamond & Related Materials2001，，： | 2 |
| 6 | Reducing role of sulfides and diamond formation in the Earth’s mantle显示文摘 | Yu.N. Palyanov Yu.M. Borzdov Yu.V. Bataleva A.G. Sokol G.A. Palyanova I.N. Kupriyanov | 2007 | Earth and Planetary Science Letters2007，，： | 2 |
| 7 | Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis显示文摘AIM:To evaluate whether crypt abscesses frominflammatory bowel disease(IBD)patients containbacteria and to establish their nature.METHODS:We studied 17 ulcerative colitis patients,11 Crohn's disease patients,7 patients with acute selflimited colitis(ASLC)and normal colonic biopsies from5 subjects who underwent colonoscopy for colon cancer screening.A fluorescent in situ hybridization techniquewas applied to colonic biopsies to assess the microbiotacomposition of the crypts and crypt abscesses.RESULTS:Crypts colonized by bacteria were observedin 42.9%and 3.6%of ASLC and IBD patients,respectively(P=0.019).Crypt abscesses colonized bybacteria were observed in 28.6%and 0.0%of ASLCand IBD patients,respectively(P=0.035).CONCLUSION:These results do not support thehypothesis that crypt abscesses in IBD are the resultof localized dysbiosis arising from persistence of livingbacteria colonizing the crypts. | Harry Sokol Nadia Vasquez Nadia Hoyeau-Idrissi Philippe Seksik Laurent Beaugerie Anne Lavergne-Slove Philippe Pochart Philippe Marteau | 2010 | World Journal of Gastroenterology2010，16，5： | 2 |
| 8 | Automated erosion wheel : A new measuring device for field erosion plots 显示文摘 | Klik A Sokol W Steindel F | 2004 | Journal of Soil and Water Conservation2004，，3： | 1 |
| 9 | Unraveling the pathogenesis and etiology of biliary atresia显示文摘 | Mack CL Sokol RJ | | 0，，5： | 1 |
| 10 | A mechanism for the initiation of allergen-induced T helper type 2 responses显示文摘 | Sokol C.L Barton G.M Farr | | 0，，03： | 1 |
| 11 | Patient characteristics that are associated with continued pessary use versus surgery after 1 year显示文摘 | Clemons JL Aguilar VC Sokol ER | 2004 | Am J Obstet Gynecol2004，191，1： | 1 |
| 12 | Ferric uptake regulator (Fur) mutants of Pseudomonas aeruginosa demonstrate defective siderophore-mediated iron uptake, altered aerobic growth, and decreased superoxide dismutase and catalase activities显示文摘 | Hassett D J Sokol P A Howell M L Ma J F Schweizer H T | 1996 | Journal of Bacteriology1996，178，14： | 1 |
| 13 | Effect of retinal blur on the peak latency of the pattern evoked potential显示文摘 | Sokol S Moskowitz A | 1981 | Vision Res1981，21，8： | 1 |
| 14 | Pathogenesis and outcome of biliary atresia:current concepts显示文摘 | Sokol B J Mack C Narkewicz MR | 2003 | J Pediatr Gastroenterol Nutr2003，37，1： | 1 |
| 15 | Frodo interacts with Dishevelled to transduce Wnt signals显示文摘 | Gloy J Hikasa H Sokol SY | 2002 | Nat CeU Biol2002，4，5： | 1 |
| 16 | Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is requ!red in muscles during larval growth显示文摘 | Sokol N S Ambros V | 2005 | Genes Dev2005，19，19： | 1 |
| 17 | Unraveling the pathogenesis and etiology of biliary atresia显示文摘 | Mack CL Sokol RJ | 2005 | Pediatr Res2005，57，52： | 1 |
| 18 | Simultaneous electroretinograms and visually evoked potential from adult amblyopia in response to a pattern stimulus显示文摘 | Sokol S Nadler D | 1979 | Invest Oph thalmol Vis Sci1979，18，8： | 1 |
| 19 | Oxidant injury to hepatic mitochondria in patients with Wilson' s disease and Bedlington terriers with copper toxicosis显示文摘 | SOKOL R J TWEDT D MCKIM JM Jr | 1994 | Gastroenterology1994，107，6： | 1 |
| 20 | Hepatobiliary disease in neonatal lupus: prevalence and clinical characteristics in cases enrolled in a national registry 显示文摘 | Lee LA Sokol RJ Buyon JP | 2002 | Pediatrics2002，109，1： | 1 |
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