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| 1 | Association of psychological risk factors and acute myocardial infarction in China: the INTER-HEART China study显示文摘背景关于关于尖锐心肌的梗塞(AMI ) 的心理因素的大多数数据从在西方的国家执行的研究被获得。从在中国的小描述的代表性的研究的结果是不确定的。这研究的目的是与这研究是的大规模盒子控制 study.Methods 在中国人口之中探索在心理风险因素和 AMI 之间的可能的协会内部心的中国学习的部分,心血管的风险因素的大国际内部心的学习的自己部分。在这盒子控制研究, 2909 个盒子和 2947 控制从 17 cities.Psychological 应力被招募,否定生活事件,生活情形的消沉和可控制性是案例报导了的 assessed.Results 在家或工作和机会比率( ORs )的更心理的应力是 3.2 (95% CI 2.1-4.9 )为永久应力并且 2.1 (95% CI 1.5-2.8 )为应力的几个时期分别地。更多的案例与控制(19.6% 对 9.3%) 相比经历了消沉, ORs 是 2.2 (95% CI 1.9-2.6 ) 。分别地,有 1, 2 和 3 的题目或更压抑的症状由 2.1, 2.2 和 2.6 褶层增加了 AMI 的风险即,更压抑的症状与 AMI (为趋势 0.0001 的 P ) 的更高的风险被联系。女人们从消沉有 AMI 的更大的风险(或 3.0, 95% CI 2.2-4.0 ) 与男人相比(或 2.0, 95% CI 1.6-2.4 ) ,为相互作用 =0.0364 的 P。在题目的否定生活事件与 AMI 的增加的风险被联系,或 1.7 (95% CI 1.4-2.0 ) 为一个事件并且 1.8 (95% CI 1.3-2.4 ) 为二或更多的事件。生活情形的可控制性的高水平为 AMI 减少了风险(或 0.8, 95%CI 0.7-1 .0 ).Conclusions 几个心理因素仔细在中国 population.Psychological 应力之中与增加的 AMI 风险被联系在男人有更大的 AMI 风险,但是消沉在女人之中是更重要的。 | XU Tao LI Wei Koon Teo WANG Xing-yu LIU Li-sheng Salim Yusuf | 2011 | Chinese Medical Journal2011，，14： | 29 |
| 2 | Immunomodulation by mesenchymal stem cells:Interplay between mesenchymal stem cells and regulatory lymphocytes显示文摘Mesenchymal stem cells(MSCs) possess immunomodulatory properties, which confer enormous potential for clinical application. Considerable evidence revealed their efficacy on various animal models of autoimmune diseases, such as multiple sclerosis, systemic lupus erythematosus and uveitis. MSCs elicit their immunomodulatory effects by inhibiting lymphocyte activation and proliferation, forbidding the secretion of proinflammatory cytokines, limiting the function of antigen presenting cells, and inducing regulatory T(Treg) and B(Breg) cells. The induction of Treg and Breg cells is of particular interest since Treg and Breg cells have significant roles in maintaining immune tolerance. Several mechanisms have been proposed regarding to the MSCs-mediated induction of Treg and Breg cells. Accordingly, MSCs induce regulatory lymphocytes through secretion of multiple pleiotropic cytokines, cell-to-cell contact with target cells and modulation of antigen-presenting cells. Here, we summarized how MSCs induce Treg and Breg cells to provoke immunosuppression. | Oscar Ka-Fai Ma Koon Ho Chan | 2016 | World Journal of Stem Cells2016，8，9： | 15 |
| 3 | Pharmacokinetic Studies of Factor VIII in Chinese Boys with Severe Hemophilia A: A Single-Center Study显示文摘 | Zhen-Ping Chen Pei-jing Li Gang Li Ling Tang Ying-Zi Zhen Xin-Yi Wu Xiao-Ling Cheng Koon Hung Luke Victor S Blanchette Man-Chiu Poon Qiu-Lan Ding Run-Hui Wu | 2018 | Chinese Medical Journal2018，，15： | 11 |
| 4 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 5 | Survival analysis of cholangiocarcinoma:A 10-year experience in Malaysia显示文摘AIM:To investigate the clinical features and survival of patients treated for cholangiocarcinoma in our institution and to analyze the factors affecting their survival.METHODS:This retrospective cohort study assessed patients diagnosed with cholangiocarcinoma between January 1997 and December 2007 at the University Malaya Medical Centre in Malaysia.The clinical data and associated outcomes were collected using a structured proforma.RESULTS:Of the 69 patients diagnosed with cholangiocarcinoma,38 (55%) were male;mean patient age was 61 years.Twelve patients (17%) had intrahepatic,38 (55%) had perihilar and 19 (28%) had distal tumors.Only 12 patients underwent curative surgery,including seven R0 resections.Only one patient died within 30 d after surgery.The overall median survival was 4 mo,whereas the median survival of R0 resected patients was 16 mo.The overall 1-,2-and 3-year cumulative survival rates were 67%,17% and 17%,respectively.Survival rates were significantly associated with curative resection (P=0.002),intrahepatic tumor (P=0.003),negative margin status (P=0.013),early tumor stage (P=0.016),higher tumor differentiation (P=0.032) and absence of jaundice (P=0.038).Multivariate analysis showed that tumor location was a significant independent predictor of patient survival.CONCLUSION:Curative,margin-negative resection of early stage,well-differentiated intrahepatic tumors is associated with improved patient survival. | Ahmad Ramzi Yusoff Mohd Muzammil Abdul Razak Yoong Boon Koon R Vijeyasingam Siti Zuraidah Mahmud | 2012 | World Journal of Gastroenterology2012，18，5： | 7 |
| 6 | 乳化剂HLB值对棕榈油基乳液功能性质的影响显示文摘以搅打充气乳液为对象,运用Turbiscan、流变仪、粒度仪、显微镜测定乳液充气前后的物理稳定性,探究食品乳化剂HLB值(3. 8~15. 0)对棕榈油基乳液功能性质的影响。结果表明:HLB值在3. 8~10. 0范围对于乳液稳定性影响不明显,但进一步增加HLB值,导致乳液热稳定性下降,颗粒聚集严重;在低乳化剂HLB值(3. 8~10. 0)范围内,乳液搅打充气时间随着HLB值的增加而延长,样品起泡率也随之增加,但硬度变化不明显;当HLB值为10. 0时,乳液的搅打起泡率达到最大,为3. 17;进一步增加乳化剂HLB值(12. 0~15. 0),样品搅打充气时间明显缩短,表明乳液脂肪部分聚集更容易发生,但得到的样品硬度偏大,且样品的稳定性随着时间的延长明显下降。最终确定最佳乳化剂HLB值为10. 0。 | 金燕 蒋将 LO Seong Koon 梁新宇 PIATKO Michael CAMPBELL Shawn 刘元法 | 2018 | 中国油脂2018，43，12： | 6 |
| 7 | Robotic nurse duties in the urology operative room:11 years of experience显示文摘The robotic nurse plays an essential role in a successful robotic surgery.As part of the robotic surgical team,the robotic nurse must demonstrate a high level of professional knowledge,and be an expert in robotic technology and dealing with robotic malfunctions.Each one of the robotic nursing team“nurse coordinator,scrub-nurse and circulating-nurse”has a certain job description to ensure maximum patient’s safety and robotic surgical efficiency.Well-structured training programs should be offered to the robotic nurse to be well prepared,feel confident,and maintain high-quality of care. | Ali Abdel Raheem Hyun Jung Song Ki Don Chang Young Deuk Choi Koon Ho Rha | 2017 | Asian Journal of Urology2017，4，2： | 6 |
| 8 | Risk of complications and urinary incontinence following cytoreductive prostatectomy: a multi-institutional study显示文摘当时,新兴的证据建议了 cytoreductive 前列腺切除术(CRP ) 允许优异 oncologic 控制与照顾雄激素剥夺标准的电流相比治疗独自一个。然而,在变形前列腺癌症(mPCa ) 的 cytoreduction 的安全和利益没被证明。因此,我们评估了在最新与 mPCa 诊断的人跟随 CRP 的复杂并发症的发生。在四个第三级的外科的中心从 2006 ~ 2014 经历了 CRP 的 68 个病人的一个总数与为临床上局部性的前列腺癌症(PCa ) 经历了激进的前列腺切除术的 598 个人相比。尿不能自制被定义为任何垫的使用。CRP 有更长起作用的时间(200 min 对 140 min, P < 0.0001 ) 并且更高估计的血损失(250 ml 对 125 ml, P < 0.0001 ) 与控制组相比。然而,外套(8.82% 对 5.85%) 和主要复杂并发症率(4.41% 对 2.17%) 在二个组之间是可比较的。重要地,尿不能自制率在在外科以后 1 年在 CRP 组是显著地更高的(57.4% 对 90.8% , P < 0.0001 ) 。Univariate 逻辑分析证明估计的血损失在 unadjusted 模型两个都是 perioperative 复杂并发症的唯一的独立预言者(或:1.18;95% CI:1.02-1.37;P = 0.025 ) 并且外科调整类型的模型(或:1.17;95% CI:1.01-1.36;P = 0.034 ) 。在结论, CRP 比激进的前列腺切除术更挑战性、与尿不能自制的尤其是更高的发生联系。不过, CRP 是为选择谁的 PCa 病人的一个技术上可行、安全的手术与节点积极或多骨的转移在场当由富有经验的外科医生表现了时。未来的、多机构的临床的试用当前是在进行之中的验证这个概念。 | Dae Keun Kim Jaspreet Singh Parihar Young Suk Kwon Sinae Kim Brian Shinder Nara Lee Nicholas Farber Thomas Ahlering Douglas Skarecky Bertram Yuh Nora Ruel Wun-lae Kim Koon Ho Rha Isaac Yi Kim | 2018 | Asian Journal of Andrology2018，20，1： | 5 |
| 9 | Telmisartan, ramipril, or both in high-risk Chinese patients: analysis of ONTARGET China data显示文摘背景从进行中的 Telmisartan 的结果独自并且在有 Ramipril 全球端点试用( ONTARGET )的联合显示血管收缩素受体 blocker telmisartan 不低于在在高风险的病人为充血的心失败减少心血管的死亡,心肌的梗塞,击或住院的合成端点的 angiotensin-converting-enzyme 禁止者 ramipril ,并且 telmisartan 与稍微优异的 tolerability 被联系。没有利益的增加,二药的联合与更不利的事件被联系。这研究试图从从在中国注册的病人的亚群获得的 ONTARGET 分析数据并且评估人口统计并且基线特征,依从,功效,并且在在 1159 个高风险的病人全部的 China.Methods A 的使随机化的病人的不同治疗策略的安全被使随机化进三个治疗组:与 390 分配了收到 telmisartan 的 80 mg, 385 分配了收到 ramipril 的 10 mg, 384 分配了收到两学习药。中部的后续时期是 4.3 years.Results 中国病人的吝啬的年龄是 65.6 年, 73.6% 病人是男性的。有在在中国的基线的 stroke/transient ischemic 攻击的病人的比例是多于全部学习人口(47.7% 对 20.9%) 的 two times。在中国病人,学习药的永久中止的比例在 telmisartan 组由于咳嗽是 0.5% ,它多不到那在联合或 ramipril 组。在在中国病人的三个治疗组之中的主要结果的发生没有重要差别。更多的击比在全部学习人口(8.5% 对 4.5%) 发生在中国病人。更大的收缩血压减小( -9.8 mmHg ),并且更多的肾的功能失败比在 ramipril 或 telmisartan 组(2.6%对1.6%和1.0%)在那里的 .Conclusions 不是 ONTARGET 的结果关于主要结果的发生在中国病人和全部学习人口之间不同的证据的在联合治疗组被注意,特别地安全。对学习药的依从好。从 ONTARGET 的证据显示在 ONTARGET 的治疗策略对在中国的病人适用。 | YU Li-tian ZHU Jun TAN Hui-qiong WANG Guo-gan Koon K. Teo LIU Li-sheng | 2011 | Chinese Medical Journal2011，，12： | 5 |
| 10 | Influence of dietary patterns on the risk of acute myocardial infarction in China population: the INTERHEART China study显示文摘 | GUO Jin LI Wei WANG Yang CHEN Tao Koon Teo LIU Li-sheng Salim Yusuf | 2013 | Chinese Medical Journal2013，，3： | 4 |
| 11 | Comparison of Perioperative Outcomes Between Robotic and Laparoscopic Partial Nephrectomy: A Systematic Review and Meta-analysis显示文摘 | Ji Eun Choi Ji Hye You Dae Keun Kim Koon Ho Rha Seon Heui Lee | 2014 | European Urology2014，，： | 3 |
| 12 | 伴有特殊表型的Wiskott-Aldrich综合征3例显示文摘病例1 患儿,男,4个月。因发现血小板减少4月余,咳嗽50 d,发热4 d入院。患儿4个月前(生后2 d)发现血小板减少(PLT 22×10^9/L),外院经骨髓细胞学检查诊断为血小板减少性紫癜,口服泼尼松及静脉丙种球蛋白治疗,血小板正常后出院。出院后不规律口服泼尼松,2个月前停用,血小板波动于50~60×10^9/L。 | 贺建新 Chan Koon Wing 徐保平 刘秀云 桂晋刚 申昆玲 江载芳 Lau Yu Lung | 2017 | 中国当代儿科杂志2017，19，2： | 2 |
| 13 | Examining patterns of traditional chinese medicine use in pediatric oncology: A systematic review, meta-analysis and data-mining study显示文摘Background Traditional Chinese medicine(TCM)is becoming a popular complementary approach in pediatric oncology.However,few or no meta-analyses have focused on clinical studies of the use of TCM in pediatric oncology.Objective We explored the patterns of TCM use and its efficacy in children with cancer,using a systematic review,meta-analysis and data mining study.Search strategy We conducted a search of five English(Allied and Complementary Medicine Database,Embase,PubMed,Cochrane Central Register of Controlled Trials,and ClinicalTrials.gov)and four Chinese databases(Wanfang Data,China National Knowledge Infrastructure,Chinese Biomedical Literature Database,and VIP Chinese Science and Technology Periodicals Database)for clinical studies published before October 2021,using keywords related to“pediatric,”“cancer,”and“TCM.”Inclusion criteria We included studies which were randomized controlled trials(RCTs)or observational clinical studies,focused on patients aged<19 years old who had been diagnosed with cancer,and included at least one group of subjects receiving TCM treatment.Data extraction and analysis The methodological quality of RCTs and observational studies was assessed using the six-item Jadad scale and the Effective Public Healthcare Panacea Project Quality Assessment Tool,respectively.Meta-analysis was used to evaluate the efficacy of combining TCM with chemotherapy.Study outcomes included the treatment response rate and occurrence of cancer-related symptoms.Association rule mining(ARM)was used to investigate the associations among medicinal herbs and patient symptoms.Results The fifty-four studies included in this analysis were comprised of RCTs(63.0%)and observational studies(37.0%).Most RCTs focused on hematological malignancies(41.2%).The study outcomes included chemotherapy-induced toxicities(76.5%),infection rate(35.3%),and response,survival or relapse rate(23.5%).The methodological quality of most of the RCTs(82.4%)and observational studies(80.0%)was rated as“moderate.”In studies of leukemia patients,adding TCM to conventional treatment significantly improved the clinical response rate(odds ratio[OR]=2.55;95%confidence interval[CI]=1.49-4.36),lowered infection rate(OR=0.23;95%CI=0.13-0.40),and reduced nausea and vomiting(OR=0.13;95%CI=0.08-0.23).ARM showed that Radix Astragali,the most commonly used medicinal herb(58.0%),was associated with treating myelosuppression,gastrointestinal complications,and infection.Conclusion There is growing evidence that TCM is an effective adjuvant therapy for children with cancer.We proposed a checklist to improve the quality of TCM trials in pediatric oncology.Future work will examine the use of ARM techniques on real-world data to evaluate the efficacy of medicinal herbs and drug-herb interactions in children receiving TCM as a part of integrated cancer therapy. | Chun Sing Lam Li Wen Peng Lok Sum Yang Ho Wing Janessa Chou Chi-Kong Li Zhong Zuo Ho-Kee Koon Yin Ting Cheung | 2022 | Journal of Integrative Medicine2022，20，5： | 2 |
| 14 | An innovative way of etching MoS2: Characterization and mechanistic investigation显示文摘 | Yuan Huang Jing Wu Xiangfan Xu Yuda Ho Guangxin Ni Qiang Zou Gavin Kok Wai Koon Weijie Zhao A. H. Castro Neto Goki Eda Chengmin Shen Barbaros Ozyilmaz | 2013 | Nano Research2013，6，3： | 2 |
| 15 | Ultility of B-natriuretic peptide in identifying patients with left ventricular systolic or diastolic dysfunction显示文摘 | Krishnaswamy P Clopton P Koon J | 2001 | Am J Med2001，111，： | 2 |
| 16 | 丝胶生物吸附剂选择性去除废水中染料的评估(英文)显示文摘The silk sericin is the main residue in silk production and it is found to be a low cost and efficient biosorbent.In this study,sericin was characterized with various techniques including SEM(scanning electron microscope),XRD,N2 physisorption,FTIR(Fourier transformed infrared spectroscopy) and XPS(X-ray photoelectron spectroscopy).The nitrogen content of sericin was ca.8.5 mmol·g-1 according to elemental analysis.Dye adsorp-tion by sericin biosorbent was investigated with the acid yellow(AY),methylene blue(MB) and copper(II) phthalocyanine-3,4'4″4'″-tetrasulfonic acid(CuPc) dyes from water.Sericin displayed large capacity for AY and CuPc adsorption with adsorption capacities of respectively 3.1 and 0.35 mmol·g-1,but it did not adsorbed methylene blue dye.This selectivity is due to the basicity of amide groups in sericin biosorbents. | CHEN Xinqing LAM Koon Fung MAK Shuk Fong CHING Wai Kwong NG Tsz Nok YEUNG King Lun | 2012 | Chinese Journal of Chemical Engineering2012，20，3： | 2 |
| 17 | Utility of B-Natriuretic Peptide in Detecting Diastolic Dysfunction: Comparison With Doppler Velocity Recordings显示文摘 | Emily Lubien Anthony DeMaria Padma Krishnaswamy Paul Clopton Jen Koon Radmila Kazanegra Nancy Gardetto Erin Wanner Alan S. Maisel | 2002 | Circulation: Journal of the American Heart Association2002，，5： | 2 |
| 18 | 天然气分散制氢的技术经济分析(英文)显示文摘It is well established that hydrogen has the potential to make a significant contribution to the world energy production.In U.S.,majority of hydrogen production plants implement steam methane reforming(SMR) for centralized hydrogen production.However,there is a wide lack of agreement on the nascent stage of using hydrogen as fuel in vehicles industry because of the difficulty in delivery and storage.By performing technological and economic analysis,this work aims to establish the most feasible hydrogen production pathway for automotives in near future.From the evaluation,processes such as thermal cracking of ammonia and centralized hydrogen production followed by bulk delivery are eliminated while on-site steam reforming of methanol and natural gas are the most technologically feasible options.These two processes are further evaluated by comprehensive economic analysis.The results showed that the steam reforming(SR) of natural gas has a shorter payback time and a higher return on investment(ROI) and internal rate of return(IRR).Sensitivity analysis has also been constructed to evaluate the impact of variables like NG feedstock price,capital of investment and operating capacity factor on the overall production cost of hydrogen.Based on this study,natural gas is prompted to be the most economically and technologically available raw material for short-term hydrogen production before the transition to renewable energy source such as solar energy,biomass and wind power. | LUK Ho Ting LEI Ho Man NG Wai Yee LAM Koon Fung | 2012 | Chinese Journal of Chemical Engineering2012，20，3： | 2 |
| 19 | Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study显示文摘 | Koon K Teo Stephanie Ounpuu Steven Hawken MR Pandey Vicent Valentin David Hunt Rafael Diaz Wafa Rashed Rosario Freeman Lixin Jiang Xiaofei Zhang Salim Yusuf | 2006 | The Lancet . 2006 (9536)2006，，9536： | 2 |
| 20 | Complications of abdominal urologic laparoscopy:longitudinal five-year analysis显示文摘 | KELLOGG J P IOANNIS V A KOON H R | 2004 | Urology2004，63，1： | 1 |
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