|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases?显示文摘Thrombotic events,both arterial and venous,are a major health concern worldwide. Further,autoimmune diseases,such as systemic lupus erythematosus,anti-neutrophil cytoplasmic antibody(ANCA)-associated vasculitis,and antiphospholipid syndrome,predispose to thrombosis,and thereby push the risk for these morbid events even higher. In recent years,neutrophils have been identified as important players in both arterial and venous thrombosis. Specifically,chromatin-based structures called neutrophil extracellular traps(NETs) play a key role in activating the coagulation cascade,recruiting platelets,and serving as scaffolding upon which the thrombus can be assembled. At the same time,neutrophils and NETs are emerging as important mediators of pathogenic inflammation in the aforementioned autoimmune diseases. Here,we first review the general role of NETs in thrombosis. We then posit that exaggerated NET release contributes to the prothrombotic diatheses of systemic lupus erythematosus,ANCA-associated vasculitis,and antiphospholipid syndrome. | Ashish N Rao Nayef M Kazzaz Jason S Knight | 2015 | World Journal of Cardiology2015，7，12： | 6 |
| 3 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 4 | Neural origins of the P300 显示文摘 | Soltani M Knight R T | 2000 | Crit Rev Neurobiol2000，14，： | 1 |
| 5 | Clinical efficacy of a single injection of ceftiofur crystalline f ree acid sterile injectable suspension versus three daily injections of ceftiofur sodium sterile powder for t he treatment of foot rot in feedlot cattle显示文摘 | Van Donkersgoed J Dussault M Knight P | 2008 | Vet Ther2008，9，2： | 1 |
| 6 | Impact of small steel spheres on glass surfaces显示文摘 | Knight C G Swain M V Chaudhri M M | 1977 | Journal of Materials Science1977，12，8： | 1 |
| 7 | Protection against heat stress-inducedoxidative damage in Arabidopsis involves calcium,abscisic acid,ethylene,and salicylic acid显示文摘 | Larkindale J Knight M R | 2002 | Plant Physiol2002，128，2： | 1 |
| 8 | Plant thermal hysteresis proteins显示文摘 | URRUTIA M E DUMAN J G KNIGHT C A | 1992 | Biochim Biophys Acta1992，1121，1： | 1 |
| 9 | The Design of High - Efficiency Line -Start Motors显示文摘 | Andrew M Knight Catherine I McClay | 2000 | IEEE Transactions on Industry Applications2000，36，6： | 1 |
| 10 | Neutrophilia and congestive heart failure after acute myocardia linfarction显示文摘 | Kyne L Hausdorff J M Knight E | 2000 | Am Heart J2000，139，： | 1 |
| 11 | M, Toyoda T, Lee DA, et aL Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose 显示文摘 | Knight M | 2006 | J Biomech2006，39，： | 1 |
| 12 | Clinical significance of early recurrences of atril fibrilltion after pulmonry vein isolation 显示文摘 | Orai H Knight BP Ozaydin M el al | 2002 | J Am Cell Ca rdiol2002，40，1： | 1 |
| 13 | Prospective national study of acute fatty liver of pregnancy in the UK显示文摘 | Knight M Nelson -Piercy C Kurinczuk JJ | 2008 | Gut2008，57，： | 1 |
| 14 | Genome size evolu- tion in relation to leaf strategy and metabolic rates revisited 显示文摘 | Beaulieu J M Leitch I J Knight C A | 2007 | Annals of Botany2007，99，： | 1 |
| 15 | Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex 显示文摘 | Hamady M Walker JJ Harris JK Gold NJ Knight R | 2008 | Nat Methods2008，5，3： | 1 |
| 16 | Isoformselective phosphoinositide 3-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia:a novel therapeutic approach显示文摘 | Niedermeier M Hennessy BT Knight ZA | 2009 | Blood2009，113，22： | 1 |
| 17 | Pericentric inversion 9-incidence and clinical significance 显示文摘 | eo SH Tan M Knight L | 1995 | Ann Acad Med Singapore1995，24，2： | 1 |
| 18 | The association between mental health, physical function and hemdeialysis mortality显示文摘 | Knight EL Ofsthun N Teng M | 2003 | Kidney Int2003，，63： | 1 |
| 19 | Effect of residual stress on ACFM crack measurements in drill collar threaded connections显示文摘 | Knight M J Brennan F P Dover W D | 2004 | NDT & E International2004，37，5： | 1 |
| 20 | A new algorithm to reduce inappropriate therapy in the S-ICD system显示文摘 | Brisben AJ Burke M C Knight B P | 2015 | J Cardiovasc Electrophysiol2015，26，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员