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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | A new perspective on recent global warming:A symmetric trends of daily maximum and minimum temperature显示文摘 | Thomas R Karl Richord W Knight Kevin P Callo | 1993 | Bulletin of the American Meteorological Society1993，74，6： | 2 |
| 3 | Innovativeness: Its antecedents and impact on business performance显示文摘 | HULT GTM HURLEY R F KNIGHT G A | 2004 | Industrial Marketing Management2004，33，5： | 1 |
| 4 | Stimulation of c Jun kinase and mitogen-activated protein kinase by isehemia and reperfusion in the perfused rat heart 显示文摘 | KNIGHT R J BUXTON D B | 1996 | Biochemical and Biophysical Research Communications1996，218，： | 1 |
| 5 | Neural origins of the P300 显示文摘 | Soltani M Knight R T | 2000 | Crit Rev Neurobiol2000，14，： | 1 |
| 6 | A new perspec-tive on recent global warming:Asymmetric of dailymaximum and minimum temperature显示文摘 | Karl T RJ ones P D Knight R We t al | 1993 | Bulletin of theAmerican Meteorological Society1993，74，6： | 1 |
| 7 | Protection against heat stress-inducedoxidative damage in Arabidopsis involves calcium,abscisic acid,ethylene,and salicylic acid显示文摘 | Larkindale J Knight M R | 2002 | Plant Physiol2002，128，2： | 1 |
| 8 | Constructed wetlands for livestock wastewater management显示文摘 | Knight R L Payne Jr V W E Borer R E | 2000 | Ecological Engineering2000，15，： | 1 |
| 9 | Metabolic differences between 2-hydroxy-4-(methylthio) butanoic acid (HMB,Alimet) and D,1-methionine (DLM) during heat stress显示文摘 | Dibner J J Swick R A Knight C D | 1992 | Poult Sci1992，71，： | 1 |
| 10 | Sediment qualityassessment of Beasley Lake: bioaccumulation and effocls of pes-ticides in Hyalella azteca 显示文摘 | LIZOTTE R E KNIGHT S S BRYANT C T | 2010 | Chemistry and Ecology2010，26，6： | 1 |
| 11 | A high incidence of nucleoside reverse transcriptase inhibitor (NRR1)-in- duced lactic acidosis in HIV-infected patients in a south African context显示文摘 | Geddes R Knight s Moosa MY | 2006 | S Afr Med J2006，96，8： | 1 |
| 12 | Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex 显示文摘 | Hamady M Walker JJ Harris JK Gold NJ Knight R | 2008 | Nat Methods2008，5，3： | 1 |
| 13 | Mast cells dis- rupt epithelial barrier function during enteric nematode infection 显示文摘 | McDermott J R Bartram R E Knight P A | 2003 | PNAS2003，100，： | 1 |
| 14 | A flexible model of consumer country - of - origin perceptions 显示文摘 | Knight G A and Calantone R J | 2000 | Interna- tional Marketing Review2000，17，2： | 1 |
| 15 | Formulation of an inproved smeared stiffener theory forbuckling analysis of gridstiffened composite panels显示文摘 | Jaunky N Knight N F Ambur D R | 1996 | Composites PartB:Engineering1996，27，5： | 1 |
| 16 | Penetration simulation for uncontained engine debris impact on fuselage-likepanels using LS-DYNA显示文摘 | Knight N F Jaunky N Lawson R E | 2000 | Finite Elements in Analysis and Design2000，，36： | 1 |
| 17 | Evaluation of pulmonary lesions with FDG-PET显示文摘 | KNIGHT S B DELBEKE D STEWART J R | 1996 | Chest1996，109，： | 1 |
| 18 | Variation in pituitary ex-pression of mRNAs encoding the putative inhibin co-receptor(be-taglycan)and type-I and type-II activin receptors during the chickenovulatory cycle显示文摘 | T M Lovell P G Knight and R T Gladwell | 2005 | Journal of Endocrinology2005，186，3： | 1 |
| 19 | Engineered communication for microbial robotics显示文摘 | Weis R Jr T F Knight | 2000 | DNA62000，6，： | 1 |
| 20 | Theileria annulata sporozoite antigen fused to hepatits B core antigen used in a vaccination trial显示文摘 | Boulter N R Glass E J Knight P A | 1995 | Vaccine1995，13，13： | 1 |
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