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| 1 | An efficient descriptor model for designing materials for solar cells显示文摘An efficient descriptor model for fast screening of potential materials for solar cell applications is presented.It works for both excitonic and non-excitonic solar cells materials,and in addition to the energy gap it includes the absorption spectrum(α(E))of the material.The charge transport properties of the explored materials are modelled using the characteristic diffusion length(Ld)determined for the respective family of compounds.The presented model surpasses the widely used Scharber model developed for bulk heterojunction solar cells.Using published experimental data,we show that the presented model is more accurate in predicting the achievable efficiencies.To model both excitonic and non-excitonic systems,two different sets of parameters are used to account for the different modes of operation.The analysis of the presented descriptor model clearly shows the benefit of includingα(E)and Ld in view of improved screening results. | Fahhad H Alharbi Sergey N Rashkeev Fedwa El-Mellouhi Hans P Lüthi Nouar Tabet Sabre Kais | 2015 | npj Computational Materials2015，，1： | 3 |
| 2 | Generation and characterization of a human nanobody against VEGFR-2显示文摘瞄准:Nanobody 是由一个单个 monomeric 变量抗体领域组成的抗体碎片,它能被用于许多 biotechnological 和治疗学的目的。这个工作的目的是从噬菌体显示器 library.Methods 对 VEGFR-2 domain3 (VEGFR D3 ) 孤立并且描绘人的信号域抗体:与与 VEGFR2 D3 的高亲密关系生产抗原特定的 recombinant nanobodies,液体阶段 panning 策略被用于 panning 的 all rounds。为 nanobody 表示和纯化,四 VEGFR2 堵住 D3 克隆是进 pETduet-biotin-MBP 表示向量的 subcloned。recombinant 蛋白质带了一个 MBP 标签由亲密关系层析便于纯化。Recombinant NTV (1-4 ) 在另外的胶化过滤层析步以后被获得。在 VEGFR2 D3 和 NTV (1-4 ) 之间的相互作用与基于光的 AlphaScreen 试金和 SPR 试金被估计。Anti-angiogenesis 效果在人的脐的静脉 endothelial 房间(HUVEC ) 被检验 .Results:在 AlphaScreen 试金, NTV1 (100 和 200 nmol/L ) 与 VEGFR2 D3 得到了最高有约束力的信号;NTV2 与 VEGFR2 D3 显示出中等相互作用;NTV3 和 NTV4 展出了有 VEGFR2 D3 的很少或没有相互作用。在 SPR 试金, NTV1 与一个平衡分离常数为 VEGFR2 D3 显示了一种高亲密关系(K 49 ± 的 D ) ; 1.8 nmol/L。NTV1 (1-1000 nmol/L ) dose-dependently 由 HUVECs.Conclusion 禁止了 HUVEC 和 endothelial 试管形成的增长:nanobody NTV1 是堵住 VEGFR2 的一个潜在的治疗学的候选人。这研究为指向 VEGFR2 的基于 nanobody 的癌症治疗学的开发提供新奇、有希望的策略。 | Lin MA Kai GU Cheng-hai ZHANG Xue-tao CHEN Yi JIANG Karsten MELCHER Juan ZHANG Min WANG H Eric XU | 2016 | Acta Pharmacologica Sinica2016，37，6： | 2 |
| 3 | Variation in CD4 T and CD8 T lymphocyte subpopulations in bo- vine mammary gland secretions during lactating and non-lactating periods显示文摘 | ASAI K KAI K RIKIISHI H | 1998 | Vet Immunol Imrnuno- patho1998，65，1： | 1 |
| 4 | Heterogenesis of prognosis in adult IgA nephropathy, especially with mild proteinuria or mild histological features显示文摘 | Usui J Yamagata K Kai H | | 0，，： | 1 |
| 5 | Coexistence of hypercholesterolemia and hypertension impairs adventitial vascularization显示文摘 | Kai H Kuwahara F Tokuda K | | 0，，2： | 1 |
| 6 | Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats显示文摘 | TAKEMIYA K KAI H YASUKAWA H | 2009 | Basic Res Cardio2009，105，3： | 1 |
| 7 | Heterogeneity of prognosis in aduh IgA nephropathy, especially with mild proteinuria or mild histological features 显示文摘 | Usui J Yamagata K Kai H | 2001 | Intern Med2001，40，8： | 1 |
| 8 | Expression analysis of MAC30in human pancreatic cancer and tumors of the gastro-intestinal tract显示文摘 | Kayed H Kleeff J Ding J | 2004 | Histol Histopathol2004，19，4： | 1 |
| 9 | Large blood pressure variabilityand hypertensive cardiac remodeling-role of cardiac inf lammation显示文摘 | Kai H Kudo H Takayama N | 2009 | Circ J2009，73，12： | 1 |
| 10 | Pressure-independent effects of angiotensin 显示文摘 | Tokuda K Kai H Kuwahara F | 2004 | Hypertension2004，43，2： | 1 |
| 11 | The effects of heat treatment on the chromium depletion, precipitate evolution, and corrosion resistance of INCONEL Alloy 690 显示文摘 | Kai J J Yu G P Tsai C H | 1989 | Metallurgical Transactions A1989，20，： | 1 |
| 12 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，6： | 1 |
| 13 | Dexamethasone suppresses mucus production and MUC-2 and MUC-5AC gene expression by NCI-H292 cells显示文摘 | Kai H Yoshitake K Hisatsune A | 1996 | Am J Physiol1996，271，31： | 1 |
| 14 | En- hanced uniaxial anisotropy and two-step magnetization process along the hard axis of polycrystalline NiFe/NiO bilayers 显示文摘 | Zhao T Fujiwara H Zhang K Hou C Kai T | 2001 | Physical Review B2001，65，01： | 1 |
| 15 | Peripheral blood levels of matrix metalloproteases-2 and -9 are elevated in patients with acute coronary syndromes显示文摘 | Kai H Ikeda H Yasukawa H | 1998 | J Am Coil Cardiol1998，32，2： | 1 |
| 16 | Wittmann size effect on specific fracture energy of concrete显示文摘 | DUAN Kai HU Xiaozhi FOLKER H | 2007 | Engineering Frac- ture Mechanics2007，，74： | 1 |
| 17 | Peripheral blood levels of matrix metalloproteinases-2 and-9 are elevated in patients with acute coronary syndromes 显示文摘 | Kai H Ikeda H Yasukawa H | 1998 | J Am Coil Cardiol1998，32，2： | 1 |
| 18 | TGF-β function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats显示文摘 | Kuwahara F Kai H Tokuda K | 2002 | Circulation2002，106，1： | 1 |
| 19 | Studies on the optimization of stem hull form based on a potential flow solver 显示文摘 | SUZUKI K Z KAI H S KASHIWABARA S T | 2005 | Marine Science and Technology2005，10，： | 1 |
| 20 | Nerve growth factor and enhancement of proliferation, invasion, and tumorigenicity of pancreatic cancer cells 显示文摘 | Zhu Z Kleeff J Kayed H | 2002 | Molecular Carcinogenisis2002，35，3： | 1 |
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