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| 1 | Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR显示文摘AIM:To investigate three isoforms of survivin in colorectal adenocarcinomas.METHODS:We used the LightCycler Technology(Roche),along with a common forward primer and reverse primers specific for the splice variants and two common hybridization probes labeled with fluorescein and LightCycler-Red fluorophore(LC-Red 640).Real time quantitative polymerase chain reaction(PCR) was performed on cDNAs from 52 tumor specimens from colorectal cancer patients and 10 unrelated normal colorectal tissues.In the patients group,carcinoembryonic antigen(CEA) and CA19-9 tumor markers were also measured immunochemically.RESULTS:Wild type survivin mRNA isoform was expressed in 48%of the 52 tumor samples,survivin-2b in 38%and survivin-ΔΕx3 in 29%,while no expression was found in normal tissues.The mRNA expression of wild type survivin presented a significant correlation with the expression of the ratio of survivin-2b,survivin-ΔΕx3,survivin-2b/wild type survivin and survivin-ΔΕx3/wild type survivin(P<0.001).The mRNA expression of wildsurvivin and survivin-ΔΕx3 was related with tumor size and invasion(P=0.006 and P<0.005,respectively).A significant difference was found between survivin-2b and morphologic cancer type.Also,the ratio of survivin-ΔEx3/ wild-survivin was significantly associated with prognosis.No association was observed between the three isoforms and grade,metastasis,Dukes stage and gender.The three isoforms were not correlated with CEA and CA19-9.CONCLUSION:Survivin isoforms may play a role in cell apoptosis and their quantification could provide information about clinical management of patients suffering from colorectal cancer. | Anastasia Pavlidou Maria Dalamaga Christos Kroupis George Konstantoudakis Maria Belimezi George Athanasas Kleanthi Dimas | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 2 | Association of survivin splice variants with prognosis and treatment of breast cancer显示文摘The purpose of this study was the overview of current knowledge regarding the use of survivin and its isoforms in prognosis and treatment of breast cancer. An advanced search of Medline was performed using the following search strategy: '(survivin isoforms) OR(survivin transcript variants) AND(breast cancer) AND(neoplasm OR tumor OR cancer OR carcinoma)'. Relevant studies were retrieved and processed thoroughly in order to analyze the related data. Besides wild-type survivin full-length transcript, another six splice variants have been identified. Overexpression of survivin and its isoforms leads to shorter overall and disease-free survival; the transcript variants are correlated with apoptosis and could assist prognosis prediction. It has been proved through numerous studies that inhibiting survivin isoforms might become a promising target of drug therapy of carcinomas. Use of small molecule YM155 could offer new therapy for triple negative breast cancer patients, while, chemotherapy with 5-fluorouracil + epirubicin + cyclophosphamide and Tax-Epi could be guided by survivin splice variants measurements. Survivin transcript variants could become prognostic biomarkers and could provide information about clinical managementof patients suffering from breast cancer. | Anastasia Pavlidou Christos Kroupis Kleanthi Dimas | 2014 | World Journal of Clinical Oncology2014，5，5： | 6 |
| 3 | Association of arterial stiffness with coronary flow reserve in revascularized coronary artery disease patients显示文摘AIM: To investigate the association of arterial wave reflection with coronary flow reserve(CFR) in coronary artery disease(CAD) patients after successful revascularization.METHODS: We assessed 70 patients with angiographically documented CAD who had undergone recent successful revascularization. We measured(1) reactive hyperemia index(RHI) using fingertip peripheral arterial tonometry(RH-PAT Endo-PAT);(2) carotid to femoral pulse wave velocity(PWVc-Complior);(3) augmentation index(AIx), the diastolic area(DAI%) and diastolic reflection area(DRA) of the central aortic pulse wave(Arteriograph);(4) CFR using Doppler echocardiography; and(5) blood levels of lipoprotein-phospholipase A2(LpPLA2).RESULTS: After adjustment for age, sex, blood pressure parameter, lipidemic, diabetic and smoking status, we found that coronary flow reserve was independently related to AIx(b =-0.38, r = 0.009), DAI(b = 0.36, P = 0.014), DRA(b = 0.39, P = 0.005) and RT(b =-0.29,P = 0.026). Additionally, patients with CFR < 2.5 had higher PWVc(11.6 ± 2.3 vs 10.2 ± 1.4 m/s, P = 0.019), SBPc(139.1 ± 17.8 vs 125.2 ± 19.1 mm Hg, P = 0.026), AIx(38.2% ± 14.8% vs 29.4% ± 15.1%, P = 0.011) and lower RHI(1.26 ± 0.28 vs 1.50 ± 0.46, P = 0.012), DAI(44.3% ± 7.9% vs 53.9% ± 6.7%, P = 0.008), DRA(42.2 ± 9.6 vs 51.6 ± 11.4, P = 0.012) and Lp PLA2(268.1 ± 91.9 vs 199.5 ± 78.4 ng/m L, P = 0.002) compared with those with CFR ≥ 2.5. Elevated Lp PLA2 was related with reduced CFR(r =-0.33, P = 0.001), RHI(r =-0.37, P < 0.001) and DRA(r =-0.35, P = 0.001) as well as increased PWVc(r = 0.34, P = 0.012) and AIx(r = 0.34, P = 0.001). CONCLUSION: Abnormal arterial wave reflections are related with impaired coronary flow reserve despite successful revascularization in CAD patients. There is a common inflammatory link between impaired aortic wall properties, endothelial dysfunction and coronary flow impairment in CAD. | Vlassis Tritakis Stavros Tzortzis Ignatios Ikonomidis Kleanthi Dima Georgios Pavlidis Paraskevi Trivilou Ioannis Paraskevaidis Giorgos Katsimaglis John Parissis John Lekakis | 2016 | World Journal of Cardiology2016，8，2： | 4 |
| 4 | Helicobacter pylori infection as an environmental risk factor for migraine without aura显示文摘 | Konstantina G. Yiannopoulou Athina Efthymiou Kleanthis Karydakis Andreas Arhimandritis Nikolaos Bovaretos Mihalis Tzivras | 2007 | The Journal of Headache and Pain2007，，6： | 2 |
| 5 | Association of Lp-PLA2 with digital reactive hyperemia, coronary flow reserve, carotid atherosclerosis and arterial stiffness in coronary artery disease显示文摘 | Ignatios Ikonomidis Nikolaos N.P. Kadoglou Vlassis Tritakis Ioannis Paraskevaidis Kleanthi Dimas Paraskevi Trivilou Ioannis Papadakis Stavros Tzortzis Helen Triantafyllidi John Parissis Maria Anastasiou-Nana John Lekakis | 2014 | Atherosclerosis2014，，1： | 2 |
| 6 | Single um- bilical artery:fetal and placenta显示文摘 | Kondi-Pafiti A Kleanthis KC Mavrlgiannaki P | 2011 | Clin Exp Obstet Gynecol2011，38，3： | 1 |
| 7 | Cytotoxicity and cellular uptake of tri-block copolymer nanoparticles with different size and surface characteristics 显示文摘 | Sourav B Dmitry E Kleanthis F | 2012 | Part Fibre Toxieol2012，9，11： | 1 |
| 8 | Single u- mbilical artery: fetal and placental histopathologieal analysis of 24 cases显示文摘 | Kondi-Pafiti A Kleanthis KC Mavrigiannaki P | 2011 | Clin Exp Obstet Gyneeol2011，38，3： | 1 |
| 9 | Integrating UML and the Function Block Concept for the Development of Distributed Control Applications显示文摘 | Christos Tranoris Kleanthis Thramboulidis | 2003 | 87 - 942003，8794，： | 1 |
| 10 | Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis显示文摘 | Niki E. Tsesmeli Kleanthis E. Giannoulis Christos G. Savopoulos Eleni E. Vretou Ippoliti A. Ekonomou Elefterios K. Giannoulis | 2007 | European Journal of Gastroenterology & Hepatology2007，，： | 1 |
| 11 | Helicobacter pylori infection as an environmental risk factor for migraine without aura显示文摘 | Konstantina G. Yiannopoulou Athina Efthymiou Kleanthis Karydakis Andreas Arhimandritis Nikolaos Bovaretos Mihalis Tzivras | 2007 | The Journal of Headache and Pain2007，，6： | 1 |
| 12 | Single umbilical artery: fetal and placental histopathological analysis of 24 cases显示文摘 | Kondi Pafiti A Kleanthis KC Mavriqiannaki P | 2011 | Clin Exp Obstet Gynecol2011，38，3： | 1 |
| 13 | Selective attention and consciousness:investigating their relation through computational modelling显示文摘 | Kleanthis C N Marios N A Costas K N | 2011 | Cognitive Computation2011，3，1： | 1 |
| 14 | The I Test: An improved dependence test for automatic parallelization and vectorization 显示文摘 | Xiangyun kong David klappholz and Kleanthis psarris | 1991 | IEEE Transactions on parallel and distributed systems1991，2，3： | 1 |
| 15 | CCAAT/Enhancer binding protein ε is critical for effective neutrophil-mediated response to inflammatory challenge显示文摘 | Julie LH Kleanthis GX | 1999 | Blood1999，93，9： | 1 |
| 16 | A rare ovarian Leydig cell tumor (hilar type ) causing virilization in a postmenopausal woman 显示文摘 | Vouza E Kairi-Vassilatou E Kleanthis CK | 2011 | Eur J Gynaecol On- col2011，32，5： | 1 |
| 17 | CCAAT/Enhancer binding protein ε is critical for effective neutrophil-mediated response to inflammatory challenge显示文摘 | Julie LH Kleanthis G Xanthopoulo S | 1999 | Blood1999，93，9： | 1 |
| 18 | Au- topsy findings in fetuses with cystic hygroma: a literature review and our center's experience显示文摘 | GRAPSA D MAVRIGIANNAKI P KLEANTHIS C | 2012 | Clin Exp Obstet Gynecol2012，39，3： | 1 |
| 19 | Towards a Tolerance of Ambiguity Model in Greek Tourism Industry显示文摘 | Kleanthis K. Katsaros Athanasios N. Tsirikas Sofia-Maria N. Bani Christos S. Nicolaidis | 2014 | Journal of Tourism and Hospitality Management2014，2，3： | 0 |
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