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| 1 | Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977-2001显示文摘AIM:An investigation into inflammatory bowel disease and colorectal cancer in Veszprem Province was conducted from 1977 to 2001.METHODS: Both hospital and outpatient records were collected and reviewed comprehensively. The majority of patients were followed up regularly.RESULTS:The population of the province was decreased from 386000 to 376000 during the period. Five hundred sixty new cases of ulcerative colitis (UC), 212 of Crohn's disease (CD), and 40 of indeterminate colitis (IC) were diagnosed. The incidence rates increased from 1.66 to 11.01 cases per 100 000 persons for UC, from 0.41 to 4.68 for CD and from 0.26 to 0.74 for IC. The prevalence rate at the end of 2001 was 142.6 for UC and 52.9 cases per 100 000 persons for CD. The peak onset age in UC patients was between 30 and 40 years, in CD between 20 and 30 years. A family history of IBD was present in 3.4% in UC and 9.9% in CD patients.Smoking increased the risk for CD (OR=1.94) while it decreased the risk for UC (OR=0.25). Twelve colorectal carcinomas were observed in this cohort, the cumulative colorectal cancer risk after 10 years in UC was 2%, after 20 years 8.8%, after 30 years 13.3%.CONCLUSION:The incidence and prevalence rates of IBD have increased steadily in Veszprem Province, now equivalent to that in Western European countries. Rapid increase in incidence rates supports a probable role for environmental factors. The rate of colorectal cancers in IBD is similar to that observed in Western countries. | Laszlo Lakatos Gabor Mester Zsuzsanna Erdelyi Mihaly Balogh Istvan Szipocs Gyorgy Kamaras Peter Laszlo Lakatos | 2004 | World Journal of Gastroenterology2004，10，3： | 17 |
| 2 | Differential mercury volatilization by tobacco organs expressing a modi-fied bacterial merA gene显示文摘Mercury pollution is a major environmental problem accompanying industrial activities. Most of the mercury released ends up and retained in the soil as complexes of the toxic ionic mercury (Hg2+), which then can be converted by microbes into the even more toxic methylmercury which tends to bioaccumulate. Mercury detoxification of the soil can also occur by microbes converting the ionic mercury into the least toxic metallic mercury (Hg0) form, which then evaporates. The remediation potentia1 of transgenic plants carrying the MerA gene from E. coLi encoding mercuric ion reductase could be evaluated. A modified version of the gene, optimized for plant codon preferences (merApe9, Rugh et al. 1996), was introduced into tobacco by Agrobacterium-mediated leaf disk transformation. Transgenic seeds were resistant to HgCl2 at 50 μM and some of them (10-20% ) could germinate on media containing as much as 350 μM HgCl2, while the control plants were fully inhibited or died on 50 μM HgCl2. The rate of elemental mercury evolution from Hg2+ (added as HgCl2) was 5-8 times higher for transgenic plants than the control. Mercury volatilization by isolated organs standardized for fresh weight was higher (up to 5 times) in the roots than in shoots or the leaves. The data suggest that it is the root system of the transgenic plants that volatilizes most of the reduced mercury (Hg0). It also suggests that much of the mercury need not enter the vascular system to be transported to the leaves for volatilization. Thansgenic plants with the merApe9 gene may be used to mercury detoxification for environmental improvement in mercury-- contaminated regions more efficiently than it had been predicted based on data on volatilization of whole plants via the upper parts only (Rugh et al. 1996). | HE YU KE, JIAN GE SUN, XIAN ZHONG FENG, MIHALY CZAKU, LASZLO MARTON Depariment of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC29208, USA National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Phy | 2001 | Cell Research2001，11，3： | 14 |
| 3 | Is early limited surgery associated with a more benign disease course in Crohn's disease?显示文摘AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,2008.Follow-up data were collected until December 31,2009.All patients included had at least 1year of follow-up available.Patients with indeterminate colitis at diagnosis were excluded from the analysis.RESULTS:Overall,73 patients(14.4%)required resective surgery within 1 year of diagnosis.Steroid exposure and need for biological therapy were lower in patients with early limited surgery(P<0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P<0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)analysis.However,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ. | Petra Anna Golovics Laszlo Lakatos Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 4 | Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort显示文摘AIM:To investigate the evolution of disease phenotypein adult and pediatric onset Crohn's disease(CD) populations,diagnosed between 1977 and 2008.METHODS:Data of 506 incident CD patients were analyzed(age at diagnosis:28.5 years,interquartile range:22-38 years).Both in-and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which included incident patients diagnosed between January 1,1977 and December 31,2008 in adult and pediatric onset CD populations.Disease phenotype according to the Montreal classification and long-term disease course was analysed according to the age at onset in time-dependent univariate and multivariate analysis.RESULTS:Among this population-based cohort,seventy-four(12.8%) pediatric-onset CD patients were identified(diagnosed ≤ 17 years of age).There was no significant difference in the distribution of disease behavior between pediatric(B1:62%,B2:15%,B3:23%) and adult-onset CD patients(B1:56%,B2:21%,B3:23%) at diagnosis,or during follow-up.Overall,the probability of developing complicated disease behaviour was 49.7% and 61.3% in the pediatric and 55.1% and 62.4% in the adult onset patients after 5-and 10-years of follow-up.Similarly,time to change in disease behaviour from non stricturing,non penetrating(B1) to complicated,stricturing or penetrating(B2/B3) disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier analysis.Calendar year of diagnosis(P = 0.04),ileal location(P < 0.001),perianal disease(P < 0.001),smoking(P = 0.038) and need for steroids(P < 0.001) were associated with presence of,or progression to,complicated disease behavior at diagnosis and during follow-up.A change in disease location was observed in 8.9% of patients and it was associated with smoking status(P = 0.01),but not with age at diagnosis.CONCLUSION:Long-term evolution of disease behavior was not different in pediatric-and adult-onset CD patients in this population-based cohort but was associated to location,perianal disease and smoking status. | Barbara Dorottya Lovasz Laszlo Lakatos Agnes Horvath Istvan Szita Tunde Pandur Michael Mandel Zsuzsanna Vegh Petra Anna Golovics Gabor Mester Mihaly Balogh Csaba Molnar Erzsebet Komaromi Lajos Sandor Kiss Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，14： | 2 |
| 5 | Valuation of investments in real assets with implications for the stock prices显示文摘 | Thomas S K Bernhard M Mihali Z | 1999 | SIAM J Control Optim1999，38，6： | 2 |
| 6 | 恩施富硒豆角中硒的形态研究显示文摘硒是一种人体必需的微量元素,在人体内充当多种含硒酶,如谷胱甘肽过氧化酶的活动中心等,保护细胞膜免受氧自由基氧化损失的作用,具有防癌抗癌的生物化学功能。硒甲基半胱氨酸及其衍生物γ-谷氨酰硒甲基半胱氨酸是国际上公认的具有抗癌效应的机硒化物(Ip et al.,2000;Stan et al.,2008),富硒食品中是否富含这两种特殊的有机硒,关系此富硒食品有无抗癌防癌的功效。 | 邵树勋 Mihaly Dernovics 龙胜桥 | 2015 | 矿物学报2015，35，S1： | 2 |
| 7 | Free-space realization of tunable pin-like optical vortex beams显示文摘We demonstrate,both analytically and experimentally,free-space pin-like optical vortex beams (POVBs). Such angular-momentum-carrying beams feature tunable peak intensity and undergo robust antidiffracting propagation,realized by judiciously modulating both the amplitude and the phase profile of a standard laser beam.Specifically,they are generated by superimposing a radially symmetric power-law phase on a helical phase structure,which allows the inclusion of an orbital angular momentum term to the POVBs. During propagation in free space,these POVBs initially exhibit autofocusing dynamics,and subsequently their amplitude patterns morph into a high-order Bessel-like profile characterized by a hollow core and an annular main lobe with a constant or tunable width during propagation. In contrast with numerous previous endeavors on Bessel beams,our work represents the first demonstration of long-distance free-space generation of optical vortex 'pins' with their peak intensity evolution controlled by the impressed amplitude structure. Both the Poynting vectors and the optical radiation forces associated with these beams are also numerically analyzed,revealing novel properties that may be useful for a wide range of applications. | DOMENICO BONGIOVANNI DENGHUI LI MIHALIS GOUTSOULAS HAO WU YI HU DAOHONG SONG ROBERTO MORANDOTTI NIKOLAOS KEFREMIDIS ZHIGANG CHEN | 2021 | Photonics Research2021，9，7： | 2 |
| 8 | Helicobacter pylori infection as an environmental risk factor for migraine without aura显示文摘 | Konstantina G. Yiannopoulou Athina Efthymiou Kleanthis Karydakis Andreas Arhimandritis Nikolaos Bovaretos Mihalis Tzivras | 2007 | The Journal of Headache and Pain2007，，6： | 2 |
| 9 | Resuspension of spherical particles due to surface vibration显示文摘In this study,particle resuspension due to surface vibration was investigated.A spherical particle was assumed to rest on top of a thin plate,and an external vibrating force was applied normal on the plate at t=0 and at distance R from the particle.The external driving force created a displacement field in both time and space domains,where deformations in the body of the plate were considered small elastic oscillations that are perpendicular to the propagation of the displacement.Free oscillations were introduced via the theory of elasticity and the creation of waves on thin plates,i.e.,bending waves.Particle motion in the vertical direction was initiated through plate displacement,provided that inertia due to particle mass is overcome.In particular,the particle was assumed to oscillate with a force(of oscillation)estimated via Newton’s second law of motion,comprising of two components:the acceleration due to the plate displacement and the particle mass.Subsequently,a simple force balance method was used to determine the conditions for resuspension.Accordingly,resuspension occurs when the oscillation force exceeds the couple of the adhesive and gravitational forces.The results suggest that the plate displacement depends on the characteristics of the applied force,material properties,and plate thickness.In addition,it was found that the oscillation force is substantially lower than the applied force and that it depends on plate displacement and particle mass.Additionally,the particle size significantly influencedthe outcome of resuspension.Thus,resuspension is favorable for large particles,strong applied forces,and high forcing frequencies. | Sofia Eirini Chatoutsidou Mihalis Lazaridis | 2021 | Particuology2021，19，1： | 2 |
| 10 | uPAR-uPA-PAI-I interactions and signaling: a vascular biologist' s view显示文摘 | Binder BR Mihaly J Prager GW | 2007 | Thromb Haemost2007，97，3： | 1 |
| 11 | Influence of dietary L-carnitine on performance and carcass quality of broiler chickens显示文摘 | RABIE M H MIHALY S GIPPERT T | 1997 | Acta Bioogical Hungarica1997，48，： | 1 |
| 12 | Antin-ociceptive effect of vinpocetine-a comprehensive survey显示文摘 | CSILLIK B MIHALY A KNYIHAR-CSILLIK E | 2010 | Ideggyogyaszati Szemle-Clinical Neuroscience2010，63，56： | 1 |
| 13 | Selective hydrogenation of enthylene over amorphous Ni - SiO2显示文摘 | Moular A Smith G V Mihaly B | 1986 | J Catal1986，101，： | 1 |
| 14 | Synthesis of sophorol,violanone,lonchocarpan,claussequinone,philenopteran,leiocalycin,and some other natural isoflavonoids by the oxidative rearrangement of chalcones with thallium(Ⅲ)nitrate显示文摘 | Lorand Farkas Agnes Gottsegen Mihaly Nogradi | 1974 | Journal of the Chemical Society1974，，： | 1 |
| 15 | Reduced conductive EMI in switched-mode DC-DC power converters without EMI filters:PWM versus randomized PWM显示文摘 | MIHALI F KOS D | 2006 | IEEE Transactions on Power Electronics2006，21，6： | 1 |
| 16 | Destination Competitiveness-Applying Different Models, The Case of Slovenia 显示文摘 | Gomezelj D O Mihalie T | 2008 | Tourism Manage- ment2008，，2： | 1 |
| 17 | The plasminogen activator inhibitor 'paradox' in cancer显示文摘 | Binder BR Mihaly J | 2008 | Immun Letters2008，118，2： | 1 |
| 18 | Topography and associations of luteinizing hormone releasing hormone and neuropeptide Y immunoreactive neuronal systems in the human diencephalons显示文摘 | Dudas B Mihaly A Merchenthaler I | 2000 | J Comp Neurol2000，427，4： | 1 |
| 19 | Feather degradation with a thermotolerant Streptomyces graminofaciens strain 显示文摘 | Szabo I Benedek A Mihaly Szabo I | 2000 | World Journal of Microbiology and Biotechnology2000，16，3： | 1 |
| 20 | Valuation of investments in real assets with implications for the stock prices显示文摘 | Thomas S K Bernhard M Mihali Z | 1999 | SIAM J Control Optim1999，38，6： | 1 |
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