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| 1 | Type 2 diabetes is associated with a worse functional outcome of ischemic stroke显示文摘AIM: To assess whether ischemic stroke severity and outcome is more adverse in patients with type 2 diabetes mellitus(T2DM). METHODS: Consecutive patients hospitalized for acute ischemic stroke between September 2010 and June 2013 were studied prospectively(n = 482; 40.2% males, age 78.8 ± 6.7 years). T2 DM was defined as self-reported T2 DM or antidiabetic treatment. Stroke severity was evaluated with the National Institutes of Health Stroke Scale(NIHSS) score at admission. The outcome was assessed with the modified Rankin scale(m RS) score at discharge and with in-hospital mortality. Adverse outcome was defined as m RS score at discharge ≥ 2 or in-hospital death. The length of hospitalization was also recorded.RESULTS: T2 DM was present in 32.2% of the study population. Patients with T2 DM had a larger waist circumference, higher serum triglyceride and glucose levels and lower serum high-density lipoprotein cholesterol levels as well as higher prevalence of hypertension, coronary heart disease and congestive heart failure than patients without T2 DM. On the other hand, diabetic patients had lower low-density lipoprotein cholesterol levels and reported smaller consumption of alcohol than non-diabetic patients. At admission, the NIHSS score did not differ between patients with and without T2DM(8.7 ± 8.8 and 8.6 ± 9.2, respectively; P = NS). At discharge, the m RS score also did not differ between the two groups(2.7 ± 2.1 and 2.7 ± 2.2 in patients with and without T2 DM, respectively; P = NS). Rates of adverse outcome were also similar in patients with and without T2DM(62.3% and 58.5%, respectively; P = NS). However, when we adjusted for the differences between patients with T2 DM and those without T2 DM in cardiovascular risk factors, T2 DM was independently associated with adverse outcome [relative risk(RR) = 2.39; 95%CI: 1.21-4.72, P = 0.012]. Inhospital mortality rates did not differ between patients with T2 DM and those without T2DM(9.0% and 9.8%, respectively; P = NS). In multivariate analysis adjusting for the difference in cardiovascular risk factors between the two groups, T2 DM was again not associated with in-hospital death. CONCLUSION: T2 DM does not appear to affect ischemic stroke severity but is independently associated with a worse functional outcome at discharge. | Konstantinos Tziomalos Marianna Spanou Stella D Bouziana Maria Papadopoulou Vasilios Giampatzis Stavroula Kostaki Vasiliki Dourliou Maria Tsopozidi Christos Savopoulos Apostolos I Hatzitolios | 2014 | World Journal of Diabetes2014，5，6： | 15 |
| 2 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 3 | Primary pancreatic anaplastic large cell lymphoma, ALK negative: A case report显示文摘We present the fourth case of a primary pancreatic anaplastic large cell lymphoma (ALCL), ALK-. An 80-year-old man was admitted to our clinic for further investigation of a fever of unknown origin. He noted anorexia, weight loss and fatigue. His laboratory tests showed anemia and a great elevation of ESR, LDH, and β2 microglobulin. In CT and MRI scan, a soft tissue mass in the pancreas was observed. A repeated endoscopy after his admission revealed an ulcerated mass-like deformity of the duodenal bulb. Explorative laparotomy confirmed a diffuse spread of an unresectable malignant pancreatic mass extending to the adjacent organs. Duodenal and surgical biopsies identified an ALCL of T-cell lineage, ALK-. The patient died in the Intensive Care Unit due to hemodynamic instability.Our case is the first one indicating that primary pancreatic lymphoma should be suspected in a patient with pancreatic mass and elevated serum LDH and β2 microglobulin. | Christos G Savopoulos NE Tsesmeli GD Kaiafa AT Zantidis MT Bobos AI Hatzitolios ST Papavramidis IS Kostopoulos | 2005 | World Journal of Gastroenterology2005，11，39： | 3 |
| 4 | 在不含酒精的脂肪肝疾病和尖锐 ischemic 击严厉和结果之间的协会显示文摘 AIM:To evaluate the association of nonalcoholic fatty liver disease(NAFLD)with acute ischemic stroke severity and in-hospital outcome.METHODS:We prospectively studied all patients who were admitted in our Department with acute ischemic stroke between September 2010 and August 2012(n=415;39.5%males,mean age 78.8±6.6 years).The severity of stroke was assessed with the National Institutes of Health Stroke Scale(NIHSS)score at admission.NALFD was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absence of other causes of elevated aminotransferases levels[chronic hepatitis B or C,drug toxicity,increased alcohol consumption(>21 and>14 drinks per week in men and women,respectively),cholestatic diseases or rhabdomyolysis].The outcome was assessed with the modified Rankin scale(mRS)score at discharge and in-hospital mortality.Adverse outcome was defined as mRS score at discharge≥2.Dependency at discharge was defined as mRS score between 2 to 5.RESULTS:NAFLD was present in 7.7%of the study population.Patients with NAFLD had lower serum high-density lipoprotein cholesterol and higher triglyceride levels than patients without NAFLD(P<0.05 for both comparisons).Demographic data,the prevalence of other cardiovascular risk factors and the prevalence of established CVD did not differ between the two groups.At admission,the NIHSS score did not differ between patients with and without NAFLD(6.3±6.4and 8.8±9.6,respectively;P=NS).At discharge,the mRS score did not differ between the two groups(1.9±2.2 and 2.6±2.2 in patients with and without NAFLD,respectively;P=NS).Rates of dependency at discharge were also similar in patients with and without NAFLD(36.8%and 55.0%,respectively;P=NS)as were the rates of adverse outcome(42.9%and58.6%,respectively;P=NS).In-hospital mortality rates also did not differ between the 2 groups(8.0%and 7.0%in patients with and without NAFLD,respectively;P=NS).CONCLUSION:The presence of NAFLD in patients admitted for acute ischemic stroke does not appear to be associated with more severe stroke or with worse in-hospital outcome. | Konstantinos Tziomalos Vasilios Giampatzis Stella D Bouziana Marianna Spanou Maria Papadopoulou Athinodoros Pavlidis Stavroula Kostaki Andreas Bozikas Christos Savopoulos Apostolos I Hatzitolios | 2013 | World Journal of Hepatology2013，5，11： | 2 |
| 5 | Efficacy of omega-3 fatty acids, atorvastatin and orlistat in non-alcoholic fatty liver disease with dyslipidemia显示文摘 | Hatzitolios A Savopoulos C Lazaraki G | 2004 | Indian J Gastroenterol2004，23，： | 1 |
| 6 | Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis显示文摘 | Tsesmeli NE Giannoulis KE Savopoulos CG el al | 2007 | Eur J Gastroenterol Hepatol2007，19，： | 1 |
| 7 | The effect of folic acid sup- plementation on carotid intima-media thickness in patients with cardio- vascular risk: a randomized, placebo-controlled trial显示文摘 | Naaios G Savopoulos C Karamitsos D | 2010 | Int J Cardiol2010，143，1： | 1 |
| 8 | Trend in incidence of cardiovascular risk factors in elderly and over-aged stroke patients between 2003 and 2007 in Greece显示文摘 | Panagiotis Kotsaftis George Ntaios Christos Savopoulos Reveka Kiparoglou Dimitrios Agapakis Maria Baltatzi Niki Tsesmeli Apostolos Hatzitolios | 2009 | Archives of Gerontology and Geriatrics2009，，3： | 1 |
| 9 | Effect of prior treatment with different statins on stroke severity and functional outcome at discharge in patients with acute ischemic stroke显示文摘 | Konstantinos Tziomalos Vasilios Giampatzis Stella D. Bouziana Marianna Spanou Athinodoros Pavlidis Maria Papadopoulou Chrysoula Boutari Dimitra Magkou Christos Savopoulos Apostolos I. Hatzitolios | 2013 | Int J Stroke2013，，7： | 1 |
| 10 | An association study between catalase -262C>T gene polymorphism, sodium-lithium countertrasport activity, insulin resistance, blood lipid parameters and their response to atorvastatin, in Greek dyslipidaemic patients and normolipidaemic controls显示文摘 | Maria Kosmidou Apostolos I. Hatzitolios Dimitra Molyva Nikolaos Raikos Christos Savopoulos Niki Daferera Vassileios Kokkas Antonis Goulas | 2009 | Free Radical Research2009，，4： | 1 |
| 11 | Discrimination indices as screening tests for β-thalassemic trait显示文摘 | George Ntaios Anastasia Chatzinikolaou Zoi Saouli Fotios Girtovitis Maria Tsapanidou Georgia Kaiafa Zisis Kontoninas Androula Nikolaidou Christos Savopoulos Ifigenia Pidonia Stiliani Alexiou-Daniel | 2007 | Annals of Hematology2007，，7： | 1 |
| 12 | Vitamins and stroke: the homocysteine hypothesis still in doubt显示文摘 | Ntaios GC Savopoulos CG Chatzinikolaou AC | 2008 | The Neurologist2008，14，1： | 1 |
| 13 | Trend in incidence of cardiovascular risk factors in elderly and over-aged stroke patients between 2003 and 2007 in Greece显示文摘 | Kotsaftis P Ntaios G Savopoulos C | 2010 | Arch Gerontol Geriatr2010，50，3： | 1 |
| 14 | Is anemia a new cardiovascular risk factor 显示文摘 | Kaiafa G Kanellos L Savopoulos C | 2015 | Int J Cardiol2015，186，4： | 1 |
| 15 | Plasma neuropeptide Y (NPY) and alpha-melanocyte stimulating hormone(MSH)levels in patients with or without hypertension and/or obesity: a pilot study 显示文摘 | Bahazi M Katsiki N Savopoulos C | 2011 | Am J Cardiovasc Dis2011，1，1： | 1 |
| 16 | The controversial role of B-vitamins in cardiovascular risk: An update显示文摘 | George Ntaios Christos Savopoulos Dimitrios Grekas Apostolos Hatzitolios | 2009 | Archives of Cardiovascular Diseases2009，，12： | 1 |
| 17 | Circadian rhythm in sudden cardiac death:a retrospective study of 2665 cases显示文摘 | Ziakas A Hatzitolios A | 2006 | Angiology2006，57，2： | 1 |
| 18 | Efficacy of omega-3 fatty acids,atorvastatin and orlistat in non-alcoholic fatty liver disease with dyslipidemia显示文摘 | Hatzitolios A Savopoulos C LazarakiG | 2004 | Indian J Gastroenterol2004，23，： | 1 |
| 19 | Efficacy of omega-3 fatty acids, atorvastatin and orlistat in non-alcoholic fatty liverdiseasewith dyslipidemia 显示文摘 | Hatzitolios A Savopoulos C Lazarakig | 2004 | Indian J gastroentero2004，23，： | 1 |
| 20 | Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis显示文摘 | Niki E. Tsesmeli Kleanthis E. Giannoulis Christos G. Savopoulos Eleni E. Vretou Ippoliti A. Ekonomou Elefterios K. Giannoulis | 2007 | European Journal of Gastroenterology & Hepatology2007，，： | 1 |
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