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| 1 | Association of arterial stiffness with coronary flow reserve in revascularized coronary artery disease patients显示文摘AIM: To investigate the association of arterial wave reflection with coronary flow reserve(CFR) in coronary artery disease(CAD) patients after successful revascularization.METHODS: We assessed 70 patients with angiographically documented CAD who had undergone recent successful revascularization. We measured(1) reactive hyperemia index(RHI) using fingertip peripheral arterial tonometry(RH-PAT Endo-PAT);(2) carotid to femoral pulse wave velocity(PWVc-Complior);(3) augmentation index(AIx), the diastolic area(DAI%) and diastolic reflection area(DRA) of the central aortic pulse wave(Arteriograph);(4) CFR using Doppler echocardiography; and(5) blood levels of lipoprotein-phospholipase A2(LpPLA2).RESULTS: After adjustment for age, sex, blood pressure parameter, lipidemic, diabetic and smoking status, we found that coronary flow reserve was independently related to AIx(b =-0.38, r = 0.009), DAI(b = 0.36, P = 0.014), DRA(b = 0.39, P = 0.005) and RT(b =-0.29,P = 0.026). Additionally, patients with CFR < 2.5 had higher PWVc(11.6 ± 2.3 vs 10.2 ± 1.4 m/s, P = 0.019), SBPc(139.1 ± 17.8 vs 125.2 ± 19.1 mm Hg, P = 0.026), AIx(38.2% ± 14.8% vs 29.4% ± 15.1%, P = 0.011) and lower RHI(1.26 ± 0.28 vs 1.50 ± 0.46, P = 0.012), DAI(44.3% ± 7.9% vs 53.9% ± 6.7%, P = 0.008), DRA(42.2 ± 9.6 vs 51.6 ± 11.4, P = 0.012) and Lp PLA2(268.1 ± 91.9 vs 199.5 ± 78.4 ng/m L, P = 0.002) compared with those with CFR ≥ 2.5. Elevated Lp PLA2 was related with reduced CFR(r =-0.33, P = 0.001), RHI(r =-0.37, P < 0.001) and DRA(r =-0.35, P = 0.001) as well as increased PWVc(r = 0.34, P = 0.012) and AIx(r = 0.34, P = 0.001). CONCLUSION: Abnormal arterial wave reflections are related with impaired coronary flow reserve despite successful revascularization in CAD patients. There is a common inflammatory link between impaired aortic wall properties, endothelial dysfunction and coronary flow impairment in CAD. | Vlassis Tritakis Stavros Tzortzis Ignatios Ikonomidis Kleanthi Dima Georgios Pavlidis Paraskevi Trivilou Ioannis Paraskevaidis Giorgos Katsimaglis John Parissis John Lekakis | 2016 | World Journal of Cardiology2016，8，2： | 4 |
| 2 | Increased levels of circulating platelet-derived microparticles in psoriasis:Possible implications for the associated cardiovascular risk显示文摘AIM To evaluate platelet activation markers in psoriasis patients, compared to controls, and investigate their association with the inflammatory burden of psoriasis.METHODS Forty psoriatic patients without cardiovascular disease,and 12 healthy controls were subjected to measurement of baseline platelet CD62 P, CD63 and CD42 b expression, platelet-leukocyte complexes, i.e., platelet-monocyte complexes(PMC), platelet-neutrophil complexes(PNC) and platelet-lymphocyte complexes, and concentrations of platelet-derived microparticles(PMPs) using flow cytometry. Both larger-size(0.5-0.9 μm) and smallersize(< 0.5 μm) PMPs were determined. Serum interleukin(IL)-12 and IL-17 levels were also measured by enzyme-linked immunosorbent assay. The severity of psoriasis was evaluated by the Psoriasis Area Severity Index(PASI).RESULTS PMP concentrations were significantly higher in psoriasis patients than controls [mean±standard error of mean(SEM): 22±5/μL vs 11±6/μL; P=0.018), for both smaller-size(10±2/μL vs 4±2/μL; P=0.033) and larger-size(12±3/μL vs 6±4/μL; P=0.014) PMPs. Platelet CD62 P, CD63 and CD42 b expression and circulating PMC and PNC were similar between the two groups. Lower circulating PLC were observed in psoriasis patients compared to controls(mean±SEM: 16%±3% vs 23%±6%; P=0.047). Larger-size PMPs were related with IL-12 levels(P<0.001) and smaller-size PMPs with both IL-12 and IL-17 levels(P<0.001). Total PMPs also correlated with IL-12(P<0.001). CD63 expression was positively correlated with both IL-12 and IL-17(P<0.05). Increased PASI score was associated with increased levels of larger-size PMPs(r=0.45; P=0.011) and increased CD63 expression(r=0.47; P<0.01).CONCLUSION PMPs, known to be predictive of cardiovascular outcomes, are increased in psoriasis patients, and associated with high inflammatory disease burden. Enhanced platelet activation may be the missing link leading to cardiovascular events in psoriatic patients. | Evangelia Papadavid Konstantina Diamanti Aris Spathis Maria Varoudi Ioanna Andreadou Kostas Gravanis Kostas Theodoropoulos Petros Karakitsos John Lekakis Dimitrios Rigopoulos Ignatios Ikonomidis | 2016 | World Journal of Cardiology2016，8，11： | 2 |
| 3 | Association of Lp-PLA2 with digital reactive hyperemia, coronary flow reserve, carotid atherosclerosis and arterial stiffness in coronary artery disease显示文摘 | Ignatios Ikonomidis Nikolaos N.P. Kadoglou Vlassis Tritakis Ioannis Paraskevaidis Kleanthi Dimas Paraskevi Trivilou Ioannis Papadakis Stavros Tzortzis Helen Triantafyllidi John Parissis Maria Anastasiou-Nana John Lekakis | 2014 | Atherosclerosis2014，，1： | 2 |
| 4 | Time Rate of Blood Pressure Variation Is Associated With Increased Common Carotid Artery Intima-Media Thickness显示文摘 | Nikos A. Zakopoulos Georgios Tsivgoulis Gerassimos Barlas Christos Papamichael Konstantinos Spengos Efstathios Manios Ignatios Ikonomidis Vassilios Kotsis Ioanna Spiliopoulou Konstantinos Vemmos Myron Mavrikakis Spyridon D. Moulopoulos | 2005 | Hypertension2005，，4： | 2 |
| 5 | Increased proinflammatorycy tokines in patients with chronic stable angina and their reduction by aspirin显示文摘 | Ignatios I Felicita A Emanouel E | 1999 | Circulation1999，100，： | 1 |
| 6 | PROGNOSTIC IMPORTANCE OF INCREASED PLASMA AMINO-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE LEVELS IN A LARGE NONCARDIAC, GENERAL INTENSIVE CARE UNIT POPULATION显示文摘 | Anastasia Kotanidou Petros Karsaliakos Marinella Tzanela Irini Mavrou Petros Kopterides Evangelos Papadomichelakis Maria Theodorakopoulou Efi Botoula Iraklis Tsangaris Michalis Lignos Ignatios Ikonomidis Ioannis Ilias Apostolos Armaganidis Stylianos E. Or | 2009 | Shock2009，，4： | 1 |
| 7 | Time Rate of Blood Pressure Variation Is Associated With Increased Common Carotid Artery Intima-Media Thickness显示文摘 | Nikos A. Zakopoulos Georgios Tsivgoulis Gerassimos Barlas Christos Papamichael Konstantinos Spengos Efstathios Manios Ignatios Ikonomidis Vassilios Kotsis Ioanna Spiliopoulou Konstantinos Vemmos Myron Mavrikakis Spyridon D. Moulopoulos | 2005 | Hypertension2005，，4： | 1 |
| 8 | Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin显示文摘 | Ignatioe I Felicita A Emanouel E | 1999 | Circulation1999，100，： | 1 |
| 9 | Similarities in coronary function and myocardial deformation between psoriasis and coronary artery disease: the role of oxidative stress and inflammation显示文摘 | Ignatios Ikonomidis George Makavos Evangelia Papadavid Maria Varoudi Ioanna Andreadou Kostas Gravanis Kostas Theodoropoulos George Pavlidis Helen Triantafyllidi John Parissis Ioannis Paraskevaidis Dimitrios Rigopoulos John Lekakis | 2014 | Canadian Journal of Cardiology2014，，： | 1 |
| 10 | Anomaly induced effects in a magnetic field显示文摘 | Ignatios A Alexey B Oleg R | 2008 | Nuclear Physics: B2008，793，12： | 1 |
| 11 | Time Rate of Blood Pressure Variation Is Associated With Increased Common Carotid Artery Intima-Media Thickness显示文摘 | Nikos A. Zakopoulos Georgios Tsivgoulis Gerassimos Barlas Christos Papamichael Konstantinos Spengos Efstathios Manios Ignatios Ikonomidis Vassilios Kotsis Ioanna Spiliopoulou Konstantinos Vemmos Myron Mavrikakis Spyridon D. Moulopoulos | 2005 | Hypertension2005，，4： | 1 |
| 12 | Arterial stiffness and coronary artery disease显示文摘 | Ignatios Ikonomidis George Makavos John Lekakis | 2015 | Current Opinion in Cardiology2015，，： | 1 |
| 13 | Inflammatory and non-invasive vascular markers: The multimarker approach for risk stratification in coronary artery disease显示文摘 | Ignatios Ikonomidis Kimon Stamatelopoulos John Lekakis Georgia D. Vamvakou Dimitrios Th Kremastinos | 2008 | Atherosclerosis2008，，： | 1 |
| 14 | Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin显示文摘 | Ignatios I Felicita A Emanouel E | 1999 | Circulation1999，100，： | 1 |
| 15 | Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by Aspirin 显示文摘 | Ignatios I Felicita A Emanouel E | 1999 | Circulation1999，100，： | 1 |
| 16 | Influence of breathing movements and Valsalva maneuver on vena caval dynamics显示文摘AIM: To study changes produced within the inferior vena cava(IVC) during respiratory movements and identify their possible clinical implications.METHODS: This study included 100 patients(46 women; 54 men) over 18 years of age who required an abdominal computed tomography(CT) and central venous access. IVC cross-sectional areas were measured on CT scans at three levels, suprarenal(SR), juxtarenal(JR) and infrarenal(IR), during neutral breathing and again during the Valsalva maneuver. All patientswere instructed on how to perform a correct Valsalva maneuver. In order to reduce the total radiation dose in our patients, low-dose CT protocols were used in all patients. The venous blood pressure(systolic, diastolic and mean) was invasively measured at the same three levels with neutral breathing and the Valsalva maneuver during venous port implantation. From CT scans, threedimensional models of the IVC were constructed and a collapsibility index was calculated for each patient. These data were then correlated with venous pressures and cross-sectional areas.RESULTS: The mean patient age was 51.64 ± 12.01 years. The areas of the ellipse in neutral breathing were 394.49 ± 85.83(SR), 380.10 ± 74.55(JR), and 342.72 ± 49.77 mm2(IR), and 87.46 ± 18.35(SR), 92.64 ± 15.36(JR) and 70.05 ± 9.64 mm2(IR) during the Valsalva(P s < 0.001). There was a correlation between areas in neutral breathing and in the Valsalva maneuver(P < 0.05 in all areas). Large areas decreased more than smaller areas. The collapsibility indices were 0.49 ± 0.06(SR), 0.50 ± 0.04(JR) and 0.50 ± 0.04(IR), with no significant differences in any region. Reconstructed three-dimensional models showed a flattening of the IVC during Valsalva, adopting an ellipsoid cross-sectional shape. The mean pressures with neutral breathing were 9.44 ± 1.78(SR), 9.40 ± 1.44(JR) and 8.84 ± 1.03 mmHg(IR), and 81.08 ± 21.82(SR), 79.88 ± 19.01(JR) and 74.04 ± 16.56 mmHg(IR) during Valsalva(P s < 0.001). There was a negative correlation between cross-sectional caval area and venous blood pressure, but this was not statistically significant in any of the cases. There was a significant correlation between diastolic and mean pressures measured during neutral breathing and in Valsalva.CONCLUSION: Respiratory movements have a major influence on IVC dynamics. The increase in intracaval pressure during Valsalva results in a significant de-crease in the IVC cross-sectional area. | Alicia Laborda Sergio Sierre Mauro Malvè Ignacio De Blas Ignatios Ioakeim William T Kuo Miguel Angel De Gregorio | 2014 | World Journal of Radiology2014，6，10： | 1 |
| 17 | An empirical study on students' ability to comprehend design pat- terns 显示文摘 | Alexander Chatzigeorgiou Nikolaos Tsantalis Ignatios Deligiannis | 2008 | Computers & Education2008，51，3： | 1 |
| 18 | PROGNOSTIC IMPORTANCE OF INCREASED PLASMA AMINO-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE LEVELS IN A LARGE NONCARDIAC, GENERAL INTENSIVE CARE UNIT POPULATION显示文摘 | Anastasia Kotanidou Petros Karsaliakos Marinella Tzanela Irini Mavrou Petros Kopterides Evangelos Papadomichelakis Maria Theodorakopoulou Efi Botoula Iraklis Tsangaris Michalis Lignos Ignatios Ikonomidis Ioannis Ilias Apostolos Armaganidis Stylianos E. Or | 2009 | Shock2009，，4： | 1 |
| 19 | Increased Proinflammatory Cytokines in Patients with Chronic stable angina and their reduction by aspirin显示文摘 | Ignatios IM Felicita AM Emanouel EM | 1999 | Circulation1999，100，： | 1 |
| 20 | 希格斯玻色子发现之后的超对称性显示文摘自从1964年理论家物理学预言Higgs粒子存在以来,将近50年后,2012年4月欧洲核子研究组织(CERN,the European Organization for Nuclear Research)的大强子对撞机(LHC)的ATLAS和CMS实验组终于确认了标准模型(SM)的Higgs粒子的存在。这是理论高能物理学家和实验物理学家取得的伟大胜利。也是上世纪由Noether引入的现代物理对称性原理的胜利。科学家们追求的下一个目标是什么?自然成为人们关注的焦点。 | Ignatios Antoniadis 丁亦兵 | 2015 | 国外科技新书评介2015，0，9： | 0 |
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