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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | 长沙市甲基苯丙胺使用情况“应答者驱动抽样”流行病学调查显示文摘目的:了解长沙市甲基苯丙胺使用的流行情况。方法:采用同伴驱动抽样(respondent-driven sampling,RDS),通过自拟问卷对长沙市最近3个月内使用过甲基苯丙胺的成年人进行抽样调查。结果:接受调查的129人以男性、汉族、有伴侣(包括配偶、男女朋友及同居者)、初高中学历、处于就业状态、年收入较高者为主;平均年龄为29.0 a±s7.8 a(最小18 a,最大48 a);102人进行过HIV抗体检测,皆为阴性;有94(72.9%)人曾使用过其他非法成瘾性物质包括k粉、摇头丸、海洛因、大麻、丁丙诺啡、曲马多、美沙酮及安定;尚未发现使用可卡因及快克者。长沙市甲基苯丙胺以冰和麻古两种形式存在并被使用。使用方式全为冰壶抽吸,使用场所均为私人场所(家里、宾馆及出租房)。最近三个月内甲基苯丙胺的平均使用天数为21.4 d±s31.3 d(中位数10 d),冰毒的平均用量为每次0.3 g,麻古3.8片。甲基苯丙胺的可及性很强,大多数人(87/126,69.0%)都能'比较容易或非常容易'地获取。使用甲基苯丙胺常见的原因有:吸毒同伴的存在、追求刺激、以及为了摆脱不良情绪状态等,很少有人用来减肥。使用甲基苯丙胺产生的不良后果主要包括对使用者的饮食、体重、健康、经济、情绪的影响以及家庭关系的伤害。结论:甲基苯丙胺在长沙易于获得、在同伴间广为传播,其使用对使用者本人及其家庭带来了严重的危害;因此相关部门有必要采取截断毒品来源、开展相关的禁毒宣传措施。 | 张官柏 刘铁桥 郝伟 Brian C Kelly 王济川 胡红星 曾敏 柳红 | 2011 | 中国药物依赖性杂志2011，20，4： | 4 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 5 | Chronological age when health care transition skills are mastered in adolescents/young adults with inflammatory bowel disease显示文摘AIM To describe the longitudinal course of acquisition of healthcare transition skills among adolescents and young adults with inflammatory bowel diseases.METHODS We recruited adolescents and young adults(AYA) with inflammatory bowel diseases(IBD), from the pediatric IBD clinic at the University of North Carolina. Participants completed the TRx ANSITION Scale? at least once during the study period(2006-2015). We used the electronic medical record to extract participants' clinical and demographic data. We used ordinary least square regressions with robust standard error clustered at patient level to explore the variations in the levels and growths of healthcare transition readiness.RESULTS Our sample(n = 144) ranged in age from 14-22 years. Age was significantly and positively associated with both the level and growth of TRx ANSITION Scale? scores(P < 0.01). Many healthcare transition(HCT) skills were acquired between ages 12 and 14 years, but others were not mastered until after age 18, including self-management skills.CONCLUSION This is one of the first studies to describe the longitudinal course of HCT skill acquisition among AYA with IBD, providing benchmarks for evaluating transition interventions. | Natalie Stollon Yi Zhong Maria Ferris Suneet Bhansali Brian Pitts Eniko Rak Maureen Kelly Sandra Kim Miranda AL van Tilburg | 2017 | World Journal of Gastroenterology2017，23，18： | 2 |
| 6 | Progression in Acute Stroke: Value of the Initial NIH Stroke Scale Score on Patient Stratification in Future Trials显示文摘 | Thomas J. DeGraba John M. Hallenbeck Karen D. Pettigrew Andrew J. Dutka Brian J. Kelly | 1999 | Stroke: A Journal of Cerebral Circulation1999，，6： | 2 |
| 7 | A randomised trial of apsychosocial intervention for cancer patients integrated into routinecare: the PROMPT study (promoting optimal outcomes in mood throughtailored psychosocial therapies)显示文摘 | Jane Turner Brian Kelly David Clarke | 2011 | BMC Cancer2011，11，2： | 1 |
| 8 | Paracrine activation of hepatic stellate cells in platelet‐derived growth factor C transgenic mice: Evidence for stromal induction of hepatocellular carcinoma显示文摘 | Jocelyn H. Wright Melissa M. Johnson Masami Shimizu‐Albergine Renay L. Bauer Brian J. Hayes James Surapisitchat Kelly L. Hudkins Kimberly J. Riehle Simon C. Johnson Matthew M. Yeh Theodor K. Bammler Richard P. Beyer Debra G. Gilbertson Charles E. Alpers N | 2014 | Int. J. Cancer2014，，4： | 1 |
| 9 | Loss of Heterozygosity for Loci on Chromosome Arms 1p and 10q in Oligodendroglial Tumors: Relationship to Outcome and Chemosensitivity显示文摘 | Brian Thiessen John A. Maguire Kelly McNeil David Huntsman Montgomery A. Martin Doug Horsman | 2003 | Journal of Neuro - Oncology2003，，3： | 1 |
| 10 | A Novel Monoclonal Antibody Against DOG1 is a Sensitive and Specific Marker for Gastrointestinal Stromal Tumors显示文摘 | Inigo Espinosa Cheng-Han Lee Mi Kyung Kim Bich-Tien Rouse Subbaya Subramanian Kelli Montgomery Sushama Varma Christopher L. Corless Michael C. Heinrich Kevin S. Smith Zhong Wang Brian Rubin Torsten O. Nielsen Robert S. Seitz Douglas T. Ross Robert B. West | 2008 | The American Journal of Surgical Pathology2008，，2： | 1 |
| 11 | Knowledge exploration:the impacts of psychological climate and knowledge management system access显示文摘 | ALEXANDRA Durcikova KELLY J Fadel BRIAN S Butler | 2011 | Information systems research2011，22，4： | 1 |
| 12 | The Novel Marker, DOG1 , Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status显示文摘 | Robert B. West Christopher L. Corless Xin Chen Brian P. Rubin Subbaya Subramanian Kelli Montgomery Shirley Zhu Catherine A. Ball Torsten O. Nielsen Rajiv Patel John R. Goldblum Patrick O. Brown Michael C. Heinrich Matt van de Rijn | 2004 | The American Journal of Pathology2004，，1： | 1 |
| 13 | What’s right ( and wrong) about the inner harbor 显示文摘 | Kelly Brian Roger Lewis | 1992 | Planning1992，58，4： | 1 |
| 14 | Biomechanical Comparison of a Novel C1 Posterior Locking Plate With the Harms Technique in A C1–C2 Fixation Model显示文摘 | Brian P. Kelly John A. Glaser Denis J. DiAngelo | 2008 | Spine2008，，24： | 1 |
| 15 | Is all red rice found in commercial rice really Oryza sativa?显示文摘 | L Kelly Vaughan Brian V Ottis Ann M Prazak-Havey | 2001 | Weed Science2001，，49： | 1 |
| 16 | The behavior of structural steels at elevated temperatures and the design of fire resistant steels 显示文摘 | Wei Sha Brian R Kirby Fergal S Kelly | 2001 | Materials Transactions2001，42，9： | 1 |
| 17 | Anger expression, gender, and ambulatory blood pressure in mild, unmedicated adults with hypertension显示文摘 | Karin F. Helmers Brian Baker Brian O’Kelly Sheldon Tobe | 2000 | Annals of Behavioral Medicine2000，，1： | 1 |
| 18 | A comparison of changes to doxorubicin pharmaco-kinetics,antitumor activity,and toxicity mediated by PE-Gy lated dendrimer and PEGy lated liposome drug deliv-ery显示文摘 | Kaminskas Lisa M McLeod Victoria M Kelly Brian D | 2012 | Nanomedicine2012，8，1： | 1 |
| 19 | Neighborhood Built Environmentand Income: Examining Multiple HealthOutcomes显示文摘 | Sallis James F Saelens Brian E Frank Law-rence D Conway Terry L Slymen Donald J Cain Kelli L Chapman James E Kerr Jac-queline | 2009 | Social Science & Medicine2009，68，7： | 1 |
| 20 | Effects of conjugated linoleic acid supplementation on blood lipids and adiposity of rats fed diets rich in saturated versus unsaturated fat显示文摘 | Rebecca Kloss Janna Linscheid Amy Johnson Brian Lawson Kylie Edwards Travis Linder Kelly Stocker Jeremy Petitte Mark Kern | 2005 | Pharmacological Research2005，，6： | 1 |
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