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| 1 | Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells. | Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Colorectal stenting for palliation and as a bridge to surgery:A 5-year follow-up study显示文摘AIM: To evaluate the long-term effectiveness of colonic stents in colorectal tumors causing large bowel obstruction.METHODS: We retrospectively analyzed data from 49 patients with colorectal cancer who had undergone colorectal stent placement between January 2008 and January 2013. Patients' symptoms,characteristics and clinicopathological data were obtained by reviewing medical records. The obstruction was diagnosed clinically and radiologically. Histopathological diagnosis was achieved endoscopically. Technical success rate(TSR)was defined as the ratio of patients with correctly placed SEMS upon stent deployment across the entire stricture length to total number of patients. Clinical success rate(CSR) was defined as the ratio of patients with technical success and successful maintenance of stent function before elective surgery(regardless of number of SEMS deployed) to total number of patients. The surgical success rate(SSR) of colorectal stent as a bridge to surgery was defined as the ratio of patients with successful surgical procedures. Unsuccessful surgical outcomes were defined as being due to insufficient colonic decompression. The technical,clinical,surgical success rates and complications after stenting were assessed.RESULTS: The median age of patients was 64(36 to 89). 44.9% of patients were male and 55.1% were female. Eighteen patients had the obstruction located in the rectum,15 patients in the rectosigmoid region,10 patients in the sigmoid region,and 6 patients had a tumor causing obstruction in the proximal colon. Each patient was categorized pathologically as stage 2(32.7%,16 patients) or stage 3(42.9%,21 patients) and 12 patients(24.4%) had metastatic disease. None of the patients received chemotherapy before stenting. Stenting was undertaken in 37 patients as a bridge to surgery,and in 12 patients stents were used for palliation. Median time to surgery after stenting was 30 ± 91.9 d. All surgery was completed in one single operation and thus no colostomy with stoma was needed. The median overall survival rate of patients with stage 2-3 colorectal cancer was 53.1 mo and stage 4 was 37.1 mo(P = 0.04). Metastatic colorectal patients who were treated palliatively with stents had backbone chemotherapy with oxaliplatin and/or irinotecan-based regimens plus antiangiogenic therapies,especially bevacizumab. Resolution of the obstruction and clinical improvement was achieved in all patients. The technical,clinical and surgical success rates were 95.9%,100% and 94.6%,respectively.CONCLUSION: The efficacy and safety of colonic stents was demonstrated both as a bridge to surgery and for palliative decompression. In addition,results emphasize the importance of the skills of the endoscopist in colonic stenting. | Baris Bayraktar Ibrahim Ali Ozemir Umut Kefeli Gokhan Demiral Julide Sagiro?lu Onur Bayraktar Gupse Adali Alp Ozcelik Osman Baran Tortum | 2015 | World Journal of Gastroenterology2015，21，31： | 3 |
| 3 | Fascin expression in uterine smooth muscle tumors 显示文摘 | Kefeli M Yildiz L Kaya FC | 2009 | Int J Gyneeol Pathol2009，28，4： | 1 |
| 4 | Chromophobe renal cell carcinoma with osseous metaplasia containing fatty bone marrow element: a case report显示文摘 | Kefeli M Yildiz LAydin o | 2007 | Pathol Res Pract2007，203，10： | 1 |
| 5 | Chromophobe renal cell carcinoma:a case report显示文摘 | Kefeli M Yildiz L Aydin O | 2007 | Pathol Res Pract2007，203，10： | 1 |
| 6 | Prognostic Significance of Perineural Invasion in Patients with Gastric Cancer Who Underwent Curative Resection显示文摘 | Ahmet Bilici MD Mesut Seker MD Bala Basak Oven Ustaalioglu MD Umut Kefeli MD Emre Yildirim MD Dilek Yavuzer MD Fatih Muhammed Aydin MD Taflan Salepci MD Mustafa Oncel MD FASCRS(Int) Mahmut Gumus MD | 2010 | Annals of Surgical Oncology2010，，8： | 1 |
| 7 | Fascin and EMMPRIN expres- sion in primary mucinous tumors of ovary : a tissue microarray stud- y 显示文摘 | Alici O Kefeli M Yildiz L | 2014 | Pathol Res Pract2014，210，12： | 1 |
| 8 | Metastasis of adeno- carcinoma of the gall bladder to an endometrial polyp detected by endometrial curettage: case report and review of the literature 显示文摘 | KEFELI M GONULLU G CAN B | 2009 | Int J Gyneeol Pathol2009，28，4： | 1 |
| 9 | Anthracotic solitary pulmonary nod- ule imitating lung malignancy on F-18 FDG PET/CT imaging 显示文摘 | Canbaz F Kefeli M Sahin Z | 2011 | Clini- cal nuclear medicine2011，36，10： | 1 |
| 10 | Anthracotic Solitary Pulmonary Nodule Imitating Lung Malignancy on F-18 FDG PET/CT Imaging显示文摘 | Canbaz F Kefeli M Sahin Z | 2011 | Clin Nucl Med2011，36，： | 1 |
| 11 | UbeHIO expression in benign, hyperplastic, and malignant endometrial curetted materials: a tissue mieroarray study 显示文摘 | Kefeli M Yildiz L Celik H | 2012 | Int J Surg Pathol2012，20，4： | 1 |
| 12 | The effects of experimental left varicocele on the epididymis 显示文摘 | Ozturk U Kefeli M Asci R | 2008 | Syst Biol Reprod Med2008，54，45： | 1 |
| 13 | De- rivatives of sinapic acid in kohlrabi seedlings 显示文摘 | KEFELI V I KUTACHEK M VATSKOVA K | 1977 | Prop Bi- ol Act1977，24，6： | 1 |
| 14 | Conservative therapy for superior mesenteric artery syndrome 显示文摘 | Kefeli A Akturk A O Yeniova A O | 2016 | Turk J Gastroenterol2016，27，1： | 1 |
| 15 | Prolonged interval in prophylactic heparin flushing for maintenance of subcutaneous implanted port care in patients with cancer 显示文摘 | Kefeli U Dane F Yumuk PF | 2009 | European Journal of Cancer Care2009，18，2： | 1 |
| 16 | Comparison of second- line treatment outcomes between sensitive and refractory small cell lung cancer patients: a retrospective analysis显示文摘 | Korkmaz T Seber S Kefeli U | 2013 | Clin Transl Oncol2013，15，7： | 1 |
| 17 | Fascin expression in uterine smooth muscle tumors 显示文摘 | Kefeli M Yildiz L Kaya FC | 2009 | Int J Gynecol Pathol2009，28，： | 1 |
| 18 | Clinical, histopathological and mineralogical analysis findings of an unusual case of pneumoconiosis显示文摘 | Kefeli M Akpolat I Zeren H | 2012 | Turk Patoloji Derg2012，28，2： | 1 |
| 19 | Perivascular Epithelioid Cell Tumor(PEComa) of the Uterine Cervix in a Patient with Tuberous Sci- erosis Complex: A Literature Review 显示文摘 | Celik H Kefeli M Cetinkaya M | 2014 | Turk Patoloji Derg2014，8，11： | 1 |
| 20 | The effect of surgical denervation on prevention of excessive dermal scarring:a study on rabbit ear hypertrophic scar model显示文摘 | Yagmur C Guneren E Kefeli M | | 0，，10： | 1 |
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