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| 1 | 尼可地尔经皮冠状动脉介入治疗(PCI)降低心肌损伤显示文摘背景尼可地尔作为辅助治疗药物,在缺血性心脏病患者的治疗中具有良好效果。本研究旨在评估尼可地尔选择性经皮冠状动脉治疗(PCI)后对心肌的保护作用。方法我们随机地将49个接受选择性PCI治疗的病人分为尼可地尔及对照这两组。PCI治疗前,尼可地尔组先静脉推注4mg尼可地尔,介入治疗后再以6mg每小时的量静脉滴注24小时。口服尼可地尔给药组持续给药直至接下来的冠状动脉造影(CAG)。PCI治疗前及PCI治疗后0、4、24及48小时分别采集各组静脉血样,检测肌酸激酶(CK)、肌酸激酶MB亚型(CK-MB)、肌钙蛋白Ⅰ(TnI)和肌红蛋白的量。通过对比治疗前后的脑室造影来评价左心室功能及左心室壁运动。结果 PCI治疗后24小时,尼可地尔组的心肌酶水平显著低于对照组;实验组及对照组的CK分别为78.1±34.9,117.4±137.9U/l,显著性P=0.0141,CK-MB为1.57±1.90,2.67±4.50U/l,显著性P=0.0485,TnI为0.37±0.55,0.86±1.65ng/ml,显著性P=0.0101。尼可地尔组的局部左心室壁运动在后期较对照组显著增强。结论尼可地尔能抑制选择性PCI治疗后心肌酶的水平,并在后期显著增强左心室壁的运动,表明尼可地尔可提高PCI治疗时对心肌的保护,降低因血管成形术造成的心肌损伤。 | Tsuyoshi Isono Hiroshi Kamihata Yasuo Sutani Masayuki Motohiro Satoshi Yamamoto Shiori Kyoui Yoshiji Iharada Kouji Kurimoto Katsuko Hara Hakuo Takahashi Toshiji Iwasaka 陈浩 | 2016 | 首都食品与医药2016，23，20： | 3 |
| 2 | Comparative study on volatile components of Nardostachys Rhizome 显示文摘 | Ken Tanaka Katsuko Komatsu | 2008 | J NatMed2008，62，1： | 1 |
| 3 | QUALITY CONTROL FOR CHINESE HERBAL DRUGS USING DNA PROBE TECHNOLOGY显示文摘INTRODUCTIONThetypeandspectrumofdiseasesarechangingsignificantlyasthesocietyagingtoday .Theautoimmunediseasessuchasseniledementia ,AIDS ,aswellascardio cerebralvasculardis easessuchashypertension ,arrhythmia ,myocardiacinfractionearebecominganintractableandglobularproblem .Recently ,peopleareverymuchconcernedwithsideeffectsofsyntheticphar maceuticalsandareanxioustoreturntotheuseofnaturalmedicine .Backtonature ,theneedforChineseherbaldrugsisincreasinggraduallyforpreventionandtherapyofdiseasesintheworld .Arec... | Katsuko KOMATSU Paul Pui Hay BUT | 2002 | 中国实验方剂学杂志2002，8，S1： | 1 |
| 4 | Inhibitory effects of methanol extracts of herbal medicines on substance P-Induced Itch-Scratch Response显示文摘 | Chihiro Tohda Yumiko Kakihara Katsuko Komatsu | 2000 | Biol pharm Bull2000，23，5： | 1 |
| 5 | Sodium tanshinone ⅡA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin Ⅱ in cultured neonatal rat cardiac cells显示文摘 | Takahashi Kyoko Ouyang X S Komatsu Katsuko | 2002 | Biochem Pharmacol2002，64，4： | 1 |
| 6 | Sodium tanshinone II A sulfonatederived from Danshen (Salvia Miltiorrhiza) attenuates hypertrophyinduced by angiotension II in cultured neonatal rat cardiac cells 显示文摘 | Kyoko T Xinshou O Katsuko K | 2002 | Biochern Pharmacol2002，64，： | 1 |
| 7 | Immunofluorescene detection of gastric H^+/K^+ -ATPase and its alteration as related to acid secretion 显示文摘 | Xiaoyan Jiang Etsuko Suzaki Katsuko Kataoka | 2002 | Histochem Cell Biol2002，117，： | 1 |
| 8 | Development of a high performance liquid chromatographic method for systematic quantitative analysis of chemical constituents in rhubarb 显示文摘 | Katsuko K Yorinobu N | 2006 | Chem Pharm Bull2006，54，： | 1 |
| 9 | Application of loop-mediated isothermal amplifi cation technique to rapid and direct detection of methicillin-resistant Staphylococcus aureus(MRSA)in blood cultures显示文摘 | Yoshiki M Atsushi Y Katsuko O | 2007 | J Infect Chemother2007，13，1： | 1 |
| 10 | Sodium tanshinone Ⅱ A sulfonate derived from Danshen(Salvia Mihiorrhiza) attenuates hypertrophyinduced by angiotension Ⅱ in cultured neonatal rat cardiac cells 显示文摘 | Kyoko T Xinshou O Katsuko K | 2002 | Biochem Pharmacol2002，64，： | 1 |
| 11 | Repair of amyloid β25 -35-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to 显示文摘 | Chihiro T Takayuki T Katsuko K | 2003 | Brain Res2003，990，12： | 1 |
| 12 | A Retrospective Study of methicillin-resistant staphylococcus aureus clinical strains in Tokyo university hospital显示文摘 | TAE T KATSUKO O AIKICHI I | 1995 | J Infect Chemother1995，1，： | 1 |
| 13 | Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways显示文摘 | Xiao-Long Hou Kyoko Takahashi Ken Tanaka Katsuhiko Tougou Feng Qiu Katsuko Komatsu Koichi Takahashi Junichi Azuma | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
| 14 | Anti - tumor - promoting activity of lignans from the aerial part of Saussurea meduse显示文摘 | Midori T Takao K Katsuko K | 2000 | Cancer Letters2000，158，1： | 1 |
| 15 | Th17 cell-derived IL-17 is dispensable for B cell antibody production显示文摘 | Akiko Shibui Eri Shimura Aya Nambu Sachiko Yamaguchi Warren J. Leonard Ko Okumura Sumio Sugano Katsuko Sudo Susumu Nakae | 2012 | Cytokine2012，，1： | 1 |
| 16 | Amides of the fruit of Zanthoxylum spp.显示文摘 | Yoshiki Kashiwada Chikashi Ito Hitoshi Katagiri Izumi Mase Katsuko Komatsu Tsuneo Namba Yasumasa Ikeshiro | 1997 | Phytochemistry1997，，6： | 1 |
| 17 | Galeetin-4 binds to sulfated glycosphingolipids and carcinoembryonie antigen in patches on the cell surface of human colon adenocarcinoma cells 显示文摘 | HIROKO I AKIRA S KATSUKO Y | 2005 | The Journal of Biological Chemistry2005，280，： | 1 |
| 18 | Development of a high performance liquid chromatographic method for systematic quantitiative analysis of chemical constituents in rhubarb 显示文摘 | Katsuko KoMATSU Yorinobu NAGAYAMA Ken TANAKA | 2006 | Chem Pharm Bul2006，54，7： | 1 |
| 19 | Ankylosing enthesitis associated with up -regulated IFN - γ and IL- 17 production in (BXSB NZB ) FI male mice:a new mouse model 显示文摘 | Yasuharu Abe Mareki Ohtsuji Naomi Ohtsuji Qingshun Lin Hiromichi Tsurui Susumu Nakae Toshikazu Shirai Katsuko Sudo Sachiko Hirose | 2009 | Mod Rheumatol2009，19，： | 1 |
| 20 | Stable cavitation induces increased cytoplasmic calcium in L929 fibroblasts exposed to 1-MHz pulsed ultrasound显示文摘 | Akira Tsukamoto Satoru Higashiyama Kenji Yoshida Yoshiaki Watanabe Katsuko S. Furukawa Takashi Ushida | 2011 | Ultrasonics2011，，8： | 1 |
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