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| 1 | 国际疼痛研究协会疼痛定义修订版:概念、挑战和折中显示文摘现行国际疼痛研究协会(IASP)将疼痛定义为'与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验',该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研究人员广泛接受,并被一些行业、政府及非政府组织(包括世界卫生组织)所采用。近年来,一些业内人士认为,随着对疼痛更深入的了解,有必要对这个定义重新审定,并提出了修改建议。因此,2018年,IASP成立了一个主席特别工作小组,该小组是由14名来自多个国家的在疼痛相关的临床和基础科学方面拥有广泛专业知识的人员组成,其任务是评估现行定义及其附带注释,并对其保留还是修改提出建议。本文提供了关键概念的摘要、对IASP会员和公众评论的分析以及两年内委员会对疼痛定义和注释的最终修订意见。特别工作小组最后建议将疼痛定义修改为'与组织损伤或潜在组织损伤相关或类似相关的一种不愉快的感觉和情感体验',并将原来的附带注释更新为一系列简要说明并提供相关词源。今年年初,IASP理事会一致接受了修订后的定义和注释。 | Raja SN.Carr DB Cohen M.Finnerup NB Flor H.Gibson S Keefe FJ.Mogil JS Ringkamp M.Sluka KA Song XJ.Stevens B Sullivan MD.Tutelman PR Ushida T.Vader K 程志祥(译) 许继军(译) 程建国(审校) 刘先国(审校) 刘延青(审校) | 2020 | 中华疼痛学杂志2020，16，5： | 137 |
| 2 | Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury显示文摘AIM: To investigate the effects of broccoli sprout extract(BSEx) on liver gene expression and acute liver injury in the rat.METHODS: First, the effects of BSEx on liver gene expression were examined. Male rats were divided into two groups. The Control group was fed the AIN-76 diet, and the BSEx group was fed the AIN-76 diet containing BSEx. After a 10-d feeding period, rats were sacrificed and their livers were used for DNA microarray and realtime reverse transcription-polymerase chain reaction(RT-PCR) analyses. Next, the effects of BSEx on acute liver injury were examined. In experiments using acute liver injury models, 1000 mg/kg acetaminophen(APAP) or 350 mg/kg D-galactosamine(D-Gal N) was used to induce injury. These male rats were divided into four groups: Control, BSEx, Inducer(APAP or D-Gal N), and Inducer+BSEx. The feeding regimens were identical for the two analyses. Twenty-four hours following APAP administration via p.o. or D-Gal N administration via i.p., rats were sacrificed to determine serum aspartate transaminase(AST) and alanine transaminase(ALT) levels, hepatic glutathione(GSH) and thiobarbituric acid-reactive substances accumulation and glutathioneS-transferase(GST) activity. RESULTS: Microarray and real-time RT-PCR analyses revealed that BSEx upregulated the expression of genes related to detoxification and glutathione synthesis in normal rat liver. The levels of AST(70.91 ± 15.74 IU/m L vs 5614.41 ± 1997.83 IU/m L, P < 0.05) and ALT(11.78 ± 2.08 IU/m L vs 1297.71 ± 447.33 IU/m L, P < 0.05) were significantly suppressed in the APAP + BSEx group compared with the APAP group. The level of GSH(2.61 ± 0.75 nmol/g tissue vs 1.66 ± 0.59 nmol/g tissue, P < 0.05) and liver GST activity(93.19 ± 16.55 U/g tissue vs 51.90 ± 16.85 U/g tissue, P < 0.05) were significantly increased in the APAP + BSEx group compared with the APAP group. AST(4820.05 ± 3094.93 IU/m L vs 12465.63 ± 3223.97 IU/m L, P < 0.05) and ALT(1808.95 ± 1014.04 IU/m L vs 3936.46 ± 777.52 IU/m L, P < 0.05) levels were significantly suppressed in the D-Gal N + BSEx group compared with the D-Gal N group, but the levels of AST and ALT in the D-Gal N + BSEx group were higher than those in the APAP + BSEx group. The level of GST activity was significantly increased in the D-Gal N + BSEx group compared with the D-Gal N group(98.04 ± 15.75 U/g tissue vs 53.15 ± 8.14 U/g tissue, P < 0.05).CONCLUSION: We demonstrated that BSEx protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis. | Kazutaka Yoshida Yusuke Ushida Tomoko Ishijima Hiroyuki Suganuma Takahiro Inakuma Nobuhiro Yajima Keiko Abe Yuji Nakai | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects显示文摘AIM: To evaluate effects of dietary supplementation of sulforaphane(SF)-rich broccoli sprout(BS) extract on hepatic abnormalities in Japanese male participants.METHODS: In a randomized,placebo-controlled,double blind trial,male participants with fatty liver received either BS capsules containing glucoraphanin [GR; a precursor of SF(n = 24)] or placebo(n = 28) for 2 mo. Liver function markers,serum levels of aspartate and alanine aminotransferases(AST and ALT,respectively) and γ-glutamyl transpeptidase(γ-GTP) and an oxidative stress marker,urinary levels of 8-hydroxydeoxyguanosine(8-OHd G),were measured and compared in participants before and after the trial period. In an animal model,chronic liver failure was induced in Sprague-Dawley rats by successive intraperitoneal injection with N-nitrosodimethylamine(NDMA) for 4 wk. Concomitantly,rats received AIN-76 diets supplemented with or without BS extract. Thereafter,rats were sacrificed,and their sera and livers were collected to measure serum liver function markers and hepatic levels of thiobarbituric acid reactive substances(TBARS) levels and hepatic glutathione S-transferase(GST) activity,a prototypical phase 2 antioxidant enzyme.RESULTS: Dietary supplementation with BS extract containing SF precursor GR for 2 mo significantly decreased serum levels of liver function markers,ALT [median(interquartile range),before: 54.0(34.5-79.0) vs after supplementation: 48.5(33.3-65.3) IU/L,P < 0.05] and γ-GTP [before: 51.5(40.8-91.3) vs after: 50.0(37.8-85.3) IU/L,P < 0.05],as well as the alkali phosphatase activity. Placebo showed no significant effects on the markers. The urinary level of 8-OHd G,an established oxidative stress marker,was significantly reduced in participants who had received BS capsules but not the placebo [before: 6.66(5.51-9.03) vs after: 5.49(4.89-6.66) ng/mg-creatinine,P < 0.05]. The reduction of urinary 8-OHd G was significantly correlated with decreased levels of both ALT and γ-GTP [?8-OHd G and ?ALT: Spearman r(r) 0.514 and P = 0.012,?8-OHd G and ?γ-GTP: r = 0.496 and P = 0.016]. Intake of BS extract prevented NDMA-induced chronic liver failure in rats,which was attributable to the suppression of the increase in TBARS through induction of hepatic phase 2 antioxidant enzymes including hepatic GST(86.6 ± 95.2 vs 107.8 ± 7.7 IU/g,P < 0.01).CONCLUSION: Dietary supplementation with BS extract containing the SF precursor GR is likely to be highly effective in improving liver function through reduction of oxidative stress. | Masahiro Kikuchi Yusuke Ushida Hirokazu Shiozawa Rumiko Umeda Kota Tsuruya Yudai Aoki Hiroyuki Suganuma Yasuhiro Nishizaki | 2015 | World Journal of Gastroenterology2015，21，43： | 3 |
| 4 | Possible chemopreventative effects of bovine lactoferrin on esophagus and lung carcinogensis in the rat显示文摘 | USHIDA Y SEKI K KUHARA T | 1999 | Jap J Cancer Res1999，90，3： | 1 |
| 5 | Milk and dairy products in cancer prevention: focus on bovine lactoferrin显示文摘 | TSUDA H SEKINE K USHIDA Y | 2000 | Murat Res2000，462，23： | 1 |
| 6 | Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice显示文摘 | LIGO M KUHARA T USHIDA Y | 1999 | Clinl Exper Meta1999，17，1： | 1 |
| 7 | High temperature solid eletrolyte fuel cells using perovskite-type oxide based on BaCeO3显示文摘 | Iwahara H Ushida H Morimoto K | | 0，，： | 1 |
| 8 | Contralateral thalamicperfusion in patients with reflex sympathetic dystrophy syndrome显示文摘 | Fukumoto M Ushida T Zinchuk VS | 1999 | Lancet1999，354，9192： | 1 |
| 9 | Effect of ionic radii of dopants on mixed ionic conduction(H++O2-) in BaCeO3-based electrolytes显示文摘 | Iwahara H Yajima T Ushida H | | 0，，： | 1 |
| 10 | Intraoperative electroneurography in the assessment of the level of operation for cervical spondylotic myelopathy in the elderly显示文摘 | Ishida K Ushida T | 2000 | J Bone Joint Surg Br2000，82，2： | 1 |
| 11 | Oscillatory perfusion seeding and culturing of osteoblast-like cells on porous beta-tricalcium phosphate scaffolds显示文摘 | Dajiang DU Furukawa K Ushida T | 2008 | J Biomed Mater Res A2008，86，3： | 1 |
| 12 | Use of isolated mature osteoblasts in abundance acts as desired-shaped bone regeneration in combination with a modified PLGA-collagen sponge显示文摘 | Ochi K Chen G Ushida T Gojo S Segawa K Tai H Ueno K Ohkawa H Mori T Yamaguchi A Toyama Y Hata J Umezawa A | | 0，，： | 1 |
| 13 | Preparation of poly( L -lactic acid) and poly( DL -lactic- co -glycolic acid) foams by use of ice microparticulates显示文摘 | Chen G P Ushida T Tateishi T | 2001 | Biomaterials2001，22，： | 1 |
| 14 | New biologi- cal function of bovine ct-lactalbumin: protective effect against ethanol-and stress-induced gastric mueosal injury in rats显示文摘 | MATSUMOTO H SHIMOKAWA Y USHIDA Y | 2001 | Bio- science Bioteehnology and Biochemistry2001，65，5： | 1 |
| 15 | Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta显示文摘 | Yusuke Ushida Toshiro Matsui Mitsuru Tanaka | 2003 | Nutrition Research2003，23，6： | 1 |
| 16 | The role of protozoa in feed digestion显示文摘 | Jouany J P Ushida K | 1999 | Review AJAS1999，12，： | 1 |
| 17 | Poly(DL-lactic-co-glycolic acid)sponge hybridized with collagen microsponges and deposited apatite particulates显示文摘 | Chen G Ushida T Tateishi T | 2001 | Biomed Mater Res2001，57，1： | 1 |
| 18 | Algorithms for computing almost periodic steady-state responseof nonlinear systems to multiple input frequencies显示文摘 | Chua Leon O Ushida Akio | 1981 | IEEE Transactions on Circuits andSystems1981，28，10： | 1 |
| 19 | A Superconducting Copper Oxide Compound with Electrons as the Charge Carriers显示文摘 | Tokura Y Takaji H Ushida S | 1989 | Nature1989，337，： | 1 |
| 20 | Platelet responsiveness to in vitro aspirin is independent of COX-1 and COX-2 protein levels and polymorphisms显示文摘 | Takahashi S Ushida M Komine R | | 0，，： | 1 |
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