|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 生物素——抗结核药物新研究方向(英文)显示文摘耐药菌的出现对全球公共卫生构成了巨大的挑战,结核分枝杆菌(TB)是结核病的病原菌,是临床上最重要的病原体之一。新抗生素的研发用以治疗耐药性结核病已成为临床及公共卫生管理亟待解决的重要问题。生物素(维生素B7)在结核杆菌的代谢途径如脂肪酸合成和三羧酸循环中发挥重要作用,通过生物素蛋白连接酶连接活性辅助因子而被激活。生物素蛋白连接酶及其相关生物合成通路是微生物合成生物素过程中必不可或缺的关键分子,因而有可能成为新的药物靶点。遗传研究表明,结核杆菌需要由菌体进行生物素的全程合成,因此,生物素合成酶在在结核杆菌代谢过程中起着至关重要的作用,引起了抗结核药物研究者的高度重视。本文论述了结核杆菌生物素合成通路,并重点分析了生物素合成过程中可能成为药物靶点的关键酶,旨在为结核病的治疗提供新思路,具有重要的临床意义。 | THOMPSON Andrew P STERNICKI Louise M WEGENER Kate L 陆伟 竺丽梅 BOOKER Grant W POLYAK Steven W 李燕 | 2016 | 江苏预防医学2016，27，3： | 4 |
| 2 | Sensitivity analysis of parameters and contrasting performance of ground filtering algorithms with UAV photogrammetry-based and LiDAR point clouds显示文摘Most ground filtering algorithms are primarily designed for airborne LiDAR point cloud processing and their successful use in identifying ground points from photogrammetric point clouds remains questionable.We compared six ground filtering algorithms implemented in Metashape,ArcGIS,CloudCompare,LAStools,and PDAL.We used UAV photogrammetry-based(acquired under leaf-off conditions)and airborne LiDAR(leaf-on)point clouds of the same area to:(i)compare accuracy of generated DTMs;(ii)evaluate the effect of vegetation density and terrain slope on filtering accuracy;and(iii)assess which algorithm parameters have the greatest effect on the filtering accuracy.Our results show that the performance of filtering algorithms was affected by the point cloud type,terrain slope and vegetation cover.The results were generally better for LiDAR(RMSE 0.13–0.19 m)than for photogrammetric(RMSE 0.19–0.23 m)point clouds.The behavior in varying vegetation and terrain conditions was consistent for LiDAR point clouds.However,when applied on photogrammetric point clouds,the algorithms’behavior was inconsistent,especially in areas of steep slope(except for the Progressive Triangulated Irregular Network in LAStools).Parameters related to the selection of the initial minimum elevation ground points were the most influential in all algorithms and point clouds. | Petr Klápště Michal Fogl Vojtěch Barták Kateřina Gdulová Rudolf Urban Vítězslav Moudrý | 2020 | International Journal of Digital Earth2020，13，12： | 2 |
| 3 | Over-expression of sphingosinekinase-1 enhances a progenitor phenotype in humanendothelial cells显示文摘 | Barrett Jeffrey M Parham Kate A Pippal Jyotsna B CockshellMichaelia P Moretti Paul A B Brice Sarah L Pitson StuartM Bonder Claudine S | 2011 | Microcirculation2011，187，： | 1 |
| 4 | Improvement in dysphagia and quality of life with self-expanding metallic stents in malignant esophageal strictures 显示文摘 | MAROJU NK ANBALAGAN P KATE V | 2006 | Indian J Gastroenterol2006，25，2： | 1 |
| 5 | Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial显示文摘 | Dileep N Lobo Kate A Bostock Keith R Neal Alan C Perkins Brain J Rowlands Simon P Allison | 2002 | The Lancet . 2002 (9320)2002，，9320： | 1 |
| 6 | Effect of carbon fiber surface functional groups on the mechanical properties of carbon composites with HTT 显示文摘 | S R Dha Kate O P Bahl | 2003 | Carbon2003，41，7： | 1 |
| 7 | Evaluation of transient elastography for fibrosis assessment compared with large biopsies in chronic hepatitis B and C 显示文摘 | VERVEER C ZONDERVAN P E TEN KATE F J W | 2012 | Liver Int2012，32，4： | 1 |
| 8 | Escape of methane gas from the seabed along the West Spitsbergen continental margin显示文摘 | Westbrook Graham K. Thatcher Kate E. Rohling Eelco J. Piotrowski Alexander M. P?like Heiko Osborne Anne H. Nisbet Euan G. Minshull Tim A. Lanoisellé Mathias James Rachael H. Hühnerbach Veit Green Darryl Fisher Rebecca E. Crocker Anya J. Chab | 2009 | Geophysical Research Letters2009，，15： | 1 |
| 9 | Impact of aging on substrate metabolism by the human heart显示文摘 | KATES A M HERRERO P DENCE C | 2003 | J Am Coll Cardiol2003，41，2： | 1 |
| 10 | Remission of active diabetic hepatitis after correction of hyperglycemia 显示文摘 | Tak P Kate F | 1993 | Liver1993，13，4： | 1 |
| 11 | International table of glycemic index and glycemic load values: 2002 显示文摘 | Kate F P Susanna H A Janette C B M | 2002 | American Journal of Clinical Nutrition2002，76，： | 1 |
| 12 | Fracture of the great trochanter trealed by dynamic hip screw plate:measure of impaction according to fracture type显示文摘 | Oger P Kate V Lecorre N | 1998 | Rew Chir Orthop Reparatrice Appar mot1998，84，： | 1 |
| 13 | Enterocutaneous fistulae :etiol- ogy,treatment,and outcome--a study from South India显示文摘 | Kumar P Maroju NK Kate V | 2011 | Saudi J Gastroenterol2011，17，6： | 1 |
| 14 | Impact of aging on substrate metabolism by the human heart显示文摘 | Kates AM I-Ierrero P Dence C Soto P Srinivasan M Delano DG | 2003 | J Am Coll Cardiol2003，41，： | 1 |
| 15 | Cloning, structure and expression of bovine interferon-γ显示文摘 | Douglas P C Kate M Alf L | 1986 | The Journal of Immunology1986，136，12： | 1 |
| 16 | Total knee arthroplasty volume,utilization,and outcomes among Medicare beneficiaries,1991-2010显示文摘 | Cram P Lu X Kates S L | 2012 | JAMA2012，308，12： | 1 |
| 17 | ‘Part of who we are as a school should include responsibility for well-Being': links between the school environment, mental health and behaviour显示文摘 | Jennifer S Janet S Kate P Cate W | 2006 | Pasto-ral Care2006，，9： | 1 |
| 18 | Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase- type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (n = 3 424)显示文摘 | HARBECK N KATES R E LOOK M P | 2002 | Cancer Res2002，62，16： | 1 |
| 19 | Coronary artery anomalies detected by MSCTcoronary angiography in the adult显示文摘 | Ten Kate G J R Weustink A C de Feyter P J | 2008 | Neth Heart J2008，16，11： | 1 |
| 20 | Mideast surpasses China as petchem'Hot Spot'显示文摘 | KATE P | 2007 | Chemical Week2007，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员