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| 1 | Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials显示文摘Hepatocellular carcinoma(HCC), the predominant form of primary liver cancer, is the sixth most common cancer worldwide and the third leading cause of cancerrelated death. The difficulty to diagnose early cancer stages, the aggressive behaviors of HCC, and the poor effectiveness of therapeutic treatments, represent the reasons for the quite similar deaths per year and incidence number. Considering the fact that the diagnosis of HCC typically occurs in the advanced stages of the disease when the therapeutic options have only modest efficacy, the possibility to identify early diagnostic markers could be of significant benefit. So far, a large number of biomarkers have been associated to HCC progression and aggressiveness, but many of them turned out not to be of practical utility. This is the reason why active investigations are ongoing in this field. Given the huge amount of published works aimed at the identification of HCC biomarkers, in this review we mainly focused on the data published in the last year, with particular attention to the role of(1) molecular and biochemical cellular markers;(2) micro-interfering RNAs;(3) epigenetic variations; and(4) tumor stroma. It is worth mentioning that a significant number of the HCC markers described in the present review may be utilized also as targets for novel therapeutic approaches, indicating the tight relation between diagnosis and therapy. In conclusion, we believe that integrated researches among the different lines of investigation indicated above should represent the winning strategies to identify effective HCC markers and therapeutic targets. | Bruna Scaggiante Maryam Kazemi Gabriele Pozzato Barbara Dapas Rosella Farra Mario Grassi Fabrizio Zanconati Gabriele Grassi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide. Current available therapeutic approaches are poorly effective,especially for the advanced forms of the disease. In the last year,short double stranded RNA molecules termed small interfering RNAs(si RNAs) and micro interfering RNAs(mi RNA),emerged as interesting molecules with potential therapeutic value for HCC. The practical use of these molecules is however limited by the identification of optimal molecular targets and especially by the lack of effective and targeted HCC delivery systems. Here we focus our discussion on the most recent advances in the identification of si RNAs/mi RNAs molecular targets and on the development of suitable si RNA/mi RNAs delivery systems. | Rossella Farra Mario Grassi Gabriele Grassi Barbara Dapas | 2015 | World Journal of Gastroenterology2015，21，30： | 5 |
| 3 | Role of E2F1-Cyclin El-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs显示文摘 | Dapas B Farra R Grassi M | 2009 | Mol Med2009，15，910： | 1 |
| 4 | Proliferation of human primary vascular smooth muscle cells depends on serum response factor显示文摘 | Daniela Werth Gabriele Grassi Nina Konjer Barbara Dapas Rossella Farra Carlo Giansante Reinhard Kandolf Gianfranco Guarnieri Alfred Nordheim Olaf Heidenreich | 2010 | European Journal of Cell Biology2010，，2： | 1 |
| 5 | Improving siRNA bio - distribution and minimizing side effects 显示文摘 | Scaggiante B Dapas B Farra R | 2011 | Curt Drug Metab2011，12，1： | 1 |
| 6 | Iron deficiency in pregnancy:effects on the newborn显示文摘 | Isa MD Diallo Dapa MD Tchernia Gil MD | 1999 | Current Opinion in Hematology1999，6，2： | 1 |
| 7 | Comparison between recombinant baculo and adenoviral-vectors as transfer system in cardiovascular cells 显示文摘 | Grassi G Kohn H Dapas B | 2006 | Arch Virol2006，151，： | 1 |
| 8 | Dissecting the expression of EEF1 A1/2 genes in human prostate cancer cells:the potential of EEF1 A2 as a hallmark for prostate transformation and progression显示文摘 | Scaggiante B Dapas B Bonin S | | 0，，： | 1 |
| 9 | Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells:the potential of EEF1A2 as a hallmark for prostate transformation and progression显示文摘 | Scaggiante B Dapas B Bonin S | | 0，，01： | 1 |
| 10 | Identification ofdifferent isoforms of eEFlA in the nuclear fractionof human T-lymphoblastic cancer cell line specifical-ly binding to aptameric cytotoxic GT oligomers 显示文摘 | Dapas B Tell G Scaloni A | 2003 | European Journal of Biochemistry2003，270，： | 1 |
| 11 | Effects of E2F1–cyclin E1–E2 circuit down regulation in hepatocellular carcinoma cells显示文摘 | Rossella Farra Barbara Dapas Gabriele Pozzato Bruna Scaggiante Francesco Agostini Cristina Zennaro Mario Grassi Natalia Rosso Carlo Giansante Nicola Fiotti Gabriele Grassi | 2011 | Digestive and Liver Disease2011，，12： | 1 |
| 12 | Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels显示文摘 | Daniele Baiz Gabriele Pozzato Barbara Dapas Rossella Farra Bruna Scaggiante Mario Grassi Laura Uxa Carlo Giansante Cristina Zennaro Gianfranco Guarnieri Gabriele Grassi | 2008 | Biochimie2008，，3： | 1 |
| 13 | Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile 显示文摘 | Dapa T Leuzzi R Ng YK | 2013 | J Bacteriol2013，195，： | 1 |
| 14 | Comparison between recombinant baculo and adenoviral-vectors as transfer system in cardiovascular cells显示文摘 | Grassi G Kohn H Dapas B | 2006 | Arch Virol2006，151，2： | 1 |
| 15 | Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression 显示文摘 | Scaggiante B Dapas B Bonin S | 2012 | BrJCancer2012，106，1： | 1 |
| 16 | Serum response factor depletion affects the proliferation of the hepatocellular car- cinoma cells HepG2 and JHH6显示文摘 | Farra R Dapas B Pozzato G | 2010 | Biochimie2010，92，5： | 1 |
| 17 | Improving siRNA bio-dis- tribution and minimizing side effects显示文摘 | Scaggiante B Dapas B Farra R | 2011 | Curr Drug Metab2011，12，1： | 1 |
| 18 | Therapeutic Potential of Nucleic Acid-Based Drugs in Coronary Hyper- Proliferative Vascular Diseases显示文摘 | G. Grassi B. Scaggiante B. Dapas R. Farra F. Tonon G. Lamberti A. Barba S. Fiorentino N. Fiotti F. Zanconati M. Abrami M. Grassi | 2013 | Current Medicinal Chemistry2013，，28： | 1 |
| 19 | Inhibitory effects of fenofibrate on apoptosis and cell proliferation in human endothelial ceils in high glucose显示文摘 | Zanetti M Stocca A Dapas B | 2008 | J Mol Med2008，86，2： | 1 |
| 20 | Inhibitory effects of fenofibrate on apoptosis and cell proliferation in human endothelial cells in high glucose显示文摘 | Zanetti M Stocca A Dapas B | 2007 | J Mol Med(Berl)2007，86，2： | 1 |
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