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| 1 | A population-based approach to the management of depression in a patient-centered medical home显示文摘Objective:This article describes the implementation of a population-based strategy to man-age depression in a patient-centered medical home.Methods:Review of English language articles;description of specific protocols utilized in one medical home.Results:Depression is a global concern estimated to affect 350 million people worldwide.Rates for depression vary between the United States and the Peoples’Republic of China,possibly due to significant factors in under diagnosis of this often hidden burden.Given the comorbidity of depres-sion with other health factors and the need for ongoing monitoring and care of this chronic illness,primary care has become a significant part of treatment interventions.Utilizing electronic health records(EHR),our strategy included the creation of a patient registry;selection of evidence-based treatment guidelines and protocols for point of care procedures;patient outreach and screening.Conclusion:The population-based program we outline is highly dependent on the EHR and the flexibility of roles and responsibilities of clinical staff.Further investigation is warranted into improved patient outcomes. | Kenneth Kushner Gwynneth Schell | 2015 | Family Medicine and Community Health2015，3，1： | 7 |
| 2 | Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia显示文摘Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a concern.In this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples.CDK9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and c-Myc.However,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of Mcl-1.Accordingly,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of venetoclax.Our preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML. | Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 3 | A striking local esophageal cytokine expression profile in eosinophilic esophagitis显示文摘 | Carine Blanchard Emily M. Stucke Beatriz Rodriguez-Jimenez Karen Burwinkel Margaret H. Collins Annette Ahrens Eileen S. Alexander Bridget K. Buckmeier Butz Sean C. Jameson Ajay Kaul James P. Franciosi Jonathan P. Kushner Philip E. Putnam J. Pablo Abonia M | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 3 |
| 4 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 5 | Metabolic and clinical correlates of acute ischemic infarction 显示文摘 | Kushner M Reivich M Fieschi C | 1987 | Neurology1987，37，： | 2 |
| 6 | Acute- phase proteins and other systemic responses to inflammation显示文摘 | GABAY C KUSHNER I | 1999 | N Engl J Med1999，340，： | 1 |
| 7 | On the existence of optimal stochastic controls显示文摘 | Kushner H J | 1965 | SIAMJ Control1965，3，： | 1 |
| 8 | Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth 显示文摘 | KUSHNER J A CIEMERYCH M A SICINSKA E | 2005 | Mol Cell Biol2005，25，9： | 1 |
| 9 | Influence of modeling and simulation on the maturation of plasma technology: Feature evolution and reactor design 显示文摘 | Graves D B Kushner M J | 2003 | Journal of Vacuum Science Technology2003，21，5： | 1 |
| 10 | Aberrant expression of cyclin A and cyclin B1 proteins in oral carcinoma显示文摘 | Kushner J Bradley G Young B | 1999 | JOral Pathol Med1999，28，2： | 1 |
| 11 | Sex hormone-binding globulin and insulin resistance in African-American women显示文摘 | Sherif K Kushner H Falkner BE | 1998 | Metabolism1998，47，： | 1 |
| 12 | Excretion of collagen derived peptides is incorased in women with stress urinary incontinence 显示文摘 | Kushner L Mathrubutham M Burney T | 2004 | Neurourol Urody2004，23，3： | 1 |
| 13 | 2009 focused updates : ACC/AHA guidelines for the management of pa- tients'with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/ AHA/SCAI guidelines on percutaneous coronary interven- tion (updating the 2005 guideline and 2007 focused up- date): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Kushner FG Hand M Smith SC Jr | 2009 | J Am Coil Cardiol2009，54，： | 1 |
| 14 | On determining the statistical parameters for pollution concentration from a truncated data set 显示文摘 | KUSHNER E J | 1976 | Atmos Environ1976，10，11： | 1 |
| 15 | 2013 ACCF/ AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | O'Gara PT Kushner FG Ascheim DD | 2013 | Circulation2013，127，4： | 1 |
| 16 | 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on pereutaneous coronary intervention (updating the 2005 guideline and 2007 focused update) a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Kushner FG Hand M Smith SC Jr | 2009 | J Am Coll Cardiol2009，54，23： | 1 |
| 17 | Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monodonal antibodies by enhancing recovery of β-cells显示文摘 | Sherey NA Chen W Kushner JA | | 0，，： | 1 |
| 18 | THE NUCLEAR HORMONE RECEPTOR GENE SUPERFAMILY显示文摘 | Ralff C. J. Ribeiro M.D Peter J. Kushner Ph.D John D. Baxter M.D | 1995 | Annual Review of Medicine1995，，： | 1 |
| 19 | Selective surgery for intermittent exotropia based on distance/near differences 显示文摘 | KUSHNER BJ | 1998 | Arch Ophthalmol1998，116，2： | 1 |
| 20 | Inhibition of fibrobast proliferation by actinobacillus actinomycetemcomitans显示文摘 | Shenker B J Kushner ME Tsai CC | 1982 | Infect Immun1982，38，： | 1 |
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