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| 1 | 世界生物精神病学会联合会(WFSBP)关于焦虑障碍、强迫症和创伤后应激障碍的药物治疗指南显示文摘这篇文章根据现有的随机、安慰剂或参照药物对照临床研究 ,向大家推荐焦虑障碍、强迫症的药物治疗。 5-HT再摄取抑制剂 (SSRI)是治疗惊恐障碍的一线药物。三环类抗抑郁药 (TCA)与SSRI疗效相当 ,但耐受性差。难治性患者 ,如没有药物依赖和耐受史 ,则可使用苯二氮 艹卓 类药物如阿普唑仑。由于单胺氧化酶抑制剂 (MAOI)苯乙肼会产生严重的不良反应 ,且会与其他药物和食物成分相互作用 ,因此只有当一线药物无效时才使用。广泛性焦虑者可用万拉法新和SSRI,也可选用丁螺环酮和丙咪嗪。SSRI可作为社交恐怖症的一线药物 ,MAOI、吗氯贝胺和苯二氮 艹卓 类药物作为二线药物。强迫症最好用SSRI或氯丙咪嗪治疗。 | Borwin Bandelow Josef Zohar Eric Hollander Siegfried Kasper Hans-J¨urgen M¨oller WFSBP Task 项志清 何燕玲 | 2003 | 中国心理卫生杂志2003，17，7： | 30 |
| 2 | Hydrogen--A sustainable energy carrier显示文摘Hydrogen may play a key role in a future sustainable energy system as a carrier of renewable energy to replace hydrocarbons. This review describes the fundamental physical and chemical properties of hydrogen and basic theories of hydrogen sorption reactions, followed by the emphasis on state-of-the-art of the hydrogen storage properties of selected interstitial metallic hydrides and magnesium hydride, especially for stationary energy storage related utilizations. Finally, new perspectives for utilization of metal hydrides in other applications will be reviewed. | Kasper T.Moller Torben R.Jensen Etsuo Akiba Hai-wen Li | 2017 | Progress in Natural Science:Materials International2017，27，1： | 10 |
| 3 | Novel adjunctive treatments of myocardial infarction显示文摘Myocardial infarction is a major cause of death and disability worldwide and myocardial infarct size is a major determinant of prognosis. Early and successful restoration of myocardial reperfusion following an ischemic event is the most effective strategy to reduce final infarct size and improve clinical outcome,but reperfusion may induce further myocardial damage itself. Development of adjunctive therapies to limit myocardial reperfusion injury beyond opening of the coronary artery gains increasing attention. A vast number of experimental studies have shown cardioprotective effects of ischemic and pharmacological conditioning,but despite decades of research,the translation into clinical effects has been challenging. Recently published clinical studies,however,prompt optimism as novel techniques allow for improved clinical applicability. Cyclosporine A,the GLP-1 analogue exenatide and rapid cooling by endovascular infusion of cold saline all reduce infarct size and may confer clinical benefit for patients admitted with acute myocardial infarcts. Equally promising,three follow-up studies of the effect of remote ischemic conditioning(RIC) show clinical prognostic benefit in patients undergoing coronary surgery and percutaneous coronary intervention. The discovery that RIC canbe performed noninvasively using a blood pressure cuff on the upper arm to induce brief episodes of limb ischemia and reperfusion has facilitated the translation of RIC into the clinical arena. This review focus on novel advances in adjunctive therapies in relation to acute and elective coronary procedures. | Michael Rahbek Schmidt Kasper Pryds Hans Erik Btker | 2014 | World Journal of Cardiology2014，6，6： | 9 |
| 4 | Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma显示文摘AIM: To investigate the role of tumor inf iltrating lym-phocytes (TIL) in primary hepatocellular and cholangio-lar carcinomas of the liver.METHODS: Immunohistochemical analysis was per-formed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-f ixed and paraff in-embed-ded tissue of 35 liver resection specimens of hepatocel-lular or cholangiocellular carcinomas. Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver interface.RESULTS: All hepatocellular carcinomas showed in-filtration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power f ields (HPF)] and in the tumor itself of CD8+ cells (54.9/10 HPF). Cholangiocarcinomas contained a heterogeneous amount of TIL, composed mainly of CD3+ T cells with a predominance of CD8+ cells in the tumor tissue (52.6/10 HPF) and of CD4+ cells in the interface region (223.1/10 HPF). CD56+ cells of the innate immune system were scarce. There was no significant difference between hepatocellular or cholangiolar carcinoma. No correlation with the clinicopathological data was seen. CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells indepen-dent of histogenetic origin. Different functions of lym-phocytes in these regions seem possible. | Hans-Udo Kasper Uta Drebber Dirk Ludger Stippel Hans Peter Dienes Anton Gillessen | 2009 | World Journal of Gastroenterology2009，15，40： | 8 |
| 5 | Novel applications of statins for bone regeneration显示文摘The use of statins for bone regeneration is a promising and growing area of research. Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl, the rate-limiting enzyme of the mevalonate pathway. Because the mevalonate pathway is responsible for the synthesis of a wide variety of important biochemical molecules, including cholesterol and other isoprenoids,the efects of statins are pleiotropic. In particular, statins can greatly afect the process of bone turnover and regeneration via efects on important cell types, including mesenchymal stem cells, osteoblasts, endothelial cells, and osteoclasts. Statins have also been shown to have anti-inlammatory and antimicrobial properties that may be useful since infection can derail normal bone healing. his review will explore the pleiotropic efects of statins, discuss the current use of statins for bone regeneration, particularly with regard to biomaterials-based controlled delivery, and ofer perspectives on the challenges and future directions of this emerging area of bone tissue engineering. | Sarita R.Shah Caroline A.Werlang F.Kurtis Kasper Antonios G.Mikos | 2015 | National Science Review2015，2，1： | 7 |
| 6 | Perspectives on the prevention and treatment of infection for orthopedic tissue engineering applications显示文摘The emergence of orthopedic tissue engineering devices as viable clinical solutions demands that the field address significant clinical complications associated with the implantation of foreign materials in the body,especially infection.While tissue engineering has focused on the development of methods to regenerate and repair,until recently there has been a relative dearth of literature regarding the intersection of tissue engineering and infection.In particular,local delivery of antimicrobials has long been of clinical interest,but only recently has that been translated into the realm of tissue engineering.In this perspective,we briefly review major modes of local delivery for infection prevention and treatment and discuss possible strategies for preventing implant-associated infections. | SHAH Sarita R KASPER F Kurtis MIKOS Antonios G | 2013 | Chinese Science Bulletin2013，58，35： | 4 |
| 7 | An INDEHISCENT-Controlled Auxin Response Specifies the Separation Layer in Early Arabidopsis Fruit显示文摘种子疏开是在植物种的生命周期的一重要时刻。在 Arabidopsis thaliana,它依赖于抄写因素果皮不裂(IND ) 调停了在裂开地区的分离层的说明在在阀门(心皮墙) 和发展中的水果的中央洋梅之间的边缘发现了。IND 由在水果开发的迟了的阶段导致本地植物生长素最小指定分离层,这被建议。这里,我们证明 ind 异种和野类型的水果之间的词法差别已经在水果开发的早阶段产生,与在阀门边缘的强壮的 IND 表示与一致。我们证明减少 IND 的 PIN-FORMED3 (PIN3 ) 植物生长素流出搬运人丰富在早水果开发期间在阀门边缘导致增加的植物生长素回答,并且形成裂开地区的伴随物房间部门缺乏 ind 变异的水果。而且, AGC kinases PINOID (PID ) 的 IND 倡导者驱动的宫外的表示和 WAG2 由通过增加的 PIN3 丰富在水果开发的阶段 14-16 从阀门边缘驱逐植物生长素导致了 indehiscence。我们的结果证明除它在 Arabidopsis 水果开发的迟了的阶段的角色以外, IND 在早阶段工作便于形成裂开地区的被触发植物生长素的房间部门。 | Kasper van Gelderen Martin van Rongen An'an Liu Anne Otten Remko Offringa | 2016 | Molecular Plant2016，9，6： | 3 |
| 8 | The contribution of small leaks in a baghouse filter to dust emission in the PM2.s range-A system approach显示文摘 | Oliver Kurtz Jorg Meyer Gerhard Kasper | 2017 | Particuology2017，15，1： | 3 |
| 9 | Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis显示文摘AIM To evaluate the liver regeneration capacity(LRC) after partial hepatectomy(PH) in experimental non-alcoholic steatohepatitis(NASH).METHODS Fifty-four female rats were fed a high-fat, high-cholesterol diet(HFCD, 65% fat, 1% cholesterol) or standard diet(STD) for 16 wk. A 70% PH was performed and the animals were euthanised before PH or 2 or 5 d postPH. LRC was evaluated using: The total number of Ki-67 positive hepatocytes in the caudate lobe, N(Ki-67, lobe) evaluated in a stereology-based design, the regenerated protein ratio(RPR), prothrombin-proconvertin ratio(PP), and m RNA expression of genes related to regeneration.RESULTS The HFCD NASH model showed significant steatosis with ballooning and inflammation, while no fibrosis was present. Mortality was similar in HFCD and STD animals following PH. HFCD groups were compared to respective STD groups and HFCD animals had a significantly elevated alanine transaminase at baseline(P < 0.001), as well as a significantly elevated bilirubin at day 2 after PH(P < 0.05). HFCD animals had a higher N(Ki-67, lobe) at baseline,(P < 0.0001), day 2 after PH(P = 0.06) and day 5 after PH(P < 0.025). We found no significant difference in RPR or PP neither 2 or 5 d post-PH. Expression of liver regeneration genes(e.g., hepatic growth factor) was higher at both day 2 and 5 post-PH in HFCD groups(P < 0.05).CONCLUSION NASH rats had a preserved LRC after hepatectomy when compared to STD rats. The methods and models of NASH are essential in understanding and evaluating LRC. | David Haldrup Sara Heeboll Karen Louise Thomsen Kasper Jarlhelt Andersen Michelle Meier Frank Viborg Mortensen Jens Randel Nyengaard Stephen Hamilton-Dutoit Henning Gronbaek | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 10 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 11 | 2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Clyde W. Yancy Mariell Jessup Biykem Bozkurt Javed Butler Donald E. Casey Mark H. Drazner Gregg C. Fonarow Stephen A. Geraci Tamara Horwich James L. Januzzi Maryl R. Johnson Edward K. Kasper Wayne C. Levy Frederick A. Masoudi Patrick E. McBride John J.V. | 2013 | Circulation2013，，16： | 2 |
| 12 | Isolation of cold agglutionation in Eperythrozoon suis infected pigs显示文摘 | SCHMIDT P KASPERS B JUNGLING A | 1992 | VetImmuno Immunopatho1992，31，： | 2 |
| 13 | 髋关节畸形的发生率及其与性别、腹股沟痛和骨关节炎发病风险的关系——一项人口调查研究显示文摘背景:关于股骨髋臼撞击症的临床结果已有较多阐述,但对髋关节解剖畸形在一般人群中的发生率、自然病史和骨关节炎发生风险评估的研究甚少。方法:此抽样调查资料来源于1991至1994年哥本哈根骨关节炎子研究的4151例人口调查影像学及问卷调查队列研究数据。调查对象主要为丹麦哥本哈根sterbro地区的白人。符合纳入标准的男性1332名,女性2288名。根据影像学标准,髋关节被分为无畸形或有畸形,畸形中包括臼窝过深、枪柄样畸形和臼窝过深合并枪柄样畸形。髋关节骨关节炎影像学上定义为最小关节间隙宽度≤21mm。结果:3620名调查对象中髓臼发育不良的发生率为男4.3%,女3.6%:臼窝过深为男15.2%,女19.4%;枪柄样畸形为男19.6%,女5.2%;臼窝过深合并枪柄样畸形为男2.9%,女0.9%。正常髋臼顶比例为男80.7%,女77.0%。我们发现影像学上显示有髋关节畸形的调查对象其腹股沟痛的发生率无显著增加(P均〉0.13)。臼窝过深是骨关节炎发生的一个显著危险因素(风险比为2.4),枪柄样畸形亦为显著危险因素(风险比为2.2)。髋臼发育不良及性别不是髋关节骨关节炎发生的显著危险因素(P值分别为0.053和0.063)。靛关节骨关节炎发生率为男9.5%,女11.2%。髋关节骨关节炎并发畸形的发生率为男71.o%,女36.6%。结论:本组调查对象中,臼窝过深及枪柄样畸形是比较常见的影像学改变,与髋关节骨关节炎的发生风险增加相关。与髋关节畸形相关的骨关节炎高发生率提示我们应该更多地关注髋关节的早期畸形。 | Kasper Kjaerlf Gosvig Steffen Jacobsen Sfig Sonne-Holm Henrik Palm Anders Troelsen 付勤(译) | 2010 | 中华骨科杂志2010，30，12： | 2 |
| 14 | The value of independent directors: Evidence from sudden deaths显示文摘 | Bang Dang Nguyen Kasper Meisner Nielsen | 2010 | Journal of Financial Economics2010，，3： | 2 |
| 15 | Beat-to-Beat QT Interval Variability: Novel Evidence for Repolarization Lability in Ischemic and Nonischemic Dilated Cardiomyopathy显示文摘 | Ronald D. Berger Edward K. Kasper Kenneth L. Baughman Eduardo Marban Hugh Calkins Gordon F. Tomaselli | 1997 | Circulation1997，，： | 2 |
| 16 | Developmental Issues in Interlanguage Pragmatics显示文摘 | Gabriele Kasper Richard Schmidt | 1996 | Studies in Second Language Acquisition1996，，2： | 2 |
| 17 | Targeted therapies in gastroesophageal cancer显示文摘 | Stefan Kasper Martin Schuler | 2014 | European Journal of Cancer2014，，： | 2 |
| 18 | 一把椅子抵住这时间的洪流显示文摘关于人与物是如何互相影响的,我想一把汉斯·瓦格纳(HANS J.WEGNER)的椅子便能说明这两者间全部的关系。 | msright PP M?bler Mikkel Adsb?l Jens Mourits S?rensen Erik Brahl Rasmus Koch Studio Katja Kejser Kasper Holst Pedersen | 2015 | 设计2015，28，22： | 2 |
| 19 | 基于锗硅芯片的光电子学前景与挑战显示文摘作为微电子材料,硅具备许多优良的电学特性.采用硅材料的器件集成度能够比其他材料高几个数量级。然而.硅是一种间接带隙材料,其光学跃迁过程会引入大量低能的声子造成跃迁几率很低.导致其光学特性(发射与吸收)远不如Ⅲ/Ⅴ族半导体材料。 | Erich Kasper | 2010 | 光学与光电技术2010，8，2： | 2 |
| 20 | Some opportunistic infections in AIDS : Candidiasis pneumocystosis, cryptosporidiosis, toxoplasmosis显示文摘 | Kasper LH Buzeni Garer D | 1998 | Parasitol Today1998，14，4： | 1 |
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