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| 1 | General competencies of problem‐based learning (PBL) and non‐PBL graduates显示文摘 | Katinka J A HPrince Patrick W L JVan Eijs Henny P ABoshuizen Cees P MVan Der Vleuten Albert J J AScherpbier | 2005 | Medical Education2005，，4： | 5 |
| 2 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 3 | Validity of the visual analogue scale as an instrument to measure self‐efficacy in resuscitation skills显示文摘 | Nigel MTurner Anita JVan De Leemput Jos M TDraaisma PaulOosterveld Olle Th JTen Cate | 2008 | Medical Education2008，，5： | 4 |
| 4 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 5 | Understanding and tuning blue-to-near-infrared photon cutting by the Tm^(3+)/Yb^(3+) couple显示文摘Lanthanide-based photon-cutting phosphors absorb high-energy photons and‘cut’them into multiple smaller excitation quanta.These quanta are subsequently emitted,resulting in photon-conversion efficiencies exceeding unity.The photon-cutting process relies on energy transfer between optically active lanthanide ions doped in the phosphor.However,it is not always easy to determine,let alone predict,which energy-transfer mechanisms are operative in a particular phosphor.This makes the identification and design of new promising photon-cutting phosphors difficult.Here we unravel the possibility of using the Tm^(3+)/Yb^(3+) lanthanide couple for photon cutting.We compare the performance of this couple in four different host materials.Cooperative energy transfer from Tm^(3+)to Yb^(3+) would enable blue-to-near-infrared conversion with 200% efficiency.However,we identify phonon-assisted cross-relaxation as the dominant Tm^(3+)-to-Yb^(3+) energy-transfer mechanism in YBO_(3),YAG,and Y_(2)O_(3).In NaYF_(4),in contrast,the low maximum phonon energy renders phonon-assisted cross-relaxation impossible,making the desired cooperative mechanism the dominant energy-transfer pathway.Our work demonstrates that previous claims of high photon-cutting efficiencies obtained with the Tm^(3+)/Yb^(3+) couple must be interpreted with care.Nevertheless,the Tm^(3+)/Yb^(3+) couple is potentially promising,but the host material-more specifically,its maximum phonon energy-has a critical effect on the energy-transfer mechanisms and thereby on the photon-cutting performance. | Dechao Yu Ting Yu Arnoldus Jvan Bunningen Qinyuan Zhang Andries Meijerink Freddy T.Rabouw | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 6 | Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis显示文摘Background:Liver regeneration following partial hepatectomy(PHx)is a complicated process involving multiple organs and several types of signaling networks.The bile acid-activated metabolic pathways occupy an auxiliary yet important chapter in the entire biochemical story.PHx is characterized by rapid but transient bile acid overload in the liver,which constitutes the first wave of proliferative signaling in the remnant hepatocytes.Bile acids trigger hepatocyte proliferation through activation of several nuclear receptors.Following biliary passage into the intestines,enterocytes reabsorb the bile acids,which results in the activation of farnesoid X receptor(FXR),the consequent excretion of fibroblast growth factor(FGF)19/FGF15,and its release into the enterohepatic circulation.FGF19/FGF15 subsequently binds to its cognate receptor,fibroblast growth factor receptor 4(FGFR4)complexed withβ-klotho,on the hepatocyte membrane,which initiates the second wave of proliferative signaling.Because some bile acids are toxic,the remnant hepatocytes must resolve the potentially detrimental state of bile acid excess.Therefore,the hepatocytes orchestrate a bile acid detoxification and elimination response as a protective mechanism in concurrence with the proliferative signaling.The response in part results in the excretion of(biotransformed)bile acids into the canalicular system,causing the bile acids to end up in the intestines.Relevance for patients:Recently,FXR agonists have been shown to promote regeneration via the gut-liver axis.This type of pharmacological intervention may prove beneficial for patients with hepatobiliary tumors undergoing PHx.In light of these developments,the review provides an in-depth account of the pathways that underlie post-PHx liver regeneration in the context of bile acid homeostasis in the liver and the gut-liver signaling axis. | Lianne de Haan Sarah Jvan der Lely Anne-Loes K.Warps Quincy Hofsink Pim B.Olthof Mark J.de Keijzer Daniel A.Lionarons Lionel Mendes-Dias Bote G.Bruinsma Korkut Uygun Hartmut Jaeschke Geoffrey C.Farrell Narci Teoh Rowan Fvan Golen Tiangang Li Michal Heger | 2018 | Journal of Clinical & Translational Research2018，4，1： | 2 |
| 7 | Why should we use multifunctional neuroprotective andneurorestorative drugs for Parkinson’s disease?显示文摘 | Moussa BH Youdim Werner JGeldenhuys Cornelis JVan derSchyf | 2007 | Parkinsonismand Related Disorders2007，13，3： | 1 |
| 8 | Differential expression of interleukin‐17 family cytokines in intact and complicated human atherosclerotic plaques显示文摘 | Onno Jde Boer Jelger Jvan der Meer PeterTeeling Chris Mvan der Loos Mirza MIdu Febevan Maldegem JanAten Allard Cvan der Wal | 2010 | J. Pathol2010，，4： | 1 |
| 9 | Development of the interval endurance ca- pacity in elite and sub elite youth field hockey players 显示文摘 | Elferink-Gemser MT Visscher C Jvan Duijn MA | 2006 | Br J Sports Med2006，40，4： | 1 |
| 10 | Production of clonal founders in the European sea bass, Dicentrarchus labrax L., by mitotic gynogenesis显示文摘 | Daniela Bertotto Fulvio Cepollaro Angelo Libertini Alvise Barbaro Antonia Francescon Paola Belvedere Jvan Barbaro Lorenzo Colombo | 2005 | Aquaculture2005，，1： | 1 |
| 11 | Large-scale evolutionary patterns of host plant asso- ciations in the Lepidoptera显示文摘 | Steph B J Menken Jacobus J Boomsma Erik Jvan Nieuk- erken | 2010 | Evolution2010，64，4： | 1 |
| 12 | ′Schmallenberg virus′--a novel orthobunyavirus emerging in Europe显示文摘 | Beer M Conraths F JVan Der Poel W H | 2013 | Epidemiol Infect2013，141，1： | 1 |
| 13 | Scanning electron microscopy of biofilm formation in denitrifying fluidized-bed reactors显示文摘 | Sich H Jvan R | 1997 | Water Research1997，，31： | 1 |
| 14 | Performance of a treatment system for inorganic nitrogen removal in intensive aquaculture systems显示文摘 | Arbiv R Jvan R | 1995 | Aquacultural Engineering1995，，14： | 1 |
| 15 | Control of translation by mRNA secondary structure in E coli 显示文摘 | DESMITHM H DUIN Jvan | 1994 | Mol Biol1994，244，： | 1 |
| 16 | Validity of the visual analogue scale as an instrument to measure self‐efficacy in resuscitation skills显示文摘 | Nigel MTurner Anita JVan De Leemput Jos M TDraaisma PaulOosterveld Olle Th JTen Cate | 2008 | Medical Education2008，，5： | 1 |
| 17 | Modeling transport in interaction with the economy显示文摘 | F W C Jvan de Vooren | 2004 | Transportation Research part E2004，40，： | 1 |
| 18 | Methylation profiles of hereditary and sporadic ovarian cancer显示文摘 | Guus MBol Karijn P MSuijkerbuijk JoostBart MarcVooijs ElskenVan Der Wall Paul JVan Diest | 2010 | Histopathology2010，，3： | 1 |
| 19 | Helical baffles in shell-and tube heatexchangers,Part Ⅰ:experimental verification显示文摘 | P Stehlik H JVan etal | 1996 | Heat Transfer Engineering1996，17，1： | 1 |
| 20 | Women older than 40 years of age and those with elevated folliele-stimulating hormone levels differ in poor response rate and embryo quality in in vitro fertilization显示文摘 | Ilse A Jvan Rooij Laszlo FJM M Bancsi | 2003 | Fertility and Sterility2003，79，3： | 1 |
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