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| 1 | Medically unexplained dyspnea:psychophysiological characteristics and role of breathing therapy显示文摘Background Medically unexplained dyspnea occurs commonly in medical settings and remains poorly understood. This study was conducted to investigate the psychophysiological characteristics of medically unexplained dyspnea and the efficacy of breathing retraining for these patients. Methods A group of patients with medically unexplained dyspnea were compared to patients with a variety of organic lung diseases and healthy subjects. In another group of patients,the influence of breathing therapy on complaints,anxiety, and breath-holding was evaluated for an average of 1.5 years. Results Patients with medically unexplained dyspnea reported more intense dyspnea than patients with a variety of organic lung diseases. Additionally,they were anxious and presented a broad range of symptoms in daily life and under challenge,for instance voluntary hyperventilation. More than one third of them qualified for panic disorder. They had shorter breath-holding time at rest,less increase in breath-holding time and higher chances of showing a “paradoxical” decrease of breath-holding time after hyperventilation. A combination of PaO2,forced expiratory volume in one second (FEV1),and anxiety measures distinguished them from organic dyspnea. Breathing retraining profoundly improved their symptoms and decreased the level of state and trait anxiety. Moreover,they better tolerated the voluntary hyperventilation and the symptoms induced were also markedly decreased after therapy. Breath-holding time was prolonged and PetCO2 in a representative group of patients increased. Conclusions Patients with medically unexplained dyspnea appear to have the feature of a “psychosomatic” patient: an anxious patient with a wide variety of symptoms of different organ systems that do not have an organic basis. They can be distinguished from organic dyspnea using a small set of physiological and psychological measures. Breathing retraining turns out to be an effective therapy for those “difficult to treat patients”. | 韩江娜 朱元珏 李舜伟 雒冬梅 胡征 Van Diest I De Peuter S Van de Woestijne KP Van den Bergh O | 2004 | Chinese Medical Journal2004，，1： | 10 |
| 2 | 呼吸前反馈调节、情景想象和过度通气显示文摘 | Ilse Van Diest 韩江娜 Karel P.Vande Woestijne Stephan Devriese Winnie Winters Omer Vanden Bergh | 2002 | 中华结核和呼吸杂志2002，25，5： | 4 |
| 3 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 4 | Fearful imagery induces hyperventilation and dyspnea in medically unexplained dyspnea显示文摘背景:医学上 unexplained 呼吸困难指呼吸困难的一种感觉描绘的一个条件并且是典型地适用于没有内在的心肺的病理,焦虑和亢奋的通风地介绍的病人。我们被感兴趣知道焦虑怎么触发亢奋的通风并且在那些病人得到自觉症状。用一个形象范例,我们在挑起亢奋的通风并且在得到症状调查了可怕的形象的角色,明确地呼吸困难。方法:有医学上 unexplained 呼吸困难和 40 个正常题目的四十个病人好久匹配,性暴露于脚本并且要求想象可怕、宁静的情形,当结束潮汐的 PCO (2 )(PetCO (2 )) 和呼吸频率被记录,自觉症状评估了时。有 PetCO (2 ) 掉落的题目从基线的超过 5 毫米汞柱并且在想象力在这底层坚持超过 15 秒被认为是一个亢奋的通风应答者。结果:在有医学上 unexplained 呼吸困难的病人,可怕的情形的想象力,特别地在一部电梯里被堵住,导致的焦急感情,并且在 PetCO (2 ) 挑起了重要下降(P <
0.05 ) 。呼吸频率趋于增加。十八从 40 个正常题目与 5 相比作为亢奋的通风应答者从 40 个病人被识别(P <
0.01 ) 。病人在一样的可怕的手迹形象报导了呼吸困难,心跳或快心搏的症状。另外, PetCO (2 ) 秋天显著地在其它上与一方面在心理形象期间经验丰富的呼吸困难和心跳的紧张,并且与焦虑症状被相关。结论:可怕的形象挑起亢奋的通风并且与医学上 unexplained 呼吸困难在病人导致呼吸困难和心跳的自觉症状。 | HAN Jiang-na ZHU Yuan-jue LUO Dong-mei LI Shun-wei Ilse Van Diest Omer Van den Bergh KarelP Van de Woestijne | 2008 | Chinese Medical Journal2008，，1： | 2 |
| 5 | EGFR expression predicts BRCA1 status in patients with breast eancer显示文摘 | van Diest PJ van der Groep P van der Wall E | 2006 | Clin Cancer Res2006，12，2： | 1 |
| 6 | Expression of proliferation and apoptosis-related proteins in usual ductal hyperplasia of the breast显示文摘 | Mommers EC van Diest PJ Leonhart AM | 1998 | Hum Pathol1998，29，12： | 1 |
| 7 | Sentinel node detection in cervical cancer 显示文摘 | Verheijen RH Pijpers R van Diest PJ | 2000 | Obstet Gynecol2000，96，： | 1 |
| 8 | Root-phosphate metabolism induced by the alkaline uptake pattern of legume utilizing symbiotically fixed nitrogen 显示文摘 | AGUILAR S A VAN Diest A | 1981 | Plant Soil1981，61，： | 1 |
| 9 | Inflammatory markers predict late cardiac events in patients who are exhausted after percu- taneous coronary intervention 显示文摘 | Kwaijtaal M van Diest R Bar FW | 2005 | Atherosclerosis2005，182，2： | 1 |
| 10 | Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases显示文摘 | Takano Y Koto Y Diest PJ | 2000 | Am J Pathol2000，156，2： | 1 |
| 11 | Lack of cyclin D1 over- expression in gastric carcinogenesis 显示文摘 | Blok P Craanen ME Van Diest PJ | 2000 | Histopathology2000，36，2： | 1 |
| 12 | Metalloprotease ADAM10 is required for Notch1 site 2 cleavage显示文摘 | van Tetering G van Diest P Verlaan I | | 0，，： | 1 |
| 13 | Concerted overexpression of the genes encoding p21 and cyclin D1 is associated with growth inhibition and differentiation in various carcinomas显示文摘 | DE JONG J S VAN DIEST P J MICHALIDES R J | 2009 | Mol Pathol2009，52，2： | 1 |
| 14 | Hypoxia-inducible factor-1alpha is associated with angiogenesis,and expression of bFGF,PDGF-BB,and EGFR in invasive breast cancer显示文摘 | Bos R van Diest PJ de Jong JS | | 0，，01： | 1 |
| 15 | Too close for comfort? Distinguishing between team intimacy and team cohesion显示文摘 | Rosh L Offermann L R Van Diest R | 2012 | Human Resource Management Re- view2012，22，2： | 1 |
| 16 | Root-phophate metabolism induced by the alkaline uptake pattern of legume utilizing symbiotically fixed nitrogen显示文摘 | Aguilar S A Van Diest A | 1981 | Plant Soil1981，61，： | 1 |
| 17 | Fibroblast growth factor receptors in breast cancer: expression, downstream effects, and possible drug targets显示文摘 | Tenhagen M van Diest PJ Ivanova IA | 2012 | En docrine Relate Cancer2012，19，4： | 1 |
| 18 | Visceral hypersensitivity in IBS:from bench to bedside显示文摘 | van Diest SA Stanisor OI de Jonge WJ | 2011 | J Pediatr Gastroenterol Nutr2011，532，： | 1 |
| 19 | Ductoscopy for pathologic nipple discharge显示文摘 | Waaijer L van Diest P van der Pol CC | 2013 | Ned Tijdschr Geneeskd2013，157，29： | 1 |
| 20 | Breast canc- er histopathology image analysis: a review 显示文摘 | VETA M PLUIM J P VAN DIEST P J | 2014 | IEEE Trans Biomed Eng2014，61，5： | 1 |
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