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| 1 | Trans-arterial chemoperfusion for the treatment of liver metastases of breast cancer and colorectal cancer: Clinical results in palliative care patients显示文摘AIM To evaluate the clinical value and efficiency of transarterial chemoperfusion(TACP) in patients with liver metastases from breast cancer(BC) and colorectal cancer(CRC).METHODS We treated 36 patients with liver metastases of BC(n = 19, 19 females) and CRC(n = 17; 8 females, 9 males) with repeated TACP. The treatment interval was 4 wk. TACP was performed with gemcitabine(1000 mg/m2) and mitomycin(10 mg/m2), administered within 1 h after positioning the catheter tip in the hepatic artery. Before treatment, the size, location, tumour volume, vascularization and number of liver tumours were evaluated using magnetic resonance imaging(MRI). Tumour response was evaluated according to the Response Evaluation Criteria in Solid Tumors guidelines.RESULTS TACP using gemcitabine and mitomycin for metastases from CRC and BC was performed without any serious side effects. The follow-up MRI showed a therapeutic response in 84.2% of the BC patients-stable disease 47.4% and partial response 36.8%. A progression was seen in 15.8%.CRC patients showed a therapeutic response in 52.9% of cases. A progression of the disease was documented in 47.1% of the patients with CRC. These data show that TACP in patients with liver metastases of BC leads to a significantly better therapeutic response compared with CRC patients(P = 0.042). The median survival time was 13.2 mo for the BC patients, which is significantly longer than for CRC patients at 9.3 mo(P = 0.001).CONCLUSION TACP for liver metastases of BC appears to be a safe and effective palliative treatment with improved outcomes in comparison to patients with CRC. | Tatjana Gruber-Rouh Marcel Langenbach Nagy NN Naguib Nour-Eldin M Nour-Eldin Thomas J Vogl Stephan Zangos Martin Beeres | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 2 | 查看详情显示文摘 | Derbyshire F J De Beer V H J Abotsi G M K Scaroni A W, Solar J M, Skrovanek D J | | 0，，： | 2 |
| 3 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 4 | Successful knowledge management projects显示文摘 | Davenport T T De Long D W Beers M C | 1998 | Sloan Management Review1998，，11： | 2 |
| 5 | Creep cavitations by vacancy diffusion in plastically deforming solid显示文摘 | BEERE D SPEIGHT M V | 1978 | Metal Science1978，12，： | 1 |
| 6 | The relation between morphology and hydrotreating activity for supported MoS2 particles 显示文摘 | HENSEN E J M KOOYMAN P J Van der MEER Y Van der KRAAN A M de BEER V H J Van VEEN J A R Van SANTEN R A | 2001 | J Catal2001，199，2： | 1 |
| 7 | Surgical techniques for vault prolapse: a review of the literature 显示文摘 | Beer M Kuhn A | 2005 | European Journal of Obstetrics & Gynecology and Reproductive Biology2005，119，2： | 1 |
| 8 | Validation of a real-time RT-PCR assay for sensitive and specific detection of classical swine fever 显示文摘 | Hoffmann B Beer M Sehelp C | 2005 | Journal of Virological Methods2005，130，12： | 1 |
| 9 | Improving knowledge work processes显示文摘 | Davenport T H S L Jarvenpaa M C Beers | 1996 | Sloan Management Review1996，37，4： | 1 |
| 10 | The accuracy of medication histories in the hospital medical records of elderly persons显示文摘 | Beers MH Munekata M Storrie M | 1990 | Am Geriatr Soc1990，38，11： | 1 |
| 11 | The Multilevel Cycle of Anthropogenic Zinc显示文摘 | Graedel T E Beers Dick van Bertram M | 2005 | Journal of Industrial Ecology2005，9，3： | 1 |
| 12 | Multiple cycles of intermittent chemotherapy in metastatic androgen - independent prostare cancer显示文摘 | Beer TM Garzotto M Henner WD | 2004 | Br J Cancer2004，91，8： | 1 |
| 13 | Antioxidant enzyme activities and mitoehondrial fatty acids in pulmonary hyperten sion syndrome (PHS) in broilers显示文摘 | Iqbal M Cawthon D Beers K | 2002 | Pouh Sci2002，81，2： | 1 |
| 14 | Localization of viral proteins in cells infected with bovine viral diarrhoea virus显示文摘 | GRUMMER B BEER M LIEBLER-TENORIO E | | 0，，： | 1 |
| 15 | Combustion in Swirling Flows: A Review 显示文摘 | Syred N Beer J M | 1974 | Combustion and Flame1974，23，2： | 1 |
| 16 | Bandaging technique after knee replacement显示文摘 | Charalambides C Beer M Melhuish J | 2005 | Acta Orthop2005，76，1： | 1 |
| 17 | Surgical techniques for vault prolapse: a review of the literature显示文摘 | Beer M Kuhn A | 2005 | Eur J Obstet Gyneeol Reprod Biol2005，119，2： | 1 |
| 18 | Dimethylthiourea reduces ischemia brain edema without affecting cerebral blood flow 显示文摘 | Martz D Beer M Betz AL | 1990 | Cereb Blood Flow Metab1990，，10： | 1 |
| 19 | Nitric oxide production and perivaseular nitration in brain after carbon monoxide poisoning in the rat显示文摘 | ISCHIROPOULOS H BEERS M F OHNISHI S T | 1996 | J Clin Invest1996，97，10： | 1 |
| 20 | Diethylstilbestrol and docetaxel:a PhaseⅡ study of tubulin active agents in patents with metastatic,androgen-independent prostate cancer显示文摘 | Montgomery RB Nelson PS lin D Ryan CW Garzotto M Beer TM | 2007 | Cancer2007，110，5： | 1 |
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