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| 1 | Burden of onchocerciasis-associated epilepsy:first estimates and research priorities显示文摘Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free areas.Although the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an association.Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic drugs.Main body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services.Epilepsy not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities involved.We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases.We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of treatment.We estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated before.The total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of 0.336.The burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to epilepsy.We estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases would have been a minimum of 12.4 million US$.Conclusions:These estimates suggest a considerable health,social and economic burden of OAE in Africa.The treatment and care for people with epilepsy,especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources. | Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe Sake Jde Vlas Andrea S.Winkler Wilma A.Stolk | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 2 | Calculation of Particle Trajectories in Solid-Rocket Motors with Arbitrary Acceleration显示文摘 | Jayant S Sabnis Frederik Jde Jong Howard J Gibeling | 1992 | Journal of Propulsion and Power1992，8，5： | 1 |
| 3 | Long-term renal function in patients with renal-cell carcinoma treated surgically:comparison between radical and partial nephrecto- my显示文摘 | Lopez-Garibay LA Cendejas-Gomez Jde J Rodriguez-Covmvubias F | 2013 | Rev Invest Clin2013，65，1： | 1 |
| 4 | Limited surgery and tamoxifen in the treatment of elderly breast cancer patients显示文摘 | Odendaal Jde V Apffelstaedt JP | 2003 | World J Surg2003，27，： | 1 |
| 5 | Shape change and phase transition of needle-like no-stoichiometric apatite crystals显示文摘 | Yubao L Klein CPAT Wijn JDE | 1994 | J Mater Sci: Mater Med1994，5，： | 1 |
| 6 | Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) / Drug-induced Hypersensitivity Syndrome ( DIHS ) : a review of current concepts 显示文摘 | Criado PR Criado RF Avancini Jde M | 2012 | An Bras Dermatol2012，87，3： | 1 |
| 7 | EPOC y al- teraciones endocrinornetab61icas 显示文摘 | Chill6n Martin MJ Diez Jde M Moreno AF | 2009 | Arch Bronconeumol2009，45，4： | 1 |
| 8 | Changes in the extracenu- lar matrix due to diabetes and their impact on urinary continence 显示文摘 | Marini G Rinaldi Jde C Damasceno DC | 2014 | Rev Bras Ginecol Obstet2014，36，7： | 1 |
| 9 | Special report:nursing diagnoses and interventions for a child with dilated cardiomyopathy requiring intra-aortic balloon pump support--case report显示文摘 | Lopes Jde L Meneguim S Soares Muniz CC et a/ | 2011 | Int J Nurs Terminol Classif2011，22，1： | 1 |
| 10 | Eval- uation of IL17A expression and of IL17A, IL17F and IL-23R gene polymorphisms in Brazilian individuals with periodontitis 显示文摘 | Saraiva AM Alvese Silva MR Correia Silva Jde F | 2013 | Hum Immunol2013，74，2： | 1 |
| 11 | Systematicreview of prognostic cohort studies on shoulder disorders显示文摘 | Kuijpers T van der Windt DA van der Hei Jde GJ | | Pain 201 O 1090，，3： | 1 |
| 12 | Cardiovascular events: a class effect by COX-2 inhibitors 显示文摘 | Araujo LF Soeiro Ade M Femandes Jde L Serrano Junior CV | 2005 | Arq Bras Cardiol2005，85，3： | 1 |
| 13 | Correlation between plaque composition as assessed by virtual histology and C-reactive protein 显示文摘 | Siqueira DA Sousa AG Costa Junior Jde R | 2013 | Arq Bras Cardiol2013，101，1： | 1 |
| 14 | TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects 显示文摘 | Garduno-Garcia Jde J Alvirde-Garcia U Lopez-Carrasco G | 2010 | Eur J Endocrinol2010，163，2： | 1 |
| 15 | Fish oil decreases C - reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients 显示文摘 | Mocellin MC Pastore e Silva Jde A Camargo Cde Q | 2013 | Lipids2013，48，9： | 1 |
| 16 | PKC412 inhibits the zinc finger198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myelopro|iferative disorder 显示文摘 | Chen JDe angelo DJ Kutok JL | 2004 | Proe Natl Acad Sei USA2004，101，14： | 1 |
| 17 | Therole of left prefrontal cortex in language and memory显示文摘 | Gabrieli JDE Poldrack RA Desmond JE | | 0，，： | 1 |
| 18 | TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects显示文摘 | Garduno-Garcia Jde J Alvirde-Garcia U L6pez-Carrasco G | 2010 | Eur J Endocrinol2010，163，2： | 1 |
| 19 | Insulin and leptin levels in obese patients with and without breast cancer显示文摘 | Romero-Figueroa Mdel S Gardu?o-García Jde J Duarte-Mote J | 2013 | Clin Breast Cancer2013，13，6： | 1 |
| 20 | Lung ab scess: analysis of 252 consecutive cases diagnosed between 1968 and 2004 显示文摘 | Moreira ida S Camargo Jde J Felicetti J C | 2006 | J Bras Pneumol2006，32，2： | 1 |
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