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| 1 | General competencies of problem‐based learning (PBL) and non‐PBL graduates显示文摘 | Katinka J A HPrince Patrick W L JVan Eijs Henny P ABoshuizen Cees P MVan Der Vleuten Albert J J AScherpbier | 2005 | Medical Education2005，，4： | 5 |
| 2 | Problem‐based learning: future challenges for educational practice and research显示文摘 | Diana H J MDolmans WillemDe Grave Ineke H A PWolfhagen Cees P MVan Der Vleuten | 2005 | Medical Education2005，，7： | 4 |
| 3 | Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma显示文摘Background:Surgery for perihilar cholangiocarcinoma(PHCC)remains a challenging procedure with high morbidity and mortality.The Academic Medical Center(Amsterdam UMC)and Memorial Sloan Kettering Cancer Center proposed a postoperative mortality risk score(POMRS)and post-hepatectomy liver failure score(PHLFS)to predict patient outcomes.This study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido University.Methods:Medical records of 260 consecutive PHCC patients who had undergone major hepatectomy with extrahepatic bile duct resection without pancreaticoduodenectomy at Hokkaido University between March 2001 and November 2018 were evaluated to validate the PHLFS and POMRS.Results:The observed risks for PHLF were 13.7%,24.5%,and 39.8%for the low-risk,intermediate-risk,and high-risk groups,respectively,in the study cohort.A receiver-operator characteristic(ROC)analysis revealed that the PHLFS had moderate predictive value,with an analysis under the curve(AUC)value of 0.62.Mortality rates based on the POMRS were 1.7%,5%,and 5.1%for the low-risk,intermediate-risk,and high-risk groups,respectively.The ROC analysis demonstrated an AUC value of 0.58.Conclusions:This external validation study showed that for PHLFS the threshold for discrimination in an Eastern cohort was reached(AUC>0.6),but it would require optimization of the model before use in clinical practice is acceptable.The POMRS were not applicable in the eastern cohort.Further external validation is recommended. | Takehiro Noji Satoko Uemura Jimme KWiggers Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Toru Nakamura Takahiro Tsuchikawa Keisuke Okamura Pim BOlthof William RJarnagin Thomas Mvan Gulik Satoshi Hirano | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 2 |
| 4 | Effects of conventional and problem‐based learning on clinical and general competencies and career development显示文摘 | JankeCohen‐Schotanus Arno M MMuijtjens JohannaSch?nrock‐Adema JelleGeertsma Cees P MVan Der Vleuten | 2008 | Medical Education2008，，3： | 2 |
| 5 | The design of low-noise bandgap reference 显示文摘 | Arie Van Staveren Chris J M Verhoeven Althur H MVan Roermund | 1996 | Transactions on Circuits and Systems1996，43，4： | 1 |
| 6 | Nutrient removal by NF and RO membranes in a decentralized sanitation system 显示文摘 | Ellen Mvan Voorthuizen Arie Zwijnenburg Matthias Wessling | 2005 | Water Res2005，39，15： | 1 |
| 7 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 8 | Slot synchronization by reducing the PPM pulse width in wireless optical systems 显示文摘 | O Rob Leo P de J Arthur H Mvan R | 1998 | IEEE Transactions on Circuits and Systems1998，45，7： | 1 |
| 9 | Patient sat- isfaction and preference with magnet, bar-clip, and ball-socket retained mandibular implant overdentures: a cross-over clinical trlal显示文摘 | Cune Mvan Kalnpen F van der Bilt A | 2005 | Int J Prosthodont2005，18，2： | 1 |
| 10 | Development and validation of the European League against rheumatism response criteria for rheumatoid arthritis 显示文摘 | A Mvan GESTEL | 1996 | Arthritis Rheum1996，39，1： | 1 |
| 11 | Effect of long-term irrigation application on the variation of soil electrical conductivity in vineyards显示文摘 | Clercq W P DE Meirvenne Mvan | 2005 | Geoderma2005，128，： | 1 |
| 12 | Differential expression of interleukin‐17 family cytokines in intact and complicated human atherosclerotic plaques显示文摘 | Onno Jde Boer Jelger Jvan der Meer PeterTeeling Chris Mvan der Loos Mirza MIdu Febevan Maldegem JanAten Allard Cvan der Wal | 2010 | J. Pathol2010，，4： | 1 |
| 13 | High resolution landform classifieation using fuzzy k-means 显示文摘 | BURROUGH P A MVAN GAANS P F MAC MILLAN R A | 2000 | Fuzzy Sets and System2000，113，： | 1 |
| 14 | Comment to: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘We have read with interest the article by Crinier et al.describing a comprehensive single-cell RNA sequencing dataset of human bone marrow natural killer(NK)cells from eight healthy donors.1 Their unbiased analysis resulted in the identification of three NK cell populations in bone marrow:hNK_Bm1,hNK_Bm2 and hNK_Bm3.These populations correspond to the NK cell populations that the authors previously described in human spleen:hNK_Spl1,hNK_Sp2 and hNK_Sp3.2 The authors compared the gene signatures of the three bone marrow populations to the conventional CD56bright and CD56dim NK cells in the blood and concluded that hNK_Bm1 cells resemble CD56dim NK cells,hNK_Bm2 cells correspond to CD56bright NK cells,and hNK_Bm3 represent a CD56bright tissue-resident NK cell population that is not present in the blood. | Janine E.Melsen Gertjan Lugthart Monique Mvan Ostaijen-ten Dam Marco W.Schilham | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 15 | A prospective 10 year follow up study of patiens with neurofibromatosis type 1显示文摘 | Goeed - Bolder A de Broek K Mvan | 1998 | Arch Dis Child1998，78，： | 1 |
| 16 | Integration:A dynamic traffic simulation/assignment model显示文摘 | Mvan Aerde | 1992 | Federal Highway Administration1992，，1： | 1 |
| 17 | Differentiation of atrial cardiomyocytes as a result of chronic atrial fibrillation显示文摘 | AUSMA J WIJFFEL S MVAN E | 1997 | Am J Pathol1997，151，： | 1 |
| 18 | An o- verview of quantitative risk measures for loss of life and economic damage显示文摘 | JONKMAN S N MVAN GELDER P H A J KVRIJLING J | 2003 | Journal of Hazardous Materials2003，99，： | 1 |
| 19 | Microbiological Risk Assessmentof foods in international trade显示文摘 | Mvan Schothorst | 2010 | SafetyScience2010，4，： | 1 |
| 20 | Separation of neo-natal rat ventricular myocytes and non-myocytes by centrifugal elutria-tion显示文摘 | Boerma Mvan der Wees CG Wondergem J | 2002 | Eur J Phy2002，444，3： | 1 |
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