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| 1 | Partial splenic artery embolization in cirrhotic patients显示文摘Splenomegaly is a common sequela of cirrhosis, and is frequently associated with decreased hematologic indices including thrombocytopenia and leukopenia. Partial splenic artery embolization(PSE) has been demonstrated to effectively increase hematologic indices in cirrhotic patients with splenomegaly. This is particularly valuable amongst those cirrhotic patients who are not viable candidates for splenectomy. Although PSE was originally developed decades ago, it has recently received increased attention. Presently, PSE is being utilized to address a number of clinical concerns in the setting of cirrhosis, including: decreased hematologic indices, portal hypertension and its associated sequela, and splenic artery steal syndrome. Following PSE patients demonstrate significant increases in platelets and leukocytes. Though progressive decline of hematologic indices occur following PSE, they remain improved as compared to pre-procedural values over long-term follow-up. PSE, however, is not without risk and complications of the procedure may occur. The most common complication of PSE is post-embolization syndrome, which involves a constellation of symptoms including fever, pain, and nausea/vomiting. The rate of complications has been shown to increase as the percent of total splenic volume embolized increases. The purpose of this review is to explore the current literature in re-gards to PSE in cirrhotic patients and to highlight their techniques, and statistically summarize their results and associated complications. | Tyson A Hadduck Justin P McWilliams | 2014 | World Journal of Radiology2014，6，5： | 31 |
| 2 | Nationwide trends and predictors of inpatient mortality in 83884 transjugular intrahepatic portosystemic shunt显示文摘AIM: To evaluate and validate the national trends and predictors of in-patient mortality of transjugular intrahepatic portosystemic shunt(TIPS) in 15 years.METHODS: Using the National Inpatient Sample which is a part of Health Cost and Utilization Project, we identified a discharge-weighted national estimate of 83884 TIPS procedures performed in the United States from 1998 to 2012 using international classification of diseases-9 procedural code 39.1. The demographic, hospital and co-morbility data were analyzed using a multivariant analysis. Using multi-nominal logistic regression analysis, we determined predictive factors related to increases in-hospital mortality. Comorbidity measures are in accordance to the Comorbidity Software designed by the Agency for Healthcare Research and Quality.RESULTS: Overall, 12.3% of patients died during hospitalization with downward trend in-hospitalmortality with the mean length of stay of 10.8 ± 13.1 d. Notable, African American patients(OR = 1.809 vs Caucasian patients, P < 0.001), transferred patients(OR = 1.347 vs non-transferred, P < 0.001), emergency admissions(OR = 3.032 vs elective cases, P < 0.001), patients in the Northeast region(OR = 1.449 vs West, P < 0.001) had significantly higher odds of inhospital mortality. Number of diagnoses and number of procedures showed positive correlations with in-hospital death(OR = 1.249 per one increase in number of procedures). Patients diagnosed with acute respiratory failure(OR = 8.246), acute kidney failure(OR = 4.359), hepatic encephalopathy(OR = 2.217) and esophageal variceal bleeding(OR = 2.187) were at considerably higher odds of in-hospital death compared with ascites(OR = 0.136, P < 0.001). Comorbidity measures with the highest odds of in-hospital death were fluid and electrolyte disorders(OR = 2.823), coagulopathy(OR = 2.016), and lymphoma(OR = 1.842).CONCLUSION: The overall mortality of the TIPS procedure is steadily decreasing, though the length of stay has remained relatively constant. Specific patient ethnicity, location, transfer status, primary diagnosis and comorbidities correlate with increased odds of TIPS in-hospital death. | Edward Wolfgang Lee Andrew Kuei Sammy Saab Ronald W Busuttil Francisco Durazo Steven-Huy Han Mohamed M El-Kabany Justin P Mc Williams Stephen T Kee | 2016 | World Journal of Gastroenterology2016，22，25： | 7 |
| 3 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 4 | Fluoroscopically assisted pedicle screw fixation for thoracic and thoracolumbar injuries显示文摘 | John J Carbone M D Justin P | 2003 | SPINE2003，28，1： | 1 |
| 5 | Inter- and intra-organizational knowledge transfer: a meta-ana- lytic review and assessment of its antecedents and eonse- quences显示文摘 | RAYMOND W JUSTIN J P J MARJORIE A L | 2008 | Journal of Management Studies2008，45，4： | 1 |
| 6 | Making sense of latent TGF 13 activation 显示文摘 | Justin P John S Daniel B | 2003 | Journal of Cell Science2003，116，： | 1 |
| 7 | Passing data and supplying power to neural implants显示文摘 | Sun M G Justin G A Roche P A | | 0，，05： | 1 |
| 8 | The utility of nal and transformational leadership for pre- performance and satisfaction within a theory framework显示文摘 | Vecchio transactlo dicting path-goal R P Justin J E Pearce C L | 2008 | Journal of Occupatio- nal and Organizational Psychology2008，81，1： | 1 |
| 9 | Top management team advice seeking and exploratory innova- tion: the moderating role of TMT heterogeneity显示文摘 | ALEXIEV ALEXANDER S JANSEN JUSTIN J P | 2010 | Jour- nal of Management Studies2010，47，7： | 1 |
| 10 | Illegitimate Cre dependent chromosome rearrangements in transgenic mouse spermatics显示文摘 | EDWARD E S DEBORAH S T JUSTIN R P | 2000 | PNAS2000，97，13： | 1 |
| 11 | Root adaptation to soil water logging显示文摘 | ARMSTRONG W JUSTIN S H F W BECKETT P M | 1991 | Aquatic Botany1991，39，2： | 1 |
| 12 | Strategic leader- ship for exploration and exploitation: the moderating role of environmental dynamism显示文摘 | JUSTIN J P VERA J B CROSSAN M | 2009 | The Leadership Quarter- ly2009，，20： | 1 |
| 13 | Strategic Leadership for Explorationand Exploitation:The Moderating Role of Environmental Dynamism显示文摘 | Justin J P Dusya V Mary C | 2009 | The Leadership Quarterly2009，20，： | 1 |
| 14 | Reinforcing poly(e-caprolactone) nanoflbers with cellulose nanocrystals显示文摘 | Justin O Z Maria S P Youssef H | 2009 | Applied Materials and Interfaces2009，1，9： | 1 |
| 15 | Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation显示文摘 | Maria E. Figueroa Omar Abdel-Wahab Chao Lu Patrick S. Ward Jay Patel Alan Shih Yushan Li Neha Bhagwat Aparna Vasanthakumar Hugo F. Fernandez Martin S. Tallman Zhuoxin Sun Kristy Wolniak Justine K. Peeters Wei Liu Sung E. Choe Valeria R. Fantin Elisabeth P | 2010 | Cancer Cell2010，，6： | 1 |
| 16 | Congenital Melanocytic Nevus and the Internet:an Evaluation of Available Web-based Resources显示文摘 | Allison L David B | 2005 | The Journal of Craniofacial Surgery2005，16，5： | 1 |
| 17 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 18 | Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis显示文摘 | Simunovic Nicole Devereaux P J Sprague Sheila Guyatt Gordon H Schemitsch Emil DeBeer Justin Bhandari Mohit | 2010 | Canadian Medical Association. Journal2010，，15： | 1 |
| 19 | Pine-cone morphology and pseudocapacitive behavior of nanoporous nickel oxide显示文摘 | Meher S K Justin P Ranga R G | 2010 | Electrochimica Acta2010，55，28： | 1 |
| 20 | Screening of high-risk and general populations for gestational diabetes显示文摘 | Justin P Lavin JR | 1985 | Diabetes1985，34，2： | 1 |
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