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| 1 | Contribution of the Compass satellite navigation system to global PNT users显示文摘As one of the four global satellite navigation systems,Compass not only enhances satellite visibility and availability for positioning,navigation and timing (PNT) for users in China and the surrounding areas,but also improves PNT precision for global users.The improvements in satellite visibility and the dilution of precision are analyzed under GNSS compatibility and interoperation conditions.The contribution of the Compass satellite navigation system to global users,especially the benefits that users can acquire from the combination of Compass,GPS,GLONASS,and Galileo navigation systems,is analyzed using simulation data. | YANG YuanXi LI JinLong XU JunYi TANG Jing GUO HaiRong HE HaiBo | 2011 | Chinese Science Bulletin2011，56，26： | 90 |
| 2 | Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein显示文摘Hepatitis B virus(HBV)is regarded as a stealth virus,invading and replicating efficiently in human liver undetected by host innate antiviral immunity.Here,we show that type I interferon(IFN)induction but not its downstream signaling is blocked by HBV replication in HepG2.2.15 cells.This effect may be partially due to HBV X protein(HBx),which impairs IFNβpromoter activation by both Sendai virus(SeV)and components implicated in signaling by viral sensors.As a deubiquitinating enzyme(DUB),HBx cleaves Lys63-linked polyubiquitin chains from many proteins except TANK-binding kinase 1(TBK1).It binds and deconjugates retinoic acid-inducible gene I(RIG I)and TNF receptor-associated factor 3(TRAF3),causing their dissociation from the downstream adaptor CARDIF or TBK1 kinase.In addition to RIG I and TRAF3,HBx also interacts with CARDIF,TRIF,NEMO,TBK1,inhibitor of kappa light polypeptide gene enhancer in B-cells,kinase epsilon(IKKi)and interferon regulatory factor 3(IRF3).Our data indicate that multiple points of signaling pathways can be targeted by HBx to negatively regulate production of type I IFN. | Junyi Jiang Hong Tang | 2010 | Protein & Cell2010，1，12： | 13 |
| 3 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 4 | Wide Band Gap Non-Fullerene Small Molecular Acceptors Containing Spirobifluorene and Benzotriazole with Three Different End-Capped Groups for P3HT-Based Organic Solar Cells显示文摘 | Xiaoyu Wen Bo Xiao Ailing Tang Junyi Hu Chunhe Yang Erjun Zhou | 2018 | Chinese Journal of Chemistry2018，36，5： | 2 |
| 5 | Brilliant blue G attenuates lipopolysaccharide-mediated microglial activation and inflammation显示文摘Previous studies have confirmed that oxidized adenosine triphosphate, a P2X7 receptor antagonist, attenuates lipopolysaccharide-mediated microglial activation and inflammatory expression following neuronal damage in rat brain. NaCl and temperature may affect the potency of oxidized adenosine triphosphate. Brilliant blue G is a derivative of a widely used food additive and has little toxicity. This study explored the effects of brilliant blue G, a selective P2X7 receptor antagonist, on microglial activation and inflammation. Results demonstrated that brilliant blue G inhibited the release of cyclooxygenase-2 and interleukin-6 in BV2 cells. Immunofluorescence displayed that brilliant blue G could suppress lipopolysaccharide-induced microglial activation. This study used RNA interference to block P2X7 receptor expression and found that small interfering RNA also suppressed the release of cyclooxygenase-2 and interleukin-6 in BV2 cells. These results suggested that downregulation of the P2X7 receptor by brilliant blue G was involved in the inhibition of microglial activation and inflammation. | Kui Lu Jue Wang Bin Hu Xiaolei Shi Junyi Zhou Yamei Tang Ying Peng | 2013 | Neural Regeneration Research2013，8，7： | 1 |
| 6 | Heart failure in hospitalized patients with diabetic foot ulcers: Clinical characteristics and their relationship with prognosis (糖尿病足溃疡住院患者的心衰:临床特点以及它们与预后的关系)显示文摘 | Lei Xu Hongjie Qian Junyi Gu Jianyuan Shi Xueming Gu Zhengyi Tang | 2013 | Journal of Diabetes2013，，： | 1 |
| 7 | stAPAminer:Mining Spatial Patterns of Alternative Polyadenylation for Spatially Resolved Transcriptomic Studies显示文摘Alternative polyadenylation(APA)contributes to transcriptome complexity and gene expression regulation and has been implicated in various cellular processes and diseases.Singlecell RNA sequencing(scRNA-seq)has enabled the profiling of APA at the single-cell level;however,the spatial information of cells is not preserved in scRNA-seq.Alternatively,spatial transcriptomics(ST)technologies provide opportunities to decipher the spatial context of the transcriptomic landscape.Pioneering studies have revealed potential spatially variable genes and/or splice isoforms;however,the pattern of APA usage in spatial contexts remains unappreciated.In this study,we developed a toolkit called stAPAminer for mining spatial patterns of APA from spatially barcoded ST data.APA sites were identified and quantified from the ST data.In particular,an imputation model based on the k-nearest neighbors algorithm was designed to recover APA signals,and then APA genes with spatial patterns of APA usage variation were identified.By analyzing wellestablished ST data of the mouse olfactory bulb(MOB),we presented a detailed view of spatial APA usage across morphological layers of the MOB.We compiled a comprehensive list of genes with spatial APA dynamics and obtained several major spatial expression patterns that represent spatial APA dynamics in different morphological layers.By extending this analysis to two additional replicates of the MOB ST data,we observed that the spatial APA patterns of several genes were reproducible among replicates.stAPAminer employs the power of ST to explore the transcriptional atlas of spatial APA patterns with spatial resolution.This toolkit is available at http://gffzz188fe103f8f1460asnpq99wb9oko96669.ffgz.tsg.suse.edu.cn/BMILAB/stAPAminer and http://gffzz77e3413bc06540edsnpq99wb9oko96669.ffgz.tsg.suse.edu.cn/biocode/tools/BT007320. | Guoli Ji Qi Tang Sheng Zhu Junyi Zhu Pengchao Ye Shuting Xia Xiaohui Wu | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 1 |
| 8 | Rewiring ERBB3 and ERK signaling confers resistance to FGFR1 inhibition in gastrointestinal cancer harbored an ERBB3-E928G mutation显示文摘Dear Editor,Recently,a large number of studies found that activation of ERBB3(Erb-B2 receptor tyrosine kinase 3,also known as HER3)may be one of the major mechanisms underlying resistance to therapies that target the EGFR(epidermal growth factor receptor),HER2,and other receptor tyrosine kinases(RTKs)(Chen et al.,2011;Choi et al.,2012;Ross et al.,2018).Interestingly,mutations in ERBB3 are commonly reported in gastrointestinal(Gl)cancer,with mutations identified in approximately 12%of stomach and colorectal cancer cases(Jaiswal et al.,2013). | Xiang Yang Hongxiao Wang Enjun Xie Biyao Tang Qingdian Mu Zijun Song Junyi Chen Fudi Wang Junxia Min | 2020 | Protein & Cell2020，11，12： | 1 |
| 9 | Fault diagno- sis approach based on volterra models显示文摘 | Tang Hao Liao Yuhe Cao Junyi | 2010 | Mechanical Systems and Signal Processing2010，24，4： | 1 |
| 10 | FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria显示文摘 | Hongcheng Sun Mujian Teng Jie Liu Dong Jin Junyi Wu Dongwang Yan Junwei Fan Xuebin Qin Huamei Tang Zhihai Peng | 2011 | Cancer Letters2011，，2： | 1 |
| 11 | Conductive Porous MXene for Bionic,Wearable,and Precise Gesture Motion Sensors显示文摘Reliable,wide range,and highly sensitive joint movement monitoring is essential for training activities,human behavior analysis,and human-machine interfaces.Yet,most current motion sensors work on the nano/microcracks induced by the tensile deformation on the convex surface of joints during joint movements,which cannot satisfy requirements of ultrawide detectable angle range,high angle sensitivity,conformability,and consistence under cyclic movements.In nature,scorpions sense small vibrations by allowing for compression strain conversion from external mechanical vibrations through crack-shaped slit sensilla.Here,we demonstrated that ultraconformal sensors based on controlled slit structures,inspired by the geometry of a scorpion’s slit sensilla,exhibit high sensitivity(0.45%deg^(-1)),ultralow angle detection threshold(~15°),fast response/relaxation times(115/72 ms),wide range(15°~120°),and durability(over 1000 cycles).Also,a user-friendly,hybrid sign language system has been developed to realize Chinese and American sign language recognition and feedback through video and speech broadcasts,making these conformal motion sensors promising candidates for joint movement monitoring in wearable electronics and robotics technology. | Shengshun Duan Yucheng Lin Zhehan Wang Junyi Tang Yinhui Li Di Zhu Jun Wu Li Tao Chang-Hwan Choi Litao Sun Jun Xia Lei Wei Baoping Wang | 2021 | Research2021，，1： | 1 |
| 12 | A chorismate mutase from Radopholus similis plays an essential role in pathogenicity显示文摘In the process of infecting plants, plant parasitic nematodes release a series of proteins that play an essential role in the successful infection and pathogenesis of plant cells and tissues through stylets or body walls. In this study,based on transcriptome data, a chorismate mutase gene of Radopholus similis(RsCM) was identified and cloned,which is a single copy gene specifically expressed in the oesophageal gland and highly expressed in juveniles and females. Transient expression of RsCM in tobacco leaves showed that it was localised in the cytoplasm and nucleus of tobacco leaf cells, which inhibited the pattern-triggered immunity(PTI) induced by flg22, including callose deposition and defence gene expression, and cell death induced by immune elicitors BAX, but could not inhibit cell death induced by immune elicitors Gpa2/RBP-1. The RNA interference(RNAi) transgenic tomato of RsCM obviously inhibited the infection, pathogenicity, and reproduction of R. similis. However, the resistance of the overexpression transgenic tomato of RsCM to R. similis infection was significantly reduced, and the expression levels of two salicylic acid(SA) pathway genes(PR1 and PR5) in roots infected by the nematode were significantly down-regulated,which indicated that RsCM might be involved in the inhibition of SA pathway. The results of this study demonstrate that RsCM suppresses the host immune system and might be a new target for the control of R. similis, which also provides new data for the function and mechanism of CM genes of migratory parasitic plant nematodes. | Sihua Yang Junyi Li Shuai Yang Shiqiao Tang Huizhong Wang Chunling Xu Hui Xie | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 13 | ASBase:The universal database for aggregate science显示文摘This paper reports the first universal and versatile database on aggregate materials for the field of aggregate science research.At the current stage,the database(http://gffzzf21103ad36c048aahnpq99wb9oko96669.ffgz.tsg.suse.edu.cn/)contains over 1000 entries of organic aggregate material systems(mainly luminescent systems at the current stage)with a unique data structure which is designed particularly for aggregate materials and containing the photophysics and physicochemical properties of the compounds in different statuses of aggregation,including dilute solution form,pristine solid-state,stable crystalline,and nanoaggregates formed in solvents.The web-based interface of the database provided functions to index,search,manipulate,fetch and deposit data entries.In addition,a background calculation service optimizes the chemical structure of new entries on different levels of accuracies.The database also provided background API for interactive developments of prediction or regression models based on machine-learning algorithms. | Junyi Gong Wanjun Gong BoWu Haoran Wang Wei He Zhongyang Dai Yangzhong Li Yong Liu Zhiming Wang Xiaojun Tuo Jacky W.Y.Lam Zijie Qiu Zheng Zhao Ben Zhong Tang | 2023 | Aggregate2023，4，1： | 0 |
| 14 | Polarity-triggered anti-Kasha system for high-contrast cell imaging and classification显示文摘Kasha’s rule,which states that all exciton emissions occur from the lowest excited state and are independent of excitation energy,makes high-energy excitons difficult to use and severely hinders the widespread applications of organic photoluminescent materials in the real world.For decades,scientists have tried to break this rule to unleash the power of high-energy excitons,but only minimal progress has been achieved,with no rational guiding principles provided,and few applications developed.So far,breaking Kasha’s rule has remained a purely academic concept.In this paper,we introduce a design principle for a purely organic anti-Kasha system and synthesise a series of compounds based on the design rule.As predicted,these compounds all display evident S_(2) emissions in dilute solutions.In addition,we introduce a highly accurate(over 90%)convolutional neural network as an assistant for the classification of cells using anti-Kasha luminogens,thereby providing a new application direction for anti-Kasha systems. | Junyi Gong Peifa Wei Junkai Liu Yuncong Chen Zheng Zhao Weijun Zhao Huilin Xie Chao Ma Jacky W.Y.Lam Kam Sing Wong Ying Li Ben Zhong Tang | 2023 | Aggregate2023，4，2： | 0 |
| 15 | Measurements of the effective mass transfer areas for the gas–liquid rotating packed bed显示文摘Rotating packed bed(RPB) is one of the most effective gas–liquid mass transfer enhancement reactors, its effective specific mass transfer area(ae) is critical to understand the mass transfer process. By using the NaOH–CO_(2) chemical absorption method, the aevalues of three RPB reactors with different rotor sizes were measured under different operation conditions. The results showed that the high gravity factor and liquid flow rate were major affecting factors, while the gas flow rate exhibited minor influence.The radius of packing is the dominant equipment factor to affect aevalue. The results indicated that the contact area depends on the dispersion of the liquid phase, thus the centrifugal force of rotating packed bed greatly influenced the aevalue. Moreover, the measured ae/ap(effective specific mass transfer area/specific surface area of packing) values were fitted with dimensionless correlation formulas. The unified correlation formula with dimensionless bed size parameter can well predict the experimental data and the prediction errors were within 15%. | Wen Tian Junyi Ji Hongjiao Li Changjun Liu Lei Song Kui Ma Siyang Tang Shan Zhong Hairong Yue Bin Liang | 2023 | Chinese Journal of Chemical Engineering2023，55，3： | 0 |
| 16 | Advances in CIGS thin film solar cells with emphasis on the alkali element post-deposition treatment显示文摘In the past tens of years,the power conversion efficiency of Cu(In,Ga)Se2(CIGS)has continuously improved and been one of the fastest growing photovoltaic technologies that can also help us achieve the goal of carbon emissions reduction.Among several key advances,the alkali element post-deposition treatment(AlK PDT)is regarded as the most important finding in the last 10 years,which has led to the improvement of CIGS solar cell efficiency from 20.4%to 23.35%.A profound understanding of the influence of alkali element on the chemical and electrical properties of the CIGS absorber along with the underlying mechanisms is of great importance.In this review,we summarize the strategies of the alkali element doping in CIGS solar cell,the problems to be noted in the PDT process,the effects on the CdS buffer layer,the effects of different alkali elements on the structure and morphology of the CIGS absorber layer,and retrospect the progress in the CIGS solar cell with emphasis on the alkali element post deposition treatment. | Chenchen Zhao Shen Yu Wei Tang Xinye Yuan Hongfei Zhou Tongqing Qi Xue Zheng De Ning Ming Ma Junyi Zhu Jie Zhang Chunlei Yang Weimin Li | 2023 | Materials Reports(Energy)2023，3，3： | 0 |
| 17 | Orientational Chirality,Its Asymmetric Control,and Computational Study显示文摘Orientational chirality was discovered and characterized by a C(sp)-C(sp3)axis-anchored chiral center and a remotely anchored blocker.X-ray structural analysis proved that orientatiomers are stabilized by through-space functional groups,making it possible for 1 R-or S-chiral center to exhibit 3 orientational isomers simply by rotating operations.A new model system was proposed,fundamentally different from the traditional Felkin-Ahn-type or Cram-type models.In these traditional models,chiral C(sp^(3))center and blocking C(sp^(3))carbons are connected adjacently,and there exist 6 energy barriers during rotating along the C(sp^(2))-C(sp^(3))axis.In comparison,the present orientational chirality model shows that a chiral C(sp)-C(sp^(3))carbon is remotely located from a blocking group.Thus,it is focused on the steric dialog between a chiral C(sp^(3))center and a remotely anchored functional group.There exist 3 energy barriers for either(R)-or(S)-C(sp)-C(sp^(3))stereogenicity in the new model.Chiral amide auxiliary was proven to be an excellent chiral auxiliary in controlling rotations of orientatiomers to give complete stereoselectivity.The asymmetric synthesis of individual orientatiomers was conducted via multistep synthesis by taking advantage of the Suzuki-Miyaura cross-coupling and Sonogashira coupling reactions.Density functional theory computational study presented optimized conformers and relative energies for individual orientatiomers.This discovery would be anticipated to result in a new stereochemistry topic and have a broad impact on chemical,biomedical,and material sciences in the future. | Shengzhou Jin Yu Wang Yao Tang Jia-Yin Wang Ting Xu Junyi Pan Sai Zhang Qiankai Yuan Anis Ur Rahman James D.McDonald Guo-Qiang Wang Shuhua Li Guigen Li | 2023 | Research2023，，1： | 0 |
| 18 | Aggregation-Induced Synthesis (AIS): Asymmetric Synthesis via Chiral Aggregates显示文摘A new chiral aggregate-based tool for asymmetric synthesis has been developed by taking advantage of chiral aggregates of GAP(Group-Assisted Purification)reagents,N-phosphonyl imines.This tool was proven to be successful in the asymmetric GAP synthesis of functionalized 2,3-dihydrobenzofurans by reacting salicyl N-phosphonyl imines with dialkyl bromomalonates in various cosolvent systems.The chiral induction can be controlled by differentiating between two asymmetric directions simply by changing the ratios of cosolvents which are commonly adopted in AIE(aggregation-induced emission)systems.The formation of chiral aggregates was witnessed by a new analytical tool-aggregation-induced polarization(AIP).The present synthetic method will be broadly extended for general organic synthesis,particularly,for asymmetric synthesis and asymmetric catalysis in the future. | Hossein Rouh Yao Tang Ting Xu Qingkai Yuan Sai Zhang Jia-Yin Wang Shengzhou Jin Yu Wang Junyi Pan Hannah LWood James D.McDonald Guigen Li | 2022 | Research2022，，4： | 0 |
| 19 | Ordered Arrangement of Different Metals in Discrete and Infinite Building Blocks for Heterometallic Metal-Organic Frameworks Construction显示文摘Construction of sophisticated metal-organic frameworks(MOFs)with multiple kinds of metals is essential for further advancement of porous materials toward various applications.Order and arrangement of the metals in the secondary building units(SBUs)greatly influence the MOF structures outcome.While most of the previous heterometallic MOFs either have multiple kinds of discrete SBUs with different metals,or single kind of SBU with mixed metals inside,other forms of metal distribution still need further exploration.Herein,a bifunctional linker is applied to achieving differential coordination toward different metals.With Ce and Cu serving as the carboxylate-philic and pyrazole-philic metal ions,three heterometallic MOFs(FDM-121—FDM-123)are synthesized.In addition to the common metal arrangement modes,the new MOFs provide a joint reticulation of a discrete SBU and an infinite chain-like SBU featuring different metals in FDM-121,and an assembly from heterometallic infinite chain-like SBU in FDM-122.This study demonstrates the potential of bifunctional linkers for the design and synthesis of heterometallic MOFs and opens up the possibilities to create MOFs with tailored properties for specific applications. | XU Huoshu YAN Yu WU Yichen WANG Junyi TANG Yi LI Qiaowei | 2023 | Chemical Research in Chinese Universities2023，39，6： | 0 |
| 20 | Red-emitting salicylaldehyde Schiff base with AIE behaviour and large Stokes shift显示文摘Three salicylaldehyde Schiff base(SSB), iso-PBP, PBP and EPB, were facilely synthesized and exhibited aggregation-induced emission. The introduction of C= N-N = C moiety in these SSB dyes largely extend the conjugation system and push their emission to yellow to red spectral region. These SSB dyes were negligibly fluorescent in dilute THF solution. In THF/water mixtures with high water fractions, they displayed strong yellow to red fluorescence(up to 617nm) and large Stokes shifts(up to 152 nm). Single crystal analysis on EBP showed the longer emission of in aggregated state was attributed to the molecular packing effect as compared with that in dilute solution. The bio-imaging application indicated EBP could specifically accumulate in lipid droplets in living cells. | Junyi Gong Peifa Wei Yuanan Su Ying Li Xing Feng Jacky W.Y.Lam Dongzhou Zhang Xiangzhi Song Ben Zhong Tang | 2018 | Chinese Chemical Letters2018，29，10： | 0 |
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