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| 1 | Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro显示文摘Ebola virus(EBOV)causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91%in Zaire,the most lethal strain.Though the viral envelope glycoprotein(GP)mediates widespread inflammation and cellular damage,these changes have mainly focused on alterations at the protein level,the role of microRNAs(miRNAs)in the molecular pathogenesis underlying this lethal disease is not fully understood.Here,we report that the miRNAs hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells(HUVECs)following expression of EBOV GP.Among the proteins encoded by predicted targets of these miRNAs,the adhesion-related molecules tissue factor pathway inhibitor(TFPI),dystroglycan1(DAG1)and the caspase 8 and FADD-like apoptosis regulator(CFLAR)were significantly downregulated in EBOV GP-expressing HUVECs.Moreover,inhibition of hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p,or overexpression of TFPI,DAG1 and CFLAR rescued the cell viability that was induced by EBOV GP.Our results provide a novel molecular basis for EBOV pathogenesis and may contribute to the development of strategies to protect against future EBOV pandemics. | SHENG MiaoMiao ZHONG Ying CHEN Yang DU JianChao JU XiangWu ZHAO Chen ZHANG GuiGen ZHANG LiFang LIU KangTai YANG Ning XIE Peng LI DangSheng ZHANG Michael Q. JIANG ChengYu | 2014 | Science China(Life Sciences)2014，57，10： | 7 |
| 2 | Multilayer 3D Chirality and Its Synthetic Assembly显示文摘3D chirality of sandwich type of organic molecules has been discovered.Te key element of this chirality is characterized by three layers of structures that are arranged nearly in parallel fashion with one on top and one down from the center plane.Individual enantiomers of these molecules have been fully characterized by spectroscopies with their enantiomeric purity measured by chiral HPLC.Te absolute confguration was unambiguously assigned by X-ray difraction analysis.Tis is the frst multilayer 3D chirality reported and is anticipated to lead to a new research area of asymmetric synthesis and catalysis and to have a broad impact on chemical,medicinal,and material sciences in future. | Guanzhao Wu Yangxue Liu Zhen Yang Nandakumar Katakam Hossein Rouh Sultan Ahmed Daniel Unruh Kazimierz Surowiec Guigen Li | 2019 | Research2019，，1： | 3 |
| 3 | Multi-layer 3D chirality:new synthesis,AIE and computational studies显示文摘New synthesis of multi-layer 3 D chiral molecules has been developed under novel conditions to give better outcomes.The aggregation-induced emission(AIE),UV irradiation/excitation,charge transfer(CT)and local excited(LE)ππ*transitions have been investigated on a representative individual enantiomer of pseudo C_2 asymmetry which was made possibly by differentiating moieties on phosphorous on N-phosphonyl ring of chiral sandwich framework.Meanwhile,a new tandem C–N/C–C coupling reaction was unexpectedly rendered providing a novel access to special benzo[a]carbazoles. | Yangxue Liu Guanzhao Wu Zhen Yang Hossein Rouh Nandakumar Katakam Sultan Ahmed Daniel Unruh Zhonghua Cui Hans Lischka Guigen Li | 2020 | Science China Chemistry2020，63，5： | 1 |
| 4 | Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum 显示文摘 | Kaiwei Li Guigen Liu Yihui Wu | 2014 | Talanta2014，120，： | 1 |
| 5 | Enantioselective assembly of multi-layer 3D chirality显示文摘The first enantioselective assembly of sandwich-shaped organo molecules has been achieved by conducting dual asymmetric Suzuki-Miyaura couplings and nine other reactions.This work also presents the first fully C-C anchored multi-layer 3D chirality with optically pure enantiomers.As confirmed by X-ray diffraction analysis that this chiral framework is featured by a unique C2-symmetry in which a nearly parallel fashion consisting of three layers:top,middle and bottom aromatic rings.Unlike the documented planar or axial chirality,the present chirality shows its top and bottom layers restrict each other from free rotation,i.e.,this multi-layer 3D chirality would not exist if either top or bottom layer is removed.Nearly all multi-layered compounds showed strong luminescence of different colors under UV irradiation,and several randomly selected samples displayed aggregation-induced emission(AIE)properties.This work is believed to have broad impacts on chemical,medicinal and material sciences including optoelectronic materials in future. | Guanzhao Wu Yangxue Liu Zhen Yang Tao Jiang Nandakumar Katakam Hossein Rouh Liulei Ma Yao Tang Sultan Ahmed Anis URahman Hongen Huang Daniel Unruh Guigen Li | 2020 | National Science Review2020，7，3： | 1 |
| 6 | Delaying application time of slow-release fertilizer increases soil rhizosphere nitrogen content,root activity,and grain yield of spring maize显示文摘Application of slow-release fertilizer(SF)is a nutrient-management measure aimed at improving maize nutrient use and yield and saving labor cost.One-time application of SF at sowing usually results in nutrient deficiency during the post-silking stage,owing to the long growth period of spring maize.This study was conducted to investigate the effects on spring maize of SF application stage(zero,three-,and six-leaf stages,designated as SF0,SF3,and SF6,respectively)on grain yield,total soil rhizosphere nitrogen(N)content,and root activity,in comparison with the conventional fertilization mode(CF,application of compound fertilizer at sowing time,and topdressing urea at six-leaf and tasseling stages)at the same fertilization level as the control.Compared with no fertilization(F0)and CF,SF increased grain number and weight.The maize cultivars Suyu 30(SY30)and Jiangyu 877(JY877)produced the highest grain yield and net return under SF6 treatment over the three years.SF6 increased enzymatic activities including oxidoreductase,hydrolase,transferase,and lyase in rhizosphere soil at silking(R1)and milking stages(R3).SF6 increased the total N contents of rhizosphere soil by 7.1%at R1 and 9.2%R3 stages compared with SF0.The activities of antioxidant enzymes in roots were increased under SF6 treatments at R1and R3.The mean root activities of SF0,SF3,and SF6 increased by 7.1%,12.8%,and 20.5%compared with CF at R1 and by 8.8%,13.0%,and 23.5%at R3.Delaying the application time of SF could increase grain yield by increasing total N content of rhizosphere soil,delaying root senescence,and increasing root activity at the late reproductive stage.Applying SF at the six-leaf stage is recommended as an effective fertilization strategy for the sustainable production of spring maize in southern China. | Guanghao Li Pengxiao Fu Guigen Cheng Weiping Lu Dalei Lu | 2022 | The Crop Journal2022，10，6： | 1 |
| 7 | Radical-Enabled Bicyclization Cascades of Oxygen-Tethered 1,7-Enynes Leading to Skeletally Diverse Polycyclic Chromen-2-ones显示文摘Catalytic bicyclization cascades of oxygen-tetheredzides have been established via subsequent multiple C1,7-enynes with simple cycloalkanes or aryl sulfonhydra-C bond-forming events from alkynyl/alkenyl functions, de-livering a series of densely functionalized tetracyclic chromen-2-ones in a functional-group-compatible manner. Inthe former, Fe-catalyzed spiro-bicyclization involves radical addition, 6-exo-dig cyclization, H-abstraction and5-endo-trig cyclization sequences under mild conditions, resulting in new spiro-fused cyclopenta[c]chromen-2-onesvia dual a,a-C(sp3)-H abstractions. The latter enables in-situ sulfonylation and desulfonylation of oxygen-tethered1,7-enynes to realize the construction of multiple C--C bonds, thereby leading to the formation of naphtho[2,3-c]-chromen-6-ones. | Bo Jiang Jie Li Yuanyuan Pan Wenjuan Hao Guigen Li Shujiang Tu | 2017 | Chinese Journal of Chemistry2017，35，3： | 1 |
| 8 | An efficient procedure for the dem ethylation of aryl-methyl ethers in optically pure unusual amino acids显示文摘 | Guigen Li Patel D Hruby VJ | 1993 | Tetrahedron Letters1993，34，34： | 1 |
| 9 | Multilayer 3D Chiral Folding Polymers and Their Asymmetric Catalytic Assembly显示文摘A novel class of polymers and oligomers of chiral folding chirality has been designed and synthesized,showing structurally compacted triple.column/multiple layer frameworks.Both uniformed and diferentiated aromatic chromophoric units were successfully constructed between naphthy!piers of this framework.Screening monomers,catalysts,and catalytic systems led 1o the success of asymmetric catalytic Suzuki-Miyaura polycouplings Enantio-and diastereochemistry were unambiguously determined by X-ray structural analysis and concurrently by comparison with a similar asymmetric induction by the same catalyst in the asymmetric synthesis of a chiral three layered product.The resuling chiral polymers exhibit intense fluorescence activity in a solid form and solution under speci fic wavelength irradiation. | Yao Tang Shengzhou Jin Sai Zhang Guan-Zhao Wu Jia-Yin Wang Ting Xu Yu Wang Daniel Unruh Kazimierz Surowiec Yanzhang Ma Shiren Wang Courtney Katz Hongjun Liang Yunze Li Wellong Cong Guigen Li | 2022 | Research2022，，2： | 0 |
| 10 | CRISPR/Sc^(++)-mediated genome editing in rice显示文摘Streptococcus canis Cas9(ScCas9)is an RNAguided endonuclease with NNG protospacer adjacent motif(PAM)specificity whose genomeediting activity in rice is locus-dependent.Here we investigated the performance of a ScCas9 variant named Sc^(++)at different NNG PAM sites in the rice genome;Sc^(++)harbors a T1227K mutation and the substitution of a positively charged loop(residues 367-376).Sc^(++)nuclease achieved broader genome editing compared to the original ScCas9,and its nickase improved targeted base editing in transgenic rice plants.Using the high-efficiency adenine base editor rBE73b,we generated many new OsGS1 alleles suitable for screening of rice germplasm for potential herbicide resistance in the future.The CRISPR/Sc^(++)system expands the genomeediting toolkit for rice. | Guigen Ma Yongjie Kuang Zhenwan Lu Xueqi Li Ziyan Xu Bin Ren Xueping Zhou Huanbin Zhou | 2021 | Journal of Integrative Plant Biology2021，63，9： | 0 |
| 11 | Seeking Convergence to advance Biomaterials Science and Translation by Chinese Association for Biomaterials显示文摘In the afternoon of April 5,2017,the Chinese Association for Biomaterials(CAB)organized a CAB Day Symposium with a theme of“Seeking Convergence to Advance Biomaterials Science and Translation.”This symposium,sponsored by the KeAi Publisher and the Advanced Medical Technology,brought together distinguished Chinese scholars and entrepreneurs from the U.S.and China in biomaterials to share their advanced research and translational work,explore collaborations and promote the mission of CAB on the campus of University of Minnesota(Photo 1). | Guigen Zhang Jian Yang Bingyun Li Kelvin Yeung Yi Hong | 2017 | Bioactive Materials2017，2，4： | 0 |
| 12 | Orientational Chirality,Its Asymmetric Control,and Computational Study显示文摘Orientational chirality was discovered and characterized by a C(sp)-C(sp3)axis-anchored chiral center and a remotely anchored blocker.X-ray structural analysis proved that orientatiomers are stabilized by through-space functional groups,making it possible for 1 R-or S-chiral center to exhibit 3 orientational isomers simply by rotating operations.A new model system was proposed,fundamentally different from the traditional Felkin-Ahn-type or Cram-type models.In these traditional models,chiral C(sp^(3))center and blocking C(sp^(3))carbons are connected adjacently,and there exist 6 energy barriers during rotating along the C(sp^(2))-C(sp^(3))axis.In comparison,the present orientational chirality model shows that a chiral C(sp)-C(sp^(3))carbon is remotely located from a blocking group.Thus,it is focused on the steric dialog between a chiral C(sp^(3))center and a remotely anchored functional group.There exist 3 energy barriers for either(R)-or(S)-C(sp)-C(sp^(3))stereogenicity in the new model.Chiral amide auxiliary was proven to be an excellent chiral auxiliary in controlling rotations of orientatiomers to give complete stereoselectivity.The asymmetric synthesis of individual orientatiomers was conducted via multistep synthesis by taking advantage of the Suzuki-Miyaura cross-coupling and Sonogashira coupling reactions.Density functional theory computational study presented optimized conformers and relative energies for individual orientatiomers.This discovery would be anticipated to result in a new stereochemistry topic and have a broad impact on chemical,biomedical,and material sciences in the future. | Shengzhou Jin Yu Wang Yao Tang Jia-Yin Wang Ting Xu Junyi Pan Sai Zhang Qiankai Yuan Anis Ur Rahman James D.McDonald Guo-Qiang Wang Shuhua Li Guigen Li | 2023 | Research2023，，1： | 0 |
| 13 | Aggregation-Induced Synthesis (AIS): Asymmetric Synthesis via Chiral Aggregates显示文摘A new chiral aggregate-based tool for asymmetric synthesis has been developed by taking advantage of chiral aggregates of GAP(Group-Assisted Purification)reagents,N-phosphonyl imines.This tool was proven to be successful in the asymmetric GAP synthesis of functionalized 2,3-dihydrobenzofurans by reacting salicyl N-phosphonyl imines with dialkyl bromomalonates in various cosolvent systems.The chiral induction can be controlled by differentiating between two asymmetric directions simply by changing the ratios of cosolvents which are commonly adopted in AIE(aggregation-induced emission)systems.The formation of chiral aggregates was witnessed by a new analytical tool-aggregation-induced polarization(AIP).The present synthetic method will be broadly extended for general organic synthesis,particularly,for asymmetric synthesis and asymmetric catalysis in the future. | Hossein Rouh Yao Tang Ting Xu Qingkai Yuan Sai Zhang Jia-Yin Wang Shengzhou Jin Yu Wang Junyi Pan Hannah LWood James D.McDonald Guigen Li | 2022 | Research2022，，4： | 0 |
| 14 | Catalytic Enantioselective Construction of 6-4 Ring-Junction All-Carbon Stereocenters and Mechanistic Insights显示文摘Comprehensive Summary Developing reactions for the synthesis of 6-6-4 and 6-4 carbocyclic scaffolds with a chiral quaternary center at the bridgehead position is highly desired,considering the existence of such skeletons in natural products with biological activities and the potential of using these molecules for downstream studies in chemical biology and medicinal chemistry.Report here is accessing these target skeletons with high chemo-,regio-and enantio-selectivities through Pd(ll)/chiral N,N'-disulfonyl bisimidazoline(Bim)ligand-catalyzed asymmetric reaction of yne-allenones and arylboronic acids. | Jia-Yin Wang Chen-Long Li Ting Xu Meng-Fan Li Wen-Juan Hao Shu-Jiang Tu Jianyi Wang Guigen Li Zhi-Xiang Yu Bo Jiang | 2022 | Chinese Journal of Chemistry2022，40，15： | 0 |
| 15 | Highly efficient twin-field quantum key distribution with neural networks显示文摘Quantum key distribution(QKD)allows two legitimate parties,Alice and Bob,to share a series of random bits that are secured by the laws of quantum mechanics.As a remarkable theoretical progress towards longer distances. | Jingyang LIU Qingqing JIANG Huajian DING Xiao MA Mingshuo SUN Jiaxin XU Chun-Hui ZHANG Shipeng XIE Jian LI Guigen ZENG Xingyu ZHOU Qin WANG | 2023 | Science China(Information Sciences)2023，66，8： | 0 |
| 16 | Triple-Columned and Multiple-Layered 3D Polymers:Design,Synthesis,Aggregation-Induced Emission(AIE),and Computational Study显示文摘Conjugated polymers and oligomers have great potentials in various fields,especially in materials and biological sciences because of their intriguing electronic and optoelectronic properties.In recent years,the through-space conjugation system has emerged as a new assembled pattern of multidimensional polymers.Here,a novel series of structurally condensed multicolumn/multilayer 3D polymers and oligomers have been designed and synthesized through one-pot Suzuki polycondensation(SPC).The intramolecularly stacked arrangement of polymers can be supported by either X-ray structural analysis or computational analysis.In all cases,polymers were obtained with modest to good yields,as determined by GPC and 1 H-NMR.MALDI-TOF analysis has proven the speculation of the step-growth process of this polymerization.The computational study of ab initio and DFT calculations based on trimer and pentamer models gives details of the structures and the electronic transition.Experimental results of optical and AIE research confirmed by calculation indicates that the present work would facilitate the research and applications in materials. | Guanzhao Wu Yangxue Liu Zhen Yang Liulei Ma Yao Tang Xianliang Zhao Hossein Rouh Qixuan Zheng Peng Zhou Jia-Yin Wang Farhan Siddique Sai Zhang Shengzhou Jin Daniel Unruh Adelia JAAquino Hans Lischka Kristin M.Hutchins Guigen Li | 2021 | Research2021，，1： | 0 |
| 17 | Catalyst-Dependent Direct and Deoxygenative Coupling of Alcohols by Convergent Paired Electrolysis显示文摘Developing a general and mild approach to upgrade alcohols into high value products is a hot topic in synthetic chemistry because alcohol is one of the most abundant raw chemicals.Specifically,direct coupling and deoxygenative coupling of alcohols are the two main approaches for the functionalization of alcohols to afford structurally diverse products,and it receives considerable attention.Despite significant advances in the field,there still remains a great challenge to develop a general approach accommodating both coupling reactions,as they commonly involve distinct pathways.Herein,we report an electrochemical approach for the direct coupling and deoxygenative coupling of alcohols with fluorenones.Under paired electrolysis,this catalyst-dependent protocol gives divergent access to diols and tertiary alcohols.Moreover,the synthetic utility of 9H-fluoren-9-ol products has been demonstrated in the synthesis of organic luminophores,phenanthrol,phenanthridine,and amino alcohol.The present approach exhibits some impressive features:(a)catalystdependent selectivity;(b)excellentfunctional-group tolerance(156 examples);(c)mild conditions;and(d)good scalability(∼20 gram scale). | Sheng Zhang Jianxue Shi Jingjing Li Man-Bo Li Guigen Li Michael Findlater | 2022 | CCS Chemistry2022，4，6： | 0 |
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