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| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons显示文摘Lgr5+intestinal stem cells(ISCs)reside within specialized niches at the crypt base and harbor self-renewal and differentiation capacities.ISCs in the crypt base are sustained by their surrounding niche for precise modulation of self-renewal and differentiation.However,how intestinal cells in the crypt niche and microbiota in enteric cavity coordinately regulate ISC stemness remains unclear.Here,we show that ISCs are regulated by microbiota and niche enteric serotonergic neurons.The gut microbiota metabolite valeric acid promotes Tph2 expression in enteric serotonergic neurons via blocking the recruitment of the NuRD complex onto Tph2 promoter.5-hydroxytryptamine(5-HT)in turn activates PGE2 production in a PGE2+macrophage subset through its receptors HTR2A/3 A;and PGE2 via binding its receptors EP1/EP4,promotes Wnt/β-catenin signaling in ISCs to promote their self-renewal.Our findings illustrate a complex crosstalk among microbiota,intestinal nerve cells,intestinal immune cells and ISCs,revealing a new layer of ISC regulation by niche cells and microbiota. | Pingping Zhu Tiankun Lu Jiayi Wu Dongdong Fan Benyu Liu Xiaoxiao Zhu Hui Guo Ying Du Feng Liu Yong Tian Zusen Fan | 2022 | Cell Research2022，32，6： | 8 |
| 3 | The Mechanisms and Applications of Quorum Sensing(QS) and Quorum Quenching(QQ)显示文摘Quorum sensing(QS)is a regulatory system that regulates the behavior of microbial populations by sensing the concentration of signal molecules that are spontaneously produced and released by bacteria.The strategy of blocking the QS system and inhibiting the production of virulence factors is termed as quorum quenching(QQ).This strategy attenuates virulence without killing the pathogens,thereby weakening the selective pressure on pathogens and postponing the evolution of QQ-mediated drug resistance.In recent years,there have been significant theoretical and practical developments in the field of QS and QQ.In particular,with the development and utilization of marine resources,more and more marine microbial species have been found to be regulated by these two mechanisms,further promoting the research progress of QS and QQ.In this review,we described the diversity of QS signals and QS-related regulatory systems,and then introduced mechanisms related to QS interference,with particular emphasis on the description of natural QQ enzymes and chemicals acting as QS inhibitors.Finally,the exploitation of quorum sensing quenchers and the practical application of QQ were introduced,while some QQ strategies were proposed as promising tools in different fields such as medicine,aquaculture,agriculture and biological pollution prevention areas. | ZHANG Jingjing FENG Tao WANG Jiayi WANG Yan ZHANG Xiao-Hua | 2019 | Journal of Ocean University of China2019，18，6： | 8 |
| 4 | Recent progress and perspective of electrochemical CO_(2) reduction towards C_(2)-C_(5) products over non-precious metal heterogeneous electrocatalysts显示文摘Electroreduction of carbon dioxide(CO_(2)ER)into value-added chemical compounds has presented as a promising route for renewable carbon cycle,which alleviates global warming concern.Compared with traditional C1 products,high-value multicarbon products converted from atmospheric CO_(2) via CO_(2)ER have attracted dramatic interest due to their significant economic efficiency,however desired catalytic selectivity of multicarbon products is difficult to achieve because of the high thermodynamic barriers and complex reaction pathways.To replace currently used precious-metal based catalysts,developing highly efficient and precious-metal-free CO_(2)ER catalysts based on earth abundant elements is the top priority to meet the requirements of industrialization.Although certain progress has been made,there are still few systematic reports on the non-precious metal heterogeneous(NPMH)CO_(2)ER electrocatalysts for efficient conversion of CO_(2) to multicarbon products.Herein,we summarize the latest research advances in recent developments of NPMH electrocatalysts,including nanostructured Cu,Cu-based bimetallic catalysts,Cu-based complexes,and carbon-based Cu-free catalysts for electroreduction of CO_(2) into high-value multicarbon products.The corresponding CO_(2)ER performances are discussed in the order of the types of multicarbon products,specifically for ethanol(C2H5OH),ethylene(C2H4),ethane(C2H6),acetic acid(CH3COOH),propanol(C3H7OH),and other O^(2+)products with a special attention paid to understand the structure-activity relationship.Moreover,key strategies and characterization techniques for catalytic mechanism insights,and unsolved issues and future trends for enhancing the CO_(2)ER performance of NPMH electrocatalysts are highlighted,which provides a constructive guidance on the development of CO_(2)ER electrocatalysts with high activity and selectivity for multicarbon products. | Jiayi Chen Tingting Wang Zhongjian Li Bin Yang Qinghua Zhang Lecheng Lei Pingyun Feng Yang Hou | 2021 | Nano Research2021，14，9： | 7 |
| 5 | Chemical probing reveals insights into the signaling mechanism of inflammasome activation显示文摘Caspase-1-mediated IL-1 尾生产被二条小径通常控制。像使用费的受体(TLR ) 认出导出病原体的产品并且导致 NF-魏 B 依赖者 pro-IL-1 尾抄写;像点头的受体(NLR ) 装配察觉到细菌的产品 / 危险信号的 caspase-1-activating inflammasome 建筑群。通过一幅指向的化学屏幕,我们识别 bromoxone,一个海洋的自然产品,一特定并且 caspase-1 小径的有势力禁止者。Bromoxone 在包括加 ATP/nigericin, cytosolic DNA, flagellin 和杆菌 anthracis 的 TLR ligands 的多样的煽动性的刺激上是有效的致命的毒素。Bromoxone 高效地也压制激活由细菌的感染的几种类型触发了的 caspase-1。在上游的 Bromoxone 行为或在以一种抄写无关的方式的 inflammasome 的水平。Bromoxone 也由在 TLR-NF-魏 B 小径指向 IKK 在上游的部件禁止 pro-IL-1 尾表示。bromoxone 的唯一的双活动被明确地堵住 Nalp3 inflammasome 激活的已知的 TAK1 禁止者分享。提示了从机械学并且 bromoxone 的药理学性质,我们进一步发现几个已知的 NF-魏 B 禁止者 IKK 在上游的那行为,然而并非下游地指向 IKK 或 IKK 的那些,是不同调停 NLRs 的 caspase-1 激活的有势力 blockers。我们的学习揭开可能的 non-transcriptional 在 NLR (Nalp3 ) 之间的分子的连接调停了 inflammasome 小径和 TLR-NF-魏 B 发信号,并且建议潜在的策略开发新反煽动性的药。 | Yi-Nan Gong Xiaoming Wang Jiayi Wang Zhenxiao Yang Shan Li Jieling Yang Liping Liu Xiaoguang Lei Feng Shao | 2010 | Cell Research2010，20，12： | 5 |
| 6 | Transition to resistance:An unexpected role of the EMT in cancer chemoresistance显示文摘Two recent studies provide intriguing evidence that challenges the role of the epithelialemesenchymal transition(EMT)as a critical mediator of cancer metastasis,while revealing an unexpected role in cancer drug resistance.1,2 While these findings may not settle the EMT’s role in metastasis,these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance. | Jing Wang Qiang Wei Xin Wang Shengli Tang Hao Liu Fugui Zhang Maryam K.Mohammed Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Xue Hu Rex C.Haydon Tong-Chuan He Hue H.Luu | 2016 | Genes & Diseases2016，3，1： | 4 |
| 7 | Influence of Deposition Temperature and Pressure on Microstructure and Tribological Properties of Arc Ion Plated Ag Films显示文摘The films deposited at low temperature(LT-films) have increasingly attracted theoretical and technical interests since such films exhibit obvious difference in structure and performances compared to those deposited at room temperature.Studies on the tribological properties of LT-films are rarely reported in available literatures.In this paper,the structure,morphology and tribological properties of Ag films,deposited at LT(166 K) under various Ar pressures on AISI 440C steel substrates by arc ion plating(AIP),are studied by X-ray diffraction(XRD),atomic force microscopy(AFM) and a vacuum ball-on-disk tribometer,and compared with the Ag films deposited at RT(300 K).XRD results show that(200) preferred orientation of the films is promoted at LT and low Ar pressure.The Crystallite sizes are 70 nm-80 nm for LT-Ag films deposited at 0.2 Pa and 0.8 Pa and larger than 100 nm for LT-Ag films deposited at 0.4 Pa and 0.6 Pa,while they are 55 nm-60 nm for RT-Ag films deposited at 0.2 Pa-0.6 Pa and 37 nm for RT-Ag films deposited at 0.8 Pa.The surfaces of LT-Ag films are fibre-like at 0.6 Pa and 0.8 Pa,terrace-like at 0.4 Pa,and sphere-like at 0.2 Pa,while the surfaces of RT-Ag films are composed of sphere-like grains separated by voids.Wear tests reveal that,due to the compact microstructure LT-Ag films have better wear resistances than RT-Ag film.These results indicate that the microstructure and wear resistance of Ag films deposited by AIP can be improved by low temperature deposition. | HU Ming GAO Xiaoming SUN Jiayi WENG Lijun ZHOU Feng LIU Weimin | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 2 |
| 8 | 植物物种多度受功能性状和负密度依赖共同影响--以中国南亚热带黑石顶森林样地为例显示文摘影响植物群落中植物物种多度的因素较多,确定关键影响因素及阐明其具体机制一直是群落生态学的研究重点之一。目前确定性的影响因素主要有两大类:植物功能性状和负密度依赖。功能性状通过影响植物的竞争能力、资源的获取效率、对环境的适应能力等方面进而影响植物的多度;负密度依赖表现在同种或异种植物个体在空间上聚集,特异性的寄主(病原菌、昆虫等)传播容易导致植物个体(主要为幼苗和小树)死亡,种群发生自疏,进而影响植物的多度。到目前为止,单一探究植物功能性状或负密度依赖对植物多度影响机制的研究己有大量报道,而将两者结合来探讨对植物多度的影响的工作相对较少。为了更深入地探索影响植物多度的机制,本研究中我们综合分析了功能性状与负密度依赖对植物多度的影响。研究地点为广东省黑石顶亚热带森林50 ha大样地;功能性状方面选取了叶面积(LA)、比叶面积(SLA)、叶片干物质含量(LDMC)、叶片氮含量(LNC)和最大电子传输速率(ETRmax);植物物种所受负密度依赖强度通过构建小树在样地两次普查期间的存活状况受邻体密度影响的层次贝叶斯模型计算;通过结构方程模型构建功能性状-负密度依赖-物种多度的内在联系框架。结构方程模型结果显示,物种多度受功能性状和负密度依赖共同作用,其中功能性状对物种多度的影响包括直接作用和通过负密度依赖的间接作用。具体来说,SLA对多度的影响包括直接和间接两种;LDMC和LNC仅间接影响物种多度;LA和ETRmax对多度只有直接影响:负密度依赖与物种多度之间存在直接的负相关关系,说明多度较高的物种受到的负密度依赖效应更强。结构方程模型对物种多度差异的解释度达到20%。以上结果表明,黑石顶植物多度分布是功能性状与负密度依赖共同作用的结果;比叶面积在所研究的因素中贡献最大。该项工作有助于提高我们对亚热带森林植物常见种和稀有种分布格局的理解。 | Weitao Wang Yun Jiang Buhang Li Nianxun Xi Yongfa Chen Dong He Jiayi Feng Chengjin Chu | 2021 | Journal of Plant Ecology2021，14，3： | 2 |
| 9 | LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin显示文摘LncMIR31HG acts as a host gene for miR-31,also known as LncHIFCAR(long non-coding HIF-1 co-activating RNA),whose deregulation has been reported to promote the development of various human cancers,including lung cancer,colorectal cancer,etc.1,2 However,the biological functions and molecular mechanisms of MIR31HG in gastric cancer are unclear. | Wen Peng Jiayi Zhang Shenghao Wang Feng Wang a Kun Wang Rui Geng Xiangfei Ding Jingping Zhang Biao Li Xiaoxue Ke Muhan Lü Hongjuan Cui | 2023 | Genes & Diseases2023，10，3： | 1 |
| 10 | Joint beamforming and power allocation for multiple primary users and secondary users in cognitive MIMO systems via game theory显示文摘 | Zhao Feng Zhang Jiayi Chen Hongbin | 2013 | KSII Transaction on Intemet and Information Systems2013，，6： | 1 |
| 11 | Parallel induction of cell proliferation and inhibition of cell differentiationin hepatic progenitor cells by hepatitis B virus X gene显示文摘 | Jiayi Huang Lihong Shen Yongliang Lu Hongli Li Xifeng Zhang Daixi Hu Tao Feng Fangzhou Song | 2012 | International Journal of Molecular Medicine2012，，4： | 1 |
| 12 | Seedling defoliation of cereal crops increases peanut growth and yield in an intercropping system显示文摘Intercropping cereals and legumes is practiced widely in the world for improving yields and economic benefits. Shorter legume crops in intercropping are shaded by taller cereals, substantially reducing legume growth and yield. Reducing shade in intercropping by shortening the plant height of cereals by seedling defoliation has been proposed as a practical approach to increase crop yields and land productivity. A two-year field experiment was conducted to investigate the effect of defoliation of cereal crops at seedling stage on the growth and yield of peanut(Arachis hypogaea L.) intercropped with corn(Zea mays L.) or millet(Setaria italica L.). In comparison with non-defoliation controls, defoliation reduced final plant height by 29 cm on average for corn and 18 cm for millet. Photosynthetically active radiation on peanut in intercropping systems with corn or millet intercropping was respectively 27.0% and 22.8% higher than those in controls, significantly improving the light environment of intercropped peanut. Net photosynthetic rates of peanut were on average 25.5% higher in corn and peanut intercropping and 19.6% higher in millet and peanut intercropping than those in non-defoliation controls. Total biomass of intercropped peanut increased owing to increased root growth. Across two years, yield of peanut intercropped with corn was 27.7% and with millet 32.8% higher than those of controls. Defoliation of cereal crops did not affect corn yield but significantly decreased millet yield by 24.5%. Our results suggest that applying seedling defoliation in intercropped corn could increase peanut yield without compromising corn yield in an intercropping system. | Bo Huang Xiaojin Zou Huasen Xu Jiayi Xu Huiyu Liu Wentao Sun Liang Gong Shiwei Niu Liangshan Feng Ning Yang Lizhen Zhang Zhanxiang Sun | 2022 | The Crop Journal2022，10，2： | 1 |
| 13 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 14 | The effects of prey lipid on female mating and reproduction of a wolf spider显示文摘As predators,the macronutrients spiders extract from their prey play important roles in their mating and reproduction.Previous studies of macronutrients on spider mating and reproduction focus on protein,the potential impact of prey lipid content on spider mating and reproduction remains largely unexplored.Here,we tested the influence of prey varying in lipid content on female mating,sexual cannibalism,reproduction,and offspring fitness in the wolf spider Pardosa pseudoannulata.We acquired 2 groups of fruit fly Drosophila melanogaster that differed significantly in lipid but not protein content by supplementing cultural media with a high or low dose of sucrose on which the fruit flies were reared(HL:high lipid and LL:low lipid).Subadult(i.e.,1 molt before adult)female spiders that fed HL flies matured with significantly higher lipid content than those fed LL flies.We found that the mated females fed with HL flies significantly shortened pre-oviposition time and resulted in a significantly higher fecundity.However,there was no significant difference in female spiders varying in lipid content on other behaviors and traits,including the latency to courtship,courtship duration,mating,copulation duration,sexual cannibalism,offspring body size,and survival.Hence,our results suggest that the lipid content of prey may be a limiting factor for female reproduction,but not for other behavioral traits in the wolf spiders P.pseudoannulata. | Qingguo FENG Lelei WEN Jiayi MA Long YU Changchun LI Xiaoguo JIAO | 2022 | Current Zoology2022，68，6： | 0 |
| 15 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 16 | Sudden Cardiac Death Due to Long QT Syndrome显示文摘Identification of sudden cardiac death(SCD)with a structurally normal heart remains an important challenge in forensic pathology.Long QT syndrome(LQTS)is known as an inherited or acquired channelopathy,which is characterized with prolonged QT interval,and is likely to cause SCD in young adults.In this circumstance,no specific pathological change in the heart can be found anatomically or histologically in the LQTS victims.Thus,postmortem LQTS diagnosis is mainly based on clinical manifestations and genetic testing.Here,we reported a 26‑year‑old woman who was found dead at home with a history of unexplained syncope.Her clinical records and an electrocardiograph(ECG)obtained 3 months before her death showed a QTc interval of 539 ms which implicates the diagnosis of LQTS.Although the autopsy and pathological examination findings lacked specificity,we noticed enhanced lipofuscin accumulation in cardiomyocytes,which might be related to LQTS.After excluding potential diseases and injuries,we made the postmortem diagnosis as LQTS according to ECG,clinical history,and forensic postmortem findings.In conclusion,we provided clinical and pathological features of an SCD case due to LQTS,which might enrich the understanding of forensic postmortem SCD diagnosis with nonstructural cardiac diseases. | Jiayi Wu Wei Tang Kai Zhang Kai Li Jianwen Wang Youjia Yu Feng Chen | 2022 | Journal of Forensic Science and Medicine2022，8，4： | 0 |
| 17 | 组蛋白分子伴侣FACT促进DNA复制偶联的核小体组装显示文摘真核生物DNA复制时,复制叉前的核小体解聚以允许复制体前行,同时在新合成的DNA子链上新的核小体必须马上组装,这被称为DNA复制偶联的核小体组装,是染色质复制的关键一步。 | Jiayi Yang Xu Zhang Jianxun Feng He Leng Shuqi Li Junyu Xiao Shaofeng Liu Zhiyun Xu Jiawei Xu Di Li Zhongshi Wang Jingyang Wang 李晴 | 2017 | 科学新闻2017，19，4： | 0 |
| 18 | Microporous Cyclodextrin Film with Funnel-type Channel Polymerized on Electrospun Cellulose Acetate Membrane as Separators for Strong Trapping Polysulfides and Boosting Charging in Lithium-Sulfur Batteries显示文摘The“shuttle effect”of polysulfides hampers the commercialization of lithium-sulfur(Li-S)batteries.Here,a thin molecular sieve film was decorated on the surface of an electrospun cellulose acetate(CA)membrane derived from recycled cigarette filters,where the truncated cone structureβ-cyclodextrin(β-CD)was selected as the building block to physically block and chemically trap polysulfides while simultaneously dramatically speeding up ion transport.Furthermore,on theβ-CD free side of the separator facing the cathode,graphite carbon(C)was sputtered as an upper current collector,which barely increases the thickness.These benefits result in an initial discharge performance of 1378.24 mAh g^(−1) and long-term cycling stability of 863.78 mAh g^(−1) after 1000 cycles at 0.2 C for the battery with theβ-CD/CA/C separator,which is more than three times that of the PP separator after 500 cycles.Surprisingly,the funnel-type channel ofβ-CD generates a differential ionic fluid pressure on both sides,speeding up ion transport by up to 69%,and a 65.3%faster charging rate of 9484 mA g^(−1) was achieved.The“funnel effect”of a separator is regarded as a novel and high-efficiency solution for fast charging of Li-S and other lithium secondary batteries. | Shuanglin Wu Jiayi Shi Xiaolin Nie Yingmei Yao Feng Jiang Qufu Wei Fenglin Huang | 2023 | Energy & Environmental Materials2023，6，2： | 0 |
| 19 | Vibration-based bearing fault diagnosis of high-speed trains:A literature review显示文摘Due to the advantages of comfort and safety,high-speed trains are gradually becoming the mainstream public transport in China.Since the operating speed and mileage of high-speed trains have achieved rapid growth,it is more and more urgent to ensure their reliability and safety.As an important component in the bogies of highspeed trains,the health state of the bearing directly affects the operational safety of the trains.It is therefore necessary to diagnoze the faults of bearings in the bogies of high-speed trains as early as possible.In this paper,the bearing fault diagnostic methods for high-speed trains have been systematically summarized with their challenges and perspectives.First,it briefly introduces the structure of bearings in the bogies as well as the fault characteristic frequencies.Then,a brief review of the research on vibration-based signal processing methods and machine learning methods has been provided.Finally,the challenges and future developments of vibrationbased bearing fault diagnostic methods for high-speed trains have been analyzed. | Wanchun Hu Ge Xin Jiayi Wu Guoping An Yilei Li Ke Feng Jerome Antoni | 2023 | High-Speed Railway2023，1，4： | 0 |
| 20 | Microenvironment responsive nanocomposite hydrogel with NIR photothermal therapy,vascularization and anti-inflammation for diabetic infected wound healing显示文摘Bacterial infection,excessive inflammation and damaging blood vessels network are the major factors to delay the healing of diabetic ulcer.At present,most of wound repair materials are passive and can’t response to the wound microenvironment,resulting in a low utilization of bioactive substances and hence a poor therapeutic effect.Therefore,it’s essential to design an intelligent wound dressing responsive to the wound microenvironment to achieve the release of drugs on-demand on the basis of multifunctionality.In this work,metformin-laden CuPDA NPs composite hydrogel(Met@CuPDA NPs/HG)was fabricated by dynamic phenylborate bonding of gelatin modified by dopamine(Gel-DA),Cu-loaded polydopamine nanoparticles(CuPDA NPs)with hyaluronic acid modified by phenyl boronate acid(HA-PBA),which possessed good injectability,self-healing,adhesive and DPPH scavenging performance.The slow release of metformin was achieved by the interaction with CuPDA NPs,boric groups(B-N coordination)and the constraint of hydrogel network.Metformin had a pH and glucose responsive release behavior to treat different wound microenvironment intelligently.Moreover,CuPDA NPs endowed the hydrogel excellent photothermal responsiveness to kill bacteria of>95%within 10 min and also the slow release of Cu^(2+)to protect wound from infection for a long time.Met@CuPDA NPs/HG also recruited cells to a certain direction and promoted vascularization by releasing Cu^(2+).More importantly,Met@CuPDA NPs/HG effectively decreased the inflammation by eliminating ROS and inhibiting the activation of NF-κB pathway.Animal experiments demonstrated that Met@CuPDA NPs/HG significantly promoted wound healing of diabetic SD rats by killing bacteria,inhibiting inflammation,improving angiogenesis and accelerating the deposition of ECM and collagen.Therefore,Met@CuPDA NPs/HG had a great application potential for diabetic wound healing. | Shuangli Zhu Bangjiao Zhao Maocai Li Hao Wang Jiayi Zhu Qingtao Li Huichang Gao Qi Feng Xiaodong Cao | 2023 | Bioactive Materials2023，，8： | 0 |
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