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| 1 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 2 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study显示文摘 | Qiujin Shen Jia Fan Xin-Rong Yang Yexiong Tan Weifeng Zhao Yang Xu Ning Wang Yongdong Niu Zheng Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Bin Yu Ning Tang Wei Chu Min Wang Jinhua Wu Zhigang Zhang Shengli Yang Jianren Gu Hongyang Wang Wenxin Qin | 2012 | Lancet Oncology2012，，8： | 4 |
| 3 | Identification and characterization of a novel peptide ligand of Tie2 for targeting gene therapy显示文摘有免疫球蛋白和表皮的生长因素相同 domain-2 (Tie2 ) 的酷氨酸 kinase 在稳固的肿瘤为基因治疗被看作了一个合理目标。以便为指向的基因治疗识别 Tie2 的新奇的肽 ligand,我们屏蔽了一个噬菌体显示肽图书馆并且识别了候选人肽 ligand NSLSNASEFRAPY (指明的 GA5 ) 。有约束力的试金和 Scatchard 分析表明 GA5 能明确地与 2.1 的一个分离常数绑在 Tie2 ?鷐 吗?? | Xianghua Wu Zonghai Li Ming Yao Huamao Wang Sumin Qu Xianlian Chen Jinjun Li Ye Sun Yuhong Xu Jianren Gu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 2 |
| 4 | Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma显示文摘我们以前在 hepatocellular 癌(HCC ) 识别了体的拷贝数字改变(CNA ) 的 1 241 个区域。在现在的学习,我们发现那新奇周期性的焦点的 amplicon, 1q24.1-24.2,在 HCC 指向 MPZL1 基因。尤其是,在 MPZL1 和 HCC 标本的 intrahepatic 转移的表示层次之间有积极关联。MPZL1 能显著地提高 HCC 房间的迁移、变形的潜力。而且,我们发现 MPZL1 由支持 HCC 房间移植的机制之一由导致支持 metastatic 蛋白质的 phosphorylation 和激活, cortactin。另外,我们发现 Src kinase 调停 cortactin 的 phosphorylation 和激活由 MPZL1 overexpression 导致了。一起拿,这些调查结果建议 MPZL1 是拷贝数字扩大的一个周期性的区域在 HCC 目标为 1q24.1-24.2 的新奇支持 metastatic 基因。 | Deshui Jia Ying Jing Zhenfeng Zhang Li Liu Jie Ding Fangyu Zhao Chao Ge Qifeng Wang Taoyang Chen Ming Yao Jinjun Li Jianren Gu Xianghuo He | 2014 | Cell Research2014，24，2： | 2 |
| 5 | Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion显示文摘 | Junping Ao Jiao Meng Lei Zhu Huizhen Nie Chenchen Yang Jinjun Li Jianren Gu Qiushi Lin Weiwen Long Xiaoqun Dong Chao Li | 2012 | Molecular Oncology2012，，5： | 1 |
| 6 | Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells显示文摘 | Haiyan You Jie Jin Huiqun Shu Bin Yu Angelo De Milito Francesco Lozupone Yun Deng Ning Tang Genfu Yao Stefano Fais Jianren Gu Wenxin Qin | 2009 | Cancer Letters2009，，1： | 1 |
| 7 | Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin显示文摘 | Jin Song Zhouhong Ge Xinrong Yang Qin Luo Cun Wang Haiyan You Tianxiang Ge Yun Deng Hechun Lin Yongqi Cui Wei Chu Ming Yao Zhigang Zhang Jianren Gu Jia Fan Wenxin Qin | 2014 | Cancer Letters2014，，： | 1 |
| 8 | Dickkopf-1 autoantibody is a novel serological biomarker for non-small cell lung cancer显示文摘 | Xiao Yao Hua Jiang Cuizhen Zhang Huamao Wang Lin Yang Yongfeng Yu Junming Yu Bizhi Shi Zhijun Shen Huiping Gao Zhiwei Chen Shujun Tian Shun Lu Zonghai Li Jianren Gu | 2010 | Biomarkers2010，，2： | 1 |
| 9 | Elevated expression of DKK1 is associated with cytoplasmic/nuclear β-catenin accumulation and poor prognosis in hepatocellular carcinomas显示文摘 | Bin Yu Xinrong Yang Yang Xu Genfu Yao Huiqun Shu Biaoyang Lin Leroy Hood Hongyang Wang Shengli Yang Jianren Gu Jia Fan Wenxin Qin | 2008 | Journal of Hepatology2008，，5： | 1 |
| 10 | Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells显示文摘 | Haiyan You Jie Jin Huiqun Shu Bin Yu Angelo De Milito Francesco Lozupone Yun Deng Ning Tang Genfu Yao Stefano Fais Jianren Gu Wenxin Qin | 2009 | Cancer Letters2009，，1： | 1 |
| 11 | Choline Transporters in Human Lung Adenocarcinoma: Expression and Functional Implications显示文摘然而,胆碱是为房间幸存和增长的必要营养素胆碱运输 ers 的表示和功能很好没在癌症被识别。在这研究,我们检测了 mRNA 和器官的阳离子 transporter 的蛋白质表示 OCT3,肉毒碱 / 阳离子运输 ers OCTN1 和 OCTN2,和在人的肺腺癌房间的像运输的 proteinCTL1 衬里的胆碱 A549, H1299 和 SPC-A-1.Their 表示模式是进一步的在 25 人的主要腺癌纸巾证实了。在这些房间线的胆碱举起被 CTL1 禁止者显著地堵住,但是仅仅部分在房间增长上由 10 月或这些禁止者的 OCTNinhibitors.The 功效禁止了密切与他们堵住胆碱运输的能力被相关。在这些运输 ers 的本国的表示下面,全部的胆碱举起被特定的 PI3K/AKT 禁止者显著地堵住。这些结果在人的肺腺癌的房间增长描述胆碱运输 ers 和他们的相关功能的表示,因此提供潜在的“胆碱饥饿”通过指向胆碱运输 ers 的癌症干扰的策略,特别 CTL1。 | Tao WANG Jinjun LI Fei CHEN Yingjun ZHAO Xianghuo HE Dafang WAN Jianren GU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 1 |
| 12 | Identification and impact of hepatitis B virus DNA and antigens in pancreatic cancer tissues and adjacent non-cancerous tissues显示文摘 | Yan Jin Hengjun Gao Hao Chen Jian Wang Min Chen Guohua Li Liwei Wang Jianren Gu Hong Tu | 2013 | Cancer Letters2013，，2： | 1 |
| 13 | Dysfunction of Murine Dendritic Cells Induced by Incubation with Tumor Cells显示文摘In vivo studies showed that dendritic cell (DC) dysfunction occurred in tumor microenvironment. As tumors were composed of many kinds of cells,the direct effects of tumor cells on immature DCs (imDCs) are needed for further studies in vitro. In the present study,bone marrow-derived imDCs were incubated with lymphoma,hepatoma and menaloma cells in vitro and surface molecules in imDCs were determined by flow cytometry. Then,imDCs incubated with tumor cells or control imDCs were further pulsed with tumor lysates and then incubated with splenocytes to perform mixed lymphocyte reaction. The DC-dependent tumor antigen-specific T cell proliferation,and IL-12 secretion were determined by flow cytometry,and enzyme-linked immunosorbent assay respectively. Finally,the DC-dependent tumor-associated antigen-specific CTL was determined by enzyme-linked immunospot assay. The results showed that tumor cell-DC incubation down-regulated the surface molecules in imDCs,such as CD80,CD54,CD11b,CD11a and MHC class Ⅱ molecules. The abilities of DC-dependent antigen-specific T cell proliferation and IL-12 secretion were also decreased by tumor cell incubation in vitro. Most importantly,the ability for antigenic-specific CTL priming of DCs was also decreased by incubation with tumor cells. In the present in vitro study demonstrated that the defective abilities of DCs induced by tumor cell co-incubation and the co-incubation system might be useful for future study of tumor-immune cells direct interaction and for drug screen of immune-modulation. | Fengguang Gao Xin Hui Xianghuo He Dafang Wan Jianren Gu | 2008 | Cellular & Molecular Immunology2008，5，2： | 0 |
| 14 | Cloning, construction of prokaryotic expression vector and expression of Escherichia coli cytosine deaminase gene显示文摘Cytosine deaminase gene of Escherichia coli strain H30 was cloned, and its initiation codon of ’GTG’ was mutated to ’ATG’ by PCR. Prokaryotic recombinant expression vector pBV220CD was constructed. Clone with high enzyme activity were selected by detecting their specific activity of cytosine deaminase. 5FC(5FC, 5fluorocytosine) could induce the lethal toxicity to cells containing active CD gene. DNA sequence analysis indicated that there were 16 altered bases and 5 of them resulted in the alteration of amino acids in predicted peptide by comparing DNA sequence of the clone H30CD11 with high enzyme activity with CD gene reported in Gene Bank. | Shengjun Ren Huiqiu Jiang Jianren Gu | 1998 | Chinese Science Bulletin1998，43，3： | 0 |
| 15 | Gene therapy research in China显示文摘Since 1980, many Chinese scientists haveinvestigated the somatic cell therapy and started thebasic research on gene therapy. From 1990’ s, someimportant advances in gene therapy research havebeen achieved in China. For example, the clinicaltrial of hemophilia B was approved in China andpublished in Human Gene Therapy. Many originalpapers have been published in the internationaljournals. Many gene therapy research projects havebeen funded by the National N atural ScienceFoundation and National High BiotechnologyFoundation. The National High BiotechnologyFoundation has supportcd 10 gene therapy | Xuetao Cuo, Jianren Gu Department of Immunology, The Second Military Medical University, Shanghai 200433 Shanghai Cancer Institute, Sliangha 200032 | 1997 | 中国实验血液学杂志1997，5，3： | 0 |
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