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| 1 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 2 | The Late Carboniferous–Early Permian Ocean-Continent Transition in the West Junggar,Central Asian Orogenic Belt: Constraints from Columnar Jointed Rhyolite显示文摘The West Junggar of the western Central Asian Orogenic Belt is one of the typical regions in the term of ocean subduction, contraction and continental growth in the Late Paleozoic. However, it is still controversial on the exact time of ocean-continent transition so far. This study investigates rhyolites with columnar joint in the West Junggar for the first time.Based on zircon U-Pb dating, we determined that the ages of the newly-discovered rhyolites are between 303.6 and 294.5 Ma, belonging to Late Carboniferous–Early Permian, which is the oldest rhyolite with columnar joint preserved in the world at present. Geochemical results show that the characteristics of the major element compositions include a high content of SiO_2(75.78–79.20 wt%) and a moderate content of Al_2O_3(12.21–13.19 wt%). The total alkali content(K_2O +Na_2O) is 6.14–8.05 wt%, among which K_2O is 2.09–4.72 wt% and the rate of K_2O/Na_2O is 0.38–3.05. Over-based minerals such as Ne, Lc, and Ac do not appear. The contents of TiO_2(0.09–0.24 wt%), CaO(0.15–0.99 wt%) and MgO(0.06–0.18 wt%) are low. A/CNK=0.91–1.68, A/NK=1.06–1.76, and as such, these are associated with the quasi-aluminum-weak peraluminous high potassium calc-alkaline and some calc-alkaline magma series. These rhyolites show a significant negative Eu anomaly with relative enrichment of LREE and LILE(Rb, Ba, Th, U, K) and depletion of Sr, HREE and HFSE(Nb, Ta, Ti, P). These rhyolites also have the characteristics of an A2-type granite, similar to the Miaoergou batholith,which indicates they both were affected by post-orogenic extension. Combining petrological, zircon U-Pb dating and geochemical characteristics of the rhyolites, we conclude that the specific time of ocean-continent transition of the West Junggar is the Late Carboniferous–Early Permian. | XU Shenglin CHEN Xuanhua LI Tingdong SHI Jianjie DING Weicui LI Bing HUANG Penghui ZHANG Yiping ZHANG Yaoyao MA Feizhou | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 9 |
| 3 | microRNAs: tiny RNA molecules, huge driving forces to move the cell显示文摘Cell migration or movement is a highly dynamic cellular process,requiring precise regulation that is essential for a variety of biological processes.microRNAs(miRNAs)are a class of tiny non-coding RNA molecules that function as critical post-transcriptional regulators of gene expression.Emerging evidence demonstrates that miRNAs play important roles in cell migration and directly contribute to extracellular matrix(ECM)remodeling,cell adhesion,and cell signalling that controls cell migration by targeting a large number of protein-coding genes.Accordingly,the dysregulation of these miRNAs has been linked to several migration-related diseases.In this review,we summarize and highlight the recent advances concerning the roles and validated targets of miRNAs in the control of cell movement. | Shenglin Huang Xianghuo He | 2010 | Protein & Cell2010，1，10： | 3 |
| 4 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 5 | N-doped carbon nanotubes formed in a wide range of temperature and ramping rate for fast sodium storage显示文摘Herein,nickel@nitrogen-doped carbon nanotubes(Ni@NCNTs)are prepared by a simple and reliable method with Ni-based complex as single-source precursor.Significantly,the formation of CNTs is not susceptible to the calcination temperature and ramping rate and Ni@NCNTs can be attained from 430 to 900℃in an inert atmosphere.Then they are the first time to be applied as the anode material for sodium-ion batteries.The presence of Ni nanoparticles(NPs)facilitates the solid electrolyte interface film over the anode surface and improves the capacity retention of the host material,especially at the high rates.Furthermore,Na+diffusion is reinforced after the introduction of Ni NPs.Ni@NCNTs obtained at 500℃(Ni@NCNTs-500)exhibit the best capacity retention and rate capability.Kinetics analyses demonstrate the faster electron transportation and ion diffusion than others prepared at other temperatures.The surficial capacitance storage favors the fast electrochemistry kinetics.It delivers a high specific capacity(192 mA h g^−1 at 0.5 A g^−1),excellent cycling stability(103 mA h g^−1 after 10,000 cycles at 10 A g^−1),and outstanding high-rate capability up to 20 A g^−1(118 mA h g^−1).The related full cells confirm a high energy density of 140 Wh kg^−1 at 38.16 W kg^−1 and 44.27 W h kg^−1 at 762 W kg^−1. | Ruchao Wei Man Huang Wenzhe Ma Baojuan Xi Zhenyu Feng Haibo Li Jinkui Feng Shenglin Xiong | 2020 | Journal of Energy Chemistry2020，29，10： | 3 |
| 6 | Production of propene from 1-butene metathesis reaction on tungsten based heterogeneous catalysts显示文摘A new propene production route from 1-butene metathesis has been developed on heterogeneous 10WO3/Al2O3-HY catalysts with different HY contents.It is found that the catalysts play bi-functionally first for the isomerization of 1-butene to 2-butene and then for the cross-metathesis between 1-butene and 2-butene to propene and 2-pentene.The combination of HY zeolite and Al2O3 is prerequisite for the production of propene.The propene yield keeps increasing with the HY content in the range of 10-70 wt%,where 10WO3/Al2O3-70HY exhibits the highest propene yield.The MS-H2-TPR and MS-O2-TPO characterizations indicate that the increase of HY content in the catalysts weakens the interaction between W species and supports,whereas enhance the probability of coking on the metal species and acid sites. | Huijuan Liu Ling Zhang Xiujie Li Shengjun Huang Shenglin Liu Wenjie Xin Sujuan Xie Longya Xu | 2009 | Journal of Natural Gas Chemistry2009，18，3： | 3 |
| 7 | HER4 promotes the growth and metastasis of osteosarcoma via the PI3K/AKT pathway显示文摘Osteosarcoma is the most common primary malignant bone tumor,which occurs in adolescents.As reported by our previous studies,HER4 indicates a poor prognosis of primary osteosarcoma.However,its mechanisms in the pathogenesis of osteosarcoma have not yet been studied.The purpose of this study was to investigate the role of HER4 in osteosarcoma and whether the PI3K/AKT pathway is involved.In this study,western blot analysis was used to investigate the expression of HER4 protein in osteosarcoma tissues and cell lines.CCK8 and transwell assays were used to detect the effects of HER4 on the proliferation,migration,and invasion of osteosarcoma cells in vitro.The effects of HER4 on the growth and metastasis of osteosarcoma in vivo were detected by tumor formation and immunofluorescence in nude mice.The role of the PI3K/AKT pathway in HER4 regulation of the growth and metastasis of osteosarcoma was examined by western blot analysis and immunofluorescence assay.We found that HER4 protein was highly expressed in clinical osteosarcoma specimens and osteosarcoma cells.HER4 markedly promoted the proliferation,migration,and invasion of osteosarcoma cells in vitro as well as the growth and metastasis of osteosarcoma in vivo.HER4 overexpression upregulated the expression of phosphorylated protein kinase B(pAKT),proliferation marker antigen Ki67,and metastasis cell marker matrix metalloproteinase 9(MMP9).Notably,PI3K/AKT inhibitor LY294002 significantly inhibited the effects of HER4 via the downregulation of pAKT,Ki67,and MMP9.Moreover,LY294002 markedly blocked the effects of HER4-induced upregulation of tum or malignancy.The present study suggests that HER4 may promote the growth and metastasis of osteosarcoma via the PI3K/AKT pathway.The HER4/PI3K/AKT pathway could serve as a potential target for the treatment of osteosarcoma. | Xiaodong Li Qingshan Huang Shenglin Wang Zhen Huang Fengqiang Yu Jianhua Lin | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 3 |
| 8 | Robust S-doped TiO_(2)@N,S-codoped carbon nanotube arrays as free-binder anodes for efficient sodium storage显示文摘Titanium dioxide(TiO_2) has been investigated broadly as a stable,safe,and cheap anode material for sodium-ion batteries in recent years.However,the poor electronic conductivity and inherent sluggish sodium ion diffusion hinder its practical applications.Herein,a self-template and in situ vulcanization strategy is developed to synthesize self-supported hybrid nanotube arrays composed of nitrogen/sulfur-codoped carbon coated sulfur-doped TiO_2 nanotubes(S-TiO_2@NS-C) starting from H_2 Ti_2 O_5-H_2 O nanoarrays.The S-TiO_2@NS-C composite with one-dimensional nano-sized subunits integrates several merits.Specifically,sulfur doping strongly improves the Na~+ storage ability of TiO_2@C-N nanotubes by narrowing the bandgap of original TiO_2.Originating from the nanoarrays structures built from hollow nanotubes,carbon layer and sulfur doping,the sluggish Na~+ insertion/extraction kinetics is effectively improved and the volume variation of the electrode material is significantly alleviated.As a result,the S-TiO_2@NS-C nanoarrays present efficient sodium storage properties.The greatly improved sodium storage performances of S-TiO_2@NS-C nanoarrays confirm the importance of rational engineering and synthesis of hollow array architectures with higher complexity. | Guangzeng Liu Man Huang Zhengchunyu Zhang Baojuan Xi Haibo Li Shenglin Xiong | 2021 | Journal of Energy Chemistry2021，30，2： | 2 |
| 9 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
| 10 | Effect of Reaction Temperature and Pressure on the Metathesis Reaction between Ethene and 2-Butene to Propene on the WO_3/Al_2O_3-HY Catalyst显示文摘在到丙烯的 ethene 和 2-butene 之间的换位反应上的反应温度和压力的效果在 WO3/| 上被学习 ?-Al2O3-HY 催化剂。这项活动被发现与提高的温度增加并且在 150 ¨ C 到达一个高原 240 ??6 号元素碳的化学符号。在那以后,这项活动经历显著减少在也高温。温度的效果被钨种类的氧化态阐明。评估结果也显示稳定性依赖于这个反应参数。中等压力(0.5 ¨ C 0.8 MPa ) 为稳定性是有利的,当时气压或也高压(> 1.0 MPa ) 败坏稳定性。为解释,紫外力,英尺红外, O2-TPO,和 TG,技术被用来描绘废催化剂。给词调音:换位;氧化钨催化剂;温度;压力;ethene;2-butene; | Shengjun Huang Shenglin Liu Wenjie Xin Sujuan Xie Qingxia Wang Longya Xu | 2006 | Journal of Natural Gas Chemistry2006，15，2： | 2 |
| 11 | Metathesis of ethane and 2-butene to propene on W/Al2O3-HY catalysts with different HY contents显示文摘 | Huang Shengjun Liu Shenglin Xin Wenjie | 2005 | Journal of Molecular Catalysis A:Chemical2005，226，： | 1 |
| 12 | The influence of preparation procedures and tungsten loading on the metathesis activity of ethane and 2-hutene over supported WO3 catalysts显示文摘 | Huang Shengjun Chen Fucun Liu Shenglin | 2007 | Journal of Molecular Catalysis A:Chemical2007，267，： | 1 |
| 13 | Two New On-Purpose Processes Enhancing Propene Production: Catalytic Cracking of C4 Alkenes to Propene and Metathesis of Ethene and 2-Butene to Propene显示文摘 | Xiangxue Zhu Xiujie Li Sujuan Xie Shenglin Liu Guoliang Xu Wenjie Xin Shengjun Huang Longya Xu | 2009 | Catalysis Surveys from Asia2009，，1： | 1 |
| 14 | MicroRNA-18la mo?dulates gene expression of zinc finger family members by directly tar?geting their coding regions显示文摘 | Shenglin Huang Shunquan Wu Jie Ding | 2010 | Nucleic Acids Research2010，38，20： | 1 |
| 15 | Dietary supplementation with 2-hydroxy-4-methyl(thio)butanoic acid and DL-methionine improves productive performance,egg quality and redox status of commercial laying ducks显示文摘This experiment aimed to study the effects of supplemental methionine sources,2-hydroxy-4 methyl(thio)butanoic acid(HMTBa)and DL-Methionine(DL-Met),on productive performance,egg quality,and redox status of laying ducks.A total of 792 healthy 25-wk-old Longyan laying ducks with similar body weights were randomly allotted to 11 treatment groups.Each treatment group had 6 replicates of 12 ducks.The trial lasted for 16 wk.Ducks were fed a basal deficient diet(Met:0.24%;Met+Cys:0.51%)or supplemented with DL-Met or HMTBa at 0.05%,0.12%,0.19%,0.26%,and 0.33%of diet,respectively.Compared with the basal diet,supplementation with either DL-Met or HMTBa increased the average egg weight,egg mass,and decreased feed to egg ratio during the whole trial period(P<0.05).Albumen weight and its ratio to total egg weight were increased,but yolk and shell ratio,albumen height,Haugh unit and shell breaking strength were decreased(P<0.05).Dietary DL-Met or HMTBa supplementation increased taurine,methionine,leucine,tryptophan and arginine content,and decreased serine and lysine content in plasma(P<0.05).The redox status of laying ducks was improved by enhancing the glutathione peroxidase and catalase activities,glutathione content and its ratio relative to glutathione(oxidized)content and decreasing malondialdehyde content and increasing mRNA expression of superoxide dismutase-1,glutathione peroxidase-1,hemeoxygenase-1 and nuclear factor-like 2 in liver and ileum with the supplementation of DL-Met or HMTBa(P<0.05).Liver health status measured by average area proportion lipid droplet was improved with supplementation of DL-Met or HMTBa(P<0.05).Villus height and villus height to crypt depth ratio in the ileum and the ileal gene expression of tight junction protein and occludin were increased with DL-Met or HMTBa supplementation(P<0.05).Taken together,these results suggested that the efficacy of dietary supplementation of HMTBa was similar to DL-Met,and it ranged from 98%to 100%for productive performance and egg albumen ratio in laying ducks(25 to 41 wk). | Yanan Zhang Zhiwei Zhuang Tahir Mahmood Yves Mercier Yongyan Jin Xuebing Huang Kaichao Li Shuang Wang Weiguang Xia Shenglin Wang Miao Yu Wei Chen Chuntian Zheng | 2023 | Animal Nutrition2023，，3： | 1 |
| 16 | Overexpression of IbSINA5 Increases Cold Tolerance through a CBF SINA-COR Mediated Module in Sweet Potato显示文摘Seven in absentia(SINA)family proteins play a central role in plant growth,development and resistance to abiotic stress.However,their biological function in plant response to cold stress is still largely unknown.In this work,a seven in absentia gene IbSINA5 was isolated from sweet potato.Quantitative real-time polymerase chain reaction(qRT-PCR)analyses demonstrated that IbSINA5 was ubiquitously expressed in various tissues and organs of sweet potato,with a predominant expression in fibrous roots,and was remarkably induced by cold,drought and salt stresses.Subcellular localization assays revealed that IbSINA5-GFP fusion protein was mainly localized in cytoplasm and nucleus.Overexpression of IbSINA5 in sweet potato led to dramatically improved resistance to cold stress in transgenic plants,which was associated with the up-regulated expression of IbCOR(cold-regulated)genes,increased proline production,and decreased malondialdehyde(MDA)and H2O2 accumulation in the leaves of transgenic plants.Furthermore,transient expression of IbCBF3,a C-repeat binding factor(CBF)gene,in the leaf protoplasts of wild type sweet potato plants up-regulated the expression of both IbSINA5 and IbCOR genes.Our results suggest that IbSINA5 could function as a positive regulator in the cold signaling pathway through a CBF-SINA-COR mediated module in sweet potato,and have a great potential to be used as a candidate gene for the future breeding of new plant species with improved cold resistance. | Shiyang Li Xue-Ao Liu Lizi Zhao Huiqing Huang Bei Li Zhizhong Song Meixia Liang Hongxia Zhang Limin Wang Shenglin Zhou | 2021 | Phyton-International Journal of Experimental Botany2021，90，3： | 1 |
| 17 | The Effect of Calcination Time on the Activity of WOJAI:O3/H Catalysts for the Metathesis Reaction Between Ethane and 2-Butene显示文摘 | Huang Shengjun Liu Shenglin Zhu Qingjun | 2007 | ApplCatal A2007，323，： | 1 |
| 18 | Stattic sensitizes osteosarcoma cells to epidermal growth factor receptor inhibitors via blocking the interleukin 6-induced STAT3 pathway显示文摘Osteosarcoma(OS),the most common malignant bone tumor with high metastatic potential,frequently affects children and adolescents.Epidermal growth factor receptor(EGFR)-targeted tyrosine kinase inhibitors exhibit encouraging anti-tumor activity for patients with solid tumors,whereas their effects on OS remain controversial.In the present study,we aimed to elucidate the anti-tumor activity of gefitinib for OS,as well as to explore the underlying mechanisms.Gefitinib inhibits cell viability,tumor growth,cell migration,and invasion and promotes cell apoptosis and G1 cycle arrest in OS at a relatively high concentration via suppressing the PI3K/Akt and ERK pathways.However,gefitinib treatment results in the feedback activation of signal transducer and activator of transcription 3(STAT3)induced by interleukin 6(IL-6)secretion.Combined treatment with gefitinib and stattic,an inhibitor for STAT3 phosphorylation,engenders more evident inhibitory effects on cell proliferation,migration,and invasion and promotive effects on cell apoptosis and G1 phase arrest in OS,compared with the single exposure to gefitinib or stattic.Western blot analysis demonstrates that stattic treatment in gefitinib-treated OS abrogates the IL-6-induced STAT3 activation and subsequently further restrains the activities of EGFR,Akt,and ERK pathways in tumor cells.This study confirms that the EGFR inhibitor of gefitinib has moderate anti-tumor effects on OS through IL-6 secretion-mediated STAT3 activation.Additional administration of stattic in EGFR-targeted therapies may contribute to improve the efficacy for OS. | Shenglin Wang Yunqing Wang Zhen Huang Hongxiang Wei Xinwen Wang Rongkai Shen Wenbin Lan Guangxian Zhong Jianhua Lin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 1 |
| 19 | Realizing simultaneously excellent energy storage and discharge properties in AgNbO_(3)based antiferroelectric ceramics via La^(3t)and Ta^(5+)co-substitution strategy显示文摘AgNbO_(3)based antiferroelectric(AFE)ceramics have large maximum polarization and low remanent polarization,and thus are important candidates for fabricating dielectric capacitors.However,their energy storage performances have been still large difference with those of lead-based AFEs because of their room-temperature ferrielectric(FIE)behavior.In this study,novel La^(3+)and Ta^(5+)co-substituted AgNbO_(3)ceramics are designed and developed.The introduction of La^(3+)and Ta^(5+)decreases the tolerance factor,reduces the polarizability of B-site cations and increases local structure heterogeneity of AgNbO_(3),which enhance AFE phase stability and refine polarization-electric field(PeE)loops.Besides,adding La^(3+)and Ta^(5+)into AgNbO_(3)ceramics causes the decrease of the grain sizes and the increase of the band gap,which contribute to increased Eb.As a consequence,a high recoverable energy density of 6.79 J/cm3 and large efficiency of 82.1%,which exceed those of many recently reported AgNbO_(3)based ceramics in terms of overall energy storage properties,are obtained in(Ag0.88La0.04)(Nb0.96Ta0.04)O_(3)ceramics.Furthermore,the discharge properties of the ceramic with discharge time of 16 ns and power density of 145.03 MW/cm3 outperform those of many lead-free dielectric ceramics. | Yuqi Zhou Shuaibing Gao Jie Huang Meng Shen Shenglin Jiang Yunbin He Qingfeng Zhang | 2023 | Journal of Materiomics2023，9，2： | 0 |
| 20 | Epidermal growth factor receptor promotes tumor progression and contributes to gemcitabine resistance in osteosarcoma显示文摘Osteosarcoma(OS)is the most common type of primary malignant tumors that originate in the bone.Resistance to chemotherapy confers a poor prognosis on OS patients.Dysregulation of the epidermal growth factor receptor(EGFR)signaling has been reported in sarcomas.However,the functional contribution of EGFR hyperactivation to the tumor biology and chemoresistance remains largely unexplored in OS.In this study,we aimed to investigate the role of EGFR in OS progression and in the response of OS to gemcitabine treatment.The EGFR expression was found to be upregulated in fibroblastic OS cell lines.EGFR knockdown suppressed OS cell proliferation,migration,and invasion in vitro and tumor formation in vivo.Conversely,EGFR overexpression promoted the growth and motility of OS cells.In terms of mechanism,the levels of phospho-Akt and phospho-ERK were decreased upon EGFR knockdown but increased as a result of EGFR overexpression,implying a possible involvement of PI3K/Akt and ERK pathways in mediating the effects of EGFR on OS cells.Moreover,the level of phospho-EGFR was increased in OS cells when exposed to gemcitabine treatment.A more profound proliferative inhibition and a higher rate of apoptosis were obtained in OS cells via inducing cell cycle arrest at G1 phase upon gemcitabine treatment combined with EGFR knockdown,as compared to gemcitabine alone.On the contrary,EGFR overexpression counteracted the growth-inhibiting and pro-apoptotic effects of gemcitabine in OS cells.The present study suggests that EGFR promotes tumor progression and contributes to gemcitabine resistance in OS. | Shenglin Wang Hongxiang Wei Zhen Huang Xinwen Wang Rongkai Shen Zhaoyang Wu Jianhua Lin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 0 |
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