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| 1 | Oral frailty and neurodegeneration in Alzheimer’s disease显示文摘Frailty is a critical intermediate status of the aging process with a multidimensional and multisystem nature and at higher risk for adverse health-related outcomes,including falls,disability,hospitalizations,institutionalization,mortality,dementia,and Alzheimer’s disease.Among different frailty phenotypes,oral frailty has been recently suggested as a novel construct defined as a decrease in oral function with a coexisting decline in cognitive and physical functions.We briefly reviewed existing evidence on operational definitions of oral frailty,assessment and screening tools,and possible relationships among oral frailty,oral microbiota,and Alzheimer’s disease neurodegeneration.Several underlying mechanism may explain the oral health-frailty links including undernutrition,sarcopenia linked to both poor nutrition and frailty,psychosocial factors,and the chronic inflammation typical of oral disease.Oral microbiota may influence Alzheimer’s disease risk through circulatory or neural access to the brain and the interplay with periodontal disease,often causing tooth loss also linked to an increased Alzheimer’s disease risk.On this bases,COR388,a bacterial protease inhibitor targeting Porphyromonas gingivalis implicated in periodontal disease,is now being tested in a double-blind,placebocontrolled Phase II/III study in mild-to-moderate Alzheimer’s disease.Therefore,oral status may be an important contributor to general health,including Alzheimer’s disease and latelife cognitive disorders,suggesting the central role of preventive strategies targeting the novel oral frailty phenotype and including maintenance and improvement of oral function and nutritional status to reduce the burden of both oral dysfunction and frailty. | Vittorio Dibello Madia Lozupone Daniele Manfredini Antonio Dibello Roberta Zupo Rodolfo Sardone Antonio Daniele Frank Lobbezoo Francesco Panza | 2021 | Neural Regeneration Research2021，16，11： | 10 |
| 2 | Hydroxytryptamine transporter gene-linked polymorphic region(5HTTLPR)is associated with delusions in Alzheimer’s disease显示文摘Background:Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease(AD)have not been fully clarified.5-Hydroxytryptamine transporter gene-linked polymorphic region(5-HTTLPR)is a variable number tandem repeats in the promoter region of serotonin transporter encoding-gene affecting transcription.Methods:We investigated the association of 5-HTTLPR with delusions in a total of 257 consecutive patients clinically diagnosed as AD according to the National Institute on Aging-Alzheimer’s Association criteria.All participants underwent a comprehensive evaluation with a standardized comprehensive geriatric assessment and Neuropsychiatric Inventory.Results:Delusion symptoms were observed in 171 patients(66.54%).In respect to AD patients without delusions,AD patients with delusions showed a low prevalence of S-plus carriers(5-HTTLPR-L/S+5-HTTLPR-S/S genotypes)[p<0.001;odds ratio(OR)=0.240,95% confidence interval(CI)=0.121–0.471].Logistic regression analysis adjusted for the apolipoprotein E polymorphism showed that in AD patients with delusions the presence of an 5-HTTLPR-S allele may reduce disease duration(p=0.005;OR=0.680,95% CI=0.522–0.886)and increase aberrant motor activity(p=0.013;OR=2.257,95% CI=1.195–4.260).The present findings suggested that 5-HTTLPR might be associated with delusions in AD.S-plus carriers might be associated with protective effect against delusions in AD.Conclusions:More studies on wider samples of high selected demented patients are needed to confirm our results.However,the present findings suggested that a genetic factor related to serotonin metabolism might exert a protective role on the clinical expression of neuropsychiatric clusters in AD with important implications regarding mechanisms underlying delusions and their possible treatment across the AD and dementia spectrum. | Grazia D’Onofrio Francesco Panza Daniele Sancarlo Michele Lauriola Mariangela P.Dagostino Giulia Paroni Madia Lozupone Antonio Mangiacotti Paola Bisceglia Carolina Gravina Maria Urbano Filomena Addante Francesco Paris Leandro Cascavilla Antonio Greco Davide Seripa | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 3 | Effect of human natural killer and gammadelta T cells on the growth of human autologous melanoma xenografts in SCID mice显示文摘 | Lozupone F Pende D Burgio VL | 2004 | Cancer Res2004，64，1： | 1 |
| 4 | Worlds with- in worlds, evolution of the vertebrate gut microbiota显示文摘 | Ley R E Lozupone C A Hamady M | 2008 | Nature Reviews Microbiology2008，，10： | 1 |
| 5 | Evolution of mammals and their gut microbes显示文摘 | LEY R E HAMADY M LOZUPONE C | 2008 | Science2008，320，： | 1 |
| 6 | QIIME allows analysis of high-throughput community sequencing data 显示文摘 | Caporaso JG Kuczynski J Stombaugh J Bittinger K Bushman FD Costello EK Fierer N Pena AG Goodrich JK Gordon JI Huttley GA Kelley ST Knights D Koenig JE Ley RE Lozupone CA Mcdonald D Muegge BD Pirrung M Reeder J Sevinsky JR Tumbaugh PJ Walters WA Widmann J Yatsunenko T Zaneveld J Knight R | 2010 | Nat Methods2010，7，5： | 1 |
| 7 | Identification and relevance of the CD95 - binding domain in the N - terminal region of ezrin显示文摘 | Lozupone F Lugini L Matarrese P | 2004 | J Biol Chem2004，279，10： | 1 |
| 8 | Fast unifrac:facilitating hight-hroughput phylogenetic analys-es of microbial communities inclu-ding analysis of pyrosequencing and phylochip data显示文摘 | Hamady M Lozupone C Knight R | 2010 | ISME J2010，4，1： | 1 |
| 9 | The role of FAS to ezrin association in FAS - mediated apoptosis显示文摘 | Fais S De Milito A Lozupone F | 2005 | Apoptosis2005，10，5： | 1 |
| 10 | Evolution of mammals and their gut microbes显示文摘 | Ley R E Hamady M Lozupone C | 2008 | Science2008，320，5883： | 1 |
| 11 | Evolution of mam- mals and their gilt microbes显示文摘 | LEX R E HAMADY M LOZUPONE C | 2008 | Science2008，320，5883： | 1 |
| 12 | UniFrac: a new phylogenetic method forcomparing microbial communities 显示文摘 | Lozupone C Knight R | 2005 | Appl Environ Microbiol2005，71，12： | 1 |
| 13 | The role of FAS to Ezrin association in FAS-mediated apoptosis 显示文摘 | Fais S De Milito A Lozupone F | 2005 | Apoptosis2005，10，5： | 1 |
| 14 | Evolution of mammals and their gut microbes显示文摘 | Ley R E Hamady M Lozupone C | 2008 | Science2008，320，5883： | 1 |
| 15 | The molecular basis of nuclear genetic code change in ciliates显示文摘 | Lozupone CA Knight RD Landweber LF | 2001 | Curr Biol2001，11，2： | 1 |
| 16 | Diversity, stability and resilience of the human gut microbiota显示文摘 | LOZUPONE C A STOMBAUGH J I GORDON J I | 2012 | Nature2012，489，： | 1 |
| 17 | Potent phagocytic activity discriminate metastatic and primary human malignat melanoma: a key role of ezrin显示文摘 | LUGINI L LOZUPONE F MATARRESE P | 2003 | Lab Invest2003，183，11： | 1 |
| 18 | Effect of intermittent mechanical force on bone tissue in vitro:preliminary results显示文摘 | Lozupone E Favia A Grimaldi A | 1992 | J Bone Miner Res1992，7，2： | 1 |
| 19 | Di- versity, stability and resilience of the human gut mi- crobiota显示文摘 | Lozupone C A Stombaugh J I Gordon J I | 2012 | Nature2012，489，7415： | 1 |
| 20 | Uni Frac:a new phylogenetic method for comparing microbial communities显示文摘 | Lozupone C Knight R | 2005 | Applied and Environmental Microbiology2005，71，12： | 1 |
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