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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | Renin-angiotensin system in the kidney: What is new?显示文摘The renin-angiotensin system(RAS)has been known for more than a century as a cascade that regulates body fluid balance and blood pressure.AngiotensinⅡ(AngⅡ)has many functions in different tissues;however it is on the kidney that this peptide exerts its main functions.New enzymes,alternative routes for AngⅡformation or even active AngⅡ-derived peptides have now been described acting on AngⅡAT1or AT2receptors,or in receptors which have recently been cloned,such as Mas and AT4.Another interesting observation was that old members of the RAS,such as angiotensin converting enzyme(ACE),renin and prorenin,well known by its enzymatic activity,can also activate intracellular signaling pathways,acting as an outside-in signal transduction molecule or on the renin/(Pro)renin receptor.Moreover,the endocrine RAS,now is also known to have paracrine,autocrine and intracrine action ondifferent tissues,expressing necessary components for local AngⅡformation.This in situ formation,especially in the kidney,increases AngⅡlevels to regulate blood pressure and renal functions.These discoveries,such as the ACE2/Ang-(1-7)/Mas axis and its antangonistic effect rather than classical deleterious AngⅡeffects,improves the development of new drugs for treating hypertension and cardiovascular diseases. | Fernanda M Ferr?o Lucienne S Lara Jennifer Lowe | 2014 | World Journal of Nephrology2014，3，3： | 5 |
| 3 | Presence and hazards of nutrients and emerging organic micropollutants from sewage lagoon discharges into Dead Horse Creek, Manitoba, Canada显示文摘 | Jules C. Carlson Julie C. Anderson Jennifer E. Low Pascal Cardinal Scott D. MacKenzie Sarah A. Beattie Jonathan K. Challis Renae J. Bennett Stephanie S. Meronek Rebecca P.A. Wilks William M. Buhay Charles S. Wong Mark L. Hanson | 2012 | Science of the Total Environment2012，，： | 1 |
| 4 | Uranium sequestration in sediment at an iron-rich contaminated site at Oak Ridge, Tennessee via.bioreduction followed by reoxidation显示文摘This study evaluated uranium sequestration performance in iron-rich (30 g/kg) sediment via bioreduction followed by reoxidation.Field tests (1383 days) at Oak Ridge,Tennessee demonstrated that uranium contents in sediments increased after bioreduced sediments were re-exposed to nitrate and oxygen in contaminated groundwater.Bioreduction of contaminated sediments (1200 mg/kg U) with ethanol in microcosm reduced aqueous U from 0.37 to 0.023 mg/L.Aliquots of the bioreduced sediment were reoxidized with O2,H2O2,and NaNO3,respectively,over 285 days,resulting in aqueous U of 0.024,1.58 and 14.4 mg/L at pH 6.30,6.63 and 7.62,respectively.The source-and the three reoxidized sediments showed different desorption and adsorption behaviors of U,but all fit a Freundlich model.The adsorption capacities increased sharply at pH 4.5 to 5.5,plateaued at pH 5.5 to 7.0,then decreased sharply as pH increased from 7.0 to 8.0.The O2-reoxidized sediment retained a lower desorption efficiency at pH over 6.0.The NO3--reoxidized sediment exhibited higher adsorption capacity at pH 5.5 to 6.0.The pH-dependent adsorption onto Fe(Ⅲ) oxides and formation of U coated particles and precipitates resulted in U sequestration,and bioreduction followed by reoxidation can enhance the U sequestration in sediment. | Peng-Song Li Wei-Min Wu Debra H.Phillips David B.Watson Shelly Kelly Bing Li Tonia Mehlhorn Kenneth Lowe Jennifer Earles Hu-Chun Tao Tong Zhang Craig S.Criddle | 2019 | Journal of Environmental Sciences2019，31，11： | 1 |
| 5 | Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment显示文摘 | Jason R. Clapper Michelle D. Hendricks Guibao Gu Carrie Wittmer Carrie S. Dolman John Herich Jennifer Athanacio Christiane Villescaz Soumitra S. Ghosh Joseph S. Heilig Carolyn Lowe Jonathan D. Roth | 2013 | AJP: Gastrointestinal and Liver Physiology2013，，7： | 1 |
| 6 | Crystal grouth of sodium oxalate from aqueous solution 显示文摘 | Jennifer Lowe etc | 2002 | Journal of Crystal Growth2002，，2002： | 1 |
| 7 | Virtual high throughput screening confirmed experimentally: porous coordination polymer hydration显示文摘 | Low John J Benin Annabelle I Jakubczak Paulina Abrahamian Jennifer F Faheem Syed A Willis Richard R | 2009 | Journal of the American Chemical Society2009，131，15： | 1 |
| 8 | Inotropes and β-blockers: Is there a need for new guidelines?显示文摘 | Michael R. Bristow Simon F. Shakar Jennifer V. Linseman Brian D. Lowes | 2001 | Journal of Cardiac Failure2001，，： | 1 |
| 9 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 1 |
| 10 | Association Between Childhood Sleep-Disordered Breathing and Disruptive Behavior Disorders in Childhood and Adolescence显示文摘 | Evelyn Constantin Nancy C. P. Low Erika Dugas Igor Karp Jennifer O’Loughlin | 2015 | Behavioral Sleep Medicine2015，，6： | 1 |
| 11 | Can early introduction of egg prevent egg allergy in infants? A population-based study显示文摘 | Jennifer J. Koplin Nicholas J. Osborne Melissa Wake Pamela E. Martin Lyle C. Gurrin Marnie N. Robinson Dean Tey Marjolein Slaa Leone Thiele Lucy Miles Deborah Anderson Tina Tan Thanh D. Dang David J. Hill Adrian J. Lowe Melanie C. Matheson Anne-Louise Pon | 2010 | The Journal of Allergy and Clinical Immunology2010，，4： | 1 |
| 12 | CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma显示文摘 | Stuart Smith Hanna Tilly Jennifer Ward Donald Macarthur James Lowe Beth Coyle Richard Grundy | 2012 | Acta Neuropathologica2012，，1： | 1 |
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