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| 1 | Histological and biochemical alterations in early-stage lobar ischemia-reperfusion in rat liver显示文摘AIM:To investigate the structural and biochemical changes in the early stage of reperfusion in the rat livers exposed to lobar ischemia-reperfusion (IR).METHODS: The median and left lobes of the liver were subjected to 60 min ischemia followed by 5, 10, 30, 45, 60 and 120 min reperfusion. Blood samples were taken at different time intervals to test enzyme activities and biochemical alterations induced by reperfusion. At the end of each reperfusion period, the animals were killed by euthanasia and tissue samples were taken for histological examination and immunohistochemistry. RESULTS: Cell vacuolation, bleb formation and focal hepatitis were the most important changes occur during ischemia. While some changes including bleb formation were removed during reperfusion, other alterations including portal hepatitis, inflammation and the induction of apoptosis were seen during this stage. The occurrence of apoptosis, as demonstrated by apoptotic cells and bodies, was the most important histological change during reperfusion. The severity of apoptosis was dependent on the time of reperfusion, and by increasing the time of reperfusion,the numbers of apoptotic bodies was significantly enhanced. The amounts of lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, creatinine and urea were significantly increased in serum obtained from animals exposed to hepatic IR.CONCLUSION: Inflammation and subsequent apoptotic cell death were the most important changes in early-stage hepatic reperfusion injury, and the number of apoptotic bodies increased with time of reperfusion. | Hossein Ali Arab Farhang Sasani Mohammad Hossein Rafiee Ahmad Fatemi Abbas Javaheri | 2009 | World Journal of Gastroenterology2009，15，16： | 16 |
| 2 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 3 | 纳米孔碳负载Fe_3O_4催化剂上苯直接羟基化制苯酚(英文)显示文摘Fe3O4/CMK-3 was prepared by impregnation and used as a catalyst for the direct hydroxylation of benzene to phenol with hydro-gen peroxide. The iron species in the prepared catalyst was Fe3O4 because of the partial reduction of iron(III) to iron(II) on the surface of CMK-3. The high catalytic activity of the catalyst arises from the formation of Fe3O4 on the surface of CMK-3 and the high selectivity for phenol is attributed to the consumption of excess hydroxyl radicals by CMK-3. The effect of temperature,reaction time,volume of H2O2,and amount of catalyst on the catalytic performance of the prepared catalyst were investigated. Under optimized conditions,the catalyst showed excellent catalytic performance for the hydroxylation of benzene to phenol and 18% benzene conversion was achieved with 92% selectivity for phenol and with a TOF value of 8.7 h-1. The stability of catalyst was investigated by determining its activity after the fourth run and it was found to have decreased to 80% of the fresh catalyst's activity. | Pezhman ARAB Alireza BADIEI Amir KOOLIVAND Ghodsi MOHAMMADI ZIARANI | 2011 | 催化学报2011，32，2： | 7 |
| 4 | Mechanical behavior and failure mechanism of polyurea nanocomposites under quasi-static and dynamic compressive loading显示文摘Polyurea is an elastomeric material that can be applied to enhance the protection ability of structures under blast and impact loading.In order to study the compressive mechanical properties of SiC/polyurea nanocomposites under quasi-static and dynamic loading,a universal testing machine and split Hopkinson pressure bar(SHPB)apparatus were used respectively.The stress-strain curves were obtained on polyurea and its composites at strain rates of 0.001e8000 s1.The results of the experiment suggested that increase in the strain rates led to the rise of the flow stress,compressive strength,strain rate sensitivity and strain energy.This indicates that all of the presented materials were dependent on strain rate.Moreover,these mechanical characters were enhanced by incorporating a small amount of SiC into polyurea matrix.The relation between yield stress and strain rates were established using the power law functions.Finally,in order to investigate the fracture surfaces and inside information of failed specimens,scanning electron microscopy(SEM)and micro X-ray computed tomography(micro-CT)were used respectively.Multiple voids,crazes,micro-cracks and cracking were observed in fracture surfaces.On the other hand,the cracking propagation was found in the micro-CT slice images.It is essential to understand the deformation and failure mechanisms in all the polyurea materials. | Qiang Liu Peng-wan Chen Yan-song Guo Jian-jun Su Lu Han Ali Arab Jian-fei Yuan | 2021 | Defence Technology(防务技术)2021，17，2： | 7 |
| 5 | Challenging loop-mediated isothermal amplification(LAMP) technique for molecular detection of Toxoplasma gondii显示文摘Objective:To compare analytical sensitivity and specificity of a newly described DNA amplification technique.LAMP and nested PCR assay targeting the RE and Bl genes for the detection of Toxoplasma gondii(T.gondii) DNA.Methods:The analytical sensitivity of LAMP and ncstcd-PCR was obtained against 10-fold serial dilutions of T.gondii DNA ranging from 1 ng to 0.01 fg.DNA samples of other parasites and human chromosomal DNA were used to determine the specificity of molecular assays.Results:After testing LAMP and nesled-PCR in duplicate,the detection limit of RE-LAMP.B1-LAMP,RE-nested PCR and B1-nested PCR assays was one fg.100 fg,1 pg and 10 pg of T.gondii DNA respectively.All the LAMP assays and nested PCRs were 100% specific.The RE-LAMP assay revealed the most sensitivity for the detection of T.gondii DNA.Conclusions:The obtained results demonstrate that the LAMP technique has a greater sensitivity for detection of T.gondii.Furthermore,these findings indicate that primers based on the RE are more suitable than those based on the B1 gene.However,the B1-LAMP assay has potential as a diagnostic tool for detection of T.gondii. | Shirzad Fallahi Zahra Arab Mazar Mehrdad Ghasemian Ali Haghighi | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 6 |
| 6 | Effects of different periods of renal ischemia on liver as a remote organ显示文摘AIM:To assess the hepatic changes after induction of different periods of renal ischemia. METHODS:Rats were subjected to either sham operation or ischemia (30,45 and 60 min) followed by 60 min reperfusion. Liver and renal functional indices were measured. Hepatic glutathione (GSH) and ferric reducing antioxidant power levels and the concentration of interleukin (IL)-10 and tumor necrosis factor (TNF-α) were evaluated. Portions of liver and kidney tissues were fixed for histological evaluation. RESULTS:Forty-five minutes renal ischemia followed by 60 min reperfusion caused significant changes in liver structure and a significant reduction in renalfunction. These rats showed a significant decrease in liver GSH,as well as a significant increase in TNF-α and IL-10 concentrations. These results demonstrated that renal ischemia caused changes in liver histology,function,oxidative stress and inflammatory status,which led to a reduction in hepatic antioxidant capacity. With 30 min ischemia,the magnitude of these changes was less than those with 45 or 60 min ischemia.CONCLUSION:A minimum of 45 min ischemia is needed to study the effects of renal injury on the liver as a remote organ. | Mehri Kadkhodaee Fereshteh Golab Maryam Zahmatkesh Rana Ghaznavi Mehdi Hedayati Hossein Ali Arab Seyed Naser Ostad Manoocher Soleimani | 2009 | World Journal of Gastroenterology2009，15，9： | 5 |
| 7 | Caries-related factors and bacterial composition of supragingival plaques in caries free and caries active Algerian adults显示文摘Objective: To compare oral hygiene practices, education and social background, food intake and oral malodor of Algerian adults suffering from dental caries with normal controls, and to determine and compare the bacterial composition of the supragingival plaques from the above-mentioned groups.Methods: Participants completed a questionnaire and were clinically examined for dental caries using decayed, missing and filled teeth index according to the criteria laid down by the World Health Organization. Supragingival plaque samples were collected from 50 caries-free adults(CF) and 50 caries-active adults(CA). Standard procedures of culture and identification of aerobic and anaerobic bacteria were used. Data were analyzed using Chi-square test.Results: A total of 117 bacterial strains were isolated from supragingival plaques in CF group subjects, 76(64.96%) of them belonged to 9 aerobic genera, and 41(35.04%) to 9anaerobic genera(P < 0.05). While in the second group, 199 strains were isolated, 119(59.80%) of the strains belonged to 10 aerobic genera and 80(40.20%) to 10 anaerobic bacteria(P < 0.05). Streptococcus mutans, Enterococcus faecium, Aerococcus viridans,Actinomyces meyeri, Lactobacillus acidophilus and Eubacterium limosum showed a significantly higher prevalence in the CA group(P < 0.05). The findings revealed that CA group had a high sugar intake(80%). A significantly higher frequency of tooth brushing(P < 0.000) and a significantly less self-reported oral malodor(P < 0.000) and tooth pain(P < 0.000) were found in CF group, while there was no association of socioeconomic levels and intake of meal snacks with dental caries.Conclusions: This study confirms the association of some aciduric bacteria with caries formation, and a direct association of sugar intake and cultural level with dental caries.Furthermore, oral hygiene practices minimize the prevalence of tooth decay. | Amina Hoceini Nihel Klouche Khelil Ilhem Ben-Yelles Amine Mesli Sara Ziouani Lotfi Ghellai Nadia Aissaoui Fatima Nas Mounia Arab | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，8： | 3 |
| 8 | High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the liver.Data on hepatic histopathological findings in COVID-19 is scarce.AIM To characterize hepatic pathological findings in patients with COVID-19.METHODS We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA guidelines.Eligible trials were those including patients of any age and COVID-19 diagnosis based on a molecular test.Histopathological reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were reviewed.Articles including less than ten patients were excluded.Proportions were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,respectively.RESULTS We identified 18 studies from 7 countries;all were case reports and case series from autopsies.All the patients were over 15 years old,and 67.2%were male.We performed a meta-analysis of 5 studies,including 116 patients.Pooled prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and necrosis.CONCLUSION We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver features.Other frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or proliferation.Further studies are needed to establish the mechanisms and implications of these findings. | Luis Antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise Juan Pablo Arab | 2020 | World Journal of Gastroenterology2020，26，48： | 3 |
| 9 | Effect of SrCO_3 addition on the dynamic compressive strength of ZTA显示文摘Ceramic parts usually experience dynamic load in armor applications. Therefore, studying the dynamic behaviors of ceramics is important. Limited data are available on the dynamic behaviors of ceramics; thus, it is helpful to predict the dynamic strength of ceramics on the basis of their mechanical properties. In this paper, the addition of SrCO_3 into zirconia-toughened alumina(ZTA) was demonstrated to improve the fracture toughness of ZTA due to the formation of the SrAl_(12)O_(19)(SA6) phase. The porosity of ZTA was found to be increased by the addition of SrCO_3. These newly formed pores served as the nucleation sites of cracks under dynamic load; these cracks eventually coalesced to form damaged zones in the samples. Although the KIC values of the samples were improved, the dynamic strength was not enhanced because of the increase in porosity; in fact, the dynamic strength of ZTA ceramics decreased with the addition of SrCO_3. | Ali Arab Roslan Ahmad Zainal Arifin Ahmad | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，4： | 3 |
| 10 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 11 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 12 | Improvement of Grain Size and Dome Height of Microalloyed Steels Using Taguchi Method Based on Grey Relational Grade in Controlled Rolling显示文摘An efficient approach was introduced for improving the condition of major controlled rolling process parameters of roughing,finishing and coiling temperatures and optimizing these parameters to obtain minimum grain size and maximum dome height simultaneously.Taguchi method combined with grey relational analysis was applied to achieve optimum grain size and dome height during controlled rolling process.For this purpose,four levels for the above temperatures were chosen and sixteen experiments were conducted based on orthogonal array of Taguchi method.Based on Taguchi approach,signal-to-noise(S/N)ratios were calculated and used in order to obtain the optimum levels for every input parameter.Analysis of variance revealed that finishing and coiling temperatures have the maximum effect on the grain size and dome height of microalloyed steels.The confirmation tests with the optimal levels of parameters indicated that the grain size and dome height of controlled rolled microalloyed steels can be improved effectively through this approach. | Mohsen Ayaz Daavood Mirahmadi Khaki Nasrollah Bani Mostafa Arab | 2013 | Journal of Iron and Steel Research(International)2013，20，12： | 2 |
| 13 | Laboratory Study of Geotextiles Performance on Reinforced Sandy Soil显示文摘This paper presents the results of triaxial tests conducted for the investigation of the influence of geotextiles on stress-strain and volumetric change behaviour of reinforced sandy soil. Tests were carried out on loose sandy soil. The experimental program includes drained compression tests on samples reinforced with different values of both geotextiles layers(Ng) and confining pressure(σ′c). Two methods of preparation were used: air pluviation(AP) and moist tamping(MT). Test results show that the geotextiles induce a quasi-linear increase in the stress deviator(q) and volume contraction in the reinforced sand. Method of preparation significantly affects the shear strength; samples prepared by the air pluviation method and mobilized deviator stresses are significantly higher than those prepared by moist tamping method. Geotextiles restrict the dilation of reinforced sandy soil and consequently the contraction increases. The mobilized friction angle increases with increasing number of layers and decreases with increasing initial confining pressure. Samples prepared by moist tamping present mobilized friction angles significantly lower than those prepared by air pluviation method. For samples prepared by the air pluviation method, the secant modulus at ε1=1% and 5% decreases with increasing geotextile layers; those prepared by the moist tamping method, secant modulus at ε1=1% and 5% increases with increasing number of geotextile layer sand confining pressure. From 10% axial strain, secant modulus increases with increasing inclusions of geotextile layers. | Brahim Abdelkader Arab Ahmed Belkhatir Mostefa Shahrour Isam | 2016 | Journal of Earth Science2016，27，6： | 2 |
| 14 | Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury显示文摘 | Kevin Bersell Shima Arab Bernhard Haring Bernhard Kühn | 2009 | Cell2009，，2： | 2 |
| 15 | Effect of the Inclination of Baffles on the Power Consumption and Fluid Flows in a Vessel Stirred by a Rushton Turbine显示文摘The role of baffles in mechanically stirred tanks is to promote the stability of power drawn by the impeller and to avoid the fluid swirling, thus enhancing mixing. The present paper numerically investigates the baffles effects in a vessel stirred by a Rushton turbine. The geometric factor of interest is the baffle inclination which is varying between 25°, 32.5°, 45°, 70° and 90° at different impeller rotational speeds. The impeller rotational direction has also been varied. The vortex size and power consumption were evaluated for each geometrical configuration. It was found that the best configuration is the baffle inclination by α = 70° at a negative angular velocity. | Youcef Kamla Mohamed Bouzit Houari Ameur Mohammed Ilies Arab Abdessalam Hadjeb | 2017 | Chinese Journal of Mechanical Engineering2017，30，4： | 2 |
| 16 | Genomic profiling of microRNA and messenger RNA reveals deregulated micro- RNA expression in prostate cancer显示文摘 | Arabs S Prueitt RL Yi M | 2008 | Cancer Res2008，68，15： | 1 |
| 17 | Lycopene and cardiovascular disease 显示文摘 | Arab L Steck S | 2000 | Am J Clin Nutr2000，71，6： | 1 |
| 18 | Oxidative stress and its association with cardiovascular disease in chronic renal failure patients显示文摘 | Hambali Z Ahmad Z Arab S | 2011 | Indian J Nephrol2011，21，1： | 1 |
| 19 | Lycopene and cardiovascular disease显示文摘 | Lenore Arab Susan Steck | 2000 | American Society for Clinical Nutrition2000，71，6： | 1 |
| 20 | workshop on corporate Environmental Responsibility显示文摘 | Arab Forum for Environment & Development | 2007 | Working Paper2007，，： | 1 |
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