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| 1 | Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model显示文摘AIM: To compare the efficacies of subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium injections for the inhibition of corneal neovascularization in an experimental rat model. METHODS: Sixteen corneas of 16 rats were chemically cauterized and randomized into four groups: bevacizumab group that treated with 0.05mL/1.25mg bevacizumab, ranibizumab group that treated with 0.05mL/0.5mg ranibizumab, pegaptanib group that treated with 0.05mL/0.15mg pegaptanib sodium, and control group that treated with 0.05mL saline solution. Digital photographs of the corneas were taken and analyzed using an image analysis software program. All corneas were excised and examined histologically on the 15 th day. RESULTS: Each treatment group had significantly less neovascularized corneal areas and fewer blood vessels than the control group (all P <0.05). In addition, bevacizumab group had significantly less neovascu-larized corneal areas and fewer blood vessels than ranibizumab and pegaptanib groups (both P <0.05). However, there was no significant difference between the ranibizumab and pegaptanib groups regarding percentage of neovascularized corneal areas and number of blood vessels (both P >0.05). CONCLUSION: Subconjunctival bevacizumab, ranibiz-umab, and pegaptanib sodium were effective with no corneal epitheliopathy for inhibiting corneal neovascularization after corneal burn in rats .Bevacizumab was more effective than ranibizumab and pegaptanib sodium. | Ebru Eren Akar Veysi ner Cem Küükerdnmez Yonca Aydin Akova | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 9 |
| 2 | Cytomegalovirus colitis in a patient with Behcet’s disease receiving tumor necrosis factor alpha inhibitory treatment显示文摘Anti-tumor necrosis factor alpha (TNF-α) inhibitors are effective in the treatment of various inflammatory rheumatic conditions. Increased risks of serious infections are the major issues concerning the long-term safety of these agents. We present a case of a young male Behcet’s patient whose disease was complicated by cytomegalovirus (CMV) colitis. Colitis started 10 d after the third Infliximab dose and responded to the cessation of TNF blocking treatment and administration of ganciclovir. Tumor necrosis factor alpha and interferon gamma act at several levels in combating viral infections.CMV infections should be kept in mind and included in the differential diagnosis of severe gastrointestinal symptoms in patients receiving anti-TNF agents. | Ismail Sari Merih Birlik Can Gonen Servet Akar Duygu Gurel Fatos Onen Nurullah Akkoc | 2008 | World Journal of Gastroenterology2008，14，18： | 5 |
| 3 | Evaluation of CA125 and NT-proBNP values in patients undergoing transcatheter aortic valve implantation显示文摘BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 是在通过手术高的风险,或不能实行的病人的最低限度地侵略的、新兴的治疗。为风险分类使用的参数在病人的选择有一些缺乏。学习是在糖类抗原 125 上评估 TAVI 的影响的这的目的(CA125 ) 和 N 终端职业人员大脑类型 Natriuretic 肽(NT-proBNP ) 作为在最近的年里经常被使用了的 biomarkers,并且也到 prognosis.Methods & 的这些 biomarkers 的关系;ResultsTranscatheter 大动脉的阀门培植在这研究在 31 个病人上被练习。然后,在病人学习在以前并且在 TAVI 以后的 CA125 和 NT-proBNP 层次被评估。病人也根据他们的左室的喷射部分(LVEF ) 被组织, CA125 铺平(LVEF ≥40% 并且 <40% ;CA125 ≤35 U/L 和 >35 U/L ) 。TAVI 手术成功地在所有病人被动。没有在里面医院死亡,在功能的能力的实质的改进在跟帖被检测。另外,统计上重要的减少在所有病人的 post-TAVI CA125 和 NT-proBNP 层次被检测(CA125 83.8 ±18.1 U/L 对 64.3 ±14.2 U/L, P = 0.008;NT-proBNP:4633.6 ±627.6 pg/mL 对 2866.3 ±536.8 pg/mL, P <0.001 ) 。在根据 CA125 层次划分的组,也在 CA125 层次有统计上重要的 post-TAVI 衰落。在 CA125 > 以内;35 U/L 和 LVEF <40% 组,对一个心律调整器的永久需要在(3.2%) 被要求病人和死亡在二被观察(6.4%) 在 TAVI 在以后的病人跟随 TAVI 能与 CA125 和 NT-proBNP 的高基线层次在病人有效地并且可靠地被执行的 up.ConclusionsThe 结果表演。当高 biomarker 层次与不希望得到的事件被联系时,这些 biomarkers 与 TAVI 实质地被减少,并且当然,这些 biomarkers 能为 TAVI 在耐心的选择被用于风险分类。 | Huseyin Ayhan Haca Ahmet Kasapkara Tahir Durmaz Telat Keles Cenk San Serdal Bastug Kemal Esref Erdogan Nihal Akar Bayram Emine Bilen Murat Akgay Engin Bozkurt | 2015 | Journal of Geriatric Cardiology2015，12，2： | 5 |
| 4 | A case study report of acute renal failure associated with Nigella sativa in a diabetic patient显示文摘1 Introduction Nigella sativa, known as black seed, has analgesic, anti-inflammatory, antioxidant and anticancer effects [1-3] . It has been shown to reduce the development of kidney failure when given prior to the use of nephrotoxic drugs particularly due to its antioxidant action [4-7] . However, as far as the authors could ascertain, there is no human study in literature showing these effects. Here we present a case of acute renal failure after the use of N. sativa, | Erol Arslan Selim Sayin Seref Demirbas Mustafa akar Nazire Gke Somak Sirzat Yesilkaya Kenan Saglam | 2013 | Journal of Integrative Medicine2013，11，1： | 2 |
| 5 | Application of the fractal theory for evaluating effects of coal comminution by waterjet显示文摘Comminution of coal to ultrafine sizes by high-pressure waterjet provides a novel method for preparation of coal-water fuels for next generation,near-zero emission electric power generation.The particle size distribution(PSD)of ground coal is a key parameter in the preparation of slurries as it determines the settling behavior of the particles and viscosity of the coal-water mixture.There are several methods available for representation and evaluation of particle size analysis data.However,fractal theory provides a means by which the entire PSD of comminuted materials can be quantified by using of a specific and exact value.In this paper,a volume-based fractal model was deduced to characterize the PSD of the coal which is ground in a specially designed comminution cell.During the size reduction process,the inlet pressures up to 276 MPa were used. | Yaqing Li Greg Galecki Gul Akar Sezai Sen Yutao Zhang | 2014 | International Journal of Coal Science & Technology2014，1，4： | 2 |
| 6 | Parathyroidcysts: diagnosis and treatment with fine needle aspiration显示文摘 | O Emrah Akar Ugur Toprak Utku Menderes | 2003 | European Journal of Radiology Extra2003，46，4： | 1 |
| 7 | Association of HLA class Ⅰ antigens and HLA class Ⅱ alleles with vitiligo in a Turkish population显示文摘 | Ta tan HB Akar A Orkanoglu FE | 2004 | Pigment Cell Res2004，17，2： | 1 |
| 8 | Tissue transglutaminase inhibits autophagy in pancreatic cancer cells显示文摘 | Akar U Ozpolat B Mehta K | 2007 | Mol Cancer Res2007，5，3： | 1 |
| 9 | Adsorption of Cu, Ni( Ⅱ ) by industrial strain of Saccharomyces cerevisiae immobilized on the biomatrix of cone biomass of Pinus nigra: Equilized and mechanism analysis 显示文摘 | Cabuk A Akar T Tunali S | 2007 | Chemical Engineering Journal2007，131，： | 1 |
| 10 | Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes:insights into the development of cell-based pacemakers显示文摘 | Xue T Cho HC Akar FG | 2005 | Circulation2005，111，1： | 1 |
| 11 | HLA class Ⅱ alleles in patients with alopecia areata显示文摘 | Akar A Orkunoglu E Sengül A | 2002 | Eur J Dermatol2002，12，： | 1 |
| 12 | A case with recurrent calf pain and swelling:recurrent spontaneous calf haematoma显示文摘 | Akar S Manisali M Birlik M | 2002 | Rheumatol Int2002，21，6： | 1 |
| 13 | High prevalence of spondy- loarthritis and ankylosing spondylitis among familial Mediterra- nean fever patients and their first - degree relatives : further evi- dence for the connection 显示文摘 | Akar S Soysal O Balci A | 2013 | Arthritis Res Ther2013，15，1： | 1 |
| 14 | Dimethyl sulfoxide in the management of patient with brain swelling and increased intracranial pressure after severe closed head injury显示文摘 | Kulah A Akar M Baykut L | 1990 | Neurochirurgia (Stuttg)1990，33，6： | 1 |
| 15 | Left ventrieular repolarization heterogeneity as an at- rhythmic substrate in heart failure显示文摘 | AKAR FG | 2010 | Minerva Cardioangiol2010，58，： | 1 |
| 16 | Frequency of mtDNA A1555G and A7445G mutations among children with prelingual deafness in Turkey显示文摘 | M. Tekin T. Duman G. Bo?o?lu A. ?ncesulu E. ?omak S. Fitoz E. Y?lmaz ?. ?lhan N. Akar | 2003 | European Journal of Pediatrics2003，，3： | 1 |
| 17 | Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia:Correlations With In Vitro and In Vivo Chemoresponses显示文摘 | SHINICHI KITADA JANET ANDERSEN SOPHIE AKAR | 1998 | Blood1998，91，： | 1 |
| 18 | Removal of chromium ( VI ) ionsfrom aqueous solutions by using Turkish montmorillonite clay : Effect ofactivation and modification显示文摘 | Akar S T Yetimoglu Y Gedikbey T | 2009 | Desalination^2009，244，3： | 1 |
| 19 | Robotic-assisted laparoscopic repair of symptomatic cesarean scar defect: a report of two cases显示文摘 | Yaleinkaya TM Akar ME Kammire LD | 2011 | ] Reprod Med2011，56，56： | 1 |
| 20 | A Switching Rollover Control- ler Coupled with Closed-loop Adaptive Vehicle Pa rameter Identification显示文摘 | AKAR M DERE A D | 2014 | IEEE Transactions on Intel- ligent Transportation Systems2014，15，4： | 1 |
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