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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Automated synthesis of analog electrical circuits by means of genetic programming 显示文摘 | Koza J R | 1997 | IEEE Trans On Evolutionary Computation1997，1，2： | 2 |
| 3 | Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism显示文摘 | K. Ganesh Kumar James L. Trevaskis Daniel D. Lam Gregory M. Sutton Robert A. Koza Vladimir N. Chouljenko Konstantin G. Kousoulas Pamela M. Rogers Robert A. Kesterson Marie Thearle Anthony W. Ferrante Randall L. Mynatt Thomas P. Burris Jesse Z. Dong Heathe | 2008 | Cell Metabolism2008，，： | 2 |
| 4 | Effects of the T-type calcium channel blockade with oral mibefradil on the electrophysiologic properties of the human heart显示文摘 | Madle A Linhartova K Koza J | 2001 | Med Sci Monit2001，7，1： | 1 |
| 5 | Genetic Programming:On the Programming of Computers by Means of Natural Selection显示文摘 | Koza J R | 1992 | Cambridge: MIT Press1992，，： | 1 |
| 6 | Vascular endothelial growth factor in serum and in the follicular fluid of patients undergoing hormonal stimulation for in vitro fertilization显示文摘 | MONCAYO H E PENZ KOZA A MARTH C | 1998 | Hum Reprod1998，13，12： | 1 |
| 7 | Human-competitive machine intelligence by means of genetic programming显示文摘 | Koza J R | 2000 | IEEE Intelligent Systems2000，15，3： | 1 |
| 8 | Calculating the Maximum Execution Time of Real-time Programs显示文摘 | Pushner P Koza C | 1989 | Real-time Systems1989，1，2： | 1 |
| 9 | Distributed fault-tolerant real-time systems: The mars approach显示文摘 | KOPETZ H DAMM A KOZA C | 1989 | IEEE Micro1989，，： | 1 |
| 10 | Automatic creation of human-competitive programs and controllers by means of genetic programming显示文摘 | KOZA J R | 2000 | Genetic Programming and Evolvable Machines2000，1，： | 1 |
| 11 | Genetic algorithms in pipeline optimization显示文摘 | GOLDBERG D E KOZA J R | 1987 | Journal of Computing in Computing in Civ Engrg1987，1，12： | 1 |
| 12 | AMP and IMP dissociateactomyosin into actin and myosin 显示文摘 | Okitani A Ichinose N Koza M^et cd | 2008 | Bioscience Biotechnology and Biochemistry2008，72，8： | 1 |
| 13 | Interaction of heparinoids with platelets: comparison with heparin and low molecular weight heparins显示文摘 | Messmore HL Griffin B Koza M | 1991 | Semin Thromb Hemost1991，17，1： | 1 |
| 14 | Rough set theory for topological spaces显示文摘 | Lashin E F Kozae A M Abo K A | 2005 | International Journal of Approximate Reasoning2005，40，12： | 1 |
| 15 | Information Asymmetry, Adverse Selection and Joint-ventures Theory and Evidence显示文摘 | Balakrishnan Srinivasan Koza Mitchell P | 1993 | Journal of Economic Behavior & Organization1993，20，1： | 1 |
| 16 | Automatic Creation of Human - Competitive Programs and Controllers by Means of Genetic programming 显示文摘 | Koza J R | 2000 | Genetic Programming and Evolvable Machines2000，1，： | 1 |
| 17 | Generalized rough sets显示文摘 | Rady E A Kozae A M Elmonsef M E | 2004 | Chaos Solitons and Fractals2004，21，1： | 1 |
| 18 | Distributed fault-tolerant real-time systems: the Mars approach 显示文摘 | KOPETZ H DAMM A KOZA C | 1989 | IEEE Micro1989，9，1： | 1 |
| 19 | Studies on the patterning effect of copper deposits in magnetic gradient fields显示文摘 | Kristina Tschulik Ralph Sueptitz Jakub Koza Margitta Uhlemann Gerd Mutschke Tom Weier Annett Gebert Ludwig Schultz | 2010 | Electrochimica Acta2010，，1： | 1 |
| 20 | Interaction of heparinoids with platelets: comparison with heparin and low molccular weight heparins显示文摘 | Messmore IlL Griffin B Koza M | 1991 | Semin Thromb Hemost1991，17，1： | 1 |
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