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| 1 | Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells显示文摘转变生长因素 --(TGF-) 在恶意的细胞的各种各样的类型上施加 apoptotic 效果,包括肝癌症细胞。然而, TGF- 由导致 apoptosis 的精确机制仍然保持糟糕已知。在现在的学习,我们显示出那 threonine 32 (Thr32 ) FoxO3 的残余是批评的让 TGF- 在 hepatocarcinoma Hep3B 房间经由 Bim 导致 apoptosis。我们的数据证明 TGF- 在 Thr32 通过特定的 de-phosphorylation 导致了 FoxO3 激活。TGF -- 激活的 FoxO3 与 Smad2/3 合作了调停 Bim 起来规定和 apoptosis。在 Thr32 的 FoxO3 (de ) phosphorylation 被酷蛋白 kinase 调整我 --(CKI-) 。由小分子 D4476 的 CKI 抑制能废除 TGF -- 导致的 FoxO/Smad 激活,反向的 Bim 起来规定,和块顺序的 apoptosis。更重要地, CKI- 和 p32FoxO3 的 deregulated 层次在人的恶意的肝纸巾被发现。一起拿,我们的调查结果建议可能有 FoxO3 的 Thr32 为 TGF 是枢轴的一台 CKI-FoxO/Smad-Bim 在引擎 -- 导致的 apoptosis,为肝癌症治疗使它成为一个潜在的治疗学的目标。 | Xiangxuan Zhao Yong Liu Lei Du Leya He Biyun Ni Junbo Hu Dahai Zhu Quan Chen | 2015 | Protein & Cell2015，6，2： | 3 |
| 2 | 新疆罗布泊东部发现球粒陨石雨显示文摘新疆罗布泊以东65 km处的三峰山区域发现了陨石(Tuya 002~007)散落区,呈3 km×11 km的椭圆状.散落区内收集到130余块普通球粒陨石,总重超过160 kg,最大的陨石重30 kg,最小的陨石重约15 g.散落区为一南东-北西向分布且陨石样品逐渐增大的椭圆形区域,这意味着陨石从南东向以较低的角度进入地球大气层.除Tuya002(760 g)外,散落区内的陨石可能来自同一次陨石雨,陨石类型为L5,冲击程度为S2,风化程度为W3.Tuya 003的宇宙射线暴露年龄为45.6±4.4 Ma,因此三峰山陨石雨的流星体可能形成于约40 Ma时普通球粒陨石L群母体的破裂事件中.Tuya 002具有和其他三峰山陨石显著不同的外表特征,表面熔壳全部脱落,球粒清晰可见,为L4型普通球粒陨石,样品中有大量的硫酸钙.其宇宙射线暴露年龄为17.0±4.1 Ma,也证明了其不是三峰山陨石雨的产物.三峰山区域陨石的研究表明三峰山区域不是陨石富集区,而是L5普通球粒陨石散落区.因此,需要对其他一些区域的陨石样品进行矿物岩石学、风化特征、宇宙射线暴露年龄和居地年龄的研究,从而确定出新疆及其周边沙漠区域的陨石富集区. | 李世杰 王世杰 LEYA Ingo SMITH Thomas 唐俊林 王鹏 曾小家 李阳 | 2017 | 科学通报2017，62，21： | 2 |
| 3 | Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease显示文摘 | Joyal D Leya F Obada-Al-Chekakie MO | 2007 | Coron Artery Dis2007，18，6： | 1 |
| 4 | Ar- gatroban anticoagulation in patients with pa- tients with heparin-induced thrombocytope- nia显示文摘 | Lewis BE Wallis DE Leya F | 2003 | Arch Intern Med2003，163，15： | 1 |
| 5 | New catheter design for cannulation of the anomalous right coronary artery arising from the left sinus of valsalva显示文摘 | QAYYUM U LEYA F STEEN L | 2003 | Catheter Cardiovasc Interv2003，60，： | 1 |
| 6 | Argatroban anticoagulation in patients with heparin-induced thrombocytopenia 显示文摘 | Lewis BE Wallis DE Leya F | 2003 | Arch Intern Med2003，163，15： | 1 |
| 7 | Argatroban antieoagulationin patients with heparin-induced thrombocytopenia 显示文摘 | Lewis BE Wallis DE Leya F | 2003 | Arch Intern Med2003，163，15： | 1 |
| 8 | Cosmogenic tungsten and the origin and earliest differentiation of the Moon 显示文摘 | Lee D C Halliday A N Leya 1 Wieler R Wiechert U | 2002 | Earth Planet Sci Lett2002，198，34： | 1 |
| 9 | Useful laboratory testsfor studying thrombogenesis in acute cardiac syndromes显示文摘 | Fareed J Hoppensteadt DA Leya F | 1998 | ClinChem1998，44，8： | 1 |
| 10 | Research on the contribution of struc- ture adjustment on carbon dioxide emissions reduction based on LMDI method 显示文摘 | Leya Wua Weihua Zeng | 2013 | Procedia Computer Science2013，，17： | 1 |
| 11 | Presence of asymmetric dimethylarginine gradients across high - grade lesions in patients with coronary artery disease 显示文摘 | Joyal D Leya F Obada A1 - Chekakie M | 2007 | Coron Artery Dis2007，18，6： | 1 |
| 12 | Useful laboratory tests for studying thrombogenesis in acute cardiac syndromes显示文摘 | Fareed J Hoppensteadt DA Leya F | 1998 | Clin Chem JT1998，44，82： | 1 |
| 13 | Useful laboratory tests for studying thrombogenesis in acute cardiac syndromes显示文摘 | Hoppensteadt DA Leya F | 1998 | Clin Chem1998，44，82： | 1 |
| 14 | Luteal phase sup-port and severe ovarian hyperstimulation syndrome显示文摘 | McClure N Leya J Radwanska E | 1992 | HumReprod1992，7，6： | 1 |
| 15 | Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease 显示文摘 | Joyal D Leya F Obada Al-Chekakie M | 2007 | Coron Art Dis2007，18，： | 1 |
| 16 | The proto-Earth as a significant source of Lunar material显示文摘 | Zhang J J Dauphas N Davis A M Leya I Fedkin A | 2012 | Nature Geoscience2012，5，： | 1 |
| 17 | High precision titanium isotope measure-ments on geological samples by high resolution MC-ICPMS 显示文摘 | Leya I Schonbachler M Wiechert U KrahenbUhl U Halliday A N | 2007 | International Journal of Mass Spectrometry2007，262，： | 1 |
| 18 | Argatroban anticoagulation in patients with heparin-induced thrombocytopenia显示文摘 | Lewis BE Wallis DE Leya F | 2003 | Arch Intern Med2003，163，15： | 1 |
| 19 | Argatroban antieoagulation in patients with heparin-indueed thromboeytopenia显示文摘 | Lewis BE Wallis DE Leya F | 2003 | Arch Intern Med2003，163，15： | 1 |
| 20 | Prevalence of recent immunisation in children with febrile convulsions显示文摘AIM:To determine the prevalence of recent immunisation amongst children under 7 years of age presenting for febrile convulsions.METHODS:This is a retrospective study of all children under the age of seven presenting with febrile convulsions to a tertiary referral hospital in Sydney.A total of 78 cases occurred in the period January 2011 to July 2012 and were included in the study.Data was extracted from medical records to provide a retrospective review of the convulsions.RESULTS:Of the 78 total cases,there were five medical records which contained information on whether or not immunisation had been administered in the preceding 48 h to presentation to the emergency department.Of these five patients only one patient(1.28%of the study population) was confirmed to have received a vaccination with Infanrix,Prevnar and Rotavirus.The majority of cases reported a current infection as a likely precipitant to the febrile convulsion.CONCLUSION:This study found a very low prevalence of recent immunisation amongst children with febrile convulsions presenting to an emergency department at a tertiary referral hospital in Sydney.This finding,however,may have been distorted by underreporting of vaccination history. | Leya Motala Guy D Eslick | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 1 |
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