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| 1 | Inflammatory model in patients with primary open angle glaucoma and diabetes显示文摘AIM: To assess the inflammatory cytokines expression in aqueous humor in diabetic primary open angle glaucoma(POAG) patients. METHODS: A cross-sectional study on 87 eyes, distributed as following: 26 eyes from diabetic patients, 16 eyes with POAG and 21 eyes from diabetic POAG patients; healthy controls(24 eyes) were recruited from patients undergoing conventional cataract surgery. A volume of 100 μL of aqueous humor(AH) was collected during phacoemulsification and 21 inflammatory markers were quantified using a Luminex~? cytometric bead assay: IL-1 Ra, IL-1α, IL-1β, IL-5, IL-6, IL-10, IL-17, GM-CSF, IFNγ, CCL2, CCL3, CCL4, CXCL5, CXCL8, bFGF, VEGF, TNFα. Main changes in cytokine profile were analyzed and compared between groups. Data on demographics, duration of glaucoma, intraocular pressure(IOP), number of anti-glaucoma substances were recorded for correlation analysis and prediction models. RESULTS: Significant differences in cytokine expression between groups were detected for CXCL5(P<0.001), CXCL8(P=0.004), IL-1α(P<0.001), IL-2(P<0.001), CCL4(P=0.003), CCL5(P<0.001) and TNFα(P=0.05). Post-hoc analysis identified IL-2(P=0.009) and CXCL5(P<0.001) as 'separation markers' between POAG and diabetic POAG eyes. In POAG patients, the 'separation markers' could highly predict the TNFα levels F(1, 16)=14.639, P<0.001, whereas in diabetic patients F(1, 24)=4.844, P=0.006 and diabetic POAG patients F(1, 19)=2.358, P=0.05 the level of prediction was inferior.CONCLUSION: Our results reveal an inflammatory model based on increased TNFα levels in POAG eyes.Simultaneous co-stimulatory molecules and additional inflammatory pathways need to be further explored in diabetic POAG cases, since the prediction model could only partially explain the increased TNFα level in this category of patients. | Anca Pantalon Otilia Obada Daniela Constantinescu Crenguta Feraru Dorin Chiselita | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 4 |
| 2 | 应用激光多普勒血流仪监测口腔黏膜血流显示文摘目的:测量中国汉族人与高加索人的健康成年人口腔黏膜血流参数,比较口腔黏膜血流灌注情况在不同人种间的异同,比较口腔黏膜在上颌与下颌、男性与女性之间的差异性,为口腔种植临床中软组织处理提供参考依据。方法:从德国波恩大学在读学生中招募20名高加索人种学生(男性10例,女性10例,平均年龄25.3岁)和20名中国汉族留学生(男性10例,女性10例,平均年龄28岁),口腔内设计8个测量点M1~M8,其中于上颌中切牙唇侧黏膜、下颌中切牙唇侧黏膜、上颌腭侧黏膜和颊黏膜各2个点。使用O2C激光多普勒血流仪进行血流参数测量,包括血氧饱和度(saturation oxygen,Sp O2)、平均血红蛋白量(relative amount of hemoglobin,r HB)、单位时间内血流量(flow)、血流速度(velocity)。结果:高加索人种和中国汉族两组之间比较,上颌中切牙血氧饱和度平均值分别为75.6%±8.2%和70.4%±7.6%;颊黏膜血红蛋白量平均值分别为79.9±5.8和83.5±6.6,差异有统计学意义,其余各位点血流参数差异无统计学意义。将测量位点各组之间进行比较:上腭黏膜的血氧饱和度为77.1%±10.9%,平均血红蛋白量为67.8±11.1,单位时间血流量194.1±63.7,相比较其他测量部位差异有统计学意义。男性多个测量位点血氧饱和度普遍低于女性,差异均有统计学意义。结论:口腔中不同解剖部位的黏膜血流灌注情况存在差别,性别之间血红蛋白氧结合能力可能存在差别,并且可能对于软组织愈合能力有一定影响;口腔黏膜血流灌注情况在小样本青年人群中的高加索人种与中国汉族人之间差异无统计学意义。 | 王莺 Obada Barry Gerhard Wahl 陈波 林野 | 2016 | 北京大学学报(医学版)2016，48，4： | 3 |
| 3 | Entangled two two-level atoms interacting with a cavity field in the presence of the stark shift terms显示文摘 | A.S.-F. Obada M.M.A. Ahmed E.M. Khalil S.I. Ali | 2013 | Optics Communications2013，，： | 2 |
| 4 | Chloride Penetration in Binary and Ternary Blended Cement Concretes as Measured by Two Different Rapid Methods显示文摘 | M Sharfuddin Ahmed Obada Kayali Wendy Anderson | 2008 | Cement and Concrete Composites2008，30，7： | 1 |
| 5 | The fate of water in fly ash-based geopolymers 显示文摘 | FANG YUAN KAYALI OBADA | 2013 | Constr Build Mater2013，39，0： | 1 |
| 6 | 对急性憩室出血患者进行早期结肠镜诊治可提高医疗资源利用率显示文摘背景:在发达国家,憩室出血是严重的急性下消化道出血最常见的原因。早期结肠镜(≤24小时)的作用仍然存在争议,目前尚无早期肠镜应用于急性憩室出血的数据。本研究旨在通过美国全国住院患者样本库,评估结肠镜诊治的时机对急性憩室出血患者预后的影响。方法:采用第9版国际疾病分类(ICD 9),对全国住院患者样本库中2012-2014年间的病例进行选择并提取资料。纳入出院诊断(包括主要诊断或第二诊断)为憩室病合并出血和憩室炎合并出血的病例,排除年龄不满18周岁以及住院期间未行结肠镜检查的病例。首要结局指标为住院时间和住院总费用。结果:共计88,600例患者纳入研究,其中45,020例(50.8%)在入院24小时内接受了结肠镜检查(早期肠镜组),而另外43,580例(49.2%)则是在入院24小时后行结肠镜检查(晚期肠镜组)。早期肠镜组较晚期肠镜组患者住院时间显著缩短(3.7天vs 5.6天,P<0.001),住院总花费显著降低($9317 vs$11,767,P<0.001)。两组患者病死率的差异无统计学意义(0.7%vs 0.8%)。对潜在致混淆因素进行校正后,两组间住院时间和住院总费用的差异仍然具有统计学意义。结论:对于急性憩室出血,早期结肠镜诊治可显著缩短住院时间,降低住院费用,而且并不会增加病死率。选择适宜的急性憩室出血病例进行早期结肠镜诊治,具有节省医疗资源的潜在意义。进一步研究需明确哪些憩室出血患者能从早期结肠镜诊治中获益。 | Hamzeh Saraireh Obada Tayyem Mohamed Tausif Siddiqui Bashar Hmoud Mohammad Bilal | 2019 | Gastroenterology Report2019，7，2： | 1 |
| 7 | Assessment of high vol- ume replacement fly ash concrete concept of performance index 显示文摘 | OBADA K SHARFUDDIN M | 2013 | Construction and Building Materials2013，39，： | 1 |
| 8 | Chloride penetration in binary and ternary blended cement con- cretes as measured by two different rapid methods 显示文摘 | Sharfuddin Ahmed M Obada Kayali Wendy Anderson | 2008 | Cem Concr Compos2008，30，7： | 1 |
| 9 | Bond of fibbed galvanized reinforcing steel in concrete 显示文摘 | Obada Kayali Stephen R Yeomans | 2000 | Cement and Concrete Composites2000，22，： | 1 |
| 10 | Presence of asymmetric dimethylarginine gradients across high - grade lesions in patients with coronary artery disease 显示文摘 | Joyal D Leya F Obada A1 - Chekakie M | 2007 | Coron Artery Dis2007，18，6： | 1 |
| 11 | Chloride penetration in binary and ternary blended cement concretes as measured by two different rapid methods显示文摘 | Sharfuddin Ahmed M Obada Kayali Wendy Anderson | 2008 | Cem Concr Compos2008，30，7： | 1 |
| 12 | Variation from number-to chaotic-state fields:A generalized geometric state显示文摘 | Obada A S F Hassan S S Puri R R | 1993 | Phys Rev A1993，48，： | 1 |
| 13 | Assessment of Treg Cells CD4+ CD25+ in Chronic Cirrhotic Liver Disease and Hepatocellular Carcinoma Egyptian Patients 显示文摘 | Bassuoni MAE Obada MA Korah T | 2008 | Hepatitis Monthly2008，8，3： | 1 |
| 14 | Quantum teleportation via entangled states generated by the Jaynes–Cummings model显示文摘 | N. Metwally M. Abdelaty A.-S.F. Obada | 2004 | Chaos, Solitons and Fractals2004，，3： | 1 |
| 15 | Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease 显示文摘 | Joyal D Leya F Obada Al-Chekakie M | 2007 | Coron Art Dis2007，18，： | 1 |
| 16 | Bunching and Antibunching Effects in a System of N Two-Level Atoms 显示文摘 | Mahran M H Obada A S F | 1987 | J of Mod Optics1987，34，11： | 1 |
| 17 | Influence of intrinsic decoherence on entanglement degree in the atom-field coupling system显示文摘 | Zidan N A Abdel-Aty M Obada A S F | 2002 | Chaos Solitons and Fractals2002，13，： | 1 |
| 18 | Dynamics of the even-binomial state in some quantum system显示文摘 | A. -S. F. Obada M. H. Mahran F. A. A. El-Orany M. Sebawe Abdalla | 1996 | International Journal of Theoretical Physics1996，，7： | 1 |
| 19 | Influence of intrinsic decoherece on entanglement degree in the atom-field coupling system显示文摘 | ZIDAN N A ABDEL-ATY M OBADA A S F | 2002 | Chaos Solitons and Fractals2002，13，： | 1 |
| 20 | Entropy and entanglement of the nonlinear Jaynes-Cummings model显示文摘 | OBADA A S F AHMED M M A FARAMAWY F K | 2004 | Chin J Phys2004，42，1： | 1 |
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