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| 1 | Molecular mechanisms of insulin resistance in chronic hepatitis C显示文摘It is now widely recognized that chronic hepatitis C (CHC)is associated with insulin resistance(IR)and type 2 diabetes,so can be considered a metabolic disease.IR is most strongly associated with hepatitis C virus(HCV)genotype 1,in contrast to hepatic steatosis, which is associated with genotype 3 infection.Apart from the well-described complications of diabetes,IR in CHC predicts faster progression to fibrosis and cirrhosis that may culminate in liver failure and hepatocellular carcinoma.More recently,it has been recognized that IR in CHC predicts a poor response to antiviral therapy. The molecular mechanisms for the association between IR and HCV infection are not well defined.This review will elaborate on the clinical associations between CHC and IR and summarize current knowledge regarding the molecular mechanisms that potentially mediate HCV-associated IR. | Mark W Douglas Jacob George | 2009 | World Journal of Gastroenterology2009，15，35： | 16 |
| 2 | Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B显示文摘AIM:To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS:A retrospective analysis of treatment naive patients receiving entecavir monotherapy through Westmead Hospital was performed.Patients were excluded if they had received previous treatment with another nucleoside or nucleotide analogue,were pregnant or less than 18 years old. RESULTS:Out of 336 patients,163 patients fulfilled the selection criteria.Range of follow up was 3-46 mo (mean 26 mo).134 patients(82.2%)had pre-treatment biopsies,with 26 patients(16.0%)demonstrating F3-4 fibrosis.In total,153 patients(93.9%)achieved at least Partial Virological Suppression(PVS),with 134 patients (82.2%)achieving complete virological suppression. The cumulative CVS and PVS rates at 36 mo were 82.1%and 96.4%,respectively.3 patients(1.8%)failed to achieve PVS,while 5 patients(3.0%)developed virological rebound.128 patients(78.5%)maintained CVS throughout follow up.Predictors of CVS included lower baseline DNA level(P=0.001),hepatitis B virus e antigen negative status(P=0.001)and increasing age at treatment(log rank 0.001).No significant adverse effects were reported necessitating cessation of entecavir. CONCLUSION:Entecavir monotherapy is efficacious and safe in an Australian tertiary care setting.Resistance and rebound rates are very low.This is similar to data from controlled and uncontrolled trials around the world. | Farzan Fahrtash-Bahin Viraj C Kariyawasam Timothy Gray Karen Byth Jacob George Mark W Douglas | 2013 | World Journal of Gastroenterology2013，19，5： | 5 |
| 3 | Characterization of the Yeast Transcriptome显示文摘 | Victor E Velculescu Lin Zhang Wei Zhou Jacob Vogelstein Munira A Basrai Douglas E Bassett Phil Hieter Bert Vogelstein Kenneth W Kinzler | 1997 | Cell1997，，2： | 4 |
| 4 | 谈提高农业水分生产率显示文摘 | Jacob W Kijne Randolph Barker David Molden 左英勇(摘译) | 2006 | 中国农村水利水电2006，，12： | 2 |
| 5 | Which Time-to-Peak Threshold Best Identifies Penumbral Flow?: A Comparison of Perfusion-Weighted Magnetic Resonance Imaging and Positron Emission Tomography in Acute Ischemic Stroke显示文摘 | J Sobesky O Zaro Weber F -G. Lehnhardt V Hesselmann A Thiel C Dohmen A Jacobs M Neveling W -D. Heiss | 2004 | Stroke2004，，12： | 2 |
| 6 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 7 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 8 | Duplex ultrasonography of vertebral and subclavian arteries显示文摘 | Kalaria VG Jacob S Irwin W | 2005 | J AM Soc Echocardiogr2005，18，10： | 1 |
| 9 | Measurement of excited-state-absorption loss for Ce^3+ in Y3Al5O12 and implications for tunable 5d→4f rare earth laser显示文摘 | Jacobs R R Krupke W F Weber M | 1978 | J Appl Phys Lett(S0003-6951)1978，，33： | 1 |
| 10 | Polycyclic aromatic hydrocarbons of environmental and importance显示文摘 | Jacob K W | 1986 | Fresenius J Anal Chem1986，323，： | 1 |
| 11 | Magnetorheological finishing显示文摘 | Kordonski W I Jacobs S D | 1996 | International Journal of Modern Physics1996，，： | 1 |
| 12 | Mesh Saliency显示文摘 | LEE C H VARSHNEY A JACOBS D W | 2005 | ACM Transaction on Graph2005，24，3： | 1 |
| 13 | Random and site -specific immobilization of catalytic antibodies 显示文摘 | Spitznagel T M Jacobs J W Clark D S | 1993 | Enzyme Microbial Technol1993，15，： | 1 |
| 14 | Lambertian reflectance and linear subspaces显示文摘 | Basri R Jacobs D W | 2003 | IEEE Trans on PAMI2003，25，2： | 1 |
| 15 | Mesh saliency显示文摘 | Lee Chang-ha Varshney A Jacobs D W | 2005 | ACM Transactions on Graphics ACM2005，24，3： | 1 |
| 16 | Subclass IgG to motor gangliosides related to infection and clinical course in Guillain Barre syndrome 显示文摘 | Jacobs BC Koga M van Rijs W | 2008 | J Neuroimmunol2008，194，12： | 1 |
| 17 | Measurement of excited-state-absorption loss for Ce3+ in Y3Al5O12 and implications for tunable 5d→4f rare-earth lasers显示文摘 | Jacobs R R Krupke W F Weber M | | 0，，： | 1 |
| 18 | A Curve Fitting Procedure to Derive Inter-annual Phenologies from Time Series of Noisy Satellite NDVI Data显示文摘 | BRADLEY B A JACOB R W HERMANCE J F | 2007 | Remote Sensing of Environment2007，106，2： | 1 |
| 19 | The effects of supply chain integration on customer satisfaction and financial performance : An organizational learning perspective 显示文摘 | YU W T JACOBS M A SALISBURY W D ENNS H | 2013 | International Journal of Production Economies2013，146，1： | 1 |
| 20 | Sulfation of extracellular polysaccharides of red microalgae: reparation, characterization and properties显示文摘 | Shimona G Anna M Jacob W | 2002 | Biochemical and Biophysical Methods2002，50，： | 1 |
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