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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks显示文摘 | Julie K Horton Mary Watson Donna F Stefanick Daniel T Shaughnessy Jack A Taylor Samuel H Wilson | 2008 | Cell Research2008，18，1： | 17 |
| 3 | Effects of creep feeding and supplemental glutamine or glutamine plus glutamate (Aminogut) on pre- and post-weaning growth performance and intestinal health of piglets显示文摘Background: Creep feeding is used to stimulate piglet post-weaning feed consumption.L-Glutamine(GLN) is an important source of fuel for intestinal epithelial cells.The objective of this study was to determine the impact of creep feeding and adding GLN or AminoGut(AG;containing glutamine + glutamate) to pre-and post-weaning diets on pig performance and intestinal health.Litters(N = 120) were allotted to four treatments during 14–21 d of lactation: 1) No creep feed(NC,n = 45);2) creep fed control diet(CFCD,n = 45);3) creep fed 1% GLN(CFGLN,n = 15);4) creep fed.88% AG(CFAG,n = 15).After weaning,the NC and CFCD groups were sub-divided into three groups(n = 15 each),receiving either a control nursery diet(NC-CD,CFCD-CD) or a diet supplemented with either GLN(NC-GLN,CFCD-GLN) or with AG(NC-AG,CFCD-AG).Litters that were creep fed with diets containing GLN or AG also were supplemented with those amino acids in the nursery diets(CFGLN-GLN,CFAG-AG).Glutamine was added at 1% in all three post-weaning diet phases and AG was added at.88% in phase 1 and 2 and at.66% in phase 3.Results: Feed conversion(feed/gain) showed means among treatment means close to significance(P = 0.056) and Tukey's test for pairwise mean comparisons showed that Pigs in the CFGLN-GLN group had the best feed conversion(feed/gain) in the first three-week period post-weaning,exceeding(P = 0.044) controls(CFCD-CD) by 34%.The NC-AG group had(P = 0.02) the greatest feed intake in the last three week of the study,exceeding controls(CFCD-CD) by 12%.CFGLN-GLN,CFCD-GLN and sow reared(SR) pigs had the greatest(P = 0.049) villi height exceeding the CFCD-AG group by 18%,20% and 19% respectively.The CFAG-AG group had the deepest(P = 0.001) crypts among all treatments.CFGLN-GLN,CFCD-GLN and SR groups had the greatest(P = 0.001) number of cells proliferating(PCNA) exceeding those in the NC-CD group by 43%,54% and 63% respectively.Sow reared pigs showed the greatest(P = 0.001) intestinal absorption capacity for xylose and mannitol.Conclusion: Supplementation of creep feed and nursery diets with GLN and/or AminoGut in the first three week improved feed conversion possibly due to improved intestinal health. | Rafael A Cabrera James L Usry Consuelo Arrellano Eduardo T Nogueira Marianne Kutschenko Adam J Moeser Jack Odle | 2013 | Journal of Animal Science and Biotechnology2013，4，3： | 17 |
| 4 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 5 | Fungicidal activity of ce-cropin A显示文摘 | Delucca A Bland J M Jacks T J | 1997 | Antimicro Agents Chemo1997，41，2： | 2 |
| 6 | The application of tow-stage Copressio methodfor XML显示文摘 | Peter S Jack T | 2001 | Data Engineering2001，101，101： | 2 |
| 7 | Analysis and modeling of the steady state behavior of static kramer induction generator显示文摘 | Refoufi L A1 Zahawi B A T Jack A G | 1999 | IEEE Transactions on Energy Conversion1999，14，3： | 1 |
| 8 | NF1 tumor suppressor gene function : narrowing the GAP显示文摘 | Cichowski K Jacks T | 2001 | Cell2001，104，： | 1 |
| 9 | Cell - cycle control and its watch- man显示文摘 | Jacks T Weinberg RA | 1996 | Nature1996，381，： | 1 |
| 10 | Spherosome membranes 显示文摘 | Yatsu L Y Jacks T J | 1972 | Plant Physiology1972，49，6： | 1 |
| 11 | Mammalian RNAi: a practical guide 显示文摘 | Sandy P Ventura A Jacks T | 2005 | Biotechniques2005，39，2： | 1 |
| 12 | Molecular and genetic mechanisms of floral control 显示文摘 | Jack T | 2004 | Plant Cell2004，，： | 1 |
| 13 | Biological souring and mitigation in oil reservoirs 显示文摘 | Gieg L M Jack T R Foght J M | 2011 | Applied Microbiology and Biotechnology2011，92，2： | 1 |
| 14 | STI571 inactivation of the gastrointestinal stromal tumor c-kit oncoprotein: biological and clinical implications显示文摘 | Tuveson DA Willis NA Jacks T | 2001 | Oncogene2001，20，36： | 1 |
| 15 | The K domain mediates heterodimerization of the Arabidopsis floral organ identity proteins ,APETALA3 and PISTILLATA 显示文摘 | YANG Y FANNING L JACK T | 2003 | Plant J2003，33，1： | 1 |
| 16 | DNA damage can induce apoptosis in proliferating lymphoid cells via p53 independent mechanisms inhibitable by Bcl-2显示文摘 | Harris AW Jacks T et aL | 1994 | Cell1994，79，2： | 1 |
| 17 | Mammalian RNAi: a practical guide显示文摘 | Sandy P Ventura A Jacks T | 2005 | Biotechniques2005，39，2： | 1 |
| 18 | Volume flexible stralegics in health services: a research framework显示文摘 | Jack E P Powers T L | 2004 | Production and Operations Management2004，，13： | 1 |
| 19 | Substrate depletionduring formation of aflatoxin and kojic acid on com inoculatedwith Aspergillus flavus 显示文摘 | LEE L S PARRISH F W JACKS T J | 1986 | Mycopathologia1986，93，2： | 1 |
| 20 | STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical'implications显示文摘 | Tuveson DA Willis NA Jacks T | 2001 | Oncogcne2001，20，36： | 1 |
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