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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | A pilot prospective randomized trial of postoperative epoetin alfa in patients undergoing major operation for upper gastrointestinal malignancy 显示文摘 | GROBMYEH SR HEMMING AW HARRIS N | 2011 | Am J Clin Oncol2011，32，6： | 1 |
| 3 | Relation between gas tric acid output,Helieobaeter pylori,and gastric metaPlasia in the duodenal bulb显示文摘 | Harris AW Gummett PA Walker MM | | 0，，04： | 1 |
| 4 | DNA damage can induce apoptosis in proliferating lymphoid cells via p53 independent mechanisms inhibitable by Bcl-2显示文摘 | Harris AW Jacks T et aL | 1994 | Cell1994，79，2： | 1 |
| 5 | Regeneration or scarring: an immunologic perspective 显示文摘 | Harry M Neff AW King MW | 2003 | Dev Dyn2003，226，2： | 1 |
| 6 | A bcr-v-abl oncogene induces lymphomas in transgenic mice显示文摘 | Hariharan IK Harris AW Crawford M | 1989 | Mol Cell Biol1989，9，： | 1 |
| 7 | DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2显示文摘 | Strasser A Harris AW Cory S | 1994 | Cell1994，79，2： | 1 |
| 8 | Bmi-1transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘 | Haupt Y Bath ML Harris AW | 1993 | Oncogene1993，8，11： | 1 |
| 9 | Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia 显示文摘 | Williams LM Das P Harris AW | 2004 | Am J Psychiatry2004，161，： | 1 |
| 10 | Experience of maintenance infliximab therapy for refractory ulcerative colitis from six centres in England显示文摘 | Russo EA Harris AW Camobell S | | 0，，03： | 1 |
| 11 | Cytokines contribute to early hepatic parenchymal injury and m icrovascular dysfuntion after bilateral hind limb ischemia显示文摘 | L aw lor DK Brock RW Harris KA | 1999 | J Vasc Surg1999，30，4： | 1 |
| 12 | Regeneration or scarring : an immunologic perspective显示文摘 | Harry M Neff AW King MW | 2003 | Dev Dyn2003，226，2： | 1 |
| 13 | Rapid detection of respiratory syncytial virus in nasopharyngeal aspirates by reverse transcription and polymerase chain reaction amplification显示文摘 | Paton AW Paton JC Lawrence A J Goldwater PN Harris RJ | 1992 | Clin Microbiol1992，30，4： | 1 |
| 14 | Regeneration or scarring:an immunologic perspective显示文摘 | Harry M Nef AW King MW | 2003 | Dev Dyn2003，226，2： | 1 |
| 15 | Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis显示文摘 | Strasser A Harris AW Huang DC | 1995 | EMBO J1995，14，24： | 1 |
| 16 | Mouse myelomas and lymphomas in culture显示文摘 | Harris AW | 1970 | Exp Cell Res1970，60，： | 1 |
| 17 | bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitars显示文摘 | O'Beilly LA Harris AW Strasser A | 1997 | Int Immunol1997，9，9： | 1 |
| 18 | Cyclin D1 as the putative bel Ⅰ oncogene显示文摘 | Harris AW Bodrug SE Warnce BJ | 1995 | Curr Top Microbiol Immunol1995，194，： | 1 |
| 19 | Relation bet~veen gastric acid output, Heli~:obacter pylori, and gastrit', metaplasia in the duodenal bulb显示文摘 | Harris AW Gummett PA Walker MM | 1996 | Gut1996，39，4： | 1 |
| 20 | Bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8 Tcell progenitors显示文摘 | Harris AW StrasserA | 1997 | Int Immunol1997，9，9： | 1 |
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