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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Comparative Evaluation of 29 Commercial H elicobacter pylori Serological Kits显示文摘 | Christophe Burucoa Jean‐Charles Delchier Anne Courillon‐Mallet Jean‐Dominique Korwin Francis Mégraud Frank Zerbib Josette Raymond Jean‐Louis Fauchère | 2013 | Helicobacter2013，，3： | 3 |
| 3 | 细胞因子和凋亡相关基因在小鼠帕金森病模型中的表达显示文摘 | 申延琴 Josette Arsaut Elisabeth Moze Pierre Jean Neveu 李康生 | 2003 | 中华神经科杂志2003，36，3： | 2 |
| 4 | Meeting Deadlines in Work Groups: Implicit and Explicit Mechanisms显示文摘 | Josette M.P.Gevers Christel G.Rutte WendelienVan Eerde | 2006 | Applied Psychology2006，，1： | 1 |
| 5 | Hydrological regime and water budget of the Red River Delta (Northern Vietnam) 显示文摘 | Luu Thi Nguyet Minh Gamier Josette | 2010 | Journal of Asian Earth Science2010，，21： | 1 |
| 6 | Measurement of procalcitonin levels in children with Bacterial or viral meningitis显示文摘 | Dominique G Josette R | 1997 | Clinical Infectious Diseases1997，24，： | 1 |
| 7 | Two-step synthesis of D3 and C3h Cryptophanes显示文摘 | CANCEIL JOSETTE COLLET ANDRE | 1988 | J Chem Soc Chem Commun1988，9，： | 1 |
| 8 | 18 F-FDG PET/CT bone/bone marrow findings in Hodgkin’s lymphoma may circumvent the use of bone marrow trephine biopsy at diagnosis staging显示文摘 | Gerard Moulin-Romsee Elif Hindié Xavier Cuenca Pauline Brice Didier Decaudin Myriam Bénamor Josette Brière Marcela Anitei Jean-Emmanuel Filmont David Sibon Eric Kerviler Jean-Luc Moretti | 2010 | European Journal of Nuclear Medicine and Molecular Imaging2010，，6： | 1 |
| 9 | Antibacterial and antioxidant activities of Artemisia annua essential oil显示文摘 | Fabien Juteau Veronique Masotti Jean Marie Bessière Michel Dherbomez Josette Viano | 2002 | Fitoterapia2002，，6： | 1 |
| 10 | Endogenous control 0f hippocampal epileptogenesis:a molecular cascade involving BDNF and NPY显示文摘 | Sophie R Yves L Josette C et a1 | 2000 | Epilepsia2000，6，： | 1 |
| 11 | Nitrification and NitrifyingBacteria in the Lower Seine River and Estuary (France)显示文摘 | AURéLIE C THIERRY B JOSETTE G | 2003 | Ap-plied and Environmental Microbiology2003，69，12： | 1 |
| 12 | Exciton Approach to The Optical Activity of C3-Cyclotrylene Derivatives 显示文摘 | JOSETTE C ANDRE C JACQUELINE G | 1985 | J Am Chem Soc1985，107，： | 1 |
| 13 | Mushroom Bodies of the Cockroach Their Participation in Place Memory显示文摘 | MAKOTO MIZUNAMI JOSETTE M.WEIBRECHT NICHOLAS J.STRAUSFELD | | 0，，： | 1 |
| 14 | Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer显示文摘 | Sébastien Le Jan Nolwenn Le Meur Aurélie Cazes Josette Philippe Martine Le Cunff Jean Léger Pierre Corvol Stéphane Germain | 2006 | FEBS Letters2006，，14： | 1 |
| 15 | The potential of organic fertilizers and water management to reduce N 2 O emissions in Mediterranean climate cropping systems. A review显示文摘 | Eduardo Aguilera Luis Lassaletta Alberto Sanz-Cobena Josette Garnier Antonio Vallejo | 2013 | Agriculture, Ecosystems and Environment2013，，： | 1 |
| 16 | Endogenous control of hippocampal epileptogenesis:a molecular eascade involving BDNF and NPY显示文摘 | Sophie R Yves L Josette C | 2000 | Epilepsia2000，41，6： | 1 |
| 17 | Nutrient dynamics and control of eutrophication in the Marne River system : Modelling the role of exchangeable phosphorus 显示文摘 | Josette Garnier Julien Nemery Gilles Billen | 2005 | Journal of Hydrology2005，304，： | 1 |
| 18 | Changing root and shoot architecture with the rol A gene from Agrobacterium rhizogenes:Interactions with gibberellic acid and polyamine metabolism显示文摘 | Gozal B H Josette M T David T | 1996 | Physiologia Plantarum1996，96，： | 1 |
| 19 | Epratuzumab,a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab显示文摘 | Josette C Rhona S Zhengxing Q | 2007 | Mol Immunol2007，44，6： | 1 |
| 20 | Psychometric qualities of the Dutch version of the Pediatric Inventory for Parents (PIP):a multi-center stufy显示文摘 | Jantien Vrijmoer-Wiersma CM Josette EHM Hoekstra-Weebers WMG | 2010 | PsychoOncology2010，19，： | 1 |
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