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| 1 | Bone mineral density and disorders of mineral metabolism in chronic liver disease显示文摘AIM:To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis.METHODS:The study was performed on 72 Indian patients with cirrhosis(63 male, 9 female;aged < 50 years).Etiology of cirrhosis was alcoholism(n = 37), hepatitis B(n = 25) and hepatitis C(n = 10).Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C.Secondary causes for metabolic bone disease and osteoporosis were ruled out.Sunlight exposure, physical activity and dietary constituents were calculated.Complete metabolic profiles were derived, and bone mineral density(BMD) was measured using dual energy X ray absorptiometry.Low BMD was defined as a Z score below-2.RESULTS:Low BMD was found in 68% of patients.Lumbar spine was the most frequently and severely affected site.Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass.Calcium intake was adequate, with unfavorable calcium:protein ratio and calcium:phosphorus ratio.Vitamin D deficiency was highly prevalent(92%).There was a high incidence of hypogonadism(41%).Serum estradiol level was elevated significantly in patients with normal BMD.Insulin-like growth factor(IGF) 1 and IGF binding protein 3 levels were below the age-related normal range in both groups.IGF-1 was signiflcantly lower in patients with low BMD.Serum osteocalcin level was low(68%) and urinary deoxypyridinoline to creatinine ratio was high(79%), which demonstrated low bone formation with high resorption.CONCLUSION:Patients with cirrhosis have low BMD.Contributory factors are reduced physical activity, low lean body mass, vitamin D def iciency and hypogonadism and low IGF-1 level. | Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana Karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah | 2009 | World Journal of Gastroenterology2009，15，28： | 15 |
| 2 | Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract显示文摘 | Debasis Bagchi Chandan K Sen Sidhartha D Ray Dipak K Das Manashi Bagchi Harry G Preuss Joe A Vinson | 2003 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2003，，： | 2 |
| 3 | Manual aspiration thrombectomy in acute ST elevation myocardial infarction:New gold standard?显示文摘Percutaneous coronary intervention(PCI) is the preferred method to treat ST segment myocardial infarction(STEMI).The use of thrombus aspiration(TA) may be particularly helpful as part of the PCI process,insofar as the presence of thrombus is essentially a universal component of the STEMI process.This article reviews evidence favoring the routine use of TA,and the limitations of these data.Based on current evidence,we consider TA to be an important maneuver during STEMI PCI,even in the absence of visible angiographic thrombus,and recommend it whenever the presence of thrombus is likely. | Brent Rochon Youssef Chami Rajesh Sachdeva Joe K Bissett Nick Willis Barry F Uretsky | 2011 | World Journal of Cardiology2011，3，2： | 2 |
| 4 | 用PDE-5抑制剂治疗勃起功能障碍的男性患者中前列腺癌的发生率:回顾性研究显示文摘本研究比较了用PDE-5抑制剂治疗勃起功能障碍(ED)7年的男性患者和与这些患者年龄及各种风险因素相似的7年内不使用PDE一5抑制剂治疗ED的男性患者中前列腺癌发生率的情况。通过分析2000年到2006年的电子病例和数据库,以年龄在50至69岁,2000年前无前列腺癌病史的ED患者作为研究对象。这些患者被分为两组:2362名曾用PDE-5抑制剂治疗的男性和2612名不曾使用过该药物的男性。比较每组的人口数据。在研究期内:97名(4.1%)接受过PDE-5抑制剂治疗的ED患者被诊断出患了前列腺癌,在非PDE-5抑制剂治疗组中,258名(9.9%)被诊断出患了前列腺癌(P〈O.0001)。在非洲裔美国人中,接受PDE-5抑制剂治疗的比例比不用的比例高(10.5%VS.7.1%,P〈0.0001)。接受过PDE-5治疗的患者,其前列腺特异性抗原增高的比例比较低(10.0%vs.13.1%,P=0.0008),但良性前列腺增生的比例比较高(38.4%vs.35.1%,P=0.0149)。接受PDE-5抑制剂治疗ED的男性不易患前列腺癌(调整后的优势比为0.4,95%CI:0.3—0.5,P〈0.0001)。我们的研究数据表明:用PDE-5抑制剂治疗ED的男性倾向于不易患前列腺癌。还需要进行更多的研究。 | Anthony H Chavez K Scott Coffield M Hasan Rajab Chanhee Joe | 2013 | Asian Journal of Andrology2013，15，2： | 2 |
| 5 | Thermal Performance of the ATST Secondary Mirror显示文摘 | Cho Myung K DeVries Joe Eric Hansen | 2007 | SPIE2007，6721，： | 1 |
| 6 | Simultaneous determination of six penicillins in cow's raw milk by a multiresidue high-performance liquid chromatographic method 显示文摘 | Sorensen L K Rasmussen B M Boison Joe O | 1997 | Journal of Chromatography B: Biomedical Sciences and Applications1997，694，2： | 1 |
| 7 | Preparation and application of organo- minerals as sorbents of phenol, benzene and toluene显示文摘 | SANG M K JOE B D | 2001 | Ap- plied Clay Science2001，，18： | 1 |
| 8 | Energy balance closure using eddy covariance above two different land surfaces and implications for CO2 flux measurements显示文摘 | Joe K Christian B Black T A | 2010 | Boundary-Layer Meteorology2010，136，2： | 1 |
| 9 | Similarity analysis of industrial alarm flood data 显示文摘 | Ahmed K Izadi I Chen Tongwen Joe D Burton T | 2013 | Automation Science and Engineering IEEE Transactions on2013，10，2： | 1 |
| 10 | Effecl of KAI1/CD82 on the beta1 integrin maturation in highly migratory carcinoma cells显示文摘 | Joe B K Lee J Y Lim Y | 2007 | Biochem Biophys Res Commun2007，359，3： | 1 |
| 11 | Finite-difference analysis of dispersive transmission lines within a circuit simulator 显示文摘 | BEHZAD K JOE L GREG E B | 2006 | IEEE Transactions on Power Delivery2006，21，1： | 1 |
| 12 | The Public Library Geographic Database:What Can It Do for Your Library? 显示文摘 | Christie M Koontz Dean K Joe Charles R McClure John Carlo Betroth | 2004 | Public Libraries2004，43，2： | 1 |
| 13 | An Integrated Thermo- mechanical-dynamic Model to Characterize Motor- ized Machine Tool Spindles During Very High Speed Rotation显示文摘 | Lin Chiwei Tu J F Joe K | 2003 | International Journal of Machine Tool & Manufacture2003，43，： | 1 |
| 14 | Direct synthesis ofdimethyl carbonate from methanol and carbon dioxide over CeO2(x)-ZnO0_x) nano-catalysts显示文摘 | KANG K H JOE W LEE C H | 2013 | Journal ofnanoscience and nanotechnology2013，13，12： | 1 |
| 15 | Poly (methylmethacry-late) hollow particles by water-in-oil-water emulsion polymerization 显示文摘 | Kim J W Joe Y G Stth K D | 1999 | Colloid Polymer Science1999，277，： | 1 |
| 16 | Thrombininduced microglial activation produces degeneration of nigral dopaminergic neurons in vivo显示文摘 | Choi S H Joe E H Kim S U Jin B K | 2003 | J Neurosci2003，23，： | 1 |
| 17 | Deoxyhypusine synthase activity is essential for cell viability in the yeast Saccharomyces cerevisiae 显示文摘 | Park M H Joe Y A Kang K R | 1998 | Journal of Biological Chemistry1998，273，3： | 1 |
| 18 | Stated preferences of tourists for eco-efficient destination planning options 显示文摘 | JOE K WOLFGANG H PETER W | 2007 | Tourism Management2007，28，： | 1 |
| 19 | Directing noble metal ion chemistry within a de- signed ferritin protein显示文摘 | CHRISTOPHER A B JOE S SEUNG G K | 2008 | Biochemistry2008，47，12： | 1 |
| 20 | An overview of glaciers, glacier retreat, and subsequent impacts in Nepal,India and China显示文摘 | Joe T K Sandeep C R | 2005 | WWF Nepal Program Report2005，，： | 1 |
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