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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | IRG1 induced by heme oxygenase- 1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production显示文摘 | Md Jamal Uddin Yeonsoo Joe Seul-Ki Kim Sun Oh Jeong Stefan W Ryter Hyun-Ock Pae Hun Taeg Chung | 2016 | Cellular & Molecular Immunology2016，13，2： | 10 |
| 3 | Breast and lung metastasis from pancreatic neuroendocrine carcinoma显示文摘Pancreatic neuroendocrine tumors(PNETs) are an uncommon malignancy,accounting for a small percentage of all pancreatic malignancies.Due to their insidious course,most PNETs present with metastatic disease.Although reports in the literature describe PNET metastasis to the liver,lung and brain,to date there are no reports of stage Ⅳ disease involving the breast.Moreover,the lack of consensus regarding classification and treatment of this entity leaves practitioners without standards of practice or a firm base from which to formulate prognosis.In this report,the case of a previously healthy 51-year-old woman with stage Ⅳ PNET is examined.After combined neoadjuvant therapy with 5-fluorouracil,carboplatin,etoposide and radiation,surgical resection revealed metastatic PNET to the breast and lung,with no microscopic evidence of residual disease within the pancreas.An extensive analysis of the presentation,diagnosis,imaging modalities,treatment options,and prognosis is included in the discussion.As demonstrated by our review,there is a need for further studies to delineate inconclusive evidence with respect to subtype classification,treatment and prognosis of PNETs. | Shevonne Satahoo-Dawes Joshua Palmer Eddie W Manning Ⅲ Joe Levi | 2011 | World Journal of Radiology2011，3，1： | 2 |
| 4 | Nitrile, aldehyde, and halonitroalkaneformation during chlorination/chloramination of primary amines显示文摘 | Joe S H Mitch W A | 2007 | Environmental Science and Technology2007，41，4： | 1 |
| 5 | Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells 显示文摘 | Joe MK Sohn S Hur W | 2003 | Biochem Biophys Res Commun2003，312，3： | 1 |
| 6 | Arc -discharge ion sources for heavy ion fusion显示文摘 | ANDRE JOE W KWAN | 2001 | Nuclear Instruments and Methods in Physics Research2001，，： | 1 |
| 7 | Parental contribution and coefficient of ancestry among maize inbreds:Pedigree,RFLP,and SSR data显示文摘 | Bernardo R Romero-Severson J Ziegle J Hauser J Joe L HookStra G Diverge R W | 2000 | Theoretical and Applied Genetics2000，100，： | 1 |
| 8 | Food safety risk Consumer per-ception and purchase behaviour显示文摘 | Ruth M W Yeung Joe Morris | | 0，，03： | 1 |
| 9 | Direct synthesis ofdimethyl carbonate from methanol and carbon dioxide over CeO2(x)-ZnO0_x) nano-catalysts显示文摘 | KANG K H JOE W LEE C H | 2013 | Journal ofnanoscience and nanotechnology2013，13，12： | 1 |
| 10 | Poly (methylmethacry-late) hollow particles by water-in-oil-water emulsion polymerization 显示文摘 | Kim J W Joe Y G Stth K D | 1999 | Colloid Polymer Science1999，277，： | 1 |
| 11 | Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells显示文摘 | Joe MK Sohn S Hur W | 2003 | Biochem Biophys Res Commun2003，312，6： | 1 |
| 12 | Effect of the solid-dispersion method on the solubility and crystalline property of tacrolimus显示文摘 | Joe J H Lee W M Park Y J | 2010 | Int J Pharm2010，21，5： | 1 |
| 13 | Stated preferences of tourists for eco-efficient destination planning options 显示文摘 | JOE K WOLFGANG H PETER W | 2007 | Tourism Management2007，28，： | 1 |
| 14 | Arc-discharge ion sources for heavy ion fusion 显示文摘 | Andre Joe W Kwan | 2001 | Nuclear Instruments and Methods in Physics Research2001，464，： | 1 |
| 15 | Modelling Tourism Destination Energy Consumption and Greenhouse Gas Emissions:Whistler , British Columbia, Canada显示文摘 | Kelly Joe Williams Peter W | 2007 | Journal of Sustainable Tourism2007，15，1： | 1 |
| 16 | An integrated thermal- mechanical- dynamic model to characterize motorized machine tool spindles during very high speed rotation 显示文摘 | Lin C W Jay F T Joe K | 2003 | International Journal of Machine Tools & Manufacture2003，43，10： | 1 |
| 17 | Shifts in affinity and enthalpy of oxygen binding to human hemoglobin A induced by pyridoxal and pyridoxal 5-phosphate显示文摘 | JUDY A W CRAIG R J JOE H S | 1997 | J Nutr Biochem1997，8，： | 1 |
| 18 | Pipeline integrity management显示文摘 | TIM W JOE D | 2012 | Society of Petroleum Engineers2012，26，： | 1 |
| 19 | Influence of Aggregate on Rutting in Asphalt Concrete Pavements显示文摘 | Button Joe W Dario Perdomo Lytton Robert L | 1990 | Transportation Research Record1990，1259，： | 1 |
| 20 | Non - surgical chemotherapeutic treatment strategies for the management of periodontal diseases 显示文摘 | Joe W Krayer DDS Renata S | 2010 | Dent Clin North Am2010，54，1： | 1 |
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