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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Bone mineral density and disorders of mineral metabolism in chronic liver disease显示文摘AIM:To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis.METHODS:The study was performed on 72 Indian patients with cirrhosis(63 male, 9 female;aged < 50 years).Etiology of cirrhosis was alcoholism(n = 37), hepatitis B(n = 25) and hepatitis C(n = 10).Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C.Secondary causes for metabolic bone disease and osteoporosis were ruled out.Sunlight exposure, physical activity and dietary constituents were calculated.Complete metabolic profiles were derived, and bone mineral density(BMD) was measured using dual energy X ray absorptiometry.Low BMD was defined as a Z score below-2.RESULTS:Low BMD was found in 68% of patients.Lumbar spine was the most frequently and severely affected site.Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass.Calcium intake was adequate, with unfavorable calcium:protein ratio and calcium:phosphorus ratio.Vitamin D deficiency was highly prevalent(92%).There was a high incidence of hypogonadism(41%).Serum estradiol level was elevated significantly in patients with normal BMD.Insulin-like growth factor(IGF) 1 and IGF binding protein 3 levels were below the age-related normal range in both groups.IGF-1 was signiflcantly lower in patients with low BMD.Serum osteocalcin level was low(68%) and urinary deoxypyridinoline to creatinine ratio was high(79%), which demonstrated low bone formation with high resorption.CONCLUSION:Patients with cirrhosis have low BMD.Contributory factors are reduced physical activity, low lean body mass, vitamin D def iciency and hypogonadism and low IGF-1 level. | Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana Karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah | 2009 | World Journal of Gastroenterology2009，15，28： | 15 |
| 3 | 慢性阻塞性肺疾病知识(一) 诊断显示文摘和其他常见的疾病一样,慢性阻塞性肺疾病(COPD)的诊断依靠相关病史和适当的检查。确诊的客观证据依靠呼吸功能测量。对于35岁以上,有吸烟史及相关呼吸道症状的患者,医生应考虑到COPD的可能。 | Graeme P Currie Joe S Legge 陈奇 | 2007 | 英国医学杂志中文版2007，10，1： | 3 |
| 4 | MIMO多输入输出网络控制系统的容错控制显示文摘针对被控对象为具有不确定因素的多输入多输出网络控制系统,设传感器与控制器均为时间驱动,执行器为事件驱动,网络诱导时延小于采样周期,将未能成功传输数据的传感器节点视为暂时失效,把具有传感器故障的网络控制系统建模为一类带有不确定因素的离散模型,借助Lyapunov定理给出了系统渐近稳定的充分条件,基于LMI方法得出观测器和控制器的分离设计方法,实现了MIMO网络控制系统的容错控制。 | 陈雨 张颖伟 Joe Qin S | 2007 | 清华大学学报(自然科学版)2007，47，z2： | 2 |
| 5 | Biliary-colonic fistula caused by cholecystectomy bile duct injury显示文摘Biliary-colonic fistula is a rare complication after laparoscopic cholecystectomy. We present a case of post-cholecystectomy iatrogenic biliary injury that resulted in a fistula between the common hepatic duct and large bowel. Magnetic resonance cholangiopancreatography provided good visualization of injury even with concurrent normal level of alkaline phosphatase. Radiologic findings and surgical management of this condition are discussed in detail. | Francisco Igor B Macedo Victor J Casillas James S Davis Joe U Levi Danny Sleeman | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 2 |
| 6 | Large cystic lesions of the liver in adults: a 15-year experience in a tertiary center 1 1 No competing interests declared.显示文摘 | Arie Regev K.Rajender Reddy Mariana Berho Dan Sleeman Joe U Levi Alan S Livingstone David Levi Unzila Ali Enrique G Molina Eugene R Schiff | 2001 | Journal of the American College of Surgeons2001，，1： | 2 |
| 7 | Measured and simulated performance of reflective roofing systems in residential buildings显示文摘 | Danny S Parker Yu Joe Huang | 1998 | ASHRAE Transactions1998，104，： | 1 |
| 8 | Nitrile, aldehyde, and halonitroalkaneformation during chlorination/chloramination of primary amines显示文摘 | Joe S H Mitch W A | 2007 | Environmental Science and Technology2007，41，4： | 1 |
| 9 | Sustained use of a household—scale water filtration device in rural Cambodia显示文摘 | Brown Joe Proum S Sobsey M D | | 0，，03： | 1 |
| 10 | Fault detection of nonlinear processes using multiway kernel independent component analysis显示文摘 | Zhang Yingwei Qin S Joe | 2007 | Industrial and Engineering Chemistry Research2007，46，23： | 1 |
| 11 | Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells 显示文摘 | Joe MK Sohn S Hur W | 2003 | Biochem Biophys Res Commun2003，312，3： | 1 |
| 12 | Chemopreventive properties of the ethanol extract of chinese licorice ( Glycyrrhiza uralensis) root : induction of apoptosis and G1 cell cycle arrest in MCF - 7 human breast cancer cells 显示文摘 | JOE H KIM S H RA J C | 2005 | Cancer Lett2005，230，2： | 1 |
| 13 | Rosengren, Will Legislated Early Intervention Prevent the Next Banking Crisis? 显示文摘 | Joe Peek and Eric S | 1997 | Southern Economic Joumal1997，268，： | 1 |
| 14 | The dimensionality of the maslach burnout inventory across small business owners and educators 显示文摘 | JAMES S B DWANE H D JOE M R | 2000 | Journal of Vocational Behavior2000，56，： | 1 |
| 15 | Magnetic properties of V-doped ZnO thin films显示文摘 | Nguyue H H Joe S Awatef H | 2005 | J Appl Phys2005，97，10： | 1 |
| 16 | Multivariate process monitoring and fault diagnosis by multi-scale PCA显示文摘 | Manish M Henry Joe Q S | 2002 | Computers and Chemical Engineering2002，26，9： | 1 |
| 17 | An overview of subspace identification 显示文摘 | Qin Joe S | 2006 | Computers and Chemical Engineering2006，30，1012： | 1 |
| 18 | Composi- tional controls on early diagenetic pathways in fine-grained sedimentary rocks : Implications for predicting unconventional reservoir attributes of mudstones 显示文摘 | Joe H S Macquaker Kevin G Taylor Margaret Keller | 2014 | AAPG Bulletin2014，98，3： | 1 |
| 19 | External field coupling to MTL net works with nonlinear junctions:numerical modeling and experimental validation显示文摘 | Joe L Joe S | 2000 | IEEE Transactions on Electromagnetic Compatibility2000，42，1： | 1 |
| 20 | Collocation methods for second kind Fredholm integral equations显示文摘 | Joe S | 1983 | Mathematical Programming and Numerical Analysis Workshop1983，，： | 1 |
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