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| 1 | Management of primary achalasia: The role of endoscopy显示文摘Achalasia is an oesophageal motor disorder which leads to the functional obstruction of the lower oesophageal sphincter(LES) and is currently incurable. The main objective of all existing therapies is to achieve a reduction in the obstruction of the distal oesophagus in order to improve oesophageal transit, relieve the symptomatology, and prevent long-term complications. The most common treatments used are pneumatic dilation(PD) and laparoscopic Heller myotomy, which involves partial fundoplication with comparable shortterm success rates. The most economic non-surgical therapy is PD, with botulinum toxin injections reserved for patients with a higher surgical risk for whom the former treatment option is unsuitable. A new technology is peroral endoscopic myotomy, postulated as a possible non-invasive alternative to surgical myotomy. Other endoluminal treatments subject to research more recently include injecting ethanolamine into the LES and using a temporary self-expanding metallic stent. At present, there is not enough evidence permitting a routine recommendation of any of these three novel methods. Patients must undergo follow-up after treatment to guarantee that their symptoms are under control and to prevent complications. Most experts are in favour of some form of endoscopic follow-up, however no established guidelines exist in this respect. The prognosis for patients with achalasia is good, although a recurrence after treatment using any method requires new treatment. | Marisol Luján-Sanchis Patricia Suárez-Callol Ana Monzá-Gallego Inmaculada Bort-Pérez Lydia Plana-Campos Luis Ferrer-Barceló Laura Sanchis-Artero María Llinares-Lloret Juan Antonio Tuset-Ruiz Javier Sempere-Garcia-Argüelles Pilar Canelles-Gamir Enrique Medina-Chuliá | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 5 |
| 2 | Melatonin treatment reduces endoplasmic reticulum stress and modulates the unfolded protein response in rabbits with lethal fulminant hepatitis of viral origin显示文摘 | María J. Tu?ón Beatriz San‐Miguel Irene Crespo Almudena Laliena Daniela Vallejo Marcelino álvarez Jesús Prieto Javier González‐Gallego | 2013 | Pineal Res2013，，3： | 1 |
| 3 | Wild Type p73 Overexpression and High-Grade Malignancy in Breast Cancer显示文摘 | Gemma Dominguez Jose M. Silva Javier Silva Jose M. Garcia Antonio Sanchez Antonia Navarro Isabel Gallego Mariano Provencio Pilar Espa?a Felix Bonilla | 2001 | Breast Cancer Research and Treatment2001，，3： | 1 |
| 4 | Inhibition of matrix metalloproteinase‐9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in H ep G 2 liver cancer cells显示文摘 | Raquel Ordo?ez Sara Carbajo‐Pescador Néstor Prieto‐Dominguez Andrés García‐Palomo Javier González‐Gallego José L. Mauriz | 2014 | J Pineal Res2014，，1： | 1 |
| 5 | Lyapunov functions for fractional order systems 显示文摘 | Norelys Aguila Camacho Manuel A Duarte Mermoud Javier A Gallegos | 2014 | Commun Nonlinear Sci Numer Simulat2014，19，9： | 1 |
| 6 | Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet‐induced mouse model of nonalcoholic fatty liver disease显示文摘 | Sandra Pisonero‐Vaquero ángel Martínez‐Ferreras María Victoria García‐Mediavilla Susana Martínez‐Flórez Anna Fernández Marta Benet José Luis Olcoz Ramiro Jover Javier González‐Gallego Sonia Sánchez‐Campos | 2015 | Mol. Nutr. Food Res2015，，5： | 1 |
| 7 | Cardiotrophin-1 in hypertensive heart disease显示文摘 | Arantxa González Bego?a López Susana Ravassa Javier Beaumont Amaia Zudaire Idoia Gallego Cristina Brugnolaro Javier Díez | 2012 | Endocrine2012，，1： | 1 |
| 8 | Cardioprotective effect of sevoflurane and propofol during anaesthesia and the postoperative period in coronary bypass graft surgery: a double-blind randomised study显示文摘 | Marina Soro Lucía Gallego Vanessa Silva María T. Ballester Julio Lloréns Ana Alvari?o María L. García-Perez Ernesto Pastor Gerardo Aguilar Francisco J. Martí Arturo Carratala F. Javier Belda | 2012 | European Journal of Anaesthesiology2012，，12： | 1 |
| 9 | Using general quadratic Lyapunov functions to prove Lyapunov uni- form stability for fractional order systems显示文摘 | MANUEL A DUARTE-MERMOUD N AGUILA-CA- MACHO JAVIER A GALLEGOS | 2015 | Commun Nonlinear Science Numer Simulat2015，22，： | 1 |
| 10 | Bilateral gluteoplasty for fecal incontinence显示文摘 | Dr. Jose M. Devesa M.D. Jose M. Fernandez Madrid M.D. Bego?a Rodríguez Gallego M.D. Emilio Vicente M.D. Javier Nu?o M.D. Jose M. Enríquez M.D | 1997 | Diseases of the Colon & Rectum1997，，8： | 1 |
| 11 | GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK显示文摘 | Beiroa Daniel Imbernon Monica Gallego Rosalía Senra Ana Herranz Daniel Villarroya Francesc Serrano Manuel Fern? Johan Salvador Javier Escalada Javier Dieguez Carlos Lopez Miguel Frühbeck Gema Nogueiras Ruben | 2014 | Diabetes2014，，10： | 1 |
| 12 | Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial显示文摘BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains unexplored.AIM To study the prognostic significance of SIRI and weight loss in metastatic pancreatic cancer.METHODS The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work group.This pilot study sought to analyze the association between weight loss and inflammatory status as defined by SIRI.The cohort stems from a proof-of-concept pilot study conducted at one of the coordinating centers.Patients with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were included.The index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation chemotherapy.This study evaluated associations between overall survival(OS),SIRI and weight loss.RESULTS A total of 50 patients were included.66%of these patients were male and the median age was 66 years.Metastasis sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple locations.Regarding the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI<2.3×10^(3)/L(4 vs 18 mo;P<0.000).Among 21 patients with>5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI levels.This difference was statistically significant(P<0.000).For patients with a SIRI<2.3×10^(3)/L,those who did not lose>5%of their weight had an OS of 20 mo,compared to 11 mo for those who did(P<0.001).No association was found between carbohydrate antigen 19-9 levels≥1000 U/mL and weight loss.CONCLUSION A higher SIRI was correlated with decreased survival rates in patients with metastatic pancreatic cancer and associated with weight loss.An elevated SIRI is suggested as a predictor of survival,emphasizing the need for prospective validation in the upcoming PANTHEIA-SEOM study. | Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas Javier Gallego A J Muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez | 2024 | World Journal of Gastrointestinal Oncology2024，16，2： | 0 |
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