|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure显示文摘Acute hepatic failure (AHF) is a severe liver injury accompanied by hepatic encephalopathy which causes multiorgan failure with an extremely high mortality rate, even if intensive care is provided. Management of severe AHF continues to be one of the most challenging problems in clinical medicine. Liver transplantation has been shown to be the most effective therapy, but the procedure is limited by shortage of donor organs. Although a number of clinical trials testing different liver assist devices are under way, these systems alone have no significant effect on patient survival and are only regarded as a useful approach to bridge patients with AHF to liver transplantation. As a result, reproducible experimental animal models resembling the clinical conditions are still needed. The three main approaches used to create an animal model for AHF are: surgical procedures, toxic liver injury and infective procedures. Most common models are based on surgical techniques (total/partial hepatectomy, complete/transient devascularization) or the use of hepatotoxic drugs (acetaminophen, galactosamine, thioacetamide, and others), and very few satisfactory viral models are available. We have recently developed a viral model of AHF by means of the inoculation of rabbits with the virus of rabbit hemorrhagic disease. This model displays biochemical and histological characteristics, and clinical features that resemble those in human AHF. In the present article an overview is given of the most widely used animal models of AHF, and their main advantages and disadvantages are reviewed. | María Jesús Tuón Marcelino Alvarez Jesús M Culebras Javier González-Gallego | 2009 | World Journal of Gastroenterology2009，15，25： | 29 |
| 2 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 3 | 几内亚比绍共和国农业生产现状显示文摘几内亚比绍共和国位于非洲西部,大陆部分北接塞内加尔,东、南邻几内亚,西濒大西洋。国土面积36125km2地势东北高西南低,除东南隅为平缓丘陵热带森林地带外(博埃山海拔300m,为全境最高点),其他地区均为海拔100m以下的平原。境内河流纵横,湖泊众多。 | 卢远华 朱穆君 杨恒 Marcelino Waz Julio Malam | 2012 | 农业开发与装备2012，，6： | 2 |
| 4 | Intravoxel incoherent motion MR imaging for prostate cancer: An evaluation of perfusion fraction and diffusion coefficient derived from different b ‐value combinations显示文摘 | Yuxi Pang Baris Turkbey Marcelino Bernardo Jochen Kruecker Samuel Kadoury Maria J. Merino Bradford J. Wood Peter A. Pinto Peter L. Choyke | 2012 | Magn Reson Med2012，，： | 2 |
| 5 | Configuration and validation of a novel prostate disease nomogram predicting prostate biopsy outcome:A prospective study correlating clinical indicators among Filipino adult males with elevated PSA level显示文摘Objective:To configure and validate a novel prostate disease nomogram providing prostate biopsy outcome probabilities from a prospective study correlating clinical indicators and diagnostic parameters among Filipino adult male with elevated serum total prostate specific antigen(PSA)level.Methods:All men with an elevated serum total PSA underwent initial prostate biopsy at our institution from January 2011 to August 2014 were included.Clinical indicators,diagnostic parameters,which include PSA level and PSA-derivatives,were collected as predictive factors for biopsy outcome.Multiple logistic-regression analysis involving a backward elimination selection procedure was used to select independent predictors.A nomogram was developed to calculate the probability of the biopsy outcomes.External validation of the nomogram was performed using separate data set from another center for determination of sensitivity and specificity.A receiver-operating characteristic(ROC)curve was used to assess the accuracy in predicting differential biopsy outcome. | Michael E.Chua Patrick P.Tanseco Jonathan S.Mendoza Josefino C.Castillo Marcelino L.Morales Jr Saturnino L.Luna Jr | 2015 | Asian Journal of Urology2015，2，2： | 2 |
| 6 | Cervical spinal cord injury complicating ankylosing spondylitis 显示文摘 | Foo D Sarkarati M Marcelino V | 1985 | Paraplegia1985，23，6： | 1 |
| 7 | Effects of tungsten carbide thermal spray coating by HP/HVOF and hard chromium electroplating on AISI 4340 high strength steel显示文摘 | Renato C S Ivancy M M | 2001 | Surface and Coatings Technology2001，138，： | 1 |
| 8 | Estimating a socially optimal water price for irrigation versus an environmentally optimal water price through the use of Geographical Information Systems and Social Accounting Matrices显示文摘 | Esteban Castellano Pablo Martínez Anguita José I Elorrieta Marcelino Pellitero Concepción Rey | 2008 | Environmental and Resource Economics2008，，3： | 1 |
| 9 | Methodology for generation of heliostat field layout in central receiver systems based on yearly normalized energy surfaces 显示文摘 | MARCELINO S | 2006 | Solar Energy2006，80，： | 1 |
| 10 | Achieving the nitrite pathway using aeration phase length control and step-feed in an SBR removing nutrients from abattoir wastewater显示文摘 | LEMAIRE R MARCELINO M YUAN Zhi-guo | 2008 | Biotechnology and Bioengineering2008，100，6： | 1 |
| 11 | Complications of liver transplantation: multimodality imaging approach 显示文摘 | Caiado AH Blasbalg R Marcelino AS | 2007 | Radiographics2007，27，5： | 1 |
| 12 | Non-invasive positive pressure ventilation improves outcomes for people with acute pulmonary edema and chronic heart failure显示文摘 | Marcelino P | | 0，，02： | 1 |
| 13 | Heteroduplexes in mixed-template amplifications: formation, consequence and elimination by reconditioning PCR显示文摘 | Thompson J Marcelino L Polz M | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 14 | Heteroduplexes in mixed-template amplifications:formation,consequence and elimination by 'reconditioning PCR'显示文摘 | Thompson J R Marcelino L A Polz M F | 2000 | Nucleic Acids Res2000，30，： | 1 |
| 15 | Sulfite residues on litchi fruit treated with sulfur dioxide显示文摘 | Robert E Paull Maria Eloisa Q Reyes Marcelino U Reyes | 1998 | Postharvest Biology and Technology1998，14，： | 1 |
| 16 | Compensatory responses of an arid land crucifer, Chorispora tenella (Brassicaceae), to experimental flower removal显示文摘 | Gómez José M Fuentes Marcelino | 2001 | Journal of Arid Environments2001，，10： | 1 |
| 17 | Transient numerical study of the effect of ambient temperature on 2 - D cereal grain storage in cy- lindrical silos 显示文摘 | Marcelino Carrera - Roddguez Gloria M Martinez - Gonz61ez | 2011 | Journal of Stored Products Research2011，47，： | 1 |
| 18 | Heteroduplexes in mixedtemplate amplifications :formation ,consequence and elimination by 'reconditioning PCR'显示文摘 | THOMPSON JR MARCELINO L A POLZ M F | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 19 | Non-invasive positive pressure ventilation improves outcomes for people with acute pulmonary edema and chronic heart failure显示文摘 | Marcelino P | | 0，，02： | 1 |
| 20 | Cervical spinal cord injury complicating ankylosing spondylitis显示文摘 | Foo D Sarkarati M Marcelino V | 1985 | Paraplegia1985，23，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员